中国科学院化学研究所导师教师师资介绍简介-刘　利

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课题组

课题组现招收硕博生（含推荐免试生）、博士生、博士后（BMS Fellow）若干名，同时欢迎本科生入组实习！

联系我们
北京市海淀区中关村北一街2号5-904
刘利研究员（，lliu@iccas.ac.cn）
程靓研究员（，chengl@iccas.ac.cn）

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课题组组长刘利研究员
在职员工程靓研究员
顾春玲副研究员
王学敏
硕博在读高玉婷
谢丽君
兰玲
程后平
刘琪
金晓阳
孙英杰
王屹瞻
武传硕
刘安娣
于松辰
孙新
刘少东
贺胤铭
已毕业学生赵翠华
陈从喜
李惠静
张海波
吴彦超
隋勇
刘哲
赵先亮
赵军岭
刘昱良
武陈
乔桢
王炎
付小普
张涛
钟能君
张甲强
任传利
轩晴晴
李扬雄
魏锋
巫洪儒
黄红岩
孔德龙
李学东
王瑞丽
刘杰杰

刘利研究员

1991-1994 中国科学院化学所博士
1994-1999 中国科学院研究生院教师
1999-2001 比利时根特大学有机化学系博士后
2002-2003 美国西雅图华盛顿大学博士后
2003-至今中国科学院化学研究所，先后任副研究员、课题组长、研究员
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研究方向
1. 不对称有机合成方法学
2. 环境友好介质中的有机反应研究
3. 杂环及生物活性分子的合成
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联系方式
电话：86-
传真：86-
邮箱：lliu@iccas.ac.cn

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RNA表观遗传修饰的直接化学干预
不对称有机合成
环境友好介质中有机反应研究
具有潜在生物活性的杂环分子的构建

导航
RNA表观遗传修饰的直接化学干预
不对称有机合成
环境友好介质中有机反应研究
具有潜在生物活性的杂环分子的构建

单篇全文显示
RNA表观遗传修饰的直接化学干预

网站地图
RNA表观遗传修饰的直接化学干预
不对称有机合成
环境友好介质中有机反应研究
具有潜在生物活性的杂环分子的构建

不对称有机合成
不对称合成
本课题组围绕着有机合成方法学中选择性的调控，旨在发展新的催化体系和高选择性的有机合成新反应。
醇的不对称取代

不对称串联反应

网站地图
RNA表观遗传修饰的直接化学干预
不对称有机合成
环境友好介质中有机反应研究
具有潜在生物活性的杂环分子的构建

环境友好介质中有机反应
环境友好介质中有机反应

在环保理念越来越得到重视的今天，绿色化学成了化学研究领域的永恒主题。本课题组致力于水以及离子液体等环境友好介质中的有机反应研究，设计与水等环境友好介质相匹配的催化体系，研究绿色介质中可能存在的特异反应过程和机制，探索在传统有机溶剂中不能或很难进行的反应。
水相促进的有机反应

离子液体中的非共价键活化

可回收的表面活性剂型Brønsted酸催化剂

网站地图
RNA表观遗传修饰的直接化学干预
不对称有机合成
环境友好介质中有机反应研究
具有潜在生物活性的杂环分子的构建

具有潜在生物活性的杂环分子的构建
具有潜在生物活性的杂环分子的构建
具有多官能化的Morita-Baylis-Hillman (MBH)加成物是有机合成中重要的合成子。本课题组致力于发展基于MBH加成物的串联反应和多组分反应，合成具有潜在生物活性的化合物。

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

2020年
Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;*Cheng, L.* "Artificial Deprenylation ofN6‐isopentenyladenosine (i6A) RNA",Angew. Chem. Int. Ed.2020, DOI: 10.1002/anie..
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Xie, L.-J.; Liu, L.;Cheng, L.* "Modifying Methionine on Proteins",ChemBioChem,2020,21, 461-463 (Invited review).

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Xie, L.-J.; Liu, L.;Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases",Biochemistry,2020,59, 230-239 (Invited review,Future of Biochemistry: The Asia-Pacific Issue).

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Wang, R. -L.; Lan, L.; Liu, L.;Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs",Chin. Chem. Lett.2020,31, 159-162.

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

2019年
Wang, R.-L.#; Jin, X.-Y.#; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.;Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA",Adv. Synth. Catal.2019,361, 5406-5411.

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Wang, C.; Zou, P.; Yang, C.; Liu, L.;Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions",Sci. China Life Sci.2019,62, 1459-1471.

Li, X.-D.#; Gao, Y.-T.#; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.;Cheng, L.* "A NaI/H2O2Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives",Org. Lett.2019,21, 6643-6647.

Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.;Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines",Adv. Synth. Catal.2019,361, 4685-4690. (VIP Article)

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Lan, L.; Wang, R. L.; Liu , L.;Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy",Anal. Chim. Acta.2019,1079, 207-211.

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程靓，兰玲，刘利，"一种基于G-四链体探针结构解旋的可视化识别microRNA的检测方法"，中国专利，申请号：3.2，申请日：2019年6月14日。

Liu, T.; Zhu, J.; Sun, X.;Cheng, L.; Wu, L.* "I2/TBHP Mediated Divergent C(sp2)-P Cleavage of Allenylphosphine Oxides: Substituent-Controlled Regioselectivity",Adv. Synth. Catal.2019,361, 3532-3537.

程靓，王瑞丽，刘利，"一种基于不对称PCR和LAMP循环扩增反应进行miRNA快速检测的方法"，中国专利，申请号：4X，申请日：2019年3月11日。

程靓，李学东，刘利，"制备5-硫/硒修饰尿嘧啶衍生物的方法"，中国专利，申请号：20**，申请日：2019年1月29日。

Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*;Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active ArtificialN6-Methyladenosine RNA Demethylase",Angew. Chem. Int. Ed.2019,58, 5028-5032.

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Liu, J.-J.; Lan, L.; Gao, Y.-T.; Liu, Q.;Cheng, L.*; Wang, D.; Liu, L.* "Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes",Adv. Synth. Catal.2019,361, 1283-1288.

