中国科学院化学研究所导师教师师资介绍简介-汪　铭

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课题组负责人

汪铭研究员地址：北京市海淀区中关村北一街2号
中国科学院化学研究所
活体分析化学重点实验室
办公室：5号楼711室
实验室：5号楼722,725室
邮编：100190
Tel: (Office)
(Lab)
Email: mingwang@iccas.ac.cn

课题组简介
本课题组成立于2016年7月，主要研究方向是蛋白质化学生物学。近期研究集中于发展化学方法和工具，实现细胞和活体层次蛋白质的化学修饰与功能调控，并进一步探索其在肿瘤治疗、神经生理和病理过程相关分子机制研究中的应用。

研究领域

蛋白质是生命活动的主要执行者，其对生命过程的调控多通过种类复杂、时空分辨的化学修饰实现。蛋白质的化学修饰研究可以在分子水平上揭示其调控生命过程的化学本质，并发展疾病诊断和治疗的分子工具。本课题组的研究集中于蛋白质化学生物学，通过发展化学原理和工具，实现细胞和活体层次蛋白质的功能调控；设计新型蛋白质递送系统，实现活体层次蛋白质递送并探索其在疾病治疗、神经生理和病理分子机制研究中的应用。
近期课题组主要研究内容包括：
1）细胞微环境调控的蛋白质化学修饰原理和方法 ?

参考文献：Acc. Chem. Res., 2019, 52, 665-675.; J. Am. Chem. Soc., 2019, 141, 18136-18141.; Chem. Commun., 2019, 55, 5163-5166; J. Am. Chem. Soc., 2018, 140, 6780?6784.
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2） CRISPR/Cas9基因编辑递送及其化学生物学应用 ?

参考文献： Acc. Chem. Res., 2019, 52, 665-675; Adv. Mater., 2019, 31, **; Chem. Commun., 2019, 55, 8170-8173; Sci. Bull., 2019, DOI:10.1016/j.scib.2019.07.035; PNAS, 2016, 113, 2868-2873.
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3）金属配位导向的蛋白质组装及其生物医学应用 ?

参考文献：J. Am. Chem. Soc., 2019, 141, 3782?3786; J. Am. Chem. Soc., 2017, 139, 5877–5882.

课题组成员
课题组组长：汪铭研究员 博士后：
常进工作人员：唐巧在读硕博：刘计梁春菁陈翔汉蔡玮琦罗添丽李汶亭王露茗盛劲菡离组人员：江天（Tufts University）杨舒媛（Rice University）

汪铭研究员
汪铭研究员
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2009年于中国科学院化学研究所获得有机化学专业博士学位（导师：张德清研究员），2009年至2016年分别在美国犹他大学化学系（合作导师：Prof. Peter J Stang）和美国Tufts大学生物医学工程系（合作导师：Prof. Qiaobing Xu）从事博士后研究。2016年回国加入中国科学院化学研究所活体分析化学院重点实验室，任研究员、博士生导师。
主要研究方向是蛋白质化学生物学和纳米医学，通过发展化学的原理和工具，实现活体层次蛋白质化学修饰及其功能调控，并进一步探索其在肿瘤治疗、神经退行性疾病分子机制研究中的应用。迄今为止，共在PNAS, Angew. Chem. Int. Ed., J. Am. Chem. Soc., Adv. Mater.等杂志发表学术论文60余篇，引用近4000次，h-index 33。

课题组成员
课题组组长：汪铭研究员 博士后：
常进工作人员：唐巧在读硕博：刘计梁春菁陈翔汉蔡玮琦罗添丽李汶亭王露茗盛劲菡离组人员：江天（Tufts University）杨舒媛（Rice University）

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2003—2007 本科山西大学 2007—2012 辅导员北京交通大学 2012—2017 博士研究生北京师范大学 2018—现在博士后中科院化学所

课题组成员
课题组组长：汪铭研究员 博士后：
常进工作人员：唐巧在读硕博：刘计梁春菁陈翔汉蔡玮琦罗添丽李汶亭王露茗盛劲菡离组人员：江天（Tufts University）杨舒媛（Rice University）

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2011-2015 本科北京科技大学 2016-2019 硕士中国人民大学 2019—至今中国科学院化学研究所

课题组成员
课题组组长：汪铭研究员 博士后：
常进工作人员：唐巧在读硕博：刘计梁春菁陈翔汉蔡玮琦罗添丽李汶亭王露茗盛劲菡离组人员：江天（Tufts University）杨舒媛（Rice University）

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2009-2013 本科安徽工业大学 2014-2017 硕士安徽工业大学 2017-至今博士中国科学院化学研究所

