组长简介
范青华，男，1966年生于湖南省茶陵县。1989年毕业于湘潭大学化学系，1992年在中国科学院化学研究所获得硕士学位，1998在香港理工大学应用生物与化学科技系获得博士学位。现任中国科学院化学研究所研究员，博士生导师，中国科学院分子识别与功能重点实验室主任。2003年获国家****科学基金资助，作为第二完成人获2005年国家自然科学二等奖，2009年获国务院政府特殊津贴。目前主要研究领域为不对称催化和树状大分子的设计合成及功能应用。[详细]
研究方向
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
联系我们
中国科学院化学研究所分子识别与功能院重点实验室
地址：北京市海淀区中关村北一街2号邮编：100190
电话：；传真：；
邮箱：fanqh@iccas.ac.cn
课题组简介
中国科学院化学研究所不对称催化与有机功能分子合成研究组成立于1998年初。目前课题组由四位工作人员和包括研究生在内的十位左右的流动人员组成，在不对称催化和树状大分子的设计合成及功能应用等领域开展基础和应用基础研究。
作为生命过程的重要化学基础，识别、组装和催化一直是有机化学研究的前沿和核心内容。课题组一方面针对手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题，发展高效、实用和环境友好的不对称催化反应，以及可方便分离回收的手性催化剂新体系；另一方面基于树状大分子结构的特异性，发展新型的功能有机分子，以及它们在不对称催化、自组装和有机功能材料领域中的应用共发表文章140余篇，著作10篇，申请专利5项......
代表性成果
组长简介
范青华，男，1966年生于湖南省茶陵县。1989年毕业于湘潭大学化学系，1992年在中国科学院化学研究所获得硕士学位，1998在香港理工大学应用生物与化学科技系获得博士学位。现任中国科学院化学研究所研究员，博士生导师，中国科学院分子识别与功能重点实验室主任。2003年获国家****科学基金资助，作为第二完成人获2005年国家自然科学二等奖，2009年获国务院政府特殊津贴。目前主要研究领域为不对称催化和树状大分子的设计合成及功能应用。[详细]
研究方向
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
联系我们
中国科学院化学研究所分子识别与功能院重点实验室
地址：北京市海淀区中关村北一街2号邮编：100190
电话：；传真：；
邮箱：fanqh@iccas.ac.cn
课题组简介
中国科学院化学研究所不对称催化与有机功能分子合成研究组成立于1998年初。目前课题组由四位工作人员和包括研究生在内的十位左右的流动人员组成，在不对称催化和树状大分子的设计合成及功能应用等领域开展基础和应用基础研究。
作为生命过程的重要化学基础，识别、组装和催化一直是有机化学研究的前沿和核心内容。课题组一方面针对手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题，发展高效、实用和环境友好的不对称催化反应，以及可方便分离回收的手性催化剂新体系；另一方面基于树状大分子结构的特异性，发展新型的功能有机分子，以及它们在不对称催化、自组装和有机功能材料领域中的应用共发表文章140余篇，著作10篇，申请专利5项......
代表性成果
课题组成员
范青华研究员
组内成员 何艳梅高级工程师
冯宇副研究员
陈飞副研究员
罗祎迩
李程皓
张珊珊
唐雨平
李发举
张树辛
潘一骁
王立人
已毕业学生 杨夕强
张锐
刘国华
杨佰远
邓国军
张毅力
易兵
李保林
黄毅勇
吴磊
刘子桐
王志坚
李永
李志伟
张凤
孙亚伟
冯宇
王天利
吕金良
陈飞
王立颖
秦杰
马保德
赵智勇
丁子元
刘继
刘志雄
宋凤涛
欧阳光辉
张建伟
吴芬
马文鹏
许聪
苗婷婷
陈娅
刘友然
联合培养 汤卫军
周海峰
赵立文
陈辉
阳珠生
彭艺
李滨
王立人
课题组成员
范青华 研究员
Prof.Qing-Hua Fan
何艳梅 高级工程师
Yan-Mei He
冯宇 副研究员
Dr.Yu Feng
陈飞 副研究员
Dr.Fei Chen
潘一骁 18博后
Yi-Xiao Pan (postdoc.)
罗祎迩 14硕博
Yi-Er Luo (D4)
李程皓 15硕博
Cheng-Hao Li(D2)
张珊珊 15硕博
Shan-ShanZhang (D2)
唐雨平16硕博
Yu-Ping Tang (D1)
张树辛 17硕博
Shu-Xin Zhang (M2)
李发举 17硕博
Fa-Ju Li (M2)
王立人 17硕士
Li-Ren Wang (M2)
Former Members
欢迎各位已毕业师兄师姐更新自己信息
请发邮件给chenfei211@iccas.ac.cn，格式可参考陈飞，群：**
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杨夕强 (Xi-Qiang Yang)
（1998-2001）
河北省承德石油高等专科
张 锐 (Rui Zhang)
（1998-2001）
刘国华 (Guo-Hua Liu)
（1999-2002）
上海师范大学
杨佰远 (Bai-Yuan Yang)
（2000-2003）
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邓国军(Guo-Jun Deng)
（1999-2004）
湘潭大学
张毅力 (Yi-Li Zhang)
（2000-2004）
易 兵 (Bing Yi)
（2001-2004）
湖南工程学院
李保林 (Bao-Lin Li)
（2002-2007）
中国科学院大学
黄毅勇 (Yi-Yong Huang)
（2004-2007）
武汉理工大学
吴 磊 (Lei Wu)
（2004-2007）
南京农业大学
刘子桐 (Zi-Tong Liu)
（2003-2008）
中国科学院化学研究所
王志坚 (Zhi-Jian Wang)
（2003-2008）
Lawrence Berkeley National Lab
李 永 (Yong Li)
（2005-2008）
河南教育学院
李志伟 (Zhi-Wei Li)
（2005-2008）
长沙理工大学
张 凤 (Feng Zhang)
（2004-2009）
湖南农业大学
孙亚伟 (Ya-Wei Sun)
（2006-2009）
中国石油大学（华东）
冯 宇 (Yu Feng)
（2005-2010）
中国科学院化学研究所
王天利 (Tian-Li Wang)
（2006-2011）
四川大学
吕金良 (Jin-Liang Lv)
（2008-2011）
湖北宜昌人福药业
陈 飞 (Fei Chen)
（2007-2012）
中国科学院化学研究所
王立颖 (Li-Ying Wang)
（2007-2012）
weliy出版社
秦 杰 (Jie Qin)
（2009-2012）
中国建筑
马保德 (Bao-De Ma)
（2008-2013）
南方科技大学
赵智勇 (Zhi-Yong Zhao）
（2008-2013）
武汉科技大学
丁子元 (Zi-Yuan Ding)
（2010-2013）
中粮集团
刘 继 (Ji Liu)
（2010-2013）
浙江新安化工
刘志雄（Zhi-Xiong Liu）
（2009-2014）
中国科学院宁波材料所
宋凤涛（Feng-Tao Song )
（2011-2014）
康龙化成新药技术有限公司
欧阳光辉 （Guang-Hui Ouyang )
（2010-2015）
中国科学院化学研究所
张建伟 （Jian-Wei Zhang )
（2012-2015）
清华大学
吴芬 （Fen Wu)
（2011-2016）
温州大学
马文鹏（Wen-Peng Ma )
（2013-2016）
清华大学
苗婷婷 （Ting-Ting Miao )
（2012-2017）
温州大学
刘友然 （You-Ran Liu )
（2014-2019）
?
许聪（CongXu )
（2015-2019）
?
陈娅 （YaChen )
（2017-2019）
?
?
?
?
Jioned Members:
汤卫军 (Wei-Jun Tang)
（2002-2008）
陕西师范大学
周海峰 (Hai-Feng Zhou)
（2003-2007）
三峡大学
赵立文 (Li-Wen Zhao)
（2003-2005）
南京圣和药业
陈辉 (Hui Chen)
（2013-2015）
阳珠生 (Zhu-Sheng Yang)
（2013-2017）
彭艺 (Yi Peng)
（2015-2017）
? ?
李滨 (Bin Li)
（2016-2018）
? ?
?
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课题组长
范青华研究员
组内成员 何艳梅高级工程师
冯宇副研究员
陈飞副研究员
罗祎迩
李程皓
张珊珊
唐雨平
李发举
张树辛
潘一骁
王立人
已毕业学生 杨夕强
张锐
刘国华
杨佰远
邓国军
张毅力
易兵
李保林
黄毅勇
吴磊
刘子桐
王志坚
李永
李志伟
张凤
孙亚伟
冯宇
王天利
吕金良
陈飞
王立颖
秦杰
马保德
赵智勇
丁子元
刘继
刘志雄
宋凤涛
欧阳光辉
张建伟
吴芬
马文鹏
许聪
苗婷婷
陈娅
刘友然
联合培养 汤卫军
周海峰
赵立文
陈辉
阳珠生
彭艺
李滨
王立人
Prof. Dr. Qing-Hua Fan
范青华 研究员（Prof. Dr. Qing-Hua Fan）
范青华，1966生于湖南省茶陵县。现任中国科学院化学研究所研究员、博士生导师，中国科学院分子识别与功能重点实验室主任。1989年毕业于湘潭大学化学系，1992年在中国科学院化学研究所获得硕士学位，1998在香港理工大学应用生物与化学科技系获得博士学位，导师为陈新滋院士。1992-1995年任中国科学院化学研究所实习研究员和助理研究员，1998年通过中国科学院化学研究所优秀人才招聘计划回所工作，任副研究、课题组长，2003年聘任为中国科学院化学研究所研究员。2003年获国家****科学基金资助，2009年获国务院政府特殊津贴。目前主要研究领域为不对称催化和树状大分子的设计合成及功能应用。共发表研究论文140余篇，其中Chem. Rev.1篇, Angew. Chem. Int. Ed.5篇, J. Am. Chem. Soc.3篇，H-因子为30；撰写和主编专著3部；应邀参加国内外学术会议并作邀请报告40余次。部分成果作为第二完成人获2005年国家自然科学二等奖。
Qing-Hua Fan was born in 1966 in Hunan Province, China. He received his B.S. degree from the Department of Chemistry, Xiangtan University in 1989, M.S. degree from Institute of Chemistry, Chinese Academy of Sciences (ICCAS) in 1992. Then he was pursued research into silicon polymers and related advanced functional materials as an assistant professor in ICCAS. In 1995, he joined Professor Albert S. C. Chan’s group at The Hong Kong Polytechnic University and obtained his Ph.D. degree in 1998. After that, he returned to Beijing to take up the position as an associate professor and became a research group leader in ICCAS. In 2003, he was promoted to professor. He received Outstanding Young Scientist Awards of National Natural Science Foundation of China in 2003. His research interests focus on asymmetric catalysis, environmentally benign catalytic reactions, synthesis of biologically active heterocyclic compounds, and molecular design and self-assembly of functional dendrimers. He has authored over 140 publications, H-index 30. In 2005,he received the second-class prize of National Natural Science Award (rank 2).
Contact Information:
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry , Chinese Academy of Sciences (CAS),
Zhongguancun North First Street 2,100190 Beijing, P. R. China
Tel.: 86-; Fax.: 86-; E-mail：fanqh@iccas.ac.cn
URL:
Research Interests
Asymmetric catalysis
Environmentally benign catalytic reactions
Molecular design and self-assembly of functional dendrimers
Synthesis of biologically active heterocyclic compounds
网站地图
范青华研究员
组内成员 何艳梅高级工程师
冯宇副研究员
陈飞副研究员
罗祎迩
李程皓
张珊珊
唐雨平
李发举
张树辛
潘一骁
王立人
已毕业学生 杨夕强
张锐
刘国华
杨佰远
邓国军
张毅力
易兵
李保林
黄毅勇
吴磊
刘子桐
王志坚
李永
李志伟
张凤
孙亚伟
冯宇
王天利
吕金良
陈飞
王立颖
秦杰
马保德
赵智勇
丁子元
刘继
刘志雄
宋凤涛
欧阳光辉
张建伟
吴芬
马文鹏
许聪
苗婷婷
陈娅
刘友然
联合培养 汤卫军
周海峰
赵立文
陈辉
阳珠生
彭艺
李滨
王立人
组内成员
?
范青华 研究员
Prof.Qing-Hua Fan
何艳梅 副研究员
Yan-Mei He
冯宇 副研究员
Dr.Yu Feng
陈飞 副研究员
Dr.Fei Chen
刘志雄 09硕博
Zhi-Xiong Liu (D3)
欧阳光辉 10硕博
Guang-Hui Ouyang (D2)
吴芬 11硕博
Fen Wu (D1)
苗婷婷 12硕博
Ting-Ting Miao (M2)
宋凤涛 11博
Feng-Tao Song (D3)
张建伟 12博
Jian-Wei Zhang (D2)
马文鹏13博
Wen-Peng Ma (D1)
网站地图
范青华研究员
组内成员 何艳梅高级工程师
冯宇副研究员
陈飞副研究员
罗祎迩
李程皓
张珊珊
唐雨平
李发举
张树辛
潘一骁
王立人
已毕业学生 杨夕强
张锐
刘国华
杨佰远
邓国军
张毅力
易兵
李保林
黄毅勇
吴磊
刘子桐
王志坚
李永
李志伟
张凤
孙亚伟
冯宇
王天利
吕金良
陈飞
王立颖
秦杰
马保德
赵智勇
丁子元
刘继
刘志雄
宋凤涛
欧阳光辉
张建伟
吴芬
马文鹏
许聪
苗婷婷
陈娅
刘友然
联合培养 汤卫军
周海峰
赵立文
陈辉
阳珠生
彭艺
李滨
王立人
已毕业学生
Ph.D.:
刘国华 (Guo-Hua Liu)
（1999-2002）
上海师范大学
邓国军(Guo-Jun Deng)
（1999-2004）
湘潭大学
张毅力 (Yi-Li Zhang)
（2000-2004）
易 兵 (Bing Yi)
（2001-2004）
湖南工程学院
李保林 (Bao-Lin Li)
（2002-2007）
中国科学院大学
黄毅勇 (Yi-Yong Huang)
（2004-2007）
武汉理工大学
吴 磊 (Lei Wu)
（2004-2007）
南京农业大学
刘子桐 (Zi-Tong Liu)
（2003-2008）
中国科学院化学研究所
王志坚 (Zhi-Jian Wang)
（2003-2008）
Lawrence Berkeley National Lab
李 永 (Yong Li)
（2005-2008）
河南教育学院
李志伟 (Zhi-Wei Li)
（2005-2008）
长沙理工大学
张 凤 (Feng Zhang)
（2004-2009）
湖南农业大学
孙亚伟 (Ya-Wei Sun)
（2006-2009）
中国石油大学（华东）
冯 宇 (Yu Feng)
（2005-2010）
中国科学院化学研究所
王天利 (Tian-Li Wang)
（2006-2011）
National University of Singapore
吕金良 (Jin-Liang Lv)
（2008-2011）
湖北宜昌人福药业
陈 飞 (Fei Chen)
（2007-2012）
中国科学院化学研究所
王立颖 (Li-Ying Wang)
（2007-2012）
Université Pierre et Marie Curie, Paris
秦 杰 (Jie Qin)
（2009-2012）
中国建筑
马保德 (Bao-De Ma)
（2008-2013）
湖南化工研究院
赵智勇 (Zhi-Yong Zhao）
（2008-2013）
香港科技大学
丁子元 (Zi-Yuan Ding)
（2010-2013）
中粮集团
刘 继 (Ji Liu)
（2010-2013）
浙江新安化工
课题组成员
范青华研究员
组内成员 何艳梅高级工程师
冯宇副研究员
陈飞副研究员
罗祎迩
李程皓
张珊珊
唐雨平
李发举
张树辛
潘一骁
王立人
已毕业学生 杨夕强
张锐
刘国华
杨佰远
邓国军
张毅力
易兵
李保林
黄毅勇
吴磊
刘子桐
王志坚
李永
李志伟
张凤
孙亚伟
冯宇
王天利
吕金良
陈飞
王立颖
秦杰
马保德
赵智勇
丁子元
刘继
刘志雄
宋凤涛
欧阳光辉
张建伟
吴芬
马文鹏
许聪
苗婷婷
陈娅
刘友然
联合培养 汤卫军
周海峰
赵立文
陈辉
阳珠生
彭艺
李滨
王立人
单篇全文显示
?