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

2018年论文
Li, X.-D.; Liu, L.;Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs",Org. Biomol. Chem.2018,16, 9191-9196.

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Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.;Cheng, L.*; Wang, D.; Liu, L.* "Iodide/H2O2Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles",Molecules,2018,23, 2265.

Liu, Q.; Liu, J.-J.;Cheng, L.*, Wang, D.; Liu, L.* "TEMPO Promoted Direct Multi-functionalization of Terminal Alkynes with 2-Oxindoles/Benzofuran-2(3H)-one",Org. Biomol. Chem.2018,16, 5228-5231.

Zhong, N.-J.; Wang, Y.-Z.;Cheng, L.*; Wang, D.; Liu, L.* "Recent advances in the annulation of Morita-Baylis-Hillman adducts",Org. Biomol. Chem.2018,16, 5214-5227.

Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.;Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands",Chin. Chem. Lett.2018,29, 1637-1640.

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Jin, X.-Y.; Xie, L.-J.; Cheng, H.-P.; Liu, A.-D.; Li, X.-D.; Wang, D.;Cheng, L.*; Liu, L.* "Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: A Synthesis of Tetrahydropyridoindoles",J. Org. Chem.2018,83, 7514-7522.

Liu, J.-J.#; Huang, H.-Y.#;Cheng, L.*; Liu, Q.; Wang, D.; Liu, L.* "Catalyst-Free Intermoleculartrans-Iodoalkylation of Alkynes",Org. Biomol. Chem.2018,16, 899-903.

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

2017年
Gu, C.-L.*; Li, Y.-X.; Xiao, L.; Fu, H.-B.; Wang, D.;Cheng, L.; Liu, L.* "Tunable Heck-Mizoroki Reaction of Dibromo Naphthalene Diimide with Aryl ethylenes: Design, Synthesis and Characterization of Coplanar NDI-based Conjugated Molecules",J. Org. Chem.2017,82, 12806-12812.

Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.;Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation ofN6-Methyl Adenines",Chem. Commun.2017,53, 10734-10737.

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程靓，谢丽君，刘利，"N6?甲基腺嘌呤的光化学脱甲基方法"，中国专利，授权公告号：CN B，申请日：2017年5月9日（授权日：2019年1月11日）。

Liu, J.-J.;Cheng, L.*; Huang, H.-Y.; Wei, F.; Wang, D.; Liu, L.* "Unprecedented Formation of 3-(Tetrahydrofuran-2-yl)-4H-chromen-4-one in the Reaction between 3,3a-Dihydro-9H-furo[3,4-b]chromen-9-one with Malononitrile",Org. Biomol. Chem.2017,15, 5078-5088.

Huang, H.-Y.;Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling",J. Org. Chem.2017,82, 2656-2663.

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

2016年
Wei, F.;Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines",Sci. China Chem.2016,59, 1311-1316.

Kong, D.-L.;Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides",J. Org. Chem.2016,81, 5337-5344.

Wu, H.-R.;Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.*"FeCl3-Mediated Radical Tandem Reactions of 3-Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles",Org. Lett.2016,18, 1382-1385.

Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.;Cheng, L.*"Metal-free Allylation of Electron-rich Heteroaryl Boronic Acids with Allylic Alcohols",Tetrahedron2016,72, 1873-1880.

Kong, D.-L.;Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.*"Metal-free Yne-addition/1,4-aryl migration/decarboxylation Cascade Reaction of Alkynoates with Csp3-H Centers",Org. Biomol. Chem.2016,14, 2210-2217.

发表论文
2020年论文
2019年论文
2018年论文
2017年论文
2016年论文
1977-2015年

1977-2015年
Wei, F.; Ren, C.-L.; Wang, D.; Liu, L. "Highly Enantioselective [3+2] Cycloaddition of Vinylcyclopropane with Nitroalkenes Catalyzed by Palladium(0) with a Chiral Bis(tert-amine) Ligand", Chem. Eur. J. 2015, 21, 2335-2338.
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Wei, F.; Huang, H.-Y.; Zhong, N.-J.; Gu, C.-L.; Wang, D.; Liu, L. "Highly Enantioselective [3 + 2]-Annulation of Isatin-Derived Morita-Baylis-Hillman Adducts with Cyclic Sulfonimines",Org. Lett.2015, 17, 1688-1691.
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Xuan, Q.-Q.;Ren, C.-L.; Liu, L.; Wang, D.; Li, C.-J. "Copper(II)-Catalyzed Highly Regio- and Stereo-selective Hydrosilylation of Unactivated Internal Alkynes with Silylborate in Water", Org. Biomol. Chem. 2015, 13, 5871-5874.
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Li, Y.; Liu, L.; Kong, D.; Wang, D.; Feng, W.; Yue, T.; Li, C., Palladium-Catalyzed Alkynylation of Morita-Baylis-Hillman Carbonates with (Triisopropylsilyl)acetylene on Water. J. Org. Chem. 2015, 80, 6283-6290.
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Huang, H.-Y.; Wu, H.-R.; Wei, F.; Wang, D.; Liu, L., Iodine-Catalyzed Direct Olefination of 2-Oxindoles and Alkenes via Cross-Dehydrogenative Coupling (CDC) in Air. Org. Lett. 2015, 17, 3702-3705.
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Wu, H.-R.; Huang, H.-Y.; Ren, C.-L.; Liu, L.; Wang, D.; Li, C.-J., FeIII-Catalyzed Cross-Dehydrogenative Arylation (CDA) between Oxindoles and Arenes under an Air Atmosphere. Chem. Eur. J. 2015, 21, 16744-16748
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Zhang, J.-Q.; Liu, J.-J.; Gu, C.-L.; Wang, D.; Liu, L., Tunable Base-Controlled Regioselective Cascade Reaction of 2-Mercaptobenzimidazole with Morita-Baylis-Hillman Acetates of Nitroalkenes. Eur. J. Org. Chem. 2014, 5885-5889
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Ren, C.-L.; Zhang, T.; Wang, X.-Y.; Wu, T.; Ma, J.; Xuan, Q.-Q.; Wei, F.; Huang, H.-Y.; Wang, D.; Liu, L., Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst.Org. Biomol. Chem. 2014, 12, 9881-9886
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Zhong, N.-J.; Wei, F.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J., Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines. Chem.Commun. 2013, 49, 11071-11073.
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Li, Y.-X.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J., A Pd(0)-Catalyzed Direct Dehydrative Coupling of Terminal Alkynes with Allylic Alcohols To Access 1,4-Enynes.J. Am. Chem. Soc.2013, 135, 12536-12539.
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Fu, X.-P.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J., Dual C-H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides. Tetrahedron. 2013, 69, 4436-4444.
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T. Zhang, Z. Qiao, Y. Wang, N. Zhong, L. Liu, D. Wang, Y.-J. Chen, Asymmetric direct [small alpha]-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid-Bronsted acid via an SN1-type pathway Chem.Commun. 2013, 49, 1636-1638.
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Zhong, N.-j.; Liu, L.; Wang, D.; Chen, Y.-J., Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones. Chem. Commun. 2013, 49, 3697-3699.
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Qiao, Z.; Zhong, N.-J.; Zhang, T.; Liu, L.; Wang, D.; Chen, Y.-J., An Organocatalytic, δ-Regioselective, Diastereoselective, and Enantioselective Nucleophilic Substitution of Cyclic Morita-Baylis-Hillman Alcohols with N-Boc-3-benzyl-2-oxindoles.Eur. J. Org. Chem. 2013, 2140-2146.
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Xuan, Q.-Q.; Zhong, N.-J.; Ren, C.-L.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J., Cu(II)-Catalyzed Allylic Silylation of Morita-Baylis-Hillman Alcohols via Dual Activation of Si-B Bond and Hydroxyl Group. J. Org. Chem. 2013, 78, 11076-11081.
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Y. Wang, T. Zhang, L. Liu, Enantioselective and α-Regioselective Allylic Amination of Morita-Baylis-Hillman Acetates with Simple Aromatic Amines Catalyzed by Planarly Chiral Ligand/Palladium Catalyst Chin. J. Chem .2012, 30, 2641-2646.
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Y. Wang, L. Liu, T. Zhang, N.-J. Zhong, D. Wang, Y.-J. Chen, Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita-Baylis-Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhos. J. Org. Chem. 2012, 77, 4143-4147.
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Y. Wang, L. Liu, D. Wang, Y.-J. Chen, Palladium-catalyzed [small alpha]-regioselective allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines Org. Biomol. Chem. 2012, 10, 6908-6913.
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X. Wang, F. Meng, Y. Wang, Z. Han, Y.-J. Chen, L. Liu, Z. Wang, K. Ding, Aromatic Spiroketal Bisphosphine Ligands: Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Morita-Baylis-Hillman Adducts Angew. Chem. Int. Ed. 2012, 51, 9276-9282.
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L. Cheng, L. Liu, C. Li, H. Jia, D. Wang, Y.-J. Chen, Nucleophilic addition of regioselectively lithiated indoline with aldimines for the syntheses of 2- and 7-indolinyl methanamine derivatives Tetrahedron Lett. 2012, 53, 4004-4007.
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Y. Wang, L. Liu, D. Wang, Y.-J. Chen, Tandem reaction of Morita-Baylis-Hillman alcohols derived from acrylic nitrile with 2-aminobenzimidazole in ionic liquid [BMIM]Cl/H₂O, Can. J. Chem. 2012, 90, 85-91