课题组成员
课题组组长：汪铭研究员 博士后：
常进工作人员：唐巧在读硕博：刘计梁春菁陈翔汉蔡玮琦罗添丽李汶亭王露茗盛劲菡离组人员：江天（Tufts University）杨舒媛（Rice University）

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2012-2016 本科太原理工大学 2016-2017 研究助理中国科学院化学研究所 2017-2020 硕士研究生塔夫茨大学

发表论文
58) Jin Chang, Weiqi Cai, Chunjing Liang, Qiao Tang, Xianghan Chen, Ying Jiang, Lanqun Mao, Ming Wang*, Enzyme-instructed activation of pro-protein therapeutics in vivo. J. Am. Chem. Soc., 2019, 141, 18136-18141. (Featured in journal cover)

57) Xiaoti Yang, Qiao Tang, Ying Jiang, Meining Zhang, Ming Wang*, Lanqun Mao*, Nanoscale ATP-responsive Zeolitic Imidazole Framework-90 as a general platform for cytosolic protein delivery and genome editing. J. Am. Chem. Soc., 2019, 141, 3782−3786. (Featured in journal cover)

56) Lijun Xie, Xiaoti Yang, Ruili Wang, Houping Cheng, Zhiyan Li, Li Liu, Lanqun Mao, Ming Wang*, Liang Cheng*, Identification of flavin mononucleotide as cell-active artificial N6-methyladenosine RNA demethylase. Angew. Chem. Int. Ed., 2019, 58, 5028-5032.

55) Ji Liu, Jin Chang, Ying Jiang, Xiandi Meng, Tianmeng Sun, Lanqun Mao, Qiaobing Xu*, Ming Wang*, Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles Adv. Mater., 2019, 31, **.

54) Jin Chang, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang*, Qiaobing Xu*, Integrating combinatorial lipid nanoparticle and chemically modified protein for intracellular delivery and genome editing. Acc. Chem. Res., 2019, 52, 665-675. (Featured in journal cover)

53) Qiao Tang, Ji Liu, Ying Jiang, Meining Zhang, Lanqun Mao, Ming Wang*, Cell-Selective messenger RNA delivery and CRISPR/Cas9 genome editing by modulating the interface of phenylboronic acid-derived lipid nanoparticles and cellular surface sialic acid. ACS Appl. Mater. Interface, 2019, 11, 46585-46590.

52) Chunjing Liang, Jin Chang, Ying Jiang*, Ji Liu, Lanqun Mao, Ming Wang*, Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles. Chem. Commun., 2019, 55, 8170-8173.

51) Qiao Tang, Jianxue Wang, Ying Jiang, Meining Zhang*, Jin Chang, Qiaobing Xu, Lanqun Mao, Ming Wang*, Developing chemically modified redox-responsive proteins as smart therapeutics. Chem. Commun., 2019, 55, 5163-5166.

50) Weiqi Cai, Ming Wang*, Engineering nucleic acid chemistry for previse and controllable CRISPR/Cas9 genome editing, Sci. Bull., 2019, 64, 1841-1849. (Emerging Investigator Issue 2019)

49) Yamin Li, Justin Bolinger, Yingjie Yu, Zachary Glass, Nicola Shi, Liu Yang, Ming Wang, Qiaobing Xu*, Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles, Biomater. Sci., 2019, 7, 596-606.

48) Wenjie Ma, Junjie Mao, Xiaoti Yang, Cong Pan, Wenxing Chen, Ming Wang, Ping Yu, Lanqun Mao*, Yadong Li, A single-atom Fe–N 4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection,Chem. Commun., 2019,55, 159-162.
47) Xun Ma, Ping Zhou, Adin Kugelmass, Denis Toskic, Melissa Warner, Lisa Lee, Terry Fogaren, Amandeep Godara, Ming Wang, Yamin Li, Liu Yang, Qiaobing Xu, Raymond L Comenzo*, A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases, Gene Ther., 2019, 26, 187.
46) Lei Sui, Ming Wang, Qianqian Han, Liming Yu, Lan Zhang, Leilei Zheng, Junxiang Lian, Jin Zhang, Paloma Valverde, Qiaobing Xu, Qisheng Tu, Jake Chen*, A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration, Biomaterials, 2019, 177, 88-97.

发表论文
62) Weiqi Cai, Tianli Luo, Lanqun Mao, Ming Wang*, Spatiotemporal Delivery of CRISPR/Cas9 Genome Editing Machinery Using Stimuli-Responsive Vehicles. Angew. Chem. Int. Ed., 2020, 59, DOI: 10.1002/ange.