Jioned Members:
汤卫军 (Wei-Jun Tang)
（2002-2008）
陕西师范大学
周海峰 (Hai-Feng Zhou)
（2003-2007）
三峡大学
赵立文 (Li-Wen Zhao)
（2003-2005）
陈辉 (Hui Chen)
（2013-2015）
阳珠生 (Zhu-Sheng Yang)
（2013-2015）
研究领域
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
研究领域
不对称催化与有机功能分子的合成
作为生命过程的重要化学基础，识别、组装和催化一直是有机化学研究的前沿和核心内容。研究工作一方面针对手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题，发展高效、实用和环境友好的不对称催化反应，以及可方便分离回收的手性催化剂新体系；另一方面基于树状大分子结构的特异性，发展新型的功能有机分子，以及它们在不对称催化、自组装及功能材料领域中的应用。具体研究方向包括：
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
一、不对称催化
一、不对称催化
亚胺和含氮芳香杂环化合物的不对称氢化：
过渡金属催化芳香杂环化合物和亚胺的不对称氢化是获得手性杂环化合物和手性胺的最简单高效的方法之一。但由于含氮化合物对催化剂的潜在毒化作用，亚胺化合物的不稳定性及多种异构体的存在，以及芳香杂环化合物的共轭稳定性等不利因素，因此，亚胺类化合物特别是含氮芳香杂环化合物的高效不对称氢化依然十分困难。针对上述问题，一方面利用非传统介质或大分子载体的特殊性质发展高效、可方便分离回收的催化剂新体系，另一方面基于离子型外层催化机理及抗衡阴离子效应发展高效、稳定的离子型手性金属二胺催化剂，实现了系列亚胺包括开链和环状N-烷基亚胺，以及喹啉、喹喔啉和邻菲啰啉等含氮芳香杂环化合物的高效、高立体选择性不对称氢化。
Figure 1. Asymmetric Hydrogenation of Imines and Heteroaromatic Compounds
手性超分子催化剂：
利用超分子识别与组装的基本原理，发展新型超分子手性催化剂及实现催化反应的超分子选择性调控是不对称催化领域新的研究热点和前沿。冠醚是一类具有柔性骨架结构的富电子大环阳离子主体分子，对于碱金属离子、碱土金属离子、有机铵离子及一些缺电子中性分子等都能够进行选择性识别，在超分子化学中显示出独特的魅力。为此，我们开展了基于冠醚/金属冠醚结构的超分子手性金属催化剂研究，发展了新颖的准轮烷手性配体/催化剂以及手性金属冠醚催化剂，实现了主-客体相互作用对催化性能的调控，为手性配体/催化剂的构筑提供了新途径。
Figure 2. Design of Supramolecular Chiral Ligands Based on Psuedorotaxanes
Figure 3. Design of Supramolecular Chiral Catalysts Based on Metallacrown Ethers
二、环境友好的催化反应
二、环境友好的催化反应
据报道，超过70%的化工过程使用溶剂，每年大约2000万吨溶剂挥发。因此，寻找环境友好的反应介质替代传统的有机溶剂是绿色化学的重要研究内容，同时，也为均相催化剂的分离与回收提供了新的途径。为此，基于水、离子液体和液态聚乙二醇等非传统反应介质的特色性质，我们开展了环境友好的不对称催化反应研究。研究发现离子液体和液态聚乙二醇等作为新的绿色反应介质，并非有机溶剂的简单替换，不仅有利于提高催化剂的选择性和稳定性，而且更加方便催化剂的分离与回收，为手性催化剂的实际应用奠定了基础。
Figure 4. Asymmetric Catalysis in Polyethylene Glycols and Ionic Liquids
三、功能树状分子的设计合成及组装
三、功能树状分子的设计合成、组装及应用
树状分子催化剂：
基于酶催化原理，以树状分子为载体，利用树状大分子独特的物理化学性质及其精确可控的分子三维立体结构，通过分子设计在树状分子的表面或核心引入（手性）催化活性中心，构建具有“协同”或“孤立”效应的（手性）催化剂新体系是催化研究领域的前沿和热点之一。我们选择性能优异的小分子配体为研究对象，发展了系列新型树状分子催化剂以及催化剂分离回收新方法。研究表明：树状分子载体不仅方便催化剂的分离与回收，而且更重要的是可以调控催化剂的催化活性和立体选择性，提高催化剂的稳定性能，为负载均相催化剂的分子设计开辟了新的途径。
Figure 5. Dendritic Ligands/Catalysts and Their Applications in Catalysis
树状分子凝胶：
有别于传统利用酰胺基、长链烷基和胆甾体等典型成胶基元所提供的典型氢键和范德华力等非共价弱相互作用来构筑树状分子凝胶体系，我们利用树状分子的协同效应和放大效应，发展了系列基于树状分子外围芳环间多重π-π堆积作用和非典型氢键作用的聚芳醚树状分子凝胶新体系。该类凝胶因子具有优异的成胶性能，成胶溶剂广，成胶浓度低，达到了目前小分子凝胶的最好水平，且突破了目前文献中认为只有低代数树状分子才能有效成胶的限制；通过揭示树状分子结构与成胶性能的关系，为理性设计新型树状分子凝胶因子开辟了新的方向和思路。同时，利用这一特色大分子凝胶因子，发展了系列具有光电功能及对外界刺激具有多重响应性的智能凝胶体系，为树状分子凝胶的功能化和应用拓展了新的方向。
Figure 6. Versatile Dendritic Organogelators & Functional Organogels
树状分子-DNA杂合体：
两亲性DNA嵌段共聚物结合了两亲分子的微相分离特性和DNA的可编程、碱基配对等特性，作为一类新型的超分子构筑基元，在纳米材料和超分子领域显示出其它材料不可比拟的优势，已成为该研究领域的新增长点。为此，我们与清华大学刘冬生教授课题组合作，选择具有不同分子体积、拓扑结构及亲疏水性质的有机高分子（特别是树状大分子），以及设计具有不同碱基序列或特异组装性能的DNA分子，通过化学键或DNA的碱基配对构建了系列两亲性DNA-有机高分子嵌段共聚物，它们在水相中展示了一些独特的组装行为及组装形貌。
Figure7. Design, Synthesis and Self-Assembly of DNA Block Copolymers
四、生物活性杂环化合物的合成
四、生物活性杂环化合物的合成
手性杂环类药物在许多重要疾病的治疗方面得到广泛的应用，如抗生素类药物中的β－内酰胺、抗病毒药物中的核苷类化合物、抗肿瘤药物中的紫杉醇、抗老年痴呆症药物中的吡咯烷、哌啶和四氢（异）喹啉类生物碱，以及抗心血管病类（如他汀类）手性杂环药物等。但缺乏高效、高立体选择性和实用性强的手性杂环合成方法往往是制约杂环类药物研发的“瓶颈”问题，例如，β－内酰胺类化合物分子中手性内酰胺环的构建、核苷类药物分子中非天然糖环的构建，以及生物碱中手性含氮杂环的构建等。为此，基于我们在负载均相催化剂和不对称氢化方面的研究基础，开发一些具有自主知识产权的、实用和绿色的合成若干重要手性杂环化合物及手性药物中间体的新方法。
Figure 8. Bioactive Compounds and Alkaloids via Asymmetric Hydrogenation
研究领域
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
不对称催化
不对称催化
亚胺和含氮芳香杂环化合物的不对称氢化：
过渡金属催化芳香杂环化合物和亚胺的不对称氢化是获得手性杂环化合物和手性胺的最简单高效的方法之一。但由于含氮化合物对催化剂的潜在毒化作用，亚胺化合物的不稳定性及多种异构体的存在，以及芳香杂环化合物的共轭稳定性等不利因素，因此，亚胺类化合物特别是含氮芳香杂环化合物的高效不对称氢化依然十分困难。针对上述问题，一方面利用非传统介质或大分子载体的特殊性质发展高效、可方便分离回收的催化剂新体系，另一方面基于离子型外层催化机理及抗衡阴离子效应发展高效、稳定的离子型手性金属二胺催化剂，实现了系列亚胺包括开链和环状N-烷基亚胺，以及喹啉、喹喔啉和邻菲啰啉等含氮芳香杂环化合物的高效、高立体选择性不对称氢化。
Figure 1. Asymmetric Hydrogenation of Imines and Heteroaromatic Compounds
手性超分子催化剂：
利用超分子识别与组装的基本原理，发展新型超分子手性催化剂及实现催化反应的超分子选择性调控是不对称催化领域新的研究热点和前沿。冠醚是一类具有柔性骨架结构的富电子大环阳离子主体分子，对于碱金属离子、碱土金属离子、有机铵离子及一些缺电子中性分子等都能够进行选择性识别，在超分子化学中显示出独特的魅力。为此，我们开展了基于冠醚/金属冠醚结构的超分子手性金属催化剂研究，发展了新颖的准轮烷手性配体/催化剂以及手性金属冠醚催化剂，实现了主-客体相互作用对催化性能的调控，为手性配体/催化剂的构筑提供了新途径。
Figure 2. Design of Supramolecular Chiral Ligands Based on Psuedorotaxanes
Figure 3. Design of Supramolecular Chiral Catalysts Based on Metallacrown Ethers
研究领域
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
环境友好的催化反应
环境友好的催化反应
据报道，超过70%的化工过程使用溶剂，每年大约2000万吨溶剂挥发。因此，寻找环境友好的反应介质替代传统的有机溶剂是绿色化学的重要研究内容，同时，也为均相催化剂的分离与回收提供了新的途径。为此，基于水、离子液体和液态聚乙二醇等非传统反应介质的特色性质，我们开展了环境友好的不对称催化反应研究。研究发现离子液体和液态聚乙二醇等作为新的绿色反应介质，并非有机溶剂的简单替换，不仅有利于提高催化剂的选择性和稳定性，而且更加方便催化剂的分离与回收，为手性催化剂的实际应用奠定了基础。
Figure 1. Asymmetric Catalysis in Polyethylene Glycols and Ionic Liquids
研究领域
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
功能树状分子的设计合成及组装
功能树状分子的设计合成、组装及应用
树状分子催化剂：
基于酶催化原理，以树状分子为载体，利用树状大分子独特的物理化学性质及其精确可控的分子三维立体结构，通过分子设计在树状分子的表面或核心引入（手性）催化活性中心，构建具有“协同”或“孤立”效应的（手性）催化剂新体系是催化研究领域的前沿和热点之一。我们选择性能优异的小分子配体为研究对象，发展了系列新型树状分子催化剂以及催化剂分离回收新方法。研究表明：树状分子载体不仅方便催化剂的分离与回收，而且更重要的是可以调控催化剂的催化活性和立体选择性，提高催化剂的稳定性能，为负载均相催化剂的分子设计开辟了新的途径。
Figure 1. Dendritic Ligands/Catalysts and Their Applications in Catalysis
树状分子凝胶：
有别于传统利用酰胺基、长链烷基和胆甾体等典型成胶基元所提供的典型氢键和范德华力等非共价弱相互作用来构筑树状分子凝胶体系，我们利用树状分子的协同效应和放大效应，发展了系列基于树状分子外围芳环间多重π-π堆积作用和非典型氢键作用的聚芳醚树状分子凝胶新体系。该类凝胶因子具有优异的成胶性能，成胶溶剂广，成胶浓度低，达到了目前小分子凝胶的最好水平，且突破了目前文献中认为只有低代数树状分子才能有效成胶的限制；通过揭示树状分子结构与成胶性能的关系，为理性设计新型树状分子凝胶因子开辟了新的方向和思路。同时，利用这一特色大分子凝胶因子，发展了系列具有光电功能及对外界刺激具有多重响应性的智能凝胶体系，为树状分子凝胶的功能化和应用拓展了新的方向。
Figure 2. Versatile Dendritic Organogelators & Functional Organogels
树状分子-DNA杂合体：
两亲性DNA嵌段共聚物结合了两亲分子的微相分离特性和DNA的可编程、碱基配对等特性，作为一类新型的超分子构筑基元，在纳米材料和超分子领域显示出其它材料不可比拟的优势，已成为该研究领域的新增长点。为此，我们与清华大学刘冬生教授课题组合作，选择具有不同分子体积、拓扑结构及亲疏水性质的有机高分子（特别是树状大分子），以及设计具有不同碱基序列或特异组装性能的DNA分子，通过化学键或DNA的碱基配对构建了系列两亲性DNA-有机高分子嵌段共聚物，它们在水相中展示了一些独特的组装行为及组装形貌。
Figure 3. Design, Synthesis and Self-Assembly of DNA Block Copolymers
研究领域
不对称催化
环境友好的催化反应
功能树状分子的设计合成及组装
生物活性杂环化合物的合成
生物活性杂环化合物的合成
生物活性杂环化合物的合成
手性杂环类药物在许多重要疾病的治疗方面得到广泛的应用，如抗生素类药物中的β－内酰胺、抗病毒药物中的核苷类化合物、抗肿瘤药物中的紫杉醇、抗老年痴呆症药物中的吡咯烷、哌啶和四氢（异）喹啉类生物碱，以及抗心血管病类（如他汀类）手性杂环药物等。但缺乏高效、高立体选择性和实用性强的手性杂环合成方法往往是制约杂环类药物研发的“瓶颈”问题，例如，β－内酰胺类化合物分子中手性内酰胺环的构建、核苷类药物分子中非天然糖环的构建，以及生物碱中手性含氮杂环的构建等。为此，基于我们在负载均相催化剂和不对称氢化方面的研究基础，开发一些具有自主知识产权的、实用和绿色的合成若干重要手性杂环化合物及手性药物中间体的新方法。
Figure . Bioactive Compounds and Alkaloids via Asymmetric Hydrogenation
研究方向
一、不对称催化 树状分子催化剂
手性二胺金属配合物催化亚胺和芳杂环的不对称氢化
环境友好的催化反应
手性超分子催化剂
二、功能树状分子的设计合成及组装 树状分子凝胶
树状分子-DNA杂合体
发表论文
2019:
184.Ya Chen, Yixiao Pan, Yan-Mei He,*andQing-Hua Fan,*"Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes",Angew. Chem. Int. Ed.2019,58, 16831-16834.
183.Youran Liu, Fei Chen, Yan-Mei He, Chenghao Li, and Qing-Hua Fan,*"Enantioselective synthesis of tunable chiral pyridine–aminophosphine ligands and their applications in asymmetric hydrogenation",Org. Biomol. Chem.2019, 17, 5099–5105.
182.Cong Xu, Yu Feng, Faju Li, Jiahong Han, Yan-Mei He, and Qing-Hua Fan,*"A Synthetic Route to Chiral Benzo-Fused N?Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes",Organometallics2019, 38, 20, 3979-3990.
181.Ya Chen, Yan-Mei He, Shanshan Zhang, Tingting Miao, and Qing-Hua Fan,*"Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination",Angew. Chem. Int. Ed. 2019, 58, 3809 –3813.
2018:
180.Bin Li, Cong Xu, Yan-Mei He, Guo-Jun Deng, and Qing-Hua Fan,*"Asymmetric Hydrogenation of Bis(quinolin-2-yl)methanes: A Direct Access to Chiral 1,3-Diamines",Chin. J.Chem.2018, 36, 1169-1173.
179.Yuping Tang, Yanmei He, Yu Feng, and Qing-Hua Fan,*"Asymmetric Supramolecular Catalysis Based on Macrocyclic Host Molecules",Progress in Chemistry 2018, 30,476-490.
2017:
178.Tingting Miao, Zi-You Tian, Yan-Mei He, Fei Chen, Ya Chen, Zhi-Xiang Yu,* andQing-Hua Fan,* "Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis", Angew.Chem.Int.Ed.2017,56, 4135–4139.
177. Zhusheng Yang, Ziyuan Ding, Fei Chen,* Yan-Mei He, Nianfa Yang,* andQing-Hua Fan,* "Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts", Eur. J. Org. Chem. 2017, 1973–1977.
176.Zhusheng Yang, Fei Chen,* Shuxin Zhang, Yanmei He, Nianfa Yang,* and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of Phenanthridine Derivatives", Org. Lett. 2017, 19, 1458−1461.
2016:
175.Tianli Wang, Ya Chen, Guanghui Ouyang, Yan-Mei He,* ZhiyanLi and Qing-Hua Fan,* "Solvent-Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(Ethylene Glycol)s through Host–Guest Interactions", Chem.Asian J. 2016, 11, 2773–2777.
174.Zhusheng Yang, Fei Chen,* Yanmei He, Nianfa Yang and Qing-Hua Fan,* "Highly Enantioselective Synthesis of Indolines: Asymmetric Hydrogenation at Ambient Temperature and Pressure with Cationic Ruthenium Diamine Catalysts", Angew.Chem.Int.Ed.2016,55, 13863–13866.
173.Wenpeng Ma, Jianwei Zhang, Cong Xu, Fei Chen, Yan-Mei He and Qing-Hua Fan,* "Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2'-Bisquinoline Derivatives"Angew. Chem. Int. Ed. 2016, 55,12891-12894.
172.Wenpeng Ma, Fei Chen, Youran Liu, Yan-Mei He, and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives" Org. Lett.2016,18, 2730–2733.
171.Huan-Li Sun, Fei Chen, Ming-Sheng Xie, Hai-Ming Guo,* Gui-Rong Qu, Yan-Mei He, and Qing-Hua Fan,* "Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues",Org. Lett.2016,18, 2260–2263.
170.Yi Peng, Yu Feng,* Guo-Jun Deng, Yan-Mei He, and Qing-Hua Fan "From Weakness to Strength: C–H/π-Interaction-Guided Self-Assembly and Gelation of Poly(benzyl ether) Dendrimers",Langmuir2016,32, 9313–9320.
169.Yu Feng,* Hui Chen, Zhi-Xiong Liu, Yan-Mei He and Qing-Hua Fan, "A Pronounced Halogen Effect on the Organogelation Properties of Peripherally Halogen Functionalized Poly(benzyl ether) Dendrons",Chem. Eur. J. 2016, 22, 4980-4990.
168.Zhi-Xiong Liu, Yihua Sun, Yu Feng,* Hui Chen, Yan-Mei He and Qing-Hua Fan, "Halogen-bonding for visual chloride ion sensing: a case study using supramolecular poly(aryl ether) dendritic organogel systems",Chem. Commun. 2016, 52, 2269-2272.
2015:
167. Jianwei Zhang, Fei Chen, Yan-Mei He, Qing-Hua Fan,*"Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins",Angew.Chem.Int.Ed.2015,54, 4622-4625.
166. Guang-Hui Ouyang, Yan-Mei He, Yong Li, Jun-Feng Xiang, Qing-Hua Fan,*"Cation-Triggered Switchable Asymmetric Catalysis with Chiral Aza-CrownPhos",Angew.Chem.Int.Ed.2015,54, 4334-4337.