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Y.-C. Wu, H.-J. Li, L. Liu, Z. Liu, D. Wang, Y.-J. Chen, Cascade reaction of β, γ-unsaturated α-ketoesters with phenols in trityl chloride/TFA system. Highly selective synthesis of 4-aryl-2H-chromenes and their applications Org. Biomol. Chem. 2011, 9, 2868-2877.
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C. Wu, H. Zeng, Z. Liu, L. Liu, D. Wang, Y. Chen, FeCl3‐and GaCl3‐Catalyzed Dehydrative Coupling Reaction of Chromone‐Derived Morita‐Baylis‐Hillman Alcohols with Terminal Alkynes Chin. J. Chem. 2011, 29, 2732-2738.
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C. Wu, H. Zeng, L. Liu, D. Wang, Y. Chen, Tandem allylic amination/ring-opening/oxa-Michael addition reactions of chromone-derived Morita-Baylis-Hillman acetates with amines Tetrahedron.2011, 67, 1231-1237.
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C. Wu, Y. Liu, H. Zeng, L. Liu, D. Wang, Y. Chen, In(III)-Catalyzed tandem reaction of chromone-derived Morita-Baylis-Hillman alcohols with amines Org. Biomol. Chem. 2011, 9, 253-256.
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T. Zhang, L. Cheng, S. Hameed, L. Liu, D. Wang, Y.-J. Chen, Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea Chem. Commun. 2011, 47, 6644-6646.
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X.-P. Fu, L. Liu, D. Wang, Y.-J. Chen, C.-J. Li, "On water"-promoted direct alkynylation of isatins catalyzed by NHC-silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones Green Chem. 2011, 13, 549-553.
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Wu, Y-C.; Li, H-J.; Liu, L.; Demoulin, N.; Liu, z.; Wang, D.; Chen, Y.-J., "Facile Synthesis of Spiropyrans from Chromene Hemiacetal Esters and Bifunctional Nucleophiles", Synlett. 2011, 1573-1578
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Wu, Y.-C.; Li, H.-J.; Liu, L.; Demoulin, N.; Liu, Z.; Wang, D. and Chen, Y.-J., "Hafnium Triflate as an Efficient Catalyst for Direct Friedel-Crafts Reactions of Chromene Hemiacetals" , Adv. Synth. Catal., 2011, 353, 907-912
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Zhang, T.; Cheng. L.; Liu, L.; Wang. D. and Chen, Y.-J., "Highly Enantioselective Michael Addition of 2-Oxindoles to Vinyl Selenone in RTILs Catalyzed by A Cinchona Alkaloid-Based Thiourea", Chem. Commun. 2011, 47, 6644-6646
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Wu, Y.-C.; Li, H-J.; Liu, L.; Liu, z.; Wang, D. and Chen, Y.-J., "Cascade Reaction of β,γ-Unsaturated α-Ketoesters with Phenols in The Presence of Trityl Chloride and TFA. Highly Selective Synthesis of 2H-Chromenes and Their Applications", Org. Biomol. Chem. 2011, 9, 2868-2877
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Fu, X.-P.; Liu, L.; Wang, D.; Chen, Y.-J. and Li, C.-J., " ‘On Water'-Promoted Direct Alkynylation of Isatins Catalyzed by NHC-Silver Complex for the Efficient Synthesis of 3-Hydroxy-3-ethynylindolin-2-ones", Green Chem. 2011, 13, 549-553
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Wu, C.; Liu, Y-L.; Zen, H.; Liu, L.; Wang, D. and Chen, Y.-J., "In(Ⅲ)-Catalyzed Tandem Reaction of Chromone-Derived Morita-Baylis- Hillman Alcohols with Amines",Org. Biomol. Chem., 2011, 9, 253-256
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Wu, C.; Zen, H.; Liu, Y.-L; Liu, L.; Wang, D. and Chen, Y.-J., "Tandem Allylic Amination/oxa-Michael Cyclization/lmine-Enamine Reaction of Chromone-Derived Morita-Baylis-Hillman Acetates with Amines", Tetrahedron, 2011, 67, 1231-1237
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Zhang, T.; Cheng. L.; Liu, L. ; Wang, D. and Chen, Y. J. "Asymmetric Organocatalytic N-nitroso-Aldol Reaction of Oxindoles", Tetrahedron Asymmetry, 2010, 21, 2800-2806
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Liu, Z.; Liu, L.; Wu, Y.-C.; and Wang, D., "Efficient and Metal-free Friedel-Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE", Lett. Org. Chem., 2010, 7661-665
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Liu, L., Wang, D. and Li, C.-J., "Asymmetric Mukaiyama Aldol Reaction" in "Stereoselective Synthesis 2", Ed. By Molander, G. A., p585-620, Thieme, Stuttgart, 2010
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Zhao, J.-L.; Liu, L.; Zhang, H.-B.; Wu, Y.-C.; Wang, D. and Chen, Y.-J., "Rapid and Convenient Synthesis of Aryl- and Heteroaryl-α-hydroxy-α-trifluoromethyl Carboxylate via Friedel-Crafts Alkylation under Solvent- and Catalyst- free Condition", Tetrahedron Lett.,2006, 47, 2511-2514
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Lei, F.; Chen Y. J.; Sui, Y.; Liu, L. and Wang, D., "Highly Diastereoselective Synthesis of 3-Indolyl-N-Substituted Glycine Derivatives via TFA-Promoted Friedel-Crafts Type Reaction of Indoles with Chiral Cyclic Glyoxylate Imine", Synlett,2003, 1160-1164
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Tian H.-Y.; Li, H.-J; Chen, Y -J.; Wang, D. and Li, C.-J. "Development of Highly Effective Encapsulating Surfactants for Mukaiyama Aldol Reactions in Water", (Invited Paper), Ind. Eng. Chem. Res. (Green Chemistry Special Issue),2002, 41, 4523-4527
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Ge, C. S.; Chen, Y.-J. and Wang, D. "Highly Diastereoselective Synthesis of N-Protected Arylglycine Derivatives via TiCl₄-Promoted Friedel-Crafts Reaction of Phenols with Chiral N, O-Hemiacetal", Synlett,2002, 37-42
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Wang, J., Xu, D.-M., Liu, Z-Y., Chen, Y.-J. and Wang, D., "ANovel Titanium Complex with Linked β-Diketonato-Indenyl Ligand for Catalytic Syndiospecific Polymerization of Styrene", Chin. J. Polym. Sci.,2002, 20, 213-217