61) Qingwei Yue, Xianchan Li, Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*, Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes. Angew. Chem. Int. Ed., 2020, 59, DOI: 10.1002/anie..

60) Chunjing Liang, Xianghan Chen, Qiao Tang, Wenliang Ji, Ying Jiang, Lanqun Mao, Ming Wang*, An Activity-based Two-photon Fluorescent Probe for Real-time and Reversible Imaging of Oxidative Stress in the Rat Brain. Chem. Commun., 2020, 56, 10.1039/D0CC01747G

59) Xiaoti Yang, Jin Chang, Ying Jiang, Qiaobing Xu, Ming Wang*, Lanqun Mao*, In Vivo Activation of Pro-protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction. CCS Chemistry, 2020, 2, in press

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45) Ying Jiang, Xiaoshu Pan, Jin Chang, Weijia Niu, Weijia Hou, Hailan Kuai, Zilong Zhao*, Ji Liu, Ming Wang*, Weihong Tan*, Supramolecularly engineered circular bivalent aptamer for enhanced functional protein delivery. J. Am. Chem. Soc.,2018, 140, 6780?6784.

44) Fei Wu, Ping Yu, Xiaoti Yang, Zhongjie Han, Ming Wang, Lanqun Mao*, Exploring Ferredoxin-Dependent Glutamate Synthase as an Enzymatic Bioelectrocatalyst, J. Am. Chem. Soc., 2018, 140, 12700-12704.

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43) Jingjing Deng, Kai Wang, Ming Wang*, Ping Yu*, Lanqun Mao*, Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells.J. Am. Chem. Soc., 2017, 139, 5877–5882.

42) Rui Tang⁺, Ming Wang⁺, Moumita Ray, Ying Jiang, Ziwen Jiang, Qiaobing Xu*, Vincent M. Rotello* Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags. J. Am. Chem. Soc., 2017, 139, 8547-8551. (⁺equal contribution)