165. Yan-Mei He, Qing-Hua Fan,*"Advances in Transfer Hydrogenation of Carbonyl Compounds in Water",ChemCatChem2015,7, 398-400.
164. Fen Wu, Juan Jin, Liying Wang, Pengfei Sun, Huanxiang Yuan, Zhongqiang Yang, Guosong Chen, Qing-Hua Fan,*Dongsheng Liu,* "Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association",ACS Appl. Mater. Interfaces2015,7, 7351−7356.
163. Fen Wu, Yongshun Song, Zhiyong Zhao, Shusheng Zhang, Zhongqiang Yang, Zhibo Li, Ming Li,*Qing-Hua Fan,*Dongsheng Liu,* "Preparation and Self-Assembly of Supramolecular Coil−Rod−Coil Triblock Copolymer PPO−dsDNA−PPO", Macromolecules2015,48, 7550−7556.
162. Yong Li, Yan-Mei He, Qing-Hua Fan,*"Ionic Liquids in Transition Metal-Catalyzed Enantioselective Reactions",Top. Organomet. Chem.2015,51, 323–348.
161. Fei Chen, Zi-Yuan Ding, Yan-Mei He, Qing-Hua Fan,*"Synthesis of Optically Active 1,2,3,4-TetrahydroquinolinesviaAsymmetric Hydrogenation Using Iridium-Diamine Catalyst",Org. Synth.2015,92, 213-226.
160. Hui Chen, Yu Feng,* Guo-Jun Deng, Zhi-Xiong Liu, Yan-Mei He, Qing-Hua Fan,*"Fluorescent Dendritic Organogels Based on 2-(2'-Hydroxyphenyl)benzoxazole: Emission Enhancement and Multiple Stimuli-Responsive Properties",Chem. Eur. J.2015,21, 11018–11028.
159. Fen Wu, Yiyang Zhang, Zhongqiang Yang,* "An Overview of Self-Assembly and Morphological Regulation of Amphiphilic DNA Organic Hybrids",Chin. J. Chem.2015,33, 511-516.
2014:
158. Yan-Mei He, Yu Feng,Qing-Hua Fan,* "Asymmetric hydrogenation in the core of dendrimers",Acc. Chem. Res.2014,47,2894-2906.
157. Yan-Mei He, Feng-Tao Song,Qing-Hua Fan,*"Advances in transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds",Top. Curr. Chem.2014,343, 145–190.
156. Zhiyong Zhao, Chun Chen, Yuanchen Dong, Zhongqiang Yang,Qing-Hua Fan,*Dongsheng Liu,* "Thermally Triggered Frame-Guided Assembly",Angew. Chem. Int. Ed.2014,53,13468-13470.
155. Guang-Hui Ouyang, Yan-Mei He,*Qing-Hua Fan,* "Podand-Based Dimeric Chromium(III)–Salen Complex for Asymmetric Henry Reaction: Cooperative Catalysis Promoted by Complexation of Alkali Metal Ions",Chem. Eur. J.2014,20, 16454-16457 (hot papaer).
154. Baode Ma, Tingting Miao, Yihua Sun, Yanmei He, Ji Liu, Yu Feng, Hui Chen,* Qing-Hua Fan,*"A new class of tunable dendritic diphosphine ligands: synthesis and applications in the ru-catalyzed asymmetric hydrogenation of functionalized ketones", Chem. Eur. J. 2014, 20, 9969-9978.
153. Yu Feng, Zhi-Xiong Liu, Hui Chen, Zhi-Chao Yan, Yan-Mei He,* Chen-Yang Liu, Qing-Hua Fan,* "A systematic study of peripherally multiple aromatic ester-functionalized poly(benzyl ether) dendrons for the fabrication of organogels: structure-property relationships and thixotropic property", Chem. Eur. J. 2014, 20, 7069-7082.
152. Zhusheng Yang, Fei Chen,* Yan-Mei He, Nianfa Yang,*Qing-Hua Fan,*"Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes",Catal. Sci. Technol.2014,4, 2887-2890.
151. Feng-Tao Song, Guang-Hui Ouyang, Yong Li, Yan-Mei He,*Qing-Hua Fan,* "New metallacrown ether catalysts containing phosphine-phosphite polyether ligands for Rh-catalyzed asymmetric hydrogenation: enhancements in activity and enantioselectivity", Eur. J. Org. Chem.2014, 30, 6713-6719.
150. Yu Feng, Yan-Mei He,Qing-Hua Fan,* "Supramolecular organogels based on dendrons and dendrimers",Chem. Asian J.2014,9, 1724-1750 (Revited Focus Review).
149. Jie Qin, Fei Chen, Yan-Mei He,Qing-Hua Fan,* "Asymmetric hydrogenation of 3-substituted 2H-1,4-benzoxazines with chiral cationic Ru-MsDPEN catalysts: remarkable counteranion effect",Org. Chem. Front.2014, 1,952-955.
148. Yong Li, Yanmei He, Fei Chen, Qinghua Fan,*"Asymmetric Hydrogenation of 2-Aryl-5,6-dihydropyrazine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts", Chin. J. Chem. 2014, 32, 991-994.
147.Zhi-Xiong Liu,Yu Feng,*Zhi-Yong Zhao, Zhi-Chao Yan,Yan-Mei He,Xu-Jun Luo,Chen-Yang LiuandQing-Hua Fan,* "A New Class of Dendritic Metallogels with Multiple Stimuli-Responsiveness and as Templates for the In Situ Synthesis of Silver Nanoparticles",Chem.Eur. J.2014,20, 533-541.
146. Ji Liu, Baode Ma, Yu Feng, Yanmei He,* andQing-Hua Fan,* "Dendritic [Rucl2(BINAP)(DPEN)] Catalysts with 'Sandwich' Multi-Layer Structure for Asymmetric Hydrogenation of Simple Aryl Ketones",Inorgan.Chim. Acta2014,409, 106-111.
145. Yigang Ji, Lei Wu*, Qing-Hua Fan,* "Recent progress of metal/metal oxide nanoparticles for asymmetric hydrogenation and transfer hydrogenation", Acta Chim. Sinica 2014, 72, 798-808. (Invited Review)
144. Yi-Yong Huang,* Xing Yang, Yu Feng, Francis Verpoort, Qing-Hua Fan,*"Chiral Ru/Ir bimetallic dendronized polymer catalysts constructedthrough sequential metal coordination and applied in asymmetrichydrogenation of quinaldine", J. Mol. Catal. A: Chem. 2014, 393,150-155.
143. Yuanchen Dong, Yawei Sun, Liying Wang, Dianming Wang, Tao Zhou, Zhongqiang Yang, Zhong Chen, Qiangbin Wang,Qinghua Fan,Dongsheng Liu*, "Frame-Guided Assembly of Vesicles with Programmed Geometry and Dimensions",Angew. Chem. Int. Ed.2014,53, 2607-2610.
2013:
142. Zi-Yuan Ding,Tianli Wang,Yan-Mei He,Fei Chen,Hai-Feng Zhou,Qing-Hua Fan,* Qingxiang Guo,*and Albert S. C. Chan, "Highly Enantioselective Synthesis of Chiral Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed Asymmetric Hydrogenation in Ionic Liquid", Adv.Synth. Catal. 2013, 355, 3727-3735.
141. Tianli Wang,Fei Chen,Jie Qin,Yan-Mei He and Qing-Hua Fan,* "Asymmetric Ruthenium-Catalyzed Hydrogenation of 2- and 2,9-Substituted 1,10-Phenanthrolines", Angew. Chem. Int. Ed. 2013,52, 7172-7176.
140. Zhiyong Zhao, Fen Wu, Zhongqiang Yang,* Dongsheng Liu and Qing-Hua Fan,* "Synthesis and Self-Assembly of DNA-Aliphatic Polyether Dendron Hybrids", Acta Chim. Sinica 2013, 71, 549-554.
139. Baode Ma, Guojun Deng, Ji Liu, Yanmei He and Qing-Hua Fan,* "Synthesis of Dendritic BINAP Ligands and Their Applications in the Asymmetric Hydrogenation: Exploring the Relationship between Catalyst Structure and Catalytic Performance", Acta Chim. Sinica 2013, 71, 528-534.
138. Baode Ma, Ziyuan Ding, Ji Liu, Yanmei He and Qing-Hua Fan,* "Highly Enantioselective Hydrogenation of 2,4-Diaryl-1,5-Benzodiazepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes", Chem. Asian J. 2013, 8, 1101-1104.
137. Ji Liu, Yu Feng, Zhi-Xiong Liu, Zhi-Chao Yan, Yan-Mei He, Chen-Yang Liu and Qing-Hua Fan,* "N-Boc-Protected 1,2-Diphenylethylenediamine-Based Dendritic Organogels with Multiple-Stimulus-Responsive Properties", Chem. Asian J. 2013, 8, 572-581.
136. Zhen Jiang, Lingjuan Zhang, Chaonan Dong, Xiaoming Su, Huanrong Li, Weijun Tang, Lijin Xu* and Qing-Hua Fan, "Direct Synthesis of 8-Aryl Tetrahydroquinolines via Pd-Catalyzed Ortho-Arylation of Aryl Ureas in Water", RSC Adv. 2013, 3, 1025-1028.
2012:
135. Ji Liu, Yu Feng, Baode Ma, Yan-Mei He and Qing-Hua Fan,* "Design and Synthesis of Janus-Type Chiral Dendritic Diphosphanes and Their Applications in Asymmetric Hydrogenation", Eur. J. Org. Chem. 2012, 6737-6744.
134. Zhi-Xiong Liu, Yu Feng, Zhi-Chao Yan, Yan-Mei He, Chen-Yang Liu and Qing-Hua Fan,* "Multistimuli Responsive Dendritic Organogels Based on Azobenzene-Containing Poly(aryl ether) Dendron", Chem. Mater. 2012, 24, 3751-3757.
133. Yu Feng, Zhixiong Liu, Liying Wang, Hui Chen, Yan-Mei He* and Qing-Hua Fan,* "Poly(Benzyl Ether) Dendrons without Conventional Gelation Motifs as A New Kind of Effective Organogelators", Chinese Sci. Bull. 2012, 57, 4289-4295.
132. Liwen Zhao, Ji Liu, Yu Feng, Yanmei He and Qing-Hua Fan,* "Facile Synthesis of Chiral Diphosphine-Containing Multiple Dendrimeric Catalysts for Enantioselective Hydrogenation", Chin. J. Chem. 2012, 30, 2009-2015.
131. Zhiyong Zhao, Liying Wang, Yu Liu, Zhongqiang Yang, Yan-Mei He, Zhibo Li, Qing-Hua Fan* and Dongsheng Liu,* "pH-Induced Morphology-Shifting of DNA-b-Poly(Propylene Oxide) Assemblies", Chem. Commun. 2012, 48, 9753-9755.
130. Fei Chen, Ziyuan Ding, Yanmei He, Jie Qin, Tianli Wang and Qing-Hua Fan,* "Asymmetric Hydrogenation of N-Alkyl and N-Aryl Ketimines using Chiral CationicRu(Diamine) Complexes as Catalysts: The Counteranion and Solvent Effects, and Substrate Scope", Tetrahedron 2012, 68, 5248-5257.
129. Zi-Yuan Ding, Fei Chen, Jie Qin, Yan-Mei He and Qing-Hua Fan,* "Asymmetric Hydrogenation of 2,4-Disubstituted 1,5-Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity", Angew. Chem. Int. Ed. 2012, 51, 5706-5710.
128. Liying Wang, Yu Feng, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Reversibly Controlled Morphology Transformation of An Amphiphilic DNA–Dendron Hybrid", Chem. Commun. 2012, 48, 3715-3717.
127. Ji Liu, Yu Feng, Yanmei He, Nianfa Yang* and Qing-Hua Fan,* "Janus Dendritic Phosphines: Synthesis and Application in Suzuki Coupling Reactions", New J. Chem. 2012, 36, 380-385.
126. Zhen Jiang, Lingjuan Zhang, Chaonan Dong, Baode Ma, Weijun Tang, Lijin Xu,* Qing-Hua Fan* and Jianliang Xiao,* "Palladium-Catalyzed Highly Regioselective and Stereoselective Arylation of Electron-Rich Allylamines with Aryl Bromides", Tetrahedron 2012, 68, 4919-4926.
125. Guangxi Huang, Baode Ma, Jianming Chen, Qian Peng, Guanxin Zhang,* Qinghua Fan and Deqing Zhang,* "Dendron-Containing Tetraphenylethylene Compounds: Dependence of Fluorescence and Photocyclization Reactivity on The Dendron Generation", Chem. Eur. J. 2012, 18, 3886-3892.
2011:
124. Jin-Liang Lv, Zhi-Yong Zhao, Zhong-Qiang Yang, Dong-Sheng Liu* and Qing-Hua Fan,* "Synthesis of Dendritic Oligodeoxyribonucleotide Analogs with NonionicDiisopropylsilyl Linkage", Tetrahedron 2011, 67, 9080-9086.
123. Lei Wu, Yan-Mei He and Qing-Hua Fan,* "Controlled Reversible Anchoring of ?6-Arene/TsDPEN Ruthenium(II) Complex onto Magnetic Nanoparticles: A New Strategy for Catalyst Separation and Recycling", Adv. Synth. Catal. 2011, 353, 2915-2919.
122. Jie Qin, Fei Chen, Ziyuan Ding, Yan-Mei He, Lijin Xu and Qing-Hua Fan,* "Asymmetric Hydrogenation of 2- and 2,3-Substituted Quinoxalines with Chiral Cationic Ruthenium Diamine Catalysts", Org. Lett. 2011, 13, 6568-6571. <Highlight by Synfacts 2012, 8, 191.>
121. Liying Wang, Yu Feng, Yawei Sun, Zhibo Li, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Amphiphilic DNA-Dendron Hybrid: A New Building Block for Functional Assemblies", Soft Matter 2011, 7, 7187-7190.
120. Fei Chen, Ziyuan Ding, Jie Qin, Tianli Wang, Yanmei He and Qing-Hua Fan,* "Highly Effective Asymmetric Hydrogenation of Cyclic N-Alkyl Imines with Chiral Cationic Ru-MsDPEN Catalysts", Org. Lett, 2011, 13, 4348-4351. <Highlight by Synfacts 2011, 10, 1092.>
119. Tianli Wang, Lian-Gang Zhuo, Zhiwei Li, Fei Chen, Ziyuan Ding, Yanmei He, Qing-Hua Fan,* Junfeng Xiang, Zhi-Xiang Yu* and Albert S. C. Chan, "Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity", J. Am. Chem. Soc. 2011, 133, 9878-9891.
118. Tianli Wang, Guanghui Ouyang, Yan-Mei He and Qing-Hua Fan,* "Asymmetric Tandem Reduction of 2-(Aroylmethyl)quinolines with Phosphine-Free Ru-TsDPEN Catalyst", Synlett 2011, 7, 939-942.
117. Fei Chen, Tianli Wang, Yanmei He, Ziyuan Ding, Zhiwei Li, Lijin Xu and Qing-Hua Fan,* "Asymmetric Hydrogenation of N-Alkyl Ketimines with Phosphine-Free, Chiral, Cationic Ru-MsDPEN Catalysts", Chem. Eur. J. 2011, 17, 1109-1113.<Highlight by Synfacts 2011, 4, 420.>
116. Zi-Tong Liu, Yi-Yong Huang, Yong Li, Yan-Mei He* and Qing-Hua Fan,* "Synthesis and Chiroptical Properties of Chiral Binaphthyl-Containing Polyfluorene Derivatives", J. Polym. Sci. Part A: Polym. Chem. 2011, 49, 680-689.
115. Jing Tan, Weijun Tang, Yawei Sun, Zhen Jiang, Fei Chen, Lijin Xu,* Qing-Hua Fan* and Jianliang Xiao,* "pH-Regulated Transfer Hydrogenation of Quinoxalines with A Cp*Ir-diamine Catalyst in Aqueous Media", Tetrahedron 2011, 67, 6206-6213.
114.Qing-Hua FanandKuiling Ding,* "Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts", Top. Organomet. Chem. 2011, 36, 207-246.
2010:
113. Xu Zhang, Ting Chen, Hui-Juan Yan, Dong Wang,* Qing-Hua Fan, Li-Jun Wan,* Koushik Ghosh, Hai-Bo Yang and Peter J. Stang, "Hydrogen Bond Partner Reorganization in The Coadsorption of A Monodendron and Pyridylethynyl Derivatives", Langmuir 2011, 27, 1292-1297.
112. Yong Li,Baode Ma,Yanmei He,Feng Zhangand Qing-Hua Fan,* "Chiral Metallacrown Ethers forAsymmetric Hydrogenation: Alkali-Metal Ion Mediated Enhancement of Enantioselectivity", Chem. Asian J. 2010, 5, 2454-2458.
111. Fei Chen, Zhiwei Li, Yanmei He and Qing-Hua Fan,* "Asymmetric Hydrogenation of Cyclic N-Sulfonylimines with Phosphine-Free Chiral Cationic Ru-MsDPEN Catalysts", Chin. J. Chem. 2010, 28, 1529-1532.
110. Yawei Sun, Huajie Liu, Lijin Xu,Liying Wang, Qing-Hua Fan* and Dongsheng Liu,* "DNA Molecular Motor Controlled Dendron Association", Langmuir 2010, 26, 12496-12499.
