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中国科学院化学研究所导师教师师资介绍简介-马会民
本站小编 Free考研考试/2020-05-17
课题组负责人
马会民 研究员
联系我们
地址：北京市海淀区中关村北一街2号 中国科学院化学研究所
邮编：100190
Tel: 86-
Email: mahm@iccas.ac.cn
课题组简介
本课题组长期从事生物分子的光学探针与生化分析研究。先后发展了水溶性高分子类、三嗪类、含反应性桥联键等一系列光学探针，并利用特殊的化学反应建立了色氨酸、单线态氧的高选择性光学分析法；基于转氨反应发展了蛋白质N-末端定位标记与局部极性检测新方法等。
课题组负责人
马会民 研究员
联系我们
地址：北京市海淀区中关村北一街2号 中国科学院化学研究所
邮编：100190
Tel: 86-
Email: mahm@iccas.ac.cn
课题组简介
本课题组长期从事生物分子的光学探针与生化分析研究。先后发展了水溶性高分子类、三嗪类、含反应性桥联键等一系列光学探针，并利用特殊的化学反应建立了色氨酸、单线态氧的高选择性光学分析法；基于转氨反应发展了蛋白质N-末端定位标记与局部极性检测新方法等。
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课题组组长
在职员工
研究生
马会民 研究员
马会民 研究员
1979-1983 山东大学化学系本科
1986年 获中国科学院化学所硕士，随后在中科院半导体所工作
1990年 获中国科学院化学所博士
1990-1992 武汉大学化学系博士后
1992-至今 中国科学院化学所工作，现任研究员，博士生导师。
曾于1996-1997年、1999年10月-2000年2月和2001年10-11月，先后三次作为德国洪堡****在 Bremen University 从事研究工作。
现任《Current Chemical Biology》、《科学通报》、《分析化学》、《分析科学学报》等刊物的编委；中国化学会永久会员。
2003年度中国分析测试协会科学技术二等奖(CAIA奖)
2006年度中国分析测试协会科学技术一等奖(CAIA奖)
2005年度获得国家基金委****基金项目资助
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课题组组长
在职员工
研究生
马会民 研究员
马会民 研究员
1979-1983 山东大学化学系本科
1986年 获中国科学院化学所硕士，随后在中科院半导体所工作
1990年 获中国科学院化学所博士
1990-1992 武汉大学化学系博士后
1992-至今 中国科学院化学所工作，现任研究员，博士生导师。
曾于1996-1997年、1999年10月-2000年2月和2001年10-11月，先后三次作为德国洪堡****在 Bremen University 从事研究工作。
现任《Current Chemical Biology》、《科学通报》、《分析化学》、《分析科学学报》等刊物的编委；中国化学会永久会员。
2003年度中国分析测试协会科学技术二等奖(CAIA奖)
2006年度中国分析测试协会科学技术一等奖(CAIA奖)
2005年度获得国家基金委****基金项目资助
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课题组组长
在职员工
研究生
李晓花 副研究员
李晓花 副研究员
1995.09 – 2001.07 西北大学分析化学专业获本科及硕士学位
2001.09 – 2004.07 中国科学院化学研究所获理学博士学位
2004.12 –2006.09 美国艾默理大学化学系博士后
2006.10 – 2008.09 德国雷根斯堡大学分析化学研究所博士后
2008.10 – 至今中国科学院化学研究工作，现为活体分析化学实验室副研究员
研究兴趣
1.功能性光学识别探针的设计与生化分析应用；
2.生物分子的荧光标记与结构功能研究；
3.环境有毒/有害物质的探针设计与光学分析（光谱、成像分析等）
史文 副研究员
史文 副研究员
2001.09 - 2005.06 武汉大学应用化学专业获本科学位
2005.09 - 2010.06 中国科学院化学研究所获理学博士学位
2010.07 - 至今中国科学院化学研究所助理研究员、副研究员
研究兴趣
1.光学探针的设计与合成
2.生理物质和毒害物质的光学分析新方法
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课题组组长
在职员工
研究生
在读研究生
宋延超 李照 万琼琼 高兴会 李丽红 王哲 贺新元 周进 龚秋雨 吴晓峰
已毕业研究生
冯端 冯婷婷 张阳阳 陈巍 陆金鑫 贾佳 孙成栋 史文 陈素明 王可 王淑娟 王晓春
李军 陈新启 孙姝娜 保志娟 董素英 段学军 苏美红 聂丽华 马泉莉 孙铭 谷涵
研究方向
本课题组的研究方向为分析化学，生化分析，光学探针与标记分析，分子识别，具体内容包括：
1. 光学识别试剂与生化分析：利用光诱导电子转移、电荷转移、能量转移等各种光物理过程，设计新型光学(包括吸光、荧光、发光)探针，研究对生物与环境毒物的标记、荧光显微分析等
2. 分子光谱的基础研究
3. 生物光谱学与选择性检测
4. 研制生物、临床医学分析中的试剂盒、临床试纸等
发表论文
Xiaohua Li*, Xinghui Gao, Wen Shi, Huimin Ma*. Design strategies for water-soluble small molecular chromogenic and fluorogenic probes. Chem. Rev. 2014, 114, 590-659.
Yangyang Zhang, Wen Shi, Xiaohua Li, Huimin Ma*. Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal. Sci. Rep. 2013, 3, 2830.
Duan Feng, Yanchao Song, Wen Shi, Xiaohua Li, Huimin Ma*. Distinguishing folate-receptor-positive cells from folate-receptor-negative cells using a fluorescence off-on nanoprobe. Anal. chem. 2013, 85, 6530-6535.
Zhao Li, Xinghui Gao, Wen Shi, Xiaohua Li, Huimin Ma*. 7-((5-Nitrothiophen -2-yl)methoxy)-3H-phenoxazin-3 -one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase. Chem. Commun. 2013, 49, 5859-5861.
Qiongqiong Wan, Yanchao Song, Zhao Li, Xinghui Gao and Huimin Ma*. In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe. Chem. Commun., 2013, 49, 502–504.
Tingting Feng and Huimin Ma*. Fluorescence sensing of adenosine deaminase based on adenosine induced self-assembly of aptamer structures. Analyst, 2013, 138, 2438–2442.
Zhao Li, Xiaohua Li*, Xinghui Gao, Yangyang Zhang, Wen Shi, and Huimin Ma*. Nitroreductase detection and hypoxic tumor cell imaging by a designed sensitive and selective fluorescent probe, 7-[(5-nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one. Anal. Chem., 2013, 85, 3926–3932.
Tingting Feng, Duan Feng, Wen Shi, Xiaohua Li* and Huimin Ma*. A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen. Mol. BioSyst., 2012, