贾琪,
孙松,
孙天昊,
林文雄^,
福建农林大学作物科学学院/作物遗传育种与综合利用教育部重点实验室/作物生态与分子生理学福建省高校重点实验室 福州 350002
基金项目: 中国博士后科学基金2014T70603
教育部留学归国人员科研启动基金Education Department Liu[2013]1792
国家自然科学基金青年科学基金项目31501232

详细信息

作者简介:贾琪, 研究方向为植物抗逆性与分子遗传学。E-mail:jiaqi@fafu.edu.cn

通讯作者:林文雄, 研究方向为植物生理与分子生态学。E-mail:wenxiong181@163.com

中图分类号:Q945;Q948.1;Q37

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出版历程

收稿日期:2017-12-15
录用日期:2018-04-20
刊出日期:2018-08-01

Mechanism of F-box protein family in plant resistance response to environmental stress

JIA Qi,
SUN Song,
SUN Tianhao,
LIN Wenxiong^,
College of Crop Sciences, Fujian Agriculture and Forestry University/Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Crop Utilization/Key Laboratory of Crop Ecology and Molecular Physiology(Fujian Province University), Fuzhou 350002, China
Funds: the China Postdoctoral Science Foundation2014T70603
the Scientific Research Starting Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of ChinaEducation Department Liu[2013]1792
the National Natural Sciences Foundation of China31501232

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Corresponding author:LIN Wenxiong, E-mail:wenxiong181@163.com

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摘要
摘要:SCF复合体泛素连接酶E3介导的泛素化蛋白降解是翻译后水平上对生命进程进行调控的一个重要方式。它的关键组分F-box蛋白负责识别被降解的靶底物蛋白。植物F-box基因家族成员众多，极具多样性。F-box蛋白N端常含F-box基序，C端常为蛋白互作保守结构域，该结构具多样性，可识别不同底物，是F-box蛋白分类的依据。研究表明，F-box蛋白参与调控植物的许多生命进程，包括抗逆反应。本文就近年来F-box蛋白在植物抗逆反应中的作用机制进行总结。F-box蛋白大多以SCF复合体泛素连接酶E3介导的泛素化蛋白降解目标蛋白的方式调控抗逆反应，也有不依赖形成SCF复合体的方式行使功能，不少F-box蛋白参与了植物激素信号传导，通过调控转录因子活性而改变下游基因的表达，由此影响了植物的抗逆反应。基因表达谱的生物信息学预测表明，大多数F-box基因参与了植物抗逆反应，目前只有其中一小部分已报道了其抗逆调节功能。在此综述了这些F-box蛋白在植物抗逆胁迫中的研究进展。在干旱和盐碱胁迫反应中，F-box基因常通过影响植物激素脱落酸、乙烯等植物激素信号传导而调控抗逆。由于干旱和盐碱胁迫具协同性，不少F-box基因同时参与抗旱和抗盐碱胁迫，但调节方式有所不同，一些F-box基因对抗干旱和盐碱的反应具协同性，从总体上调控植物的渗透胁迫和离子毒害反应；而另一些F-box基因对干旱和盐胁迫反应的调节作用相反，它们可能在植物抗逆的精细调节中起作用。在低温胁迫反应中，F-box蛋白可调节植物抗低温的CBF信号途径。在生物胁迫反应中，F-box基因常通过影响植物激素茉莉酸和水杨酸途径来调控抗病，病原菌也以攻击植物SCF复合体使植物致病。此外，植物激素信号途径之间相互作用，共同影响抗逆反应。
关键词:F-box蛋白家族/
SCF复合体/
植物/
环境胁迫/
抗逆反应
Abstract:The UPS (ubiquitin proteasome system) mediated by SCF type E3 ubiquitin-ligase is an important mechanism to regulate biological progress at post-translation level. F-box protein, as a key component in SCF complex, could recognize its target protein for degradation. F-box gene family contains numerous members with vast diversity. In general, F-box protein contains F-box motif at N terminus and conserved domain of protein-protein interaction for recognizing target at C terminus. Due to vast diversity of conserved C terminus domains, F-box proteins could recognize wide varieties of targets. Also based on C terminal domains, F-box proteins could be divided into several subfamilies. It showed that plant F-box proteins were involved in many life processes, including response to environmental stress. Here, we reviewed current knowledge of plant F-box proteins in responding to stress. Most of the reported F-box proteins had been shown to function via SCF-dependent protein degradation, with few using SCF-independent mechanisms. Some well-understood F-box proteins were involved in phytohormone signaling pathways. Some reacted to stress through regulating the activity of transcription factors, which influenced expression of downstream genes responding to stress. Bioinformatics analyses of transcriptome showed that many predicted F-box genes were involved in stress-response reactions. Among these, only a few studies had dealt with the functions. The knowledge on the functions under environmental stress was summarized in this study. For drought, salinity and alkality stresses, F-box genes often regulated abscisic acid or ethylene signal pathways. Since drought and salt-alkaline stresses often occurred concomitantly, quite a few F-box genes had been identified to be involved in the response to both stresses in different ways. Some regulated the response to osmotic stress and ionic stress synergistically. However, some functioned inversely, suggesting that they played a role in fine regulations. For cold stress, F-box genes regulated CBF signal pathways. For biotic stress, F-box genes always regulated jasmonate and salicylic acid pathways. Meanwhile, pathogens attacked plant SCF complex for infection. Moreover, phytohormones had crosstalk to coordinate resistance in plants.
Key words:F-box protein/
SCF complex/
Plant/
Environment stress/
Response to stress