109. Qun Chen, Yu Feng, Deqing Zhang,* Guanxin Zhang, Qing-Hua Fan,* Shuna Sun and Daoben Zhu, "Light-Triggered Self-Assembly of A Spiropyran-Functionalized Dendron into Nano-/Micrometer-Sized Particles and Photoresponsive Organogel with Switchable Fluorescence", Adv. Funct. Mater. 2010, 20, 36-42.
108. Yan-Mei He and Qing-Hua Fan* "Phosphine-Free Chiral Metal Catalysts for Highly Effective Asymmetric Catalytic Hydrogenation", Org. Biomol. Chem. 2010, 8, 2497-2504.
107. Ji Liu, Baode Ma, Nianfa Yang* and Qinghua Fan,* "Soluble Polymer-Supported Homogeneous Catalysts", Prog. Chem. 2010, 22, 1457-1470.
106. Baode Ma and Qinghua Fan,* "Progress on Chiral Dendrimeric Phosphorous Ligands in Asymmetric Catalytic Hydrogenations", Sci. Sinica Chim. 2010, 40, 827-836.
105. Xu Zhang, Ting Chen, Hui-Juan Yan, Dong Wang,* Qing-Hua Fan, Li-Jun Wan,* Koushik Ghosh, Hai-Bo Yang and Peter J. Stang,* "Engineering of Linear Molecular Nanostructures by A Hydrogen-Bond-Mediated Modular and Flexible Host-Guest Assembly", ACS Nano 2010, 4, 5685-5692.
104. Qun Chen, Deqing Zhang,* Guanxin Zhang, Xingyuan Yang, Yu Feng, Qing-Hua Fan and Daoben Zhu, "Multicolor Tunable Emission from Organogels Containing Tetraphenylethene, Perylenediimide, and Spiropyran Derivatives", Adv. Funct. Mater. 2010, 20, 3244-3251.
103. Ping Chen, Yawei Sun, Huajie Liu, Lijin Xu,* Qinghua Fan and Dongsheng Liu,* "A pH Responsive Dendron-DNA-Protein Hybrid Supramolecular", Soft Matter 2010, 6, 2143-2145.
102. Wei-Jun Tang, Jing Tan, Li-Jin Xu,* Kim-Hung Lam, Qing-Hua Fan and Albert S. C. Chan, "Highly Enantioselective Hydrogenation of Quinoline and Pyridine Derivatives with Iridium-(P-Phos) Catalyst", Adv. Synth. Catal. 2010, 352, 1055-1062.
101. Weijun Tang, Yawei Sun, Lijin Xu,* Tianli Wang, Qing-Hua Fan, Kim-Hung Lam and Albert S. C. Chan, "Highly Efficient and Enantioselective Hydrogenation of Quinolines and Pyridines with Ir-Difluorphos Catalyst", Org. Biomol. Chem. 2010, 8, 3464-3471.
100. Bing Yi,* Hua-Ping He and Qing-Hua Fan, "Synthesis and Application of Peripherally Alkyl-Functionalized Dendritic Pyrphos Ligands: Homogeneous-Supported Catalysts for Enantioselective Hydrogenation", J. Mol. Catal. A: Chem. 2010, 315, 82-85.
99. Yong Li,* Zhiling Wang, Yanmei He and Qinghua Fan, "Advance in Preparation and Application of Supramolecular Bidentate Phosphorus Ligands", Chinese J. Org. Chem. 2010, 30, 338-344.
2009:
98. Feng Zhang and Qing-Hua Fan,* "Synthesis and Application of Bulky Phosphoramidites: Highly Effective Monophosphorus Ligands for Asymmetric Hydrosilylation of Styrenes", Org. Biomol. Chem. 2009, 7, 4470-4474.
97. Weijun Tang, Lijin Xu,* Qing-Hua Fan,* Jun Wang, Baomin Fan, Zhongyuan Zhou, Kim-hung Lam and Albert S. C. Chan, "Asymmetric Hydrogenation of Quinoxalines with Diphosphinite Ligands: A Practical Synthesis of Enantioenriched, Substituted Tetrahydroquinoxalines", Angew. Chem. Int. Ed. 2009, 48, 9135-9138.
96. Zhi-Jian Wang, Hai-Feng Zhou, Tian-Li Wang, Yan-Mei He and Qing-Hua Fan,* "Highly Enantioselective Hydrogenation of Quinolines under Solvent-Free or Highly Concentrated Conditions", Green Chem. 2009, 11, 767-769.
95. Yu Feng, Zi-Tong Liu, Ji Liu, Yan-Mei He,* Qi-Yu Zheng and Qing-HuaFan,* "Peripherally Dimethyl Isophthalate-Functionalized Poly(benzyl ether) Dendrons: A New Kind of Unprecedented Highly Efficient Organogelators", J. Am. Chem. Soc. 2009, 131, 7950-7951.
94. Yong Li, Yan-Mei He, Zhi-Wei Li, Feng Zhang and Qing-Hua Fan,* "Supramolecular Chiral Dendritic Monophosphites Assembled by Hydrogen Bonding and Their Use in The Rh-Catalyzed Asymmetric Hydrogenation", Org. Biomol. Chem. 2009, 7, 1890-1895.
93. Enjun Cheng, Yongzheng Xing, Ping Chen, Yang Yang, Yawei Sun, Dejian Zhou,* Lijin Xu, Qinghua Fan and Dongsheng Liu,* "A pH-Triggered, Fast-Responding DNA Hydrogel", Angew. Chem. Int. Ed. 2009, 48, 7660-7663.
92. Xu Zhang, Ting Chen, Qing Chen,] Guo-Jun Deng, Qing-Hua Fan and Li-Jun Wan,* "One Solvent Induces A Series of Structural Transitions in Monodendron Molecular Self-Assembly from Lamellar to Quadrangular to Hexagonal", Chem. Eur. J. 2009, 15, 9669-9673.
91. Xu Zhang, Qing Chen, Guo-Jun Deng, Qing-Hua Fan and Li-Jun Wan,* "Structural Diversity of A Monodendron Molecule Self-Assembly in Different Solvents Investigated by Scanning Tunneling Microscopy: from Dispersant to Counterpart", J. Phys. Chem. C 2009, 113, 16193-16198.
90. Daihua Tang,* Dayong Wu, Qun Luo, Wenbing Hu, Fuyi Wang,* Shixiong Liu, Xinhou Liu and Qing-Hua Fan, "Single-Molecule Behavior of Dendritic Poly(Ethylene Glycol) Structures Towards Lithium Ions", Chem. Eur. J. 2009, 15, 10352-10355.
89. Kui-ling Ding* andQing-Hua Fan, "手性催化研究的新进展与展望",Chemical Newsletter2009, 6, 22-28.
2008:
88. Feng Zhang, Yong Li, Zhi-Wei Li, Yan-Mei He, Shou-Fei Zhu, Qing-Hua Fan* and Qi-Lin Zhou,* "Modular Chiral Dendritic Monodentate Phosphoramidite Ligands for Rh(II)-Catalyzed Asymmetric Hydrogenation: Unprecedented Enhancement of Enantioselectivity", Chem. Commun. 2008, 6048-6050.
87. Zhi-Wei Li, Tian-Li Wang, Yan-Mei He, Zhi-Jian Wang, Qing-Hua Fan,* Jie Pan and Li-Jin Xu,* "Air-Stable and Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of Quinoline Derivatives", Org. Lett. 2008, 10, 5265-5268.<Highlight by Synfacts 2009, 2, 174.>
86. Haifeng Zhou, Zhiwei Li, Zhijian Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,* Jie Pan, Lianquan Gu and Albert S. C. Chan,* "Hydrogenation of Quinolines Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid", Angew. Chem. Int. Ed. 2008, 47, 8464-8467.
85. Yong Li, Yu Feng, Yan-Mei He, Fei Chen, Jie Pan and Qing-Hua Fan,* "Supramolecular Chiral Phosphorous Ligands Based on A [2]Pseudorotaxane Complex for Asymmetric Hydrogenation", Tetrahedron Lett. 2008, 49, 2878-2881.
84. Lei Wu, Zhi-Wei Li, Feng Zhang, Yan-Mei He and Qing-Hua Fan,* "Air-Stable and Highly Active Dendritic Phosphine Oxide-Stabilized Palladium Nanoparticles: Preparation, Characterization and Applications in the Carbon-Carbon Bond Formation and Hydrogenation Reactions", Adv. Synth. Catal. 2008, 350, 846-862.<Highlight by Synfacts 2008, 8, 882.>
83. Bao-Lin Li, Zi-Tong Liu, Yan-Mei He, Jie Pan and Qing-Hua Fan,* "Functionalization of Conjugated Copolymers with Phosphorescent Iridium Complexes and Carbazole/1,3,4-Oxadiazole Dendrons via Click Chemistry", Polymer 2008, 49, 1527-1537.
82. Zi-Tong Liu, Yan-Mei He, Zhi-Jian Wang, Yu Feng and Qing-Hua Fan,* "Synthesis, Optical Properties, and Spectral Stability of Chiral Dendronized Binaphthyl-Containing Polyfluorene Derivatives", J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 886-896.
2007:
81. HaifengZhou, Qing-Hua Fan,* Yanmei He, Lianquan Gu* and Albert S. C. Chan,*"Application of Liquid Poly( Ethylene Glycol)s as Green Reaction Media in Organic Reactions", Prog. Chem. 2007, 19, 1517-1528.
80. Sau Hing Chan, Kim Hung Lam,* Yue-Ming Li, Lijin Xu, Weijun Tang, Fuk Loi Lam, Wai Hung Lo, Wing Yiu Yu, Qing-Hua Fan* and Albert S. C. Chan,* "Asymmetric Hydrogenation of Quinolines with Recyclable and Air-Stable Iridium Catalyst Systems", Tetrahedron: Asymmetry 2007, 18, 2625-2631.
79. Hai-Feng Zhou, Qing-Hua Fan,* Yi-Yong Huang, Lei Wu, Yan-Mei He, Wei-Jun Tang, Lian-Quan Gu* and Albert S. C. Chan,* "Mixture of Poly(Ethylene Glycol) and Water as Environmentally Friendly Media for Efficient Enantioselective Transfer Hydrogenation and Catalyst Recycling", J. Mol. Catal. A: Chem. 2007, 275, 47-53.
78. Bao-Lin Li, Zi-Tong Liu, Guo-Jun Deng and Qing-Hua Fan,* "The Synthesis of Dendritic β-Diketonato Ligands and Their Europium Complexes", Eur. J. Org. Chem. 2007, 508-516.
77. Zi-Tong Liu, Yan-Mei He, Bao-Lin Li, Ji Liu and Qing-Hua Fan,* "A Click Approach to Chiral-Dendronized Polyfluorene Derivatives", Macromol. Rapid Commun. 2007, 28, 2249-2255.
76. Bao-Lin Li, Lei Wu, Yan-Mei He and Qing-Hua Fan,* "The Synthesis and Properties of Iridium(III)-Cored Dendrimers With Carbazole Peripherally Functionalized β-Diketonato Dendrons", Dalton Trans. 2007, 2048–2057.
75. Wei-Jun Tang, Shou-Fei Zhu, Li-Jin Xu,* Qi-Lin Zhou, Qing-Hua Fan,* Hai-Feng Zhou, Kimhung Lam and Albert S. C. Chan,* "Asymmetric Hydrogenation of Quinolines With High Substrate/Catalyst Ratio", Chem. Commun. 2007, 613-615.<Highlight by Synfacts 2007, 4, 363.>
74. Yu Feng, Yan-Mei He, Li-Wen Zhao, Yi-Yong Huang and Qing-Hua Fan,* "A Liquid-Phase Approach to Functionalized Janus Dendrimers: Novel Soluble Supports for Organic Synthesis", Org. Lett. 2007, 9, 2261-2264.
73. Zhi-Jian Wang, Guo-Jun Deng, Yong Li, Yan-Mei He, Wei-Jun Tang and Qing-Hua Fan,* "Enantioselective Hydrogenation of Quinolines Catalyzed by Ir(BINAP)-Cored Dendrimers: Dramatic Enhancement of Catalytic Activity" Org. Lett. 2007, 9, 1243-1246.
72. Liqin Qiu, Yue-Ming Li, Fuk Yee Kwong, Wing-Yiu Yu, Qing-Hua Fan and Albert S. C. Chan, "Highly Efficient Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids Catalyzed by Ruthenium(II)-Dipyridylphosphine Complexes", Adv. Synth Catal. 2007, 349, 517-520.
71. Lijin Xu, Kim Hung Lam, Jiwu Ruan, Qing-Hua Fan and Albert S. C. Chan, "Ruthenium Catalyzed Asymmetric Hydrogenation of α- and β-Ketoesters in Room Temperature Ionic Liquids Using Chiral P-Phos Ligand", ACS Symposium Series 2007, 950,224-234.
70. Xuefeng Guo, Yucheng Zhou, Min Feng, Yu Xu, Deqing Zhang,* Hongjun Gao, Qinghua Fan and Daoben Zhu,* "Tetrathiafulvalene-, 1,5-Dioxynaphthalene-, and Cyclobis(Paraquat-P-Phenylene)-Based [2]Rotaxanes with Cyclohexyl and Alkyl Chains as Spacers: Synthesis, Langmuir–Blodgett Films, and Electrical Bistability", Adv. Funct. Mater. 2007, 17, 763-769.
2006:
69. Liwen Zhao, Qing-Hua Fan,* Haifeng Zhou, Yanmei He, Lianquan Gu* and Albert S. C. Chan,* "Study of Dendrimers as Supports for Organic Synthesis", Prog. Chem. 2006, 18, 317-330.
68. Wei-Jun Tang, Yi-Yong Huang, Yan-Mei He and Qing-Hua Fan,* "Dendritic MonoPhos: Synthesis and Application in Rh-Catalyzed Asymmetric Hydrogenation", Tetrahedron: Asymmetry 2006, 17, 536-543.
67. Yi-Li Zhang, Feng Zhang, Wei-Jun Tang, Qing-Lai Wu and Qing-Hua Fan,* "Synthesis and Application of 3,3′-Diarylmethyl BINOLs", Synlett 2006, 8,1250-1254.
66. Guo-Jun Deng, Guo-Rui Li, Ling-Yun Zhu, Hai-Feng Zhou,Yan-Mei He, Qing-Hua Fan* and Zhi-Gang Shuai,* "Dendritic BIPHEP: Synthesis and Application in Asymmetric Hydrogenation of β-Ketoesters", J. Mol. Catal. A: Chem.2006, 244, 118-123.
65. Hai-Feng Zhou, Qing-Hua Fan,* Wei-Jun Tang, Li-Jin Xu, Yan-Mei He, Guo-Jun Deng, Li-Wen Zhao, Lian-Quan Gu* and Albert S. C. Chan,* "Polyethylene Glycol as an Environmentally Friendly and Recyclable Reaction Medium for Enantioselective Hydrogenation", Adv. Synth. Catal. 2006, 348, 2172-2182.
64. Lei Wu, Bao-Lin Li, Yi-Yong Huang, Hai-Feng Zhou, Yan-Mei He and Qing-Hua Fan,* "Phosphine Dendrimer-Stabilized Palladium Nanoparticles, a Highly Active and Recyclable Catalyst for the Suzuki-Miyaura Reaction and Hydrogenation", Org. Lett. 2006, 8, 3605-3608.<Highlight by Synfacts 2006, 11, 1185.>
63. Yi-Yong Huang, Yan-Mei He, Hai-Feng Zhou, Lei Wu, Bao-Lin Li and Qing-Hua Fan,* "Thermomorphic System with Non-Fluorous Phase-Tagged Ru(BINAP) Catalyst: Facile Liquid/Solid Catalyst Separation and Application in Asymmetric Hydrogenation", J. Org. Chem. 2006, 71, 2874-2877.
62. Hang Gong, Chang-Qun Cai, Nian-Fa Yang,* Li-Wen Yang, Jin Zhang, Qing-Hua Fan, "Application of Non-Imidazolium-Based Ionic Liquid in the Baylis–Hillman Reactions: Rate and Yield Promoted", J. Mol. Catal. A: Chem.2006, 249, 236-239.
61. Guo-Hua Liu,* Yun-Ning Xue, Qing-Hua Fan, "The Synthesis of Soluble Polymer-Supported Chiral BINOL Ligands and Asymmetric Addition Reactions", Acta Polymerica Sinica 2006, 371-376.
2005:
60. Yi-Yong Huang, Hai-Liang Zhang, Guo-Jun Deng, Wei-Jun Tang, Xia-Yu Wang,* Yan-Mei He and Qing-Hua Fan,* "Synthesis of Triphenylphosphine-Functionalized Dendrimers and Application to Olefin Hydroformylation", J. Mol. Catal. A: Chem. 2005, 227, 91-96.
59. Kim Hung Lam, Lijin Xu,* Lichun Feng, Qing-Hua Fan,* Fuk Loi Lam, Wai-hung Lo and Albert S. C. Chan,* "Highly Enantioselective Iridium-Catalyzed Hydrogenation of Quinoline Derivatives Using Chiral Phosphinite H8-BINAPO", Adv. Synth. Catal. 2005, 347, 1755-1758.
