1 山西师范大学教育科学学院心理系
2 山西师范大学现代文理学院教育系
3 山西师范大学网络信息中心, 临汾041004
收稿日期:2018-07-03出版日期:2019-07-26发布日期:2019-06-25基金资助:*山西省应用基础研究计划面上青年项目(201801D 221391);山西省高等学校哲学社会科学研究项目(201803014);山西省教育科学“十三五”规划课题(GH-17028);2018年度山西师范大学现代文理学院基础研究重点项目(2018JCYJ13)Modulating maladaptive human memory: Evidence from reconsolidation
LIU Peng1,2, SHEN Hongkui31 Department of Psychology, Institute of Education Sciences, Shanxi Normal University, Linfen 041000, China
2 Institute of Education, Modern College of Humanities and Sciences of Shanxi Normal University, Linfen 041000, China
3 Shanxi Normal University Network Information Center, Linfen 041000, China
Received:2018-07-03Online:2019-07-26Published:2019-06-25摘要/Abstract
摘要： 已经巩固的长时记忆被再次提取后, 进入一个记忆的不稳定期, 在此过程中, 记忆可被更新、强化、削弱甚至抹除, 这个过程称为再巩固。人类不良记忆再巩固研究揭示记忆激活后口服普萘洛尔(propranolol)或进行消退训练可削弱或抹除不良情绪记忆, 此过程中涉及杏仁核、海马、前额叶皮层等脑区的参与及其构成的神经环路的调控。当前临床上利用再巩固原理可通过药物治疗、行为干预或无创脑部刺激的方法改变不良记忆。然而, 由于其形成过程复杂并受多种因素影响, 未来研究应尽可能模拟临床中人类不良记忆形成的复杂环境, 深入探讨再巩固“边界问题”, 推动实验室研究向临床应用的转化。
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