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Liu, T. J.; Chen, Y. J.; Zhang, K. S.; Wang, D.; Guo, D. W. and Yang, X. Z., "Enantiomeric Recognition of Chiral 3,3-Bridged-1,1'-Binaphthol Dimer toward α-Phenylethylamine and α-Amino Acid Ester", Chirality,2001, 13, 595-600
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Liu, T.J.; Zhang, K. S.; Chen, Y. J.; Wang, D. and Li, C. J., "Chiral Conjugated Oligomer Based on 1,1'-BINOL with 3,3'-Acetylene- Phenylene Acetylene Spacer",Chin. J. Polym. Sci.,2001, 19, 521-526
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Huang, T.-S.; Meng, Y.; Venkatraman, S.; Wang, D. and Li, C. J., "Remarkable Electronic Effect on Rhodium-Catalyzed Carbonyl Addition and Conjugated Additions with Organometallic Reagents", JAm. Chem, Soc.,2001, 123, 7451-7452
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Wang, M. W.; Chen, Y. J. and Wang, D., "Catalytic Allylation of Hydrates of α-KetoAldehyde and Glyoxylate with Allyltrimethylsilane Using Non- Fluorine containing Sulfonic Acids as Catalysts",Heteroatom Chem., 2001, 12, 534-538
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Ding, R.; Chen, Y. J.; Wang, D. and Li, C. J., "Rhodium-Catalyzed Conjugated Addition of Aryllead Reagents to Unsaturated Carbonyl Compounds in Air and Water", Synlett, 2001,1470-1472
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Wang, J., Liu, Z.-Y.; Guo, C.-M.; Chen, Y.-J. and Wang, D. "Preparation of PE/MT Composite by Copolymerization of Ethylene with in situ Produced Ethylene-Oligomers under A Dual Functional Catalyst System Intercalated into MT Layer", Macromol.Rapid Commun.2001, 22,1422-1426
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Wang, D.; Wang, Z. G.; Wang, M. W.; Chen. Y. J; Liu, L. and Zhou, Y., "Asymmetric Allylation of Aldehydes and Glyoxylates through Chiral Pentacoordinates Allylsilicates or Promoted by Lewis Acid", Tetrahedron: Asymmetry,1999, 10, 327-338
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Li, L. H.; Wang, D.; Chan, T. H., "Asymmetric Epoxidation of Nearly Symmetrical cis-Alkenes. Sharpless Epoxidation of (12-Dialkyl)vinylsilanols", Tetrahedron Letter, 1997, 101-104
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张静, 刘晖, 王东, 眭秀楣, "以手性醇修饰LiAIH₄不对称还原α一亚胶酮", 化学通报, 1997, (10), 46-47
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Wang, D.; Liu, T. J.; Li, C.J. and Slaven Ⅳ, W. T, "A Chiral Conjugated Oligomer Based on1,1'-Binaphthol with 3,3'-Acetyene Spacer", Polymer Bulletin, 1997, 39, 265-270
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Yang, Y.; Wang, M. W. and Wang, D., "Yb(OTf)₃ Catalyzed Allylation of The Hydrate of α-Ketoaldehydes And Glyoxylates with Allylsilane", Chem. Commun., 1997, 1651-1652
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杨扬, 王东, "陈氏重排—Chan Rearrangement", 化学通报, 1997, （11）, 30-32
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Yang, Y. and Wang, D., "The Addition of Trimethylsilyl Cyanide to Carbonyl Compounds Using Yb(OTf)₃ as Lewis Acid Catalyst", Synlett, 1997, 1379-1380
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王东, 叶蕴华, "高选择性合成", 《21世纪初科学发展趋势》, 1996, 科学出版社, 北京, pp 193-195
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Li, C. J.; Wang, D and Steven IV, W. T., "Synthesis of a Bis-(binaphthol)", Tetrahedron Letters,1996, 37, 4459-4462
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Wang, Z. G.; Wang, D. and Sui, X. M., "Asymmetric Allylation of Aldehydes withAllyltrichlorosilane via a Chiral Pentacoordinate Silicate", Chem. Commun., 1996, 2261-2262
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Wang, Z. G.; Liu, S. G.; Wang, D. and Sui, X. M., "An Optically Active Pentacoordinate Silicate: (+)-Bis(triethylammonium) Bis[(R,R)-tartrato(4-)]- diphenyl-disilicate", Acta Cryst. Sec. C,1996, C52, 3179-3181
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Liu, L; Li, L. H. and Wang, D., "Regioselective Reaction of α-(Alkoxydimethylsilyl)-allyl Carbanions with Alkyl Halides and Aldehydes", Chin. Chem. Letters, 1996, 7, 1069-1072
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Feng, W. C. andWang, D.,"Sharpless Asymmetric Epoxidation of Heptenylphenyl-methylsilanol",Chin.Chem.
Letters,1995,6,647-650
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Chan, T. H. and. Wang, D., "Silylallyl Anions in Organic Synthesis: A Study in Regio- and Stereoselectivity", Chem. Rev., 1995, 95, 1279-1292
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Li, C. J.; Wan, D. and Chen, D. L., "Reshuffling of Functionalities Catalyzed by ?Ruthenium Complex in Water", J. Am. Chem. Soc., 1995, 117, 12867-12868
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Chen, Y. J.; Wang, D. and Li, J. S., "Lewis Acid Promoted Asymmetric Ene Reaction of (-)-Menthyl Glyoxylate with Homoallyl Silyl Ether", Chin. Chem. Letters,1994, 5. 1-4
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Chen, Y. J; Huang, L.; Wang, D. and Li, J. S., "Study on Lewis Acid Promoted Condensation of Allylalkoxysilanes with (-)-Menthyl Glyoxylate", Chin. J. Chem., 1994, 12, 440-448
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Li, L. H.; Wang, D. and Chan, T. H., "Synthesis of Carbonyl Compounds via Ethyl (n-butoxy or isopropoxy) dimethylsilane as a Reversely Polarized ⁺CH₂CO^- Equivalent", Organometallics, 1994, 13, 1757-1761
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陈蓓, 眭秀楣, 王东, "含硅芳香二胺的合成及其聚酰亚胺硅氧烷的热性能", 高分子学报, 1994, 717-724
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Wang, D. X.; Li, S.; Wang, D. and Li, Y., "Application of an HeⅠPhotoelectron Spectroscopic (UPS) Technique to The Kinetic Study of Chemical Reactions. Determination of The Kinetic Study of Chemical Reaction of 2(3H) Furanone to 2(5H) Furanone", J. Electron. Spectros. Relat. Phenomena,1994, 70, 173-178