58. Lijin Xu, Kim Hung Lam, Jianxin Ji, Jing Wu, Qing-Hua Fan,* Wai-Hung Lo and Albert S. C. Chan,* "Air-Stable Ir-(P-Phos) Complex for Highly Enantioselective Hydrogenation of Quinolines and Their Immobilization in Poly(Ethyleneglycol) Dimethyl Ether (DMPEG)", Chem. Commun. 2005, 1390-1392.<Highlight by Synfacts 2005, 0, 37.>
57. Yi-Li Zhang and Qing-Hua Fan,* "Synthesis of New Bifunctional BINOL Derivatives", J. Chem. Res. 2005, 778-779.
56. Kim Hung Lam, Lijin Xu, Lichun Feng, Jiwu Ruan, Qing-Hua Fan andAlbert S. C. Chan,* "Ruthenium Catalyzed Asymmetric Hydrogenation of α- and β-keto Esters in Ionic Liquids Using Chiral P-Phos Ligand", Can. J. Chem. 2005, 83, 903-908.
55. Kim Hung Lam, Lijin Xu, Qing-Hua Fan, Li-Qing Qiu, Jing Wu, Chi-Hung Yeung, Wai-Hung Lo, Albert S. C. Chan, "Catalytic Asymmetric Hydrogenation in Room Temperature Ionic Liquids ", Abstr. Papers Am. Chem. Soc. 2005, 228, 118.
54. Nian-Fa Yang*, Hang Gong, Wei-Jun Tang, Qing-Hua Fan, Chang-Qun Cai andLi-Wen Yang, "Phase Selectively Soluble Dendritic Derivative of 4-(N,N-Dimethylamino)Pyridine: An Easily Recyclable Catalyst for Baylis-Hillman Reactions", J. Mol. Catal. A: Chem. 2005, 233, 55-59.
53. Hang Gong,Nian-Fa Yang,* Wei-Jun Tang,Qing-Hua Fan andLi-Wen Yang, "Phase Selectively Soluble Dendritic Derivative of 4-(Dimethylamino)Pyridine: An Easily Recyclable Catalyst for Baylis-Hillman Reactions", Chinese Chem. Lett. 2005, 16, 1017-1020.
52. Weiguo Liu, Xin Cui, Linfeng Cun, Jun Wu, Jin Zhu, Jingen Deng* and Qing-Hua Fan, "Novel Dendritic Ligands of Chiral 1,2-Diamine and Their Application in Asymmetric Hydrogenation of Simple Aryl Ketones", Synlett 2005, 1591-1595.
51. Jian-Ru Gong, Sheng-Bin Lei, Ge-Bo Pan, Li-Jun Wan,* Qing-Hua Fan and Chun-Li Bai,* "Monitoring Molecular Motion and Structure Near Defect With STM", Colloids Surf. A: Physicochem. Eng. Aspects 2005, 257-258, 9-13.
2004:
50. Qing-Hua Fan, "Polymeric Materials in Organic Synthesis and Catalysis", Angew. Chem. Int. Ed. 2004, 43, 6236-6237.
49. Yi-Yong Huang, Guo-Jun Deng, Xia-Yu Wang,Yan-Mei He and Qing-Hua Fan,* "Improved Synthesis of 5,5-Diamino BINAP and Application to Asymmetric Hydrogenation", Chin. J. Chem. 2004, 22, 891-893.
48. Dai-Hua Tang, Xiao-Min Chen and Qing-Hua Fan,* "A Convenient Route to Dendritic Binaphthyl-Containing Chiral Crown Ethers", J. Chem. Res. 2004, 702-703.
47. Wei-Jun Tang, Nian-Fa Yang,* Bing Yi, Guo-Jun Deng, Yi-Yong Huang and Qing-Hua Fan,* "Phase Selectively Soluble Dendrimer-Bound Osmium Complex: A Highly Effective and Easily Recyclable Catalyst for Olefin Dihydroxylation", Chem. Commun. 2004, 1378-1379.
46. Guo-Jun Deng, Bing Yi, Yi-Yong Huang, Wei-Jun Tang, Yan-Mei He and Qing-Hua Fan,* "Dendronized Poly(Ru-BINAP) Complexes: Highly Effective and Easily Recyclable Catalysts for Asymmetric Hydrogenation", Adv. Synth. Catal. 2004, 346, 1440-1444.
45. Bing Yi, Qing-Hua Fan,* Guo-Jun Deng, Yue-Ming Li, Li-Qin Qiu and Albert S. C. Chan,* "Novel Chiral Dendritic Diphosphine Ligands for Rh(I)-Catalyzed Asymmetric Hydrogenation: Remarkable Structural Effects on Catalytic Properties", Org. Lett. 2004, 6, 1361-1364.
44. Xue-Feng Guo, De-Qing Zhang,* Qing-Hua Fan and Dao-Ben Zhu,* "Synthesis and Characterization of Donor-Acceptor-Donor Triads Containing Tetrathiafulvalene and Naphthalene Diimide Units: Towards Regulation of the Intermolecular Charge-Transfer Interaction by Varying the Attached Side Groups", Chin. J. Chem. 2004, 22, 296-305.
43. Jing Yuan, Guojun Deng, Qing-Hua Fan and Minghua Liu,* "Supramolecular Assembly of a Series of Chiral Dendrimers in Interfacial Films", Thin Solid Films 2004, 466, 295-302.
42. Mei-Juan Han, Dong Wang, Ju-Min Hao, Li-Jun Wan,* Qing-Dao Zeng, Qing-Hua Fan and Chun-Li Bai,* "Absolute Configuration of Monodentate Phosphine Ligand Enantiomers on Cu(III)", Anal. Chem. 2004, 76, 627-631.
41. Liqin Qiu, Jing Wu, Shusun Chan, Terry T.-L. Au-Yeung, Jian-Xin Ji, Rongwei Guo, Cheng-Chao Pai, Zhongyuan Zhou, Xingshu Li, Qing-Hua Fan and Albert S. C. Chan,* "Remarkably Diastereoselective Synthesis of A Chiral Biphenyl Diphosphine Ligand and Its Application in Asymmetric Hydrogenation", P. Natl. Acad. Sci. USA.2004, 101, 5815-5820.
2003:
40. Guo-Hua Liu and Qing-Hua Fan,* Xi-Qiang Yang and Xiao-Min Chen, "Chiral BINOL-Centered Dendrimers for The Enantioselective Lewis Acid Catalyzed Diethylzinc Addition to Aldehydes", Arkivoc 2003, 123-132.
39. Dai-Hua Tang and Qing-Hua Fan,* "Convergent Synthesis of AB2-AB3 Hybrid-Type of Amphiphilic Oligoethyleneoxy-Modified Poly(Benzyl Ether) Dendrons", J. Chem. Res. 2003, 698-699.
38. Qing-Hua Fan, Xi-Qiang Yang, Guo-Hua Liu, Xiao-Min Chen and Albert S. C. Chan, "Synthesis of New Dendritic Chiral BINOL Ligands and Their Applications in Enantioselective Lewis Acid Catalyzed Addition of Diethylzinc to Aldehydes", Chem. J. Chinese. Univ. 2003, 274-277.
37. Guo-Jun Deng, Qing-Hua Fan,* Xiao-Min Chen and Guo-Hua Liu, "Dendritic BINAP Based System for Asymmetric Hydrogenation of Simple Aryl Ketones", J. Mol. Catal. A: Chem.2003, 193, 21-25.
36. Bai-Yuan Yang, Xiao-Min Chen,* Guo-Jun Deng, Yi-Li Zhang and Qing-Hua Fan,* "Chiral Dendritic Bis(Oxazoline) Copper(II) Complexes as Lewis Acid Catalysts for Enantioselective Aldol Reactions in Aqueous Media", Tetrahedron Lett. 2003, 44, 3535-3538.
35. Guo-Hua Liu, Wei-Jun Tang and Qing-Hua Fan,* "Dendritic BINOL Ligands for Asymmetric Aatalysis: Effect of the Linking Positions and Generations of the Dendritic Wedges on Catalyst Properties", Tetrahedron 2003, 59, 8603-8611.
34. Sai-Long Xu, Shi-Zhao Kang, Guo-Jun Deng, Peng Wu, Qing-Hua Fan, Chen Wang, Li-Jun Wan and Chun-Li Bai,* "Nanofrictional Properties of Dendron Langmuir–Blodgett Films", Chem. Lett. 2003, 32, 290-291.
33. Xuefeng Guo, Deqing Zhang,* Huijuan Zhang, Qing-Hua Fan, Wei Xu, Xicheng Ai, Louzheng Fan and Daoben Zhu,* "Donor–Acceptor–Donor Triads Incorporating Tetrathiafulvalene and Perylene Diimide Units: Synthesis, Electrochemical and Spectroscopic Studies", Tetrahedron 2003, 59, 4843-4850.
32. Shi-Zhao Kang, Sai-Long Xu, Guojun Deng, Peng Wu, Qing-Hua Fan, Chen Wang,* Lijun Wan, Chunli Bai,* "Langmuir Film Behaviors of Dendrons at Water–Air Interface", Chem. Phy. Lett. 2003, 370, 542-547.
31. Jian-Ru Gong, Sheng-Bin Lei, Li-Jun Wan,* Guo-Jun Deng, Qing-Hua Fan and Chun-Li Bai,* "Structure and Dynamic Process of Two-Dimensional Monodendron Assembly", Chem. Mater. 2003, 15, 3098-3104.
30. Can-Ping Du,* Guo-Qiang Lin, Ming Shi, Mei-Xiang WangandQing-Hua Fan, "Key Scientific Issues in the Development of Chiral Science and Chiral Drugs", Science Foundation in China 2003, 17, 72-75.
2002:
28. Qing-Hua Fan,* Rui Zhang, Guo-Jun Deng and Xiao-Min Chen, "The Synthesis of Amphiphilic Chiral Dendritic 1,1'-Bi-2-Naphthol Derivatives and Their Application as Amphiphiles in Aqueous Asymmetric Hydrogenation", J. Chem. Res. 2002, 318-320.
27. Qing-Hua Fan, Rui Wang and Albert S. C. Chan,* "Polymer-Supported Chiral Catalysts with Positive Support Effects", Bioorg. Med. Chem. Lett. 2002, 12, 1867-1871.
26. Guo-Jun Deng, Qing-Hua Fan,* Xiao-Min Chen, Dong-Shen Liu and Albert S. C. Chan, "A Novel System Consisting of Dendritic Ru-BINAP for Asymmetric Hydrogenation and Catalyst Recycling", Chem. Commun. 2002, 1570-1571.
25. Qing-Hua Fan, Yue-Ming Li* and Albert S. C. Chan,* "Recoverable Catalysts for Asymmetric Organic Synthesis", Chem. Rev. 2002, 102, 3385-3466.
24. Peng Wu, Guojun Deng, Sailong Xu, Qing-Hua Fan, Lijun Wan, Chen Wang and Chunli Bai, "Effect of Alkyl Substitutions on Self-Assembly", Chinese. Sci. Bull. 2002, 47, 1514-1517.
23. Peng Wu, Guojun Deng, Qing-Hua Fan, Qingdao Zeng, Chen Wang, Lijun Wan and Chunli Bai,* "Assembling Behavior of BINAP Derivative", Chem. Lett. 2002, 706-707.
22. Peng Wu, Qing-Hua Fan, Guojun Deng, Qingdao Zeng, Chen Wang* and Chunli Bai,* "Real Space Visualization of the Disklike Assembly Structure of Dendritic Molecules on Graphite", Langmuir 2002, 18, 4342-4344.
21. Peng Wu, Qing-Hua Fan, Qingdao Zeng, Chen Wang, Guojun Deng and Chunli Bai,* "Observation of Functional Group Mediated Assembling of Dendritic Molecules by STM", ChemPhysChem 2002, 3, 633-637.
2001:
20. Qing-Hua Fan,* Guo-Hua Liu, Guo-Jun Deng, Xiao-Min Chen and Albert S. C. Chan,* "New Soluble Bifunctional Polymeric Chiral Ligands for Enantioselectively Catalytic Reactions", Tetrahedron Lett. 2001, 42, 9047-9050.
19. Qing-Hua Fan,* Guo-Hua Liu, Xiao-Min Chen, Guo-Jun Deng and Albert S. C. Chan,* "The Synthesis of Dendritic BINOL Ligands and Their Applications in Enantioselective Lewis Acid Catalyzed Addition of Diethylzinc to Aldehydes", Tetrahedron: Asymmetry 2001, 12, 1559-1565.
18. Qing-Hua Fan,* Guo-Jun Deng, Chi-Ching Lin and Albert S. C. Chan,* "Preparation and Use of Meo-PEG-Supported Chiral Diphosphine Ligands: Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", Tetrahedron: Asymmetry 2001, 12, 1241-1247.
2000:
17. Qing-Hua Fan,* Guojun Deng, Xiaomin Chen, Wenchun Xie, Dazhi Jiang, Dongsheng Liu and Albert S. C. Chan,* "A Highly Effective Water-soluble Polymer-supported Catalyst for the Two-phase Asymmetric Hydrogenation: Preparation and Use of a PEG-bound BINAP Ligand", J. Mol. Catal. A: Chem.2000, 159, 37-43.
16. Qing-Hua Fan,* Yong-Ming Chen, Xiao-Min Chen, Da-Zhi Jiang, Fu Xi and Albert S. C. Chan,* "Highly Effective and Recyclable Dendritic BINAP Ligands for Asymmetric Hydrogenation", Chem. Commun. 2000, 789-790.
15. Aijun Gong, Qing-Hua Fan,Yongming Chen, Hongwei Liu, Chuanfu Chen and Fu Xi,* "Two-Phase Hydroformylation Reaction Catalysed by Rhodium-Complexed Water-Soluble Dendrimers", J. Mol. Catal. A: Chem. 2000, 159, 225-232.
14. Jiarong Duan, Jing Jiang, Junfang Gong, Qing-Hua Fan and Dazhi Jiang,* "Synthesis of Phenylacetic Acid by Carbonylation", J. Mol. Catal. A: Chem. 2000, 159, 89-96.
1999:
13. Qing-Hua Fan, Chang-Yu Ren, Chi-Hung Yeung, Wen-Hao Hu and Albert S. C. Chan,*"Highly Effective Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", J. Am. Chem. Soc. 1999, 121, 7407-7408.
12. Junfang Gong, Qing-Hua Fan and Dazhi Jiang,* "Nickel-Catalyzed Carbonylation of Methyl Acetate to Acetic Anhydride" J. Mol. Catal. A: Chem. 1999, 147, 113-124.
11. Ai-Jun Gong, Qing-Hua Fan, Yong-Ming Chen, Xi Zhang, Hong-Wei Liu, Chuan Fu Chen and Fu Xi,* "Hydroformylation Reaction Catalyzed by Rhodium-complexed Water Soluble Dendrimers", J. Mol. Sci. 1999, 15, 91-92.
1998-1992:
10. Qing-Hua Fan, Chi-Hung Yeung and Albert S. C. Chan,* "An Improved Synthesis of Chiral Diols via The Asymmetric Catalytic Hydrogenation of Prochiral Diones", Tetrahedron: Asymmetry 1997, 8, 4041-4045.
9. Qing-Hua Fan, Chi-Hung Yeung, Yi-Ching Li and Albert S. C. Chan,* "Soluble Chiral Polymer-Bound Binap Ligand and Its Applications in Asymmetric Hydrogenation", Abstr. Papers Am. Chem. Soc. 1997, 213, 219-Inor.
8. Qing-Hua Fan, Chi-Hung Yeung, Yi-Ching Li and Albert S. C. Chan,* "Synthesis of Novel Soluble BINAP-Containing Aromatic Polyamides and Their Applications in Asymmetric Catalysis", Abstr. Papers Am. Chem. Soc. 1997, 214, 89-Inor.
7. Albert S. C. Chan*, Ting-Ti Huang, Qing-Hua Fan, Cheng-Chao Pai and Yi-Ching Li, "Recent Advancements in Catalytic Asymmetric Hydrogenation", Chemistry (The Chinese Chem. Soc. TAIPEI), 1997, 55, 117-142.
6. Qing-Hua Fan, Ying Huang, Xiang-Lan Liu and Xu Zhang, "Preparation of Polysiloxane-Acrylic Composite Latexes Having Core-Shell Structure", Chinese Journal of Applied Chemistry 1995, 3, 52-56.
5. Qing-Hua Fan, Ying Huang and Xiang-Lan Liu, "Properties of Films of Siloxane Modified Styene-Butylacrylate Copolymer Latexes", China Synthetic Rubber Industry 1995, 5, 276-278.
4. Qing-Hua Fan, Ying Huang and Xiang-Lan Liu, "Styrene-Butylacrylate Copolymer Emulsion Modified by Silicone Emulsion II. Emulsion Copolymerization", Silicone Material 1995, 4, 1-3.
3. Qing-Hua Fan, Ying Huang and Xiang-Lan Liu, "Styrene-Butylacrylate Copolymer Emulsion Modified by Silicone Emulsion I. Emulsion Blending", Silicone Material 1995, 3, 8-10.
2. Qing-Hua Fan, Ying Huang and Xiang-Lan Liu, "A Studies on The Properties of The Films of Silicone-Modified Latexes", Silicone Material 1995, 1, 24-27.
1. Zi-Chen Li, Xi-Ming Xie, Qing-Hua Fan and Yi-Fei Fang,* "Polyeleostearic Acid Vesicles", Chinese Journal of Polymer Science 1992, 1, 26-31.
不对称催化
一、不对称催化 树状分子催化剂
手性二胺金属配合物催化亚胺和芳杂环的不对称氢化
环境友好的催化反应
手性超分子催化剂
二、功能树状分子的设计合成及组装 树状分子凝胶
树状分子-DNA杂合体
不对称催化
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103.Youran Liu, Fei Chen, Yan-Mei He, Chenghao Li, andQing-Hua Fan,*"Enantioselective synthesis of tunable chiral pyridine–aminophosphine ligands and their applications in asymmetric hydrogenation",Org. Biomol. Chem.2019,17, 5099–5105.
