) 电子科技大学生命科学与技术学院, 神经信息教育部重点实验室, 成都 611731
收稿日期:2021-03-17发布日期:2021-10-26通讯作者:姚树霞E-mail:yaoshuxia@uestc.edu.cn基金资助:中国博士后科学基金一等面上项目(2017M620419)The modulatory effects of oxytocin on learning and memory: Evidence from animal and human studies
ZHOU Menghan, ZHANG Yuan, GAO Shan, Keith M. Kendrick, YAO Shuxia() Key Laboratory of Neuroinformation, Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China
Received:2021-03-17Published:2021-10-26Contact:YAO Shuxia E-mail:yaoshuxia@uestc.edu.cn摘要/Abstract
摘要： 作为一种神经肽, 催产素对于个体社会认知和情绪加工有着非常重要的调节作用, 其中就包括对在人们工作和生活中扮演着关键角色的学习和记忆活动的影响。采用不同模态技术的动物和人类研究一致表明了外源性催产素对于学习和记忆具有重要的调节作用, 这一作用可能是外源性催产素通过与多巴胺奖赏通路、边缘系统等学习和记忆关键脑网络中广泛分布的催产素受体相结合, 进而调整其功能状态实现的; 但与此同时, 催产素对学习和记忆的促进或抑制作用会因实验范式、刺激材料、给药时间、位置和剂量等因素的不同而存在差异。未来需要协同动物和人类研究的各自优势, 采用规范化的实验任务设置和给药程序克服当前该领域的研究局限, 并积极发掘催产素在干预相关精神疾病患者学习和记忆加工缺陷中的应用潜力。
图/表 5
图1催产素调节动物和人类学习和记忆效应示意图. Hippocampus:海马; Dorsal septal nucleus: 背侧隔核; Hippocampal dentate gyrus: 海马齿状回; Dorsal raphe nucleus: 中脑背侧中缝核; Nucleus basalis of Meynert: 迈内特基底核; Anterior cingulate cortex: 前扣带回皮层; Caudate nucleus: 尾状核; Thalamus: 丘脑; Putamen: 壳核; Prefrontal cortex: 前额叶皮层; Amygdala: 杏仁核
图1催产素调节动物和人类学习和记忆效应示意图. Hippocampus:海马; Dorsal septal nucleus: 背侧隔核; Hippocampal dentate gyrus: 海马齿状回; Dorsal raphe nucleus: 中脑背侧中缝核; Nucleus basalis of Meynert: 迈内特基底核; Anterior cingulate cortex: 前扣带回皮层; Caudate nucleus: 尾状核; Thalamus: 丘脑; Putamen: 壳核; Prefrontal cortex: 前额叶皮层; Amygdala: 杏仁核表1催产素对动物学习的影响研究
| 研究 | 被试 | 实验范式 | 给药位置 | 剂量 | 给药时间点 | 结论 |
|---|---|---|---|---|---|---|
| Bohus, Urban等人( | 大鼠 | 被动回避 | 脑室 | 0.1/1.0 ng | 测试前24小时 | ↓ |
| Bohus, Kovács等人( | 大鼠 | 被动回避 | 脑室 | 1 μg | 学习后0/3/6/23小时 | ↓ |
| Kovács等人( | 大鼠 | 被动回避 | 背侧隔核/海马齿状回/中脑背侧中缝核 | 25/25/50 pg | 测试前10天 | ↑/↓/↓ |
| Tomizawa等人( | 小鼠 | 迷宫任务 | 脑室 | 2 ng | 测试前连续12天 | ↑ |
| Wu等人( | 大鼠 | 记忆测试 | 迈内特基底核 | 0.2/2/10 nmol | 测试前1小时 | ↓(2/10 nmol) |
表1催产素对动物学习的影响研究
| 研究 | 被试 | 实验范式 | 给药位置 | 剂量 | 给药时间点 | 结论 |
|---|---|---|---|---|---|---|
| Bohus, Urban等人( | 大鼠 | 被动回避 | 脑室 | 0.1/1.0 ng | 测试前24小时 | ↓ |
| Bohus, Kovács等人( | 大鼠 | 被动回避 | 脑室 | 1 μg | 学习后0/3/6/23小时 | ↓ |
| Kovács等人( | 大鼠 | 被动回避 | 背侧隔核/海马齿状回/中脑背侧中缝核 | 25/25/50 pg | 测试前10天 | ↑/↓/↓ |
| Tomizawa等人( | 小鼠 | 迷宫任务 | 脑室 | 2 ng | 测试前连续12天 | ↑ |
| Wu等人( | 大鼠 | 记忆测试 | 迈内特基底核 | 0.2/2/10 nmol | 测试前1小时 | ↓(2/10 nmol) |
表2催产素对人类学习的影响研究
 |
表2催产素对人类学习的影响研究
| |
表3催产素对动物记忆的影响研究
| 研究 | 被试 | 实验范式 | 给药位置 | 剂量 | 给药时间点 | 结论 |
|---|---|---|---|---|---|---|