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Wang, D. X; Wang, D.; Li, S. and Li, Y., "He Ⅰ Photoelectron Spectroscopic Studies of The Electronic Structure of 2(3H) Furanone and 2(5H) Furanone", J. Electron. Spectros. Relat. Phenomena,1994, 70, 167-172
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陈德恒, 王东,"有机硅化合物在合成中应用的新进展", 《有机合成化学进展》, 戴立信, 钱廷龙主编, 化工出版社, 北京, 1993, 第十章
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Chan, T. H.; Chen, L. M.; Wang. D. and Li, L. H., "Enantioselective Synthesis of Epoxides via Sharpless Epoxidation of Alkenylsilanols", Can. J. Chem., 1993, 71, 60-67
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冯维春, 王东, "动力学拆分在有机合成中的应用", 化学通报, 1993, (1), 23-30
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Wang. D.; Li. L. H.; Chen, Y. J.; Huang. L.; Feng, W. C.; Wei, Z. Y.; Li, J. S. and Chan, T. H., "Enantioselective Synthesis using Organosilicon Compounds", Proceedings of The Sixth Japan-Korea Seminar on Organic Chemistry, p157-162, 1992, Nagoya
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冯维春, 王东, 李连海, "(E)-烯基甲基苯基硅醇的合成", 有机化学, 1992, 372-377
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王殿勋, 王东, 赵恒奇, 唐青, 徐广智, "某些杂氮环己烷系列化合物的气相HeⅠα紫外光电子能谱(UPS)研究", 物理化学学报, 1992, 5, 467-471
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王殿勋, 王东, 赵恒奇, 唐青, 徐广智, "分子内孤对（n）轨道间相互作用的又一例证---某些杂氮环己烷系列化合物的气相HeⅠα紫外光电子能谱(UPS)研究", 物理化学学报, 1992, 8, 809-813
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Chan, T. H. and Wang. D., "Chiral organosilicon Compounds in Asymmetric synthesis", Chem. Rev., 1992, 92, 995-1006
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Chan, T. H.; Wang, D., Pellon, P.; Lamote, S.; Wei, Z. Y.; Li, L. H. and Chen, L. M. "Enantioselective Synthesis Using Organosilicon Compounds" in "Frontiers of organosilicon Chemistry", Ed. by Bassindale and Gaspar, P. P., The Royal Society of Chemistry, 1991, pp 344-355
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齐德林, 王东, "结晶紫和结晶紫母体的¹HNMR溶剂效应的研究及与取代基常数间的关系", 波普学杂志, 1991, 8, 187-194
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Li, L. H.; Wang, D. and Chan, T. H., "Regioselective Alkylation of 1-silyl-2-methylallyl Carbanions", Tetrahedron Letters, 1991, 32, 2879-2882
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孙小静, 王东, 陈德恒, "油松毛虫性引诱剂(5Z,7E)-十二碳二烯醇及其乙酸酯和丙酸醋的合成", 化学学报, 1990, 48, 489-493
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王东, 徐彦平, 唐青, "前手性硅甲基的非等时性--分子结构对化学位移差值的影响", 化学学报, 1990, 48, 153-156
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王东, 陈德恒, "二甲基硅烯与含烯丙基甲醚结构的化合物的反应", 化学学报, 1990, 48, 516-520
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唐青, 王东, "双不对称合成反应", 化学通报, 1990, (7), 1-6
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Chan, T. H. and Wang, D., "Chiral organosolicon Compounds in Organic Synthesis II. Enantioselective Synthesis of Homoallylic Alcohols", TetrahedronLetters, 1989, 30, 3041-3044
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王东, 徐彦平, 唐青, "前手性硅甲基的非等时性--卤化烷经溶剂对化学位移差值的影响", 有机化学, 1989, 454-456
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Wei, Z. Y.; Wang, D.; Li, J. S. and Chan, T. H., "Lewis Acid Promoted Condensation of Allylalkoxysilanes with Carbonyl Compounds Synthesis of Tetrahydropyrans", J. Org. Chem., 1989, 54, 5768-5774
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Chan, T. H.; Komaglo, K.; Hovath, R.; Wang. D.; Wei, Z. Y.; Yi, G. L. and Li, J. S., "Effect of Substitutions on Reaction Remode from Silicon--Application in Organic Synthesis" in "Silicon Chemistry",Ed. by Corey, Y. J.; Corey, E. R.; Gasper, P. P., Ellis Howood Ltd., Chichester, Chapter 5, 1988
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Chan, T. H.; Chen, L. M. and Wang, D., "Enantioselective Synthesis of Epoxides: Sharpless Epoxidation of Alkenylsilanols", J. Chem. Soc., Chem. Commun., 1988, 1280-1281
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易国良, 王东, 陈德恒, "手性有机硅化合物Ⅱ. 手性烯丙基硅烷与酚醛类化合物的不对成合成反应", 有机化学, 1988,8,115-120
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Wang, D. and Chan, T. H., "Reaction of Dimethylsilylene with Pinenes", Can. J. Chem, 1987. 65, 2727-2731
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Wei, Z. Y.; Li, J. S.; Wang, D. and Chan, T. H., "Lewis Acid Promoted Condensation ofCarbonyl Compounds with Alkoxyallylsilanes- Synthesis of Substituted Tetrahydropyrrans", Tetrahedron Letters, 1987, 28, 3441-3444
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Chan, T. H.; Peng, Q. J.; Wang, D. and Guo, J. A., "Chiral Silyl Acetals as ConvenientReagents for Determining Purity of Alcohols", J. Chem. Soc., Chem. Commun.,1987, 325-326
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张仁恩, 刘克里, 王东, 陈德恒, "新型反相液相色谱固定相的研究", 色谱, 1985, 10-13
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Wang. D. and Chan, T. H, "Synthesis of Karahanaenol from Geraniol vin an Allylsilane", J. Chem. Soc., Chem. Commun.,1984, 1273-1274
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Wang, D.; Chan, T. H., "Chiral Silicon Compounds, Asymmetric Reduction of Ketones", Tetrahedron Letters,1983, 24, 1573-1576
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王东, 黄志镗, "N-苯基双环[2.2.1]庚-5-烯-2.3-二甲酰亚胺的热聚合反应", 高分子通讯, 1981, 212-218
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王东, 吴瑶曼, 李家泽, 张崇立, 喻商英, 金鉴溶, 黄志镗, "双环[2.2.1]庚-5-烯-2.3-二羧酸酐封头的聚酰亚胺树脂及其复合材料", 高分子通讯, 1980,152-158
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八室一组, "低压酚醛树脂", 化学研究, 1977, （2）, 30-36