102.Cong Xu, Yu Feng, Faju Li, Jiahong Han, Yan-Mei He, andQing-Hua Fan,*"A Synthetic Route to Chiral Benzo-Fused N?Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes",OrganometallicDOI: 10.1021/acs.organomet.9b00183.
101.Ya Chen, Yan-Mei He, Shanshan Zhang, Tingting Miao, andQing-Hua Fan,*"Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination",Angew. Chem. Int. Ed.2019,58, 3809 –3813.
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100.Bin Li, Cong Xu, Yan-Mei He, Guo-Jun Deng, andQing-Hua Fan,*"Asymmetric Hydrogenation of Bis(quinolin-2-yl)methanes: A Direct Access to Chiral 1,3-Diamines",Chin. J.Chem.2018,36, 1169-1173.
99.Yuping Tang, Yanmei He, Yu Feng,andQing-Hua Fan,*"Asymmetric Supramolecular Catalysis Based on Macrocyclic Host Molecules",Progress in Chemistry2018,30,476-490.
98.Tingting Miao, Zi-You Tian, Yan-Mei He, Fei Chen, Ya Chen, Zhi-Xiang Yu,* andQing-Hua Fan,* "Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis", Angew.Chem.Int.Ed.2017,56, 4135–4139.
97. Zhusheng Yang, Ziyuan Ding, Fei Chen,* Yan-Mei He, Nianfa Yang,* andQing-Hua Fan,* "Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts", Eur. J. Org. Chem. 2017, 1973–1977.
96.Zhusheng Yang, Fei Chen,* Shuxin Zhang, Yanmei He, Nianfa Yang,* and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of Phenanthridine Derivatives", Org. Lett. 2017, 19, 1458?1461.
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95.Tianli Wang, Ya Chen, Guanghui Ouyang, Yan-Mei He,* ZhiyanLi and Qing-Hua Fan,* "Solvent-Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(Ethylene Glycol)s through Host–Guest Interactions", Chem.Asian J. 2016, 11, 2773–2777.
94.Zhusheng Yang, Fei Chen,* Yanmei He, Nianfa Yang andQing-Hua Fan,* "Highly Enantioselective Synthesis of Indolines: Asymmetric Hydrogenation at Ambient Temperature and Pressure with Cationic Ruthenium Diamine Catalysts",Angew.Chem.Int.Ed.2016,55,13863–13866.
93.Wenpeng Ma, Jianwei Zhang, Cong Xu, Fei Chen, Yan-Mei He andQing-Hua Fan,* "Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2'-Bisquinoline Derivatives"Angew.Chem.Int.Ed.2016, 55,2891-12894.
92.Wenpeng Ma, Fei Chen, Youran Liu, Yan-Mei He, andQing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives"Org. Lett.2016,18, 2730–2733.
91.Huan-Li Sun, Fei Chen, Ming-Sheng Xie, Hai-Ming Guo,* Gui-Rong Qu, Yan-Mei He, andQing-Hua Fan,* "Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues",Org. Lett.2016,18, 2260–2263.
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90. Jianwei Zhang, Fei Chen, Yan-Mei He,Qing-Hua Fan*,"Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins",Angew.Chem.Int.Ed.2015,54, 4622-4625.
89. Guang-Hui Ouyang, Yan-Mei He, Yong Li, Jun-Feng Xiang,Qing-Hua Fan*,"Cation-Triggered Switchable Asymmetric Catalysis with Chiral Aza-CrownPhos",Angew.Chem.Int.Ed.2015,54, 4334-4337.
88. Yan-Mei He,Qing-Hua Fan*,"Advances in Transfer Hydrogenation of Carbonyl Compounds in Water",ChemCatChem2015,7, 398-400.
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87. Yong Li, Yan-Mei He,Qing-Hua Fan,"Ionic Liquids in Transition Metal-Catalyzed Enantioselective Reactions",Top. Organomet. Chem.2015,51, 323–348.
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86. Fei Chen, Zi-Yuan Ding, Yan-Mei He,Qing-Hua Fan*,"Synthesis of Optically Active 1,2,3,4-TetrahydroquinolinesviaAsymmetric Hydrogenation Using Iridium-Diamine Catalyst",Org. Synth.2015,92, 213-226.
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85. Yan-Mei He, Yu Feng,Qing-Hua Fan*, "Asymmetric hydrogenation in the core of dendrimers",Acc. Chem. Res.2014,47,2894-2906.
84. Yan-Mei He, Feng-Tao Song,Qing-Hua Fan*, "Advances in transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds",Top. Curr. Chem.2014,343, 145–190.
83. Guang-Hui Ouyang, Yan-Mei He,*Qing-Hua Fan*, "Podand-Based Dimeric Chromium(III)–Salen Complex for Asymmetric Henry Reaction: Cooperative Catalysis Promoted by Complexation of Alkali Metal Ions",Chem. Eur. J.2014,20, 16454-16457 (hot papaer).
82. Baode Ma, Tingting Miao, Yihua Sun, Yanmei He, Ji Liu, Yu Feng, Hui Chen,*Qing-Hua Fan*, "A new class of tunable dendritic diphosphine ligands: synthesis and applications in the ru-catalyzed asymmetric hydrogenation of functionalized ketones",Chem. Eur. J.2014,20, 9969-9978.
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81. Zhusheng Yang, Fei Chen,* Yan-Mei He, Nianfa Yang*,Qing-Hua Fan*, "Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes",Catal. Sci. Technol.2014,4, 2887-2890.
80. Feng-Tao Song, Guang-Hui Ouyang, Yong Li, Yan-Mei He*,Qing-Hua Fan*, "New metallacrown ether catalysts containing phosphine-phosphite polyether ligands for Rh-catalyzed asymmetric hydrogenation: enhancements in activity and enantioselectivity",Eur. J. Org. Chem.2014, 30,6713-6719.
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79. Jie Qin, Fei Chen, Yan-Mei He,Qing-Hua Fan*, "Asymmetric hydrogenation of 3-substituted 2H-1,4-benzoxazines with chiral cationic Ru-MsDPEN catalysts: remarkable counteranion effect",Org. Chem. Front.2014, 1,952-955.
78. Yong Li, Yanmei He, Fei Chen,Qinghua Fan*,"Asymmetric Hydrogenation of 2-Aryl-5,6-dihydropyrazine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts",Chin. J. Chem.2014,32, 991-994.
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77. Ji Liu, Baode Ma, Yu Feng, Yanmei He,* andQing-Hua Fan,* "Dendritic [Rucl2(BINAP)(DPEN)] Catalysts with 'Sandwich' Multi-Layer Structure for Asymmetric Hydrogenation of Simple Aryl Ketones",Inorgan.Chim. Acta2014,409, 106-111.
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76. Yigang Ji, Lei Wu*,Qing-Hua Fan,*"Recent progress of metal/metal oxide nanoparticles for asymmetric hydrogenation and transfer hydrogenation",Acta Chim. Sinica2014,72, 798-808. (Invited Review)
75. Yi-Yong Huang,* Xing Yang, Yu Feng, Francis Verpoort,Qing-Hua Fan,*"Chiral Ru/Ir bimetallic dendronized polymer catalysts constructedthrough sequential metal coordination and applied in asymmetrichydrogenation of quinaldine",J. Mol. Catal. A: Chem.2014,393,150-155.
74.Zi-Yuan Ding,Tianli Wang,Yan-Mei He,Fei Chen,Hai-Feng Zhou,Qing-Hua Fan,*Qingxiang Guo,*and Albert S. C. Chan, "Highly Enantioselective Synthesis of Chiral Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed Asymmetric Hydrogenation in Ionic Liquid",Adv.Synth. Catal.2013,355, 3727-3735.
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73. Tianli Wang,Fei Chen,Jie Qin,Yan-Mei He and Qing-Hua Fan,* "Asymmetric Ruthenium-Catalyzed Hydrogenation of 2- and 2,9-Substituted 1,10-Phenanthrolines", Angew. Chem. Int. Ed. 2013,52, 7172-7176.
72. Baode Ma, Guojun Deng, Ji Liu, Yanmei He and Qing-Hua Fan,* "Synthesis of Dendritic BINAP Ligands and Their Applications in the Asymmetric Hydrogenation: Exploring the Relationship between Catalyst Structure and Catalytic Performance", Acta Chim. Sinica 2013, 71, 528-534.
71. Baode Ma, Ziyuan Ding, Ji Liu, Yanmei He and Qing-Hua Fan,* "Highly Enantioselective Hydrogenation of 2,4-Diaryl-1,5-Benzodiazepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes", Chem. Asian J. 2013, 8, 1101-1104.
70. Ji Liu, Yu Feng, Baode Ma, Yan-Mei He and Qing-Hua Fan,* "Design and Synthesis of Janus-Type Chiral Dendritic Diphosphanes and Their Applications in Asymmetric Hydrogenation", Eur. J. Org. Chem. 2012, 6737-6744.
69. Liwen Zhao, Ji Liu, Yu Feng, Yanmei He and Qing-Hua Fan,* "Facile Synthesis of Chiral Diphosphine-Containing Multiple Dendrimeric Catalysts for Enantioselective Hydrogenation", Chin. J. Chem. 2012, 30, 2009-2015.
68. Fei Chen, Ziyuan Ding, Yanmei He, Jie Qin, Tianli Wang and Qing-Hua Fan,* "Asymmetric Hydrogenation of N-Alkyl and N-Aryl Ketimines using Chiral CationicRu(Diamine) Complexes as Catalysts: The Counteranion and Solvent Effects, and Substrate Scope", Tetrahedron 2012, 68, 5248-5257.
67. Zi-Yuan Ding, Fei Chen, Jie Qin, Yan-Mei He and Qing-Hua Fan,* "Asymmetric Hydrogenation of 2,4-Disubstituted 1,5-Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity", Angew. Chem. Int. Ed. 2012, 51, 5706-5710.
66. Ji Liu, Yu Feng, Yanmei He, Nianfa Yang* and Qing-Hua Fan,* "Janus Dendritic Phosphines: Synthesis and Application in Suzuki Coupling Reactions", New J. Chem. 2012, 36, 380-385.
65. Lei Wu, Yan-Mei He and Qing-Hua Fan,* "Controlled Reversible Anchoring of ?6-Arene/TsDPEN Ruthenium(II) Complex onto Magnetic Nanoparticles: A New Strategy for Catalyst Separation and Recycling", Adv. Synth. Catal. 2011, 353, 2915-2919.
64. Jie Qin, Fei Chen, Ziyuan Ding, Yan-Mei He, Lijin Xu and Qing-Hua Fan,* "Asymmetric Hydrogenation of 2- and 2,3-Substituted Quinoxalines with Chiral Cationic Ruthenium Diamine Catalysts", Org. Lett. 2011, 13, 6568-6571. <Highlight by Synfacts 2012, 8, 191.>
63. Fei Chen, Ziyuan Ding, Jie Qin, Tianli Wang, Yanmei He and Qing-Hua Fan,* "Highly Effective Asymmetric Hydrogenation of Cyclic N-Alkyl Imines with Chiral Cationic Ru-MsDPEN Catalysts", Org. Lett, 2011, 13, 4348-4351. <Highlight by Synfacts 2011, 10, 1092.>
62. Tianli Wang, Lian-Gang Zhuo, Zhiwei Li, Fei Chen, Ziyuan Ding, Yanmei He, Qing-Hua Fan,* Junfeng Xiang, Zhi-Xiang Yu* and Albert S. C. Chan, "Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity", J. Am. Chem. Soc. 2011, 133, 9878-9891.
61. Tianli Wang, Guanghui Ouyang, Yan-Mei He and Qing-Hua Fan,* "Asymmetric Tandem Reduction of 2-(Aroylmethyl)quinolines with Phosphine-Free Ru-TsDPEN Catalyst", Synlett 2011, 7, 939-942.
60. Fei Chen, Tianli Wang, Yanmei He, Ziyuan Ding, Zhiwei Li, Lijin Xu and Qing-Hua Fan,* "Asymmetric Hydrogenation of N-Alkyl Ketimines with Phosphine-Free, Chiral, Cationic Ru-MsDPEN Catalysts", Chem. Eur. J. 2011, 17, 1109-1113.<Highlight by Synfacts 2011, 4, 420.>
59. Jing Tan, Weijun Tang, Yawei Sun, Zhen Jiang, Fei Chen, Lijin Xu,* Qing-Hua Fan* and Jianliang Xiao,* "pH-Regulated Transfer Hydrogenation of Quinoxalines with A Cp*Ir-diamine Catalyst in Aqueous Media", Tetrahedron 2011, 67, 6206-6213.
58.Qing-Hua FanandKuiling Ding,* "Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts", Top. Organomet. Chem. 2011, 36, 207-246.
57. Yong Li,Baode Ma,Yanmei He,Feng Zhangand Qing-Hua Fan,* "Chiral Metallacrown Ethers forAsymmetric Hydrogenation: Alkali-Metal Ion Mediated Enhancement of Enantioselectivity", Chem. Asian J. 2010, 5, 2454-2458.
56. Fei Chen, Zhiwei Li, Yanmei He and Qing-Hua Fan,* "Asymmetric Hydrogenation of Cyclic N-Sulfonylimines with Phosphine-Free Chiral Cationic Ru-MsDPEN Catalysts", Chin. J. Chem. 2010, 28, 1529-1532.
55. Yan-Mei He and Qing-Hua Fan* "Phosphine-Free Chiral Metal Catalysts for Highly Effective Asymmetric Catalytic Hydrogenation", Org. Biomol. Chem. 2010, 8, 2497-2504.
54. Ji Liu, Baode Ma, Nianfa Yang* and Qinghua Fan,* "Soluble Polymer-Supported Homogeneous Catalysts", Prog. Chem. 2010, 22, 1457-1470.
53. Baode Ma and Qinghua Fan,* "Progress on Chiral Dendrimeric Phosphorous Ligands in Asymmetric Catalytic Hydrogenations", Sci. Sinica Chim. 2010, 40, 827-836.
52. Wei-Jun Tang, Jing Tan, Li-Jin Xu,* Kim-Hung Lam, Qing-Hua Fan and Albert S. C. Chan, "Highly Enantioselective Hydrogenation of Quinoline and Pyridine Derivatives with Iridium-(P-Phos) Catalyst", Adv. Synth. Catal. 2010, 352, 1055-1062.
51. Weijun Tang, Yawei Sun, Lijin Xu,* Tianli Wang, Qing-Hua Fan, Kim-Hung Lam and Albert S. C. Chan, "Highly Efficient and Enantioselective Hydrogenation of Quinolines and Pyridines with Ir-Difluorphos Catalyst", Org. Biomol. Chem. 2010, 8, 3464-3471.
50. Bing Yi,* Hua-Ping He and Qing-Hua Fan, "Synthesis and Application of Peripherally Alkyl-Functionalized Dendritic Pyrphos Ligands: Homogeneous-Supported Catalysts for Enantioselective Hydrogenation", J. Mol. Catal. A: Chem. 2010, 315, 82-85.
49. Yong Li,* Zhiling Wang, Yanmei He and Qinghua Fan, "Advance in Preparation and Application of Supramolecular Bidentate Phosphorus Ligands", Chinese J. Org. Chem. 2010, 30, 338-344.
48. Feng Zhang and Qing-Hua Fan,* "Synthesis and Application of Bulky Phosphoramidites: Highly Effective Monophosphorus Ligands for Asymmetric Hydrosilylation of Styrenes", Org. Biomol. Chem. 2009, 7, 4470-4474.
47. Weijun Tang, Lijin Xu,* Qing-Hua Fan,* Jun Wang, Baomin Fan, Zhongyuan Zhou, Kim-hung Lam and Albert S. C. Chan, "Asymmetric Hydrogenation of Quinoxalines with Diphosphinite Ligands: A Practical Synthesis of Enantioenriched, Substituted Tetrahydroquinoxalines", Angew. Chem. Int. Ed. 2009, 48, 9135-9138.
46. Zhi-Jian Wang, Hai-Feng Zhou, Tian-Li Wang, Yan-Mei He and Qing-Hua Fan,* "Highly Enantioselective Hydrogenation of Quinolines under Solvent-Free or Highly Concentrated Conditions", Green Chem. 2009, 11, 767-769.
45. Yong Li, Yan-Mei He, Zhi-Wei Li, Feng Zhang and Qing-Hua Fan,* "Supramolecular Chiral Dendritic Monophosphites Assembled by Hydrogen Bonding and Their Use in The Rh-Catalyzed Asymmetric Hydrogenation", Org. Biomol. Chem. 2009, 7, 1890-1895.
44. Feng Zhang, Yong Li, Zhi-Wei Li, Yan-Mei He, Shou-Fei Zhu, Qing-Hua Fan* and Qi-Lin Zhou,* "Modular Chiral Dendritic Monodentate Phosphoramidite Ligands for Rh(II)-Catalyzed Asymmetric Hydrogenation: Unprecedented Enhancement of Enantioselectivity", Chem. Commun. 2008, 6048-6050.
43. Zhi-Wei Li, Tian-Li Wang, Yan-Mei He, Zhi-Jian Wang, Qing-Hua Fan,* Jie Pan and Li-Jin Xu,* "Air-Stable and Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of Quinoline Derivatives", Org. Lett. 2008, 10, 5265-5268.<Highlight by Synfacts 2009, 2, 174.>
42. Haifeng Zhou, Zhiwei Li, Zhijian Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,* Jie Pan, Lianquan Gu and Albert S. C. Chan,* "Hydrogenation of Quinolines Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid", Angew. Chem. Int. Ed. 2008, 47, 8464-8467.