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图1复合体介导的蛋白泛素化降解
Figure1.SCF complex mediated protein ubiquitylation and protein degradation


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表1参与植物激素信号传导的F-box蛋白
Table1.F-box proteins involved in phytohormone signaling

F-box蛋白 F-box protein	靶蛋白结合序列 Conserved domains for interaction with targets	物种 Species	激素途径 Phytohormone pathways	靶蛋白 Targets	参考文献 References
TIR1, AFB1-5	LRR	拟南芥? Arabidopsis thaliana	生长素受体?Auxin receptor	AUX/IAA(负调控蛋白) (Negative regulator)	[39-40, 42-43]
COI1	LRR	拟南芥? Arabidopsis thaliana	茉莉酸受体?JA receptor	JAZ(负调控蛋白) (Negative regulator)	[44-46]
SLY1, SNE	GGF, LSL	拟南芥? Arabidopsis thaliana	与赤霉素受体GID1互作?Interact with GA receptor GID1	DELLAs	[47-49]
GID2	GGF, LSL	水稻?Oryza sativa		DELLAs	[50-52]
EBF1-2	LRR	拟南芥? Arabidopsis thaliana	乙烯?Ethylene	EIN3, EIL1(正调控蛋白) ? (Positive regulator)	[53-55]
ETP1-2	FBA			EIN2 (稳定EIN3, EIL1) ? (Stabilize EIN3, EIL1)	[56-57]
MAX2	LRR	拟南芥? Arabidopsis thaliana	与独角金内酯受体D14互作?Interact with SL receptor D14	BES1	[58-60]
DWARF3 (D3)	LRR	水稻?Oryza sativa		D53	[61-62]
RMS4	LRR	豌豆? Pisum sativum	独角金内酯途径, 与MAX2同源?SL pathway, homolog of MAX2	—	[63]
MAX2a	LRR	矮牵牛花? Petunia hybrida	与拟南芥、水稻独角金内酯受体D14同源的DAD2互作?Interact with DAD2, a homolog of D14	—	[64-65]
RIFP1	LRR	拟南芥? Arabidopsis thaliana	ABA途径, 负调控蛋白?ABA pathway, negative regulator	RCAR3(ABA受体) (ABA receptor)	[66]
PP2-B11	PP2		ABA途径, 负调控蛋白?ABA pathway, negative regulator	SnRK2.3/AtLEA14	[67-69]
DOR	FBA		ABA合成, 负调控蛋白?ABA synthesis, negative regulator		[70]
EDL3	LRR		ABA途径, 正调控蛋白?ABA pathway, positive regulator	—	[71]
TLP9	Tubby		ABA途径, 正调控蛋白?ABA pathway, positive regulator	—	[72]
FOA1	FBA		ABA途径, 负调控蛋白?ABA pathway, negative regulator	—	[73]
AFBA1	FBA	拟南芥? Arabidopsis thaliana	ABA途径, 正调控蛋白, 与MYB44结合, 保持其稳定性?ABA pathway, positive regulator, interact with MYB44 to stabilize it	？转录因子TCP4, TCP4, MYB44 Transcriptor factors	[74]
CPR1/CPR30	FBA	拟南芥? Arabidopsis thaliana	水杨酸途径, 负调控蛋白?SA pathway, negative regulator	SNC1 RPS2	[75-78]
KIB1	Kelch	拟南芥? Arabidopsis thaliana	芸苔素途径, 正调控蛋白?BR pathway, positive regulator	BIN2	[79]
“?”表示酵母双杂交找到的互作底物蛋白, 未有介导26S蛋白水解酶降解的证据。“?”: the substrates had been identified by yeast two hybrid, but no evidence supported that they would be degraded by 26S proteasome.

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