活动合影
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2014在十渡

2013年在桃源仙谷

毕业留念

任传利博士，轩晴晴博士，张甲强博士以及李扬雄博士毕业

张涛博士毕业

Professor

Professor Li Liu

Contact
Tel：
Fax：
E-mail：lliu@iccas.ac.cn
Address： Zhongguancun North First Street 2,100190 Beijing, PR China

To the future
To the Future
Welcome to the group of Professor Li Liu.Our lab is always embarking on study of Methodology, such as metal or metal-free catalyzed asymmetric organic synthesis, organic reactions in environmental benign media and construction of heterocycles and bioactive molecules, ect.
Our lab is affiliated to Key Laborary of Molecular Recognition and Function,Institute of Chemistry.Therefore, we own advanced hardware facilities and professional supervisors, which can provide excellent academic atmosphere.
Noteworthily,in recent years, our group has made some gratifying progresses.Meanwhile,our lab is a challengable, innovative, solidarity group. Herein, we hope sincerely that more and more young and aspiring students who love organic chemistry will join us.
If you have some questions about our lab, just make a call or send email to us, we will do our best to help you.
Look forward to your inquiry.
Good Luck!

Research Interests
Research in our group focus on the development of efficient and highly selective asymmetric reactions and practical multi-component tandem reactions for the synthesis of compounds with potential biological activities. Our studies are also driven by the discovery of the specific reaction processes and mechanisms that may exist in the green media. By designing suitable catalytic system, some reactions could be carried out better in green media such as water than in organic solvents.
?Asymmetric synthesis
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?Organic reactions in environmental benign media
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?Synthetic methodology on heterocyclesand bioactive molecules
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Professor
Research Assistant Chun-li Gu
Graduate Students Neng-jun Zhong
Chuan-li Ren
Qing-qing Xuan
Jia-qiang Zhang
Yang-xiong Li
Feng Wei
Hong-yan Huang
Graduated Tao Zhang

Professor Li Liu
B.Sci. Beijing Normal University1987; M.Sci. Beijing Normal University 1990; Ph.D. Institute of Chemistry, CAS 1995; Assoc. Prof. Graduated School of CAS 1995-1999; Fellow in Ghent University,Belgium 1999-2001 Fellow in the University of Washington at Seattle 2001-2003 Assoc.Prof. Institute of Chemistry 2003-2009 Prof. Institute of Chemistry 2009

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Professor
Research Assistant Chun-li Gu
Graduate Students Neng-jun Zhong
Chuan-li Ren
Qing-qing Xuan
Jia-qiang Zhang
Yang-xiong Li
Feng Wei
Hong-yan Huang
Graduated Tao Zhang

Neng-jun Zhong

Neng-jun Zhong
Born in Jiangxi Province
email：zhongnj@icccas.ac.cn
Tel:
Educational Background
B. Sci. Jiangxi Normal University 2003.09-2007.07
Ph.D. Institute of Chemistry 2009-now
Publications
Neng-jun Zhong,Li Liu,* Dong Wang and Yong-Jun Chen,*Chem. Commun.,2013,49,3697.
Zhen Qiao,Neng-Jun Zhong,Tao Zhang, Li Liu,* Dong Wang, Yong-Jun Chen,*Eur. J. Org. Chem.2013,11,2140.
T. Zhang, Z. Qiao, Y. Wang,N. Zhong, L. Liu, D. Wang, Y.-J. Chen,Chem.Commmun.2013,49, 1636.
Y. Wang, L. Liu, T. Zhang,N.-J. Zhong, D. Wang, Y.-J. Chen,J. Org. Chem. 2012,77, 4143.

网站地图
Professor
Research Assistant Chun-li Gu
Graduate Students Neng-jun Zhong
Chuan-li Ren
Qing-qing Xuan
Jia-qiang Zhang
Yang-xiong Li
Feng Wei
Hong-yan Huang
Graduated Tao Zhang

Tao Zhang

Tao Zhang
Born in HeNan Province
Email：zhangtao2005@iccas.ac.cn.
Tel:
Educational Background
B. Sci. ZhengZhou University 2004-2008
Ph.D Institute of Chemistry 2008-2013
Publications
Zhang, T.; Qiao, Z.; Wang, Y.; Zhong, N.; Liu, L.; Wang, D.; Chen, Y.-J.Chem. Commun.2013,49,1636.
Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.; Wang, D.; Chen, Y.-J.Chem.Commun.2011,47,6644.
Zhang, T.; Cheng, L.; Liu, L.; Wang, D.; Chen, Y.-J.Tetrahedron: Asymmetry.2010,21,2800.
Qiao, Z.; Zhong, N.-J.;Zhang, T.; Liu, L.; Wang, D.; Chen, Y.-J.Eur. J. Org. Chem.2013,2140.
Wang, Y.; Liu, L.;Zhang, T.; Zhong, N.-J.; Wang, D.; Chen, Y.-J.J. Org. Chem.2012,77,4143.

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2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

网站地图
2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

2013 papers
Zhong, N.-J.; Wei, F.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J.,Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines.Chem.Commun.2013. DOI:10.1039/C3CC46490C
Li, Y.-X.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J.,A Pd(0)-Catalyzed Direct Dehydrative Coupling of Terminal Alkynes with Allylic Alcohols To Access 1,4-Enynes.J. Am. Chem. Soc.2013 DOI:10.1021/ja406025p
Fu, X.-P.; Xuan, Q.-Q.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J.,Dual C–H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides.Tetrahedron.2013,69, 4436-4444.
T. Zhang, Z. Qiao, Y. Wang, N. Zhong, L. Liu, D. Wang, Y.-J. Chen,Asymmetric direct [small alpha]-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid-Bronsted acid via an SN1-type pathwayChem.Commun.2013,49, 1636-1638.
Zhong, N.-j.; Liu, L.; Wang, D.; Chen, Y.-J.,Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones.Chem. Commun.2013,49, 3697-3699.
Qiao, Z.; Zhong, N.-J.; Zhang, T.; Liu, L.; Wang, D.; Chen, Y.-J.,An Organocatalytic, δ-Regioselective, Diastereoselective, and Enantioselective Nucleophilic Substitution of Cyclic Morita–Baylis–Hillman Alcohols with N-Boc-3-benzyl-2-oxindoles.Eur. J. Org. Chem.2013,11,2140-2146.
Xuan, Q.-Q.; Zhong, N.-J.; Ren, C.-L.; Liu, L.; Wang, D.; Chen, Y.-J.; Li, C.-J., Cu(II)-Catalyzed Allylic Silylation of Morita–Baylis–Hillman Alcohols via Dual Activation of Si–B Bond and Hydroxyl Group. J. Org. Chem. 2013, 78 (21), 11076-11081.