41. Yong Li, Yu Feng, Yan-Mei He, Fei Chen, Jie Pan and Qing-Hua Fan,* "Supramolecular Chiral Phosphorous Ligands Based on A [2]Pseudorotaxane Complex for Asymmetric Hydrogenation", Tetrahedron Lett. 2008, 49, 2878-2881.
40. Lei Wu, Zhi-Wei Li, Feng Zhang, Yan-Mei He and Qing-Hua Fan,* "Air-Stable and Highly Active Dendritic Phosphine Oxide-Stabilized Palladium Nanoparticles: Preparation, Characterization and Applications in the Carbon-Carbon Bond Formation and Hydrogenation Reactions", Adv. Synth. Catal. 2008, 350, 846-862.<Highlight by Synfacts 2008, 8, 882.>
39. HaifengZhou, Qing-Hua Fan,* Yanmei He, Lianquan Gu* and Albert S. C. Chan,*"Application of Liquid Poly( Ethylene Glycol)s as Green Reaction Media in Organic Reactions", Prog. Chem. 2007, 19, 1517-1528.
38. Sau Hing Chan, Kim Hung Lam,* Yue-Ming Li, Lijin Xu, Weijun Tang, Fuk Loi Lam, Wai Hung Lo, Wing Yiu Yu, Qing-Hua Fan* and Albert S. C. Chan,* "Asymmetric Hydrogenation of Quinolines with Recyclable and Air-Stable Iridium Catalyst Systems", Tetrahedron: Asymmetry 2007, 18, 2625-2631.
37. Hai-Feng Zhou, Qing-Hua Fan,* Yi-Yong Huang, Lei Wu, Yan-Mei He, Wei-Jun Tang, Lian-Quan Gu* and Albert S. C. Chan,* "Mixture of Poly(Ethylene Glycol) and Water as Environmentally Friendly Media for Efficient Enantioselective Transfer Hydrogenation and Catalyst Recycling", J. Mol. Catal. A: Chem. 2007, 275, 47-53.
36. Wei-Jun Tang, Shou-Fei Zhu, Li-Jin Xu,* Qi-Lin Zhou, Qing-Hua Fan,* Hai-Feng Zhou, Kimhung Lam and Albert S. C. Chan,* "Asymmetric Hydrogenation of Quinolines With High Substrate/Catalyst Ratio", Chem. Commun. 2007, 613-615.<Highlight by Synfacts 2007, 4, 363.>
35. Zhi-Jian Wang, Guo-Jun Deng, Yong Li, Yan-Mei He, Wei-Jun Tang and Qing-Hua Fan,* "Enantioselective Hydrogenation of Quinolines Catalyzed by Ir(BINAP)-Cored Dendrimers: Dramatic Enhancement of Catalytic Activity" Org. Lett. 2007, 9, 1243-1246.
34. Liqin Qiu, Yue-Ming Li, Fuk Yee Kwong, Wing-Yiu Yu, Qing-Hua Fan and Albert S. C. Chan, "Highly Efficient Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids Catalyzed by Ruthenium(II)-Dipyridylphosphine Complexes", Adv. Synth Catal. 2007, 349, 517-520.
33. Lijin Xu, Kim Hung Lam, Jiwu Ruan, Qing-Hua Fan and Albert S. C. Chan, "Ruthenium Catalyzed Asymmetric Hydrogenation of α- and β-Ketoesters in Room Temperature Ionic Liquids Using Chiral P-Phos Ligand", ACS Symposium Series 2007, 950,224-234.
32. Liwen Zhao, Qing-Hua Fan,* Haifeng Zhou, Yanmei He, Lianquan Gu* and Albert S. C. Chan,* "Study of Dendrimers as Supports for Organic Synthesis", Prog. Chem. 2006, 18, 317-330.
31. Wei-Jun Tang, Yi-Yong Huang, Yan-Mei He and Qing-Hua Fan,* "Dendritic MonoPhos: Synthesis and Application in Rh-Catalyzed Asymmetric Hydrogenation", Tetrahedron: Asymmetry 2006, 17, 536-543.
30. Yi-Li Zhang, Feng Zhang, Wei-Jun Tang, Qing-Lai Wu and Qing-Hua Fan,* "Synthesis and Application of 3,3′-Diarylmethyl BINOLs", Synlett 2006, 8,1250-1254.
29. Guo-Jun Deng, Guo-Rui Li, Ling-Yun Zhu, Hai-Feng Zhou,Yan-Mei He, Qing-Hua Fan* and Zhi-Gang Shuai,* "Dendritic BIPHEP: Synthesis and Application in Asymmetric Hydrogenation of β-Ketoesters", J. Mol. Catal. A: Chem.2006, 244, 118-123.
28. Hai-Feng Zhou, Qing-Hua Fan,* Wei-Jun Tang, Li-Jin Xu, Yan-Mei He, Guo-Jun Deng, Li-Wen Zhao, Lian-Quan Gu* and Albert S. C. Chan,* "Polyethylene Glycol as an Environmentally Friendly and Recyclable Reaction Medium for Enantioselective Hydrogenation", Adv. Synth. Catal. 2006, 348, 2172-2182.
27. Lei Wu, Bao-Lin Li, Yi-Yong Huang, Hai-Feng Zhou, Yan-Mei He and Qing-Hua Fan,* "Phosphine Dendrimer-Stabilized Palladium Nanoparticles, a Highly Active and Recyclable Catalyst for the Suzuki-Miyaura Reaction and Hydrogenation", Org. Lett. 2006, 8, 3605-3608.<Highlight by Synfacts 2006, 11, 1185.>
26. Yi-Yong Huang, Yan-Mei He, Hai-Feng Zhou, Lei Wu, Bao-Lin Li and Qing-Hua Fan,* "Thermomorphic System with Non-Fluorous Phase-Tagged Ru(BINAP) Catalyst: Facile Liquid/Solid Catalyst Separation and Application in Asymmetric Hydrogenation", J. Org. Chem. 2006, 71, 2874-2877.
25. Yi-Yong Huang, Hai-Liang Zhang, Guo-Jun Deng, Wei-Jun Tang, Xia-Yu Wang,* Yan-Mei He and Qing-Hua Fan,* "Synthesis of Triphenylphosphine-Functionalized Dendrimers and Application to Olefin Hydroformylation", J. Mol. Catal. A: Chem. 2005, 227, 91-96.
24. Kim Hung Lam, Lijin Xu,* Lichun Feng, Qing-Hua Fan,* Fuk Loi Lam, Wai-hung Lo and Albert S. C. Chan,* "Highly Enantioselective Iridium-Catalyzed Hydrogenation of Quinoline Derivatives Using Chiral Phosphinite H8-BINAPO", Adv. Synth. Catal. 2005, 347, 1755-1758.
23. Lijin Xu, Kim Hung Lam, Jianxin Ji, Jing Wu, Qing-Hua Fan,* Wai-Hung Lo and Albert S. C. Chan,* "Air-Stable Ir-(P-Phos) Complex for Highly Enantioselective Hydrogenation of Quinolines and Their Immobilization in Poly(Ethyleneglycol) Dimethyl Ether (DMPEG)", Chem. Commun. 2005, 1390-1392.<Highlight by Synfacts 2005, 0, 37.>
22. Weiguo Liu, Xin Cui, Linfeng Cun, Jun Wu, Jin Zhu, Jingen Deng* and Qing-Hua Fan, "Novel Dendritic Ligands of Chiral 1,2-Diamine and Their Application in Asymmetric Hydrogenation of Simple Aryl Ketones", Synlett 2005, 1591-1595.
21. Qing-Hua Fan, "Polymeric Materials in Organic Synthesis and Catalysis", Angew. Chem. Int. Ed. 2004, 43, 6236-6237.
20. Yi-Yong Huang, Guo-Jun Deng, Xia-Yu Wang,Yan-Mei He and Qing-Hua Fan,* "Improved Synthesis of 5,5-Diamino BINAP and Application to Asymmetric Hydrogenation", Chin. J. Chem. 2004, 22, 891-893.
19. Wei-Jun Tang, Nian-Fa Yang,* Bing Yi, Guo-Jun Deng, Yi-Yong Huang and Qing-Hua Fan,* "Phase Selectively Soluble Dendrimer-Bound Osmium Complex: A Highly Effective and Easily Recyclable Catalyst for Olefin Dihydroxylation", Chem. Commun. 2004, 1378-1379.
18. Guo-Jun Deng, Bing Yi, Yi-Yong Huang, Wei-Jun Tang, Yan-Mei He and Qing-Hua Fan,* "Dendronized Poly(Ru-BINAP) Complexes: Highly Effective and Easily Recyclable Catalysts for Asymmetric Hydrogenation", Adv. Synth. Catal. 2004, 346, 1440-1444.
17. Bing Yi, Qing-Hua Fan,* Guo-Jun Deng, Yue-Ming Li, Li-Qin Qiu and Albert S. C. Chan,* "Novel Chiral Dendritic Diphosphine Ligands for Rh(I)-Catalyzed Asymmetric Hydrogenation: Remarkable Structural Effects on Catalytic Properties", Org. Lett. 2004, 6, 1361-1364.
16. Guo-Hua Liu and Qing-Hua Fan,* Xi-Qiang Yang and Xiao-Min Chen, "Chiral BINOL-Centered Dendrimers for The Enantioselective Lewis Acid Catalyzed Diethylzinc Addition to Aldehydes", Arkivoc 2003, 123-132.
15. Qing-Hua Fan, Xi-Qiang Yang, Guo-Hua Liu, Xiao-Min Chen and Albert S. C. Chan, "Synthesis of New Dendritic Chiral BINOL Ligands and Their Applications in Enantioselective Lewis Acid Catalyzed Addition of Diethylzinc to Aldehydes", Chem. J. Chinese. Univ. 2003, 274-277.
14. Guo-Jun Deng, Qing-Hua Fan,* Xiao-Min Chen and Guo-Hua Liu, "Dendritic BINAP Based System for Asymmetric Hydrogenation of Simple Aryl Ketones", J. Mol. Catal. A: Chem.2003, 193, 21-25.
13. Bai-Yuan Yang, Xiao-Min Chen,* Guo-Jun Deng, Yi-Li Zhang and Qing-Hua Fan,* "Chiral Dendritic Bis(Oxazoline) Copper(II) Complexes as Lewis Acid Catalysts for Enantioselective Aldol Reactions in Aqueous Media", Tetrahedron Lett. 2003, 44, 3535-3538.
12. Guo-Hua Liu, Wei-Jun Tang and Qing-Hua Fan,* "Dendritic BINOL Ligands for Asymmetric Aatalysis: Effect of the Linking Positions and Generations of the Dendritic Wedges on Catalyst Properties", Tetrahedron 2003, 59, 8603-8611.
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11. Qing-Hua Fan,* Rui Zhang, Guo-Jun Deng and Xiao-Min Chen, "The Synthesis of Amphiphilic Chiral Dendritic 1,1'-Bi-2-Naphthol Derivatives and Their Application as Amphiphiles in Aqueous Asymmetric Hydrogenation", J. Chem. Res. 2002, 318-320.
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10. Qing-Hua Fan, Rui Wang and Albert S. C. Chan,* "Polymer-Supported Chiral Catalysts with Positive Support Effects", Bioorg. Med. Chem. Lett. 2002, 12, 1867-1871.
9. Guo-Jun Deng, Qing-Hua Fan,* Xiao-Min Chen, Dong-Shen Liu and Albert S. C. Chan, "A Novel System Consisting of Dendritic Ru-BINAP for Asymmetric Hydrogenation and Catalyst Recycling", Chem. Commun. 2002, 1570-1571.
8. Qing-Hua Fan, Yue-Ming Li* and Albert S. C. Chan,* "Recoverable Catalysts for Asymmetric Organic Synthesis", Chem. Rev. 2002, 102, 3385-3466.
7. Qing-Hua Fan,* Guo-Hua Liu, Guo-Jun Deng, Xiao-Min Chen and Albert S. C. Chan,* "New Soluble Bifunctional Polymeric Chiral Ligands for Enantioselectively Catalytic Reactions", Tetrahedron Lett. 2001, 42, 9047-9050.
6. Qing-Hua Fan,* Guo-Hua Liu, Xiao-Min Chen, Guo-Jun Deng and Albert S. C. Chan,* "The Synthesis of Dendritic BINOL Ligands and Their Applications in Enantioselective Lewis Acid Catalyzed Addition of Diethylzinc to Aldehydes", Tetrahedron: Asymmetry 2001, 12, 1559-1565.
5. Qing-Hua Fan,* Guo-Jun Deng, Chi-Ching Lin and Albert S. C. Chan,* "Preparation and Use of Meo-PEG-Supported Chiral Diphosphine Ligands: Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", Tetrahedron: Asymmetry 2001, 12, 1241-1247.
4. Qing-Hua Fan,* Guojun Deng, Xiaomin Chen, Wenchun Xie, Dazhi Jiang, Dongsheng Liu and Albert S. C. Chan,* "A Highly Effective Water-soluble Polymer-supported Catalyst for the Two-phase Asymmetric Hydrogenation: Preparation and Use of a PEG-bound BINAP Ligand", J. Mol. Catal. A: Chem.2000, 159, 37-43.
3. Qing-Hua Fan,* Yong-Ming Chen, Xiao-Min Chen, Da-Zhi Jiang, Fu Xi and Albert S. C. Chan,* "Highly Effective and Recyclable Dendritic BINAP Ligands for Asymmetric Hydrogenation", Chem. Commun. 2000, 789-790.
2. Qing-Hua Fan, Chang-Yu Ren, Chi-Hung Yeung, Wen-Hao Hu and Albert S. C. Chan,*"Highly Effective Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", J. Am. Chem. Soc. 1999, 121, 7407-7408.
1. Qing-Hua Fan, Chi-Hung Yeung and Albert S. C. Chan,* "An Improved Synthesis of Chiral Diols via The Asymmetric Catalytic Hydrogenation of Prochiral Diones", Tetrahedron: Asymmetry 1997, 8, 4041-4045.
功能树状分子的设计合成及组装
一、不对称催化 树状分子催化剂
手性二胺金属配合物催化亚胺和芳杂环的不对称氢化
环境友好的催化反应
手性超分子催化剂
二、功能树状分子的设计合成及组装 树状分子凝胶
树状分子-DNA杂合体
功能树状分子的设计合成及组装
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52.Yi Peng, Yu Feng,* Guo-Jun Deng, Yan-Mei He, andQing-Hua Fan"From Weakness to Strength: C–H/π-Interaction-Guided Self-Assembly and Gelation of Poly(benzyl ether) Dendrimers",Langmuir2016,32, 9313–9320.
51.Yu Feng,* Hui Chen, Zhi-Xiong Liu, Yan-Mei He andQing-Hua Fan, "A Pronounced Halogen Effect on the Organogelation Properties of Peripherally Halogen Functionalized Poly(benzyl ether) Dendrons",Chem. Eur. J.2016,22, 4980-4990.
50.Zhi-Xiong Liu, Yihua Sun, Yu Feng,* Hui Chen, Yan-Mei He andQing-Hua Fan, "Halogen-bonding for visual chloride ion sensing: a case study using supramolecular poly(aryl ether) dendritic organogel systems",Chem. Commun.2016,52, 2269-2272.
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49. Hui Chen, Yu Feng*, Guo-Jun Deng, Zhi-Xiong Liu, Yan-Mei He,Qing-Hua Fan*,"Fluorescent Dendritic Organogels Based on 2-(2'-Hydroxyphenyl)benzoxazole: Emission Enhancement and Multiple Stimuli-Responsive Properties",Chem. Eur. J.2015,21, 11018–11028.
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48. Fen Wu, Juan Jin, Liying Wang, Pengfei Sun, Huanxiang Yuan, Zhongqiang Yang, Guosong Chen,Qing-Hua Fan*,Dongsheng Liu*, "Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association",ACS Appl. Mater. Interfaces2015,7, 7351?7356.
47. Fen Wu, Yongshun Song, Zhiyong Zhao, Shusheng Zhang, Zhongqiang Yang, Zhibo Li, Ming Li*,Qing-Hua Fan*,Dongsheng Liu*, "Preparation and Self-Assembly of Supramolecular Coil?Rod?Coil Triblock Copolymer PPO?dsDNA?PPO",Macromolecules2015,48, 7550?7556.
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46. Fen Wu,Yiyang Zhang, Zhongqiang Yang*, "An Overview of Self-Assembly and Morphological Regulation of Amphiphilic DNA Organic Hybrids",Chin. J. Chem.2015,33, 511-516.
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45. Yu Feng, Zhi-Xiong Liu, Hui Chen, Zhi-Chao Yan, Yan-Mei He,* Chen-Yang Liu,Qing-Hua Fan*, "A systematic study of peripherally multiple aromatic ester-functionalized poly(benzyl ether) dendrons for the fabrication of organogels: structure-property relationships and thixotropic property",Chem. Eur. J.2014,20, 7069-7082.
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44. Yu Feng, Yan-Mei He,Qing-Hua Fan*, "Supramolecular organogels based on dendrons and dendrimers",Chem. Asian J.2014,9, 1724-1750 (Revited Focus Review).