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41) Ming Wang, John A Zuris, Fantao meng, Holly Rees, Shuo Sun, Pu Deng, Yong Han, Xue Gao, Dimitra Pouli, Qi Wu, Irene Georgakoudi, David R Liu, Qiaobing Xu, Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles PNAS, 2016, 113, 2868-2873.
40) Sarah A Alt?no?lu, Ming Wang, Kathleen Q Li, Yuyang Li, Qiaobing Xu*, Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy Biomater. Sci., 2016, 4, 1773-1780.
39) Qin Jiang, Ming Wang, Lifen. Yang, Hui Chen, Lanqun Mao* Synergistic coordination and hydrogen bonding interaction modulate the emission of iridium complex for highly sensitive glutamine imaging in live cells, Anal. Chem., 2016, 88, 10322-10327.
38) Yuji S Takeda, Ming Wang, Pu Deng, Qiaobing Xu*, Synthetic bioreducible lipid‐based nanoparticles for miRNA delivery to mesenchymal stem cells to induce neuronal differentiation, Bioeng. Tranl. Med., 2016, 1, 160-167.
37) Ming Wang, Guanxin Zhang, Deqing Zhang*, Enzyme-driven i-motif DNA folding for logic operations and fluorescent biosensing,Chem. Commun., 2015, 51(18), 3812-3815.
36) Ming Wang, Sarah Alt?noglu, Yuji S. Takeda, Qiaobing Xu*, Integrating protein engineering and bioorthogonal click conjugation for extracellular vesicle modulation and intracellular delivery, PLoS one,2015, 10(11):e**.
35) Sarah Alt?no?lu, Ming Wang, Qiaobing Xu*, Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications, Nanomedicine,2015,10(4), 643-657.
34) Ming Wang, Shuo Sun, CalebI. Neufeld, Bernardo Perez-Ramirez, Qiaobing Xu*, Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy, Angew. Chem. Int. Ed., 2014,53, 13444-13448.
33) Ming Wang, Kyle Alberti, Shuo Sun, Carlos L. Arellano,Qiaobing Xu*, Combinatorially-designed lipid-like nanoparticlesfor intracellular delivery of cytotoxic proteins for cancer therapy, Angew. Chem. Int. Ed., 2014, 53, 2893-2898.
32) Ming Wang, Kyle Alberti, Antonio Varone, Dimitra Pouli, Irene Georgakoudi, Qiaobing Xu*, Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles, Adv. Healthcare Mater., 2014, 3(9), 1398-1403.
31) Xiao-Xia Xia, Ming Wang, Yinan Lin, Qiaobing Xu, David L. Kaplan*, Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery, Biomacromolecules,2014, 15(3), 908-914.
30) Yinnan Lin, Xiaoxia Xia, Ming Wang, Qianrui Wang, Bo An, Hu Tao, Qiaobing Xu, David Kaplan*, Genetically programmable thermoresponsive plasmonic gold/silk-elastin protein core/shell nanoparticles, Langmuir,2014, 30(15), 4406-4414.
29) Shuo Sun, Ming Wang, Kyle Alberti, Alex Choy, Qiaobing Xu*, DOPE facilitates quaternized lipidoids (QLDs) for in vitro DNA Delivery, Nanomedicine: Nanotechnology, Biology, and Medicine, 2013, 9(7), 849-854.
28) Vaishali Vajpayee, Sunmi Lee, Seol-Hee Kim, Se Chan Kang,* Timothy R. Cook, Hyunuk Kim, Dong Wook Kim, Shashi Verma, Myoung Soo Lah, In Su Kim, Ming Wang, Peter J. Stang*, Ki-Whan Chi*,Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity, Dalton Trans.,2013,42(2),466-475.
27) Ming Wang, Shuo Sun, Kyle Alberti, Qiaobing Xu*, A combinatorial library of unsaturated lipidoids for efficient intracellular gene delivery, ACS Synth. Biol., 2012, 1(9), 403-407.
26) Shuo Sun, Ming Wang, Sarah A. Knupp, Yadira Soto-Feliciano, Xiao Hu, David L. Kaplan, Robert Langer, Daniel G. Anderson, Qiaobing Xu*, Combinatorial library of lipidoids for in vitro DNA delivery, Bioconjugate Chem., 2012,23(1), 135-140.
25) Anurag Mishra, Vaishali Vajpayee, Hyunuk Kim, Min Hyung Lee, Hyunji Jung, Ming Wang, Peter J. Stang, Ki-Whan Chi*, Self-assembled metalla-bowls for selective sensing of multi-carboxylate anions, Dalton Trans.,2012,41(4),1195-1201.
24) Vaishali Vajpayee, Young Ho Song, Young Jun Jung, Se Chan Kang, Hyunuk Kim, In Su Kim, Ming Wang, Timothy R. Cook, Peter J. Stang, Ki-Whan Chi*, Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies, Dalton Trans.,2012,41(10),3046-3052.
23) Ming Wang, Wen-Jie Lan, Yao-Rong Zheng, Timothy R. Cook, Henry S. White*, Peter J. Stang*, Post-Self-Assembly covalent chemistry of discrete multicomponent metallo- supramolecular hexagonal prisms, J. Am. Chem. Soc., 2011, 133(28), 10752-10755.
22) Ming Wang, Vaishali Vajpayee, Sankarasekaran Shanmugaraju, Yao-Rong Zheng, Zhigang Zhao, Hyunuk Kim, Partha Sarathi Mukherjee*, Ki-Whan Chi*, Peter J. Stang*, Coordination-driven self-assembly of M₃L₂ trigonal cages from pre-organized metalloligands incorporating octahedral metal centers and fluorescent detection of nitroaromatics, Inorg. Chem., 2011, 50(4), 1506-1512.
21) Ming Wang, Yao-Rong Zheng, Timothy R. Cook, Peter J. Stang*, Construction of functionalized metallosupramolecular tetragonal prisms via multicomponent coordination- driven self-assembly, Inorg. Chem., 2011, 50(13), 6107-6113.