| Benelli等人( | 大鼠 | 社会识别任务 | 脑室 | 1 fg~10 ng | 首次接触后5分钟 | ↑ |
| Dantzer等人( | 大鼠 | 社会识别任务 | 脑室 | 6 μg/kg | 识别前30分钟 | ↓ |
| Ferguso等人( | 小鼠 | 迷宫任务/基因敲除 | 脑室 | 1 ng | 测试前 | ↑ |
| Gard等人( | 大鼠 | 新事物识别 | 脑室 | 0.1 ng/kg | 训练后 | ↑ |
| Popik和Vetulani( | 大鼠 | 社会记忆范式 | 外周 | 12/24 μg/kg | 首次接触后 | ↓(24 μg/kg) |
| Popik等人( | 大鼠 | 社会识别任务 | / | 0.09 ~ 6 ng. kg-1 | 首次接触后 | ↑ |
表3催产素对动物记忆的影响研究
| 研究 | 被试 | 实验范式 | 给药位置 | 剂量 | 给药时间点 | 结论 |
|---|---|---|---|---|---|---|
| Benelli等人( | 大鼠 | 社会识别任务 | 脑室 | 1 fg~10 ng | 首次接触后5分钟 | ↑ |
| Dantzer等人( | 大鼠 | 社会识别任务 | 脑室 | 6 μg/kg | 识别前30分钟 | ↓ |
| Ferguso等人( | 小鼠 | 迷宫任务/基因敲除 | 脑室 | 1 ng | 测试前 | ↑ |
| Gard等人( | 大鼠 | 新事物识别 | 脑室 | 0.1 ng/kg | 训练后 | ↑ |
| Popik和Vetulani( | 大鼠 | 社会记忆范式 | 外周 | 12/24 μg/kg | 首次接触后 | ↓(24 μg/kg) |
| Popik等人( | 大鼠 | 社会识别任务 | / | 0.09 ~ 6 ng. kg-1 | 首次接触后 | ↑ |
表4催产素对人类记忆的影响研究
| 研究 | 被试 | 实验范式 | 给药方式 | 剂量 | 给药时间点 | 刺激类型 | 神经基础 | 结论 |
|---|---|---|---|---|---|---|---|---|
| Bruins等 ( | 20女/ 23男 | 记忆测试 | 鼻喷 | 20 IU | 测试前10分钟 | 抽象/社会性刺激(积极/消极面孔) | / | ↓(抽想词汇) |
| Guastella等 ( | 69男 | 记忆测试 | 鼻喷 | 24 IU | 学习前45分钟 | 社会性刺激(中性/高兴/愤怒面孔) | / | ↑(高兴面孔) |
| Heinrichs等 ( | 38男 | 外显/内隐测试 | 鼻喷 | 24 IU | 学习前50分钟 | 词汇(与繁殖相关/中性) | / | ↓(内隐繁殖词汇/外显) |
| Herzmann等 ( | 28男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性(中性面孔)/非社会性刺激 | / | ↓ |
| Herzmann等 ( | 26女/ 26男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性刺激(中性/高兴面孔) | / | ↑ |
| Rimmele等 ( | 41男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性刺激(中性/积极/消极面孔) | / | ↑(社会性刺激) |
| Savaskan等 ( | 18女/ 18男 | 再认记忆测试 | 鼻喷 | 20 IU | 学习后 | 社会性刺激(中性/高兴/愤怒面孔) | / | ↑(中性/愤怒面孔) |
表4催产素对人类记忆的影响研究
| 研究 | 被试 | 实验范式 | 给药方式 | 剂量 | 给药时间点 | 刺激类型 | 神经基础 | 结论 |
|---|---|---|---|---|---|---|---|---|
| Bruins等 ( | 20女/ 23男 | 记忆测试 | 鼻喷 | 20 IU | 测试前10分钟 | 抽象/社会性刺激(积极/消极面孔) | / | ↓(抽想词汇) |
| Guastella等 ( | 69男 | 记忆测试 | 鼻喷 | 24 IU | 学习前45分钟 | 社会性刺激(中性/高兴/愤怒面孔) | / | ↑(高兴面孔) |
| Heinrichs等 ( | 38男 | 外显/内隐测试 | 鼻喷 | 24 IU | 学习前50分钟 | 词汇(与繁殖相关/中性) | / | ↓(内隐繁殖词汇/外显) |
| Herzmann等 ( | 28男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性(中性面孔)/非社会性刺激 | / | ↓ |
| Herzmann等 ( | 26女/ 26男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性刺激(中性/高兴面孔) | / | ↑ |
| Rimmele等 ( | 41男 | 再认记忆测试 | 鼻喷 | 24 IU | 学习前40分钟 | 社会性刺激(中性/积极/消极面孔) | / | ↑(社会性刺激) |
| Savaskan等 ( | 18女/ 18男 | 再认记忆测试 | 鼻喷 | 20 IU | 学习后 | 社会性刺激(中性/高兴/愤怒面孔) | / | ↑(中性/愤怒面孔) |
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