43.Zhi-Xiong Liu,Yu Feng,*Zhi-Yong Zhao, Zhi-Chao Yan,Yan-Mei He,Xu-Jun Luo,Chen-Yang LiuandQing-Hua Fan,* "A New Class of Dendritic Metallogels with Multiple Stimuli-Responsiveness and as Templates for the In Situ Synthesis of Silver Nanoparticles",Chem.Eur. J.2014,20, 533-541.
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42. Zhiyong Zhao, Chun Chen, Yuanchen Dong, Zhongqiang Yang,Qing-Hua Fan*,Dongsheng Liu*, "Thermally Triggered Frame-Guided Assembly",Angew. Chem. Int. Ed.2014,53,13468-13470.
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41. Zhiyong Zhao, Fen Wu, Zhongqiang Yang,* Dongsheng Liu and Qing-Hua Fan,* "Synthesis and Self-Assembly of DNA-Aliphatic Polyether Dendron Hybrids", Acta Chim. Sinica 2013, 71, 549-554.
40. Ji Liu, Yu Feng, Zhi-Xiong Liu, Zhi-Chao Yan, Yan-Mei He, Chen-Yang Liu and Qing-Hua Fan,* "N-Boc-Protected 1,2-Diphenylethylenediamine-Based Dendritic Organogels with Multiple-Stimulus-Responsive Properties", Chem. Asian J. 2013, 8, 572-581.
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39. Zhi-Xiong Liu, Yu Feng, Zhi-Chao Yan, Yan-Mei He, Chen-Yang Liu and Qing-Hua Fan,* "Multistimuli Responsive Dendritic Organogels Based on Azobenzene-Containing Poly(aryl ether) Dendron", Chem. Mater. 2012, 24, 3751-3757.
38. Yu Feng, Zhixiong Liu, Liying Wang, Hui Chen, Yan-Mei He* and Qing-Hua Fan,* "Poly(Benzyl Ether) Dendrons without Conventional Gelation Motifs as A New Kind of Effective Organogelators", Chinese Sci. Bull. 2012, 57, 4289-4295.
37. Zhiyong Zhao, Liying Wang, Yu Liu, Zhongqiang Yang, Yan-Mei He, Zhibo Li, Qing-Hua Fan* and Dongsheng Liu,* "Ph-Induced Morphology-Shifting of DNA-b-Poly(Propylene Oxide) Assemblies", Chem. Commun. 2012, 48, 9753-9755.
36. Liying Wang, Yu Feng, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Reversibly Controlled Morphology Transformation of An Amphiphilic DNA–Dendron Hybrid", Chem. Commun. 2012, 48, 3715-3717.
35. Guangxi Huang, Baode Ma, Jianming Chen, Qian Peng, Guanxin Zhang,* Qinghua Fan and Deqing Zhang,* "Dendron-Containing Tetraphenylethylene Compounds: Dependence of Fluorescence and Photocyclization Reactivity on The Dendron Generation", Chem. Eur. J. 2012, 18, 3886-3892.
34. Jin-Liang Lv, Zhi-Yong Zhao, Zhong-Qiang Yang, Dong-Sheng Liu* and Qing-Hua Fan,* "Synthesis of Dendritic Oligodeoxyribonucleotide Analogs with NonionicDiisopropylsilyl Linkage", Tetrahedron 2011, 67, 9080-9086.
33. Liying Wang, Yu Feng, Yawei Sun, Zhibo Li, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Amphiphilic DNA-Dendron Hybrid: A New Building Block for Functional Assemblies", Soft Matter 2011, 7, 7187-7190.
32. Xu Zhang, Ting Chen, Hui-Juan Yan, Dong Wang,* Qing-Hua Fan, Li-Jun Wan,* Koushik Ghosh, Hai-Bo Yang and Peter J. Stang, "Hydrogen Bond Partner Reorganization in The Coadsorption of A Monodendron and Pyridylethynyl Derivatives", Langmuir 2011, 27, 1292-1297.
31. Yawei Sun, Huajie Liu, Lijin Xu,Liying Wang, Qing-Hua Fan* and Dongsheng Liu,* "DNA Molecular Motor Controlled Dendron Association", Langmuir 2010, 26, 12496-12499.
30. Qun Chen, Yu Feng, Deqing Zhang,* Guanxin Zhang, Qing-Hua Fan,* Shuna Sun and Daoben Zhu, "Light-Triggered Self-Assembly of A Spiropyran-Functionalized Dendron into Nano-/Micrometer-Sized Particles and Photoresponsive Organogel with Switchable Fluorescence", Adv. Funct. Mater. 2010, 20, 36-42.
29. Xu Zhang, Ting Chen, Hui-Juan Yan, Dong Wang,* Qing-Hua Fan, Li-Jun Wan,* Koushik Ghosh, Hai-Bo Yang and Peter J. Stang,* "Engineering of Linear Molecular Nanostructures by A Hydrogen-Bond-Mediated Modular and Flexible Host-Guest Assembly", ACS Nano 2010, 4, 5685-5692.
28. Qun Chen, Deqing Zhang,* Guanxin Zhang, Xingyuan Yang, Yu Feng, Qing-Hua Fan and Daoben Zhu, "Multicolor Tunable Emission from Organogels Containing Tetraphenylethene, Perylenediimide, and Spiropyran Derivatives", Adv. Funct. Mater. 2010, 20, 3244-3251.
27. Ping Chen, Yawei Sun, Huajie Liu, Lijin Xu,* Qinghua Fan and Dongsheng Liu,* "A ph Responsive Dendron-DNA-Protein Hybrid Supramolecular", Soft Matter 2010, 6, 2143-2145.
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25. Yu Feng, Zi-Tong Liu, Ji Liu, Yan-Mei He,* Qi-Yu Zheng and Qing-Hua Fan,* "Peripherally Dimethyl Isophthalate-Functionalized Poly(benzyl ether) Dendrons: A New Kind of Unprecedented Highly Efficient Organogelators", J. Am. Chem. Soc. 2009, 131, 7950-7951.
23. Enjun Cheng, Yongzheng Xing, Ping Chen, Yang Yang, Yawei Sun, Dejian Zhou,* Lijin Xu, Qinghua Fan and Dongsheng Liu,* "A pH-Triggered, Fast-Responding DNA Hydrogel", Angew. Chem. Int. Ed. 2009, 48, 7660-7663.
22. Xu Zhang, Ting Chen, Qing Chen,] Guo-Jun Deng, Qing-Hua Fan and Li-Jun Wan,* "One Solvent Induces A Series of Structural Transitions in Monodendron Molecular Self-Assembly from Lamellar to Quadrangular to Hexagonal", Chem. Eur. J. 2009, 15, 9669-9673.
21. Xu Zhang, Qing Chen, Guo-Jun Deng, Qing-Hua Fan and Li-Jun Wan,* "Structural Diversity of A Monodendron Molecule Self-Assembly in Different Solvents Investigated by Scanning Tunneling Microscopy: from Dispersant to Counterpart", J. Phys. Chem. C 2009, 113, 16193-16198.
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19. Bao-Lin Li, Zi-Tong Liu, Yan-Mei He, Jie Pan and Qing-Hua Fan,* "Functionalization of Conjugated Copolymers with Phosphorescent Iridium Complexes and Carbazole/1,3,4-Oxadiazole Dendrons via Click Chemistry", Polymer 2008, 49, 1527-1537.
18. Zi-Tong Liu, Yan-Mei He, Zhi-Jian Wang, Yu Feng and Qing-Hua Fan,* "Synthesis, Optical Properties, and Spectral Stability of Chiral Dendronized Binaphthyl-Containing Polyfluorene Derivatives", J. Polym. Sci. A: Polym. Chem. 2008, 46, 886-896.
17. Bao-Lin Li, Zi-Tong Liu, Guo-Jun Deng and Qing-Hua Fan,* "The Synthesis of Dendritic β-Diketonato Ligands and Their Europium Complexes", Eur. J. Org. Chem. 2007, 508-516.
16. Zi-Tong Liu, Yan-Mei He, Bao-Lin Li, Ji Liu and Qing-Hua Fan,* "A Click Approach to Chiral-Dendronized Polyfluorene Derivatives", Macromol. Rapid Commun. 2007, 28, 2249-2255.
15. Bao-Lin Li, Lei Wu, Yan-Mei He and Qing-Hua Fan,* "The Synthesis and Properties of Iridium(III)-Cored Dendrimers With Carbazole Peripherally Functionalized β-Diketonato Dendrons", Dalton Trans. 2007, 2048–2057.
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13. Xuefeng Guo, Yucheng Zhou, Min Feng, Yu Xu, Deqing Zhang,* Hongjun Gao, Qinghua Fan and Daoben Zhu,* "Tetrathiafulvalene-, 1,5-Dioxynaphthalene-, and Cyclobis(Paraquat-P-Phenylene)-Based [2]Rotaxanes with Cyclohexyl and Alkyl Chains as Spacers: Synthesis, Langmuir–Blodgett Films, and Electrical Bistability", Adv. Funct. Mater. 2007, 17, 763-769.
12. Jian-Ru Gong, Sheng-Bin Lei, Ge-Bo Pan, Li-Jun Wan,* Qing-Hua Fan and Chun-Li Bai,* "Monitoring Molecular Motion and Structure Near Defect With STM", Colloids Surf. A: Physicochem. Eng. Aspects 2005, 257-258, 9-13.
11. Xue-Feng Guo, De-Qing Zhang,* Qing-Hua Fan and Dao-Ben Zhu,* "Synthesis and Characterization of Donor-Acceptor-Donor Triads Containing Tetrathiafulvalene and Naphthalene Diimide Units: Towards Regulation of the Intermolecular Charge-Transfer Interaction by Varying the Attached Side Groups", Chin. J. Chem. 2004, 22, 296-305.
10. Jing Yuan, Guojun Deng, Qing-Hua Fan and Minghua Liu,* "Supramolecular Assembly of a Series of Chiral Dendrimers in Interfacial Films", Thin Solid Films 2004, 466, 295-302.
9. Mei-Juan Han, Dong Wang, Ju-Min Hao, Li-Jun Wan,* Qing-Dao Zeng, Qing-Hua Fan and Chun-Li Bai,* "Absolute Configuration of Monodentate Phosphine Ligand Enantiomers on Cu(III)", Anal. Chem. 2004, 76, 627-631.
8. Sai-Long Xu,Shi-Zhao Kang, Guo-Jun Deng, Peng Wu, Qing-Hua Fan, Chen Wang, Li-Jun Wan and Chun-Li Bai,* "Nanofrictional Properties of Dendron Langmuir–Blodgett Films", Chem. Lett. 2003, 32, 290-291.
7. Xuefeng Guo, Deqing Zhang,* Huijuan Zhang, Qing-Hua Fan, Wei Xu, Xicheng Ai, Louzheng Fan and Daoben Zhu,* "Donor–Acceptor–Donor Triads Incorporating Tetrathiafulvalene and Perylene Diimide Units: Synthesis, Electrochemical and Spectroscopic Studies", Tetrahedron 2003, 59, 4843-4850.
6. Shi-Zhao Kang, Sai-Long Xu, Guojun Deng, Peng Wu, Qing-Hua Fan, Chen Wang,* Lijun Wan, Chunli Bai,* "Langmuir Film Behaviors of Dendrons at Water–Air Interface", Chem. Phy. Lett. 2003, 370, 542-547.
5. Jian-Ru Gong, Sheng-Bin Lei, Li-Jun Wan,* Guo-Jun Deng, Qing-Hua Fan and Chun-Li Bai,* "Structure and Dynamic Process of Two-Dimensional Monodendron Assembly", Chem. Mater. 2003, 15, 3098-3104.
4. Peng Wu, Guojun Deng, Sailong Xu, Qing-Hua Fan, Lijun Wan, Chen Wang and Chunli Bai, "Effect of Alkyl Substitutions on Self-Assembly", Chinese. Sci. Bull. 2002, 47, 1514-1517.
3. Peng Wu, Guojun Deng, Qing-Hua Fan, Qingdao Zeng, Chen Wang, Lijun Wan and Chunli Bai,* "Assembling Behavior of BINAP Derivative", Chem. Lett. 2002, 706-707.
2. Peng Wu, Qing-Hua Fan, Guojun Deng, Qingdao Zeng, Chen Wang* and Chunli Bai,* "Real Space Visualization of the Disklike Assembly Structure of Dendritic Molecules on Graphite", Langmuir 2002, 18, 4342-4344.
1. Peng Wu, Qing-Hua Fan, Qingdao Zeng, Chen Wang, Guojun Deng and Chunli Bai,* "Observation of Functional Group Mediated Assembling of Dendritic Molecules by STM", ChemPhysChem 2002, 3, 633-637.
学术专著
专 著：
丁奎岭，范青华主编，《不对称催化新概念与新方法》，化学工业出版社，2009年。
李月明，范青华，陈新滋主编，《不对称有机反应》，化学工业出版社，2004年。
李月明，范青华，陈新滋著，《不对称有机反应— —催化剂的回收与再利用》，化学工业出版社，2003年。
章 节：
7. Qing-Hua Fan, Kuiling Ding, “Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts” In Asymmetric Catalysis from a Chinese Perspective, Ed, Sheng-Ming Ma, Top. Organomet. Chem. Springer-Verlag Berlin, 2011, 36, 207-246.
6. Qing-Hua Fan, Guo-Jun Deng, Yu Feng, Yan-Mei He, “Enantioselective Catalysis Using Dendrimer Supports” In Handbook of Asymmetric Heterogeneous Catalysis, Eds, Kuiling Ding and Yasuhiro Uozumi, Wiley-VCH: Weinheim, 2008, p131-180.
5. 丁奎岭，范青华，刘元红，胡文浩，杨震，王正，李贵杰，朱映光，有机合成化学（第一章），p 32-108。杜灿屏，麻生明主编，《有机化学学科前沿与展望》，科学出版社，2011年。
4. 王东，张俊良，戚朝荣，江焕峰，范青华，龚流柱，绿色化学（第十章），p 589-655。杜灿屏，麻生明主编，《有机化学学科前沿与展望》，科学出版社，2011年。
3. 范青华，黄毅勇，何艳梅，李永，“手性催化剂负载化中的若干新概念与新方法”，丁奎岭，范青华主编，《不对称催化新概念与新方法》，第16章（p 493-542），化学工业出版社，2008年。
2. 何艳梅，范青华，“树状分子负载手性催化剂”，林国强，王梅祥，杜灿屏、吴镭主编，《手性合成与手性药物》，第9章（p 354-383），2008年。
1. 范青华，邓国军，易兵，陈新滋，“负载手性膦金属催化剂及其在不对称氢化反应中的应用”，李月明，范青华，陈新滋主编，《不对称有机反应》，第25章（p 398-421），2004年。
专利
授权专利：
3. 范青华，周海峰，何艳梅，汤卫军，陈新滋，古练权，一种进行不对称催化氢化的方法，中国发明专利，专利号: ZL7.3，授权日期，2011年12月21日（申请日期2006年8月3日）。
2. 范青华，李志伟，周海峰，何艳梅，徐立进，王志坚，陈新滋，古练权，一种喹啉类衍生物进行不对称催化氢化的方法，中国发明专利，专利号：ZL6.X，授权日期，2011年5月4日（申请日期2008年5月22日）。
1. 范青华，邓国军，陈晓闽，一种树状分子手性膦配体及应用，中国发明专利，专利号：ZL**.3，授权日期，2009年9月9日（申请日期2002年6月21日）。
申请专利：
2. 范青华，陈飞，何艳梅，环内N-烷基亚胺的不对称催化氢化反应的方法，中国发明专利，申请号：CN9.X，申请日期2011年7月15日。
1. 范青华，陈飞，何艳梅，一种酮衍生的N-烷基亚胺的不对称催化氢化方法，中国发明专利，申请号：CN1.2，申请日期2010年12月7日。
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代表性论文 发表论文 20-4-3 下午4:49 已批准 分子识别-陈飞
王立人 课题组成员 19-6-24 上午9:10 已批准 分子识别-陈飞
李发举 课题组成员 19-6-18 下午12:08 已批准 分子识别-陈飞
张树辛 课题组成员 19-6-18 下午12:07 已批准 分子识别-陈飞
潘一骁 课题组成员 19-6-18 下午12:02 已批准 分子识别-陈飞
唐雨平 课题组成员 19-6-18 上午11:30 已批准 分子识别-陈飞
李滨 课题组成员 16-12-9 下午3:02 已批准 分子识别-陈飞
彭艺 课题组成员 16-12-9 下午2:54 已批准 分子识别-陈飞
陈娅 课题组成员 16-12-9 下午2:47 已批准 分子识别-陈飞
张珊珊 课题组成员 16-12-9 下午2:44 已批准 分子识别-陈飞
李程皓 课题组成员 16-12-9 下午2:41 已批准 分子识别-陈飞
罗祎迩 课题组成员 16-12-9 下午1:13 已批准 分子识别-陈飞
刘友然 课题组成员 16-12-9 下午12:50 已批准 分子识别-陈飞
许聪 课题组成员 16-12-9 上午11:18 已批准 分子识别-陈飞
学术活动 组内活动 13-9-24 上午7:05 已批准 分子识别-陈飞
功能树状分子的设计合成及组装 研究领域 13-9-18 上午7:43 已批准 分子识别-陈飞
生物活性杂环化合物的合成 研究领域 13-9-18 上午7:41 已批准 分子识别-陈飞
环境友好的催化反应 研究领域 13-9-18 上午7:39 已批准 分子识别-陈飞
不对称催化 研究领域 13-9-18 上午7:37 已批准 分子识别-陈飞
功能树状分子的设计合成及组装 研究领域 13-9-18 上午7:30 已批准 分子识别-陈飞