20) Yao-Rong Zheng, Wen-Jie Lan, Ming Wang, Timothy R. Cook, Peter J. Stang*, Designed post-self-assembly structural and functional modifications of a truncated tetrahedron, J. Am. Chem. Soc., 2011, 133(42), 17045-17055.
19) Yao-Rong Zheng, Ming Wang, Shiho Kobayashi, Peter J. Stang*, Self-assembly of coordinative supramolecular polygons with open binding sites, Tetrahedron Lett.,2011, 52(17), 2188-2191.
18) Vaishali Vajpayee, Yoon Jung Yang, Se Chan Kang*, Hyunuk Kim, In Su Kim, Ming Wang, Peter J. Stang, * Ki-Whan Chi *, Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents, Chem. Commun., 2011, 47(18), 5184-5186.
17) Vaishali Vajpayee, Young Ho Song, Min Hyung Lee*, Hyunuk Kim, Ming Wang, Peter J. Stang*, Ki-Whan Chi*, Self-assembled arene-ruthenium-based rectangles for the selective sensing of multicarboxylate anions, Chem. Eur. J., 2011, 17(28), 7837-7844.
16) Vaishali Vajpayee, Young Ho Song, Yong Jung Yang, Se Chan Kang*, Hyunuk Kim, In Su Kim, Ming Wang, Peter J. Stang, * Ki-Whan Chi *, Coordination driven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers, Organometallics, 2011, 30(12), 3242-3245.
15) Anurag Mishra, Sambandam Ravikumar, Soon Ho Hong*, Hyunuk Kim, Vaishali Vajpayee, Hye Woo Lee, ByungChan Ahn, Ming Wang, Peter J. Stang, Ki-Whan Chi*, DNA binding and unwinding by self-assembled supramolecular heterobimetallacycles, Organometallics, 2011, 30(23), 6343-6346.
14) Vaishali Vajpayee, Young Ho Song, Yong Jung Yang, Se Chan Kang*, Timothy R. Cook, Dong Wook Kim, In Su Kim, Ming Wang, Peter J. Stang, * Ki-Whan Chi *, Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological Studies, Organometallics, 2011, 30(23), 6482-6489.
13) Ming Wang*, Yao-Rong Zheng, Koushik Ghosh, Peter J. Stang*, Metallosupramolecular tetragonal prisms via multicomponent coordination-driven template-free self-assembly,J. Am. Chem. Soc., 2010, 132(18), 6282-6283.
12) Ming Wang, Guanxin Zhang, Deqing Zhang*, Daoben Zhu*, Ben Zhong Tang*, Fluorescent bio/chemosensors based on silole and tetraphenylethene luminogens with aggregation-induced emission feature,J. Mater. Chem., 2010, 20(10), 1858-1867.
11) Yao-Rong Zheng*, Zhigang Zhao,Ming Wang, Koushik Ghosh, J. Bryant Pollock, Timothy R. Cook, Peter J. Stang*, A Facile approach toward multicomponent supramolecular structures: selective self-sssembly via charge separation,J. Am. Chem. Soc., 2010, 132(47), 11873-11882.
10) Zhigang Zhao, Yao-Rong Zheng, Ming Wang, J. Bryant Pollock, Peter J. Stang*, Construction of hexagonal prisms of variable size via coordination-driven multicomponent self-assembly, Inorg. Chem.,2010, 49(19), 8653-8655.
9) Ming Wang, Koushik Ghosh, J. Bryant Pollock, Ki-Whan Chi, Peter J. Stang*, Coordination-driven self-assembly of truncated tetrahedra capable of encapsulating 1,3,5-Triphenylbenzene,Inorg. Chem., 2010, 49(49), 10238-10240.
8) Ming Wang, Xinggui Gu, Deqing Zhang*,Guanxin Zhang, Daoben Zhu, Convenient and continuous fluorometric assay method for acetylcholinesterase and inhibitor screening based on the Aggregation-Induced Emission,Anal. Chem., 2009, 81(11), 4444-4449.
7) Ming Wang, Deqing Zhang*,Guanxin Zhang, Daoben Zhu, Fluorescence enhancement upon gelation and thermally-driven fluorescence switch based on tetraphenylsilole-based organic gelators,Chem. Phys. Lett., 2009, 475(1), 64-67.
6) Ming Wang, Xinggui Gu, Deqing Zhang*, Guanxin Zhang, Daoben Zhu, Continuous colorimetric assay for acetylcholinesterase and inhibitor screening with gold nanoparticles, Langmuir, 2009, 25(4), 2504-2507.
5) Manchun Zhao,Ming Wang, Huajie Liu, Dongsheng Liu*, Guanxin Zhang, Deqing Zhang*, Daoben Zhu, Continuous on-site label-free ATP fluorometric assay based on aggregation-induced emission of silole, Langmuir, 2009, 25(2), 676-678.
4) Lihua Peng, Ming Wang, Guanxin Zhang, Deqing Zhang*, Daoben Zhu, A fluorescence turn-on detection of cyanide in aqueous solution based on the aggregation-induced emission, Org. Lett., 2009, 11(9), 1943-1946.
3) Jing Huang, Ming Wang, Yangyang Zhou, Xiaocheng Weng, Liang Shuai, Xiang Zhou*, Deqing Zhang*, Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorg. Med. Chem., 2009, 17(22), 7743-7748.
2) Ming Wang, Deqing Zhang*,Guanxin Zhang, Yanli Tang, Shu Wang, Daoben Zhu*, Fluorescence turn-on detection of DNA and label-free fluorescence nuclease assay based on the aggregation-induced enhanced emission (AIE) of silole, Anal. Chem., 2008,80(16), 6443-6448.
1) Ming Wang, Deqing Zhang*,Guanxin Zhang, Daoben Zhu*, The convenient fluorescence turn-on detection of heparin with a silole derivative featuring an ammonium group, Chem. Commun., 2008, 37(37), 4469-4471.