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2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

2012 papers
Y. Wang, T. Zhang, L. Liu, Enantioselective and α-Regioselective Allylic Amination of Morita-Baylis-Hillman Acetates with Simple Aromatic Amines Catalyzed by Planarly Chiral Ligand/Palladium CatalystChin. J. Chem .2012,30, 2641-2646.
Y. Wang, L. Liu, T. Zhang, N.-J. Zhong, D. Wang, Y.-J. Chen,Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita–Baylis–Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhosJ. Org. Chem. 2012,77, 4143-4147.
Y. Wang, L. Liu, D. Wang, Y.-J. Chen,Palladium-catalyzed [small alpha]-regioselective allylic amination of Morita-Baylis-Hillman acetates with simple aromatic aminesOrg. Biomol. Chem.2012,10, 6908-6913.
X. Wang, F. Meng, Y. Wang, Z. Han, Y.-J. Chen, L. Liu, Z. Wang, K. Ding,Aromatic Spiroketal Bisphosphine Ligands: Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Morita–Baylis–Hillman AdductsAngew. Chem. Int. Ed.2012,51, 9276-9282.
L. Cheng, L. Liu, C. Li, H. Jia, D. Wang, Y.-J. Chen,Nucleophilic addition of regioselectively lithiated indoline with aldimines for the syntheses of 2- and 7-indolinyl methanamine derivativesTetrahedron Lett.2012,53, 4004-4007.
Y. Wang, L. Liu, D. Wang, Y.-J. Chen,Tandem reaction of Morita–Baylis–Hillman alcohols derived from acrylic nitrile with 2-aminobenzimidazole in ionic liquid [BMIM]Cl/H2OCan.J. Chem.2012,90, 85-91

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2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

2011 papers
Y.-C. Wu, H.-J. Li, L. Liu, Z. Liu, D. Wang, Y.-J. Chen,Cascade reaction of β, γ-unsaturated α-ketoesters with phenols in trityl chloride/TFA system. Highly selective synthesis of 4-aryl-2H-chromenes and their applicationsOrg. Biomol. Chem.2011,9, 2868-2877.
C. Wu, H. Zeng, Z. Liu, L. Liu, D. Wang, Y. Chen,FeCl3‐and GaCl3‐Catalyzed Dehydrative Coupling Reaction of Chromone‐Derived Morita‐Baylis‐Hillman Alcohols with Terminal AlkynesChin. J. Chem.2011,29, 2732-2738.
C. Wu, H. Zeng, L. Liu, D. Wang, Y. Chen,Tandem allylic amination/ring-opening/oxa-Michael addition reactions of chromone-derived Morita–Baylis–Hillman acetates with aminesTetrahedron.2011,67, 1231-1237.
C. Wu, Y. Liu, H. Zeng, L. Liu, D. Wang, Y. Chen,In(III)-Catalyzed tandem reaction of chromone-derived Morita–Baylis–Hillman alcohols with aminesOrg. Biomol. Chem.2011,9, 253-256.
T. Zhang, L. Cheng, S. Hameed, L. Liu, D. Wang, Y.-J. Chen,Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thioureaChem. Commun.2011,47, 6644-6646.
X.-P. Fu, L. Liu, D. Wang, Y.-J. Chen, C.-J. Li,"On water"-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-onesGreen Chem.2011,13, 549-553.

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2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

2010 papers
Y. Wang, Z. Shafiq, L. Liu, D. Wang, Y.-J. Chen,Efficient synthesis of benzimidazo[1,2-a]pyrimidinone derivatives via catalyst-free reactions of Baylis–Hillman acetates, alcohols, and amines with 2-aminobenzimidazoleJ. Heterocyclic Chem.2010,47, 373-378.
C. Ren, Y. Wang, D. Wang, Y. Chen, L. Liu,Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo [1, 2-a] pyrimidinone derivativesSci. China Chem.2010,53, 1492-1496.
Z. Qiao, Z. Shafiq, L. Liu, Z.-B. Yu, Q.-Y. Zheng, D. Wang, Y.-J. Chen,An Organocatalytic, δ‐Regioselective, and Highly Enantioselective Nucleophilic Substitution of Cyclic Morita–Baylis–Hillman Alcohols with IndolesAngew. Chem. Int. Ed.2010,49, 7294-7298.
T. Zhang, L. Cheng, L. Liu, D. Wang, Y.-J. Chen,Asymmetric organocatalytic N-nitroso-aldol reaction of oxindolesTetrahedron: Asymmetry2010,21, 2800-2806.
刘利，王东,"水上" ("on water") 有机反应,化学进展2010,22(07)1233-124

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2013 papers
2012 papers
2011 papers
2010 papers
2009 papers

2009 papers
Shafiq, Z.; Qiao, Z.; Liu, L.; Zheng, Q.-Y.; Wang, D.; Chen, Y.-J.,Tunable, Regioselective Control of Iodine-Catalyzed Allylic Substitution of Cyclic Baylis-Hillman Adducts with Indoles.Synlett.2009,18, 2965-2970.
Liu, Y.-L.; Liu, L.; Wang, D.; Chen, Y.-J.,A highly α-regioselective In(OTf)3-catalyzed N-nucleophilic substitution of cyclic Baylis–Hillman adducts with aromatic amines.Tetrahedron2009,65, 3473-3479.
Gu, C.-L.; Liu, L.; Wang, D.; Chen, Y.-J.,Facile Synthesis of δ-Amino-β-ketoesters and Piperidinediones via a Vinylogous Mannich-Type Reaction of Brassard-Type Diene with Aldimines without Catalyst.Synth. Commun.2009,39, 2989-3002.
Gu, C.-L.; Liu, L.; Wang, D.; Chen, Y.-J.,Tunable and Highly Regio- and Diastereoselective Vinylogous Mannich-Type Reaction of Dioxinone-Derived Silyl Dienolate.J. Org. Chem.2009,74, 5754-5757.
Cheng, L.; Liu, L.; Wang, D.; Chen, Y.-J.,Highly Enantioselective and Organocatalytic α-Amination of 2-Oxindoles.Org. Lett.2009,11, 3874-3877.
Cheng, L.; Liu, L.; Jia, H.; Wang, D.; Chen, Y.-J.,Enantioselective Organocatalytic anti-Mannich-Type Reaction of N-Unprotected 3-Substituted 2-Oxindoles with Aromatic N-Ts-aldimines.J. Org. Chem.2009,74, 4650-4653.
C. Wu, L. Liu, D. Wang, Y.-J. Chen,TfOH-catalyzed allylation of alkynes with cyclic Baylis–Hillman alcohols.Tetrahedron Lett.2009,50, 3786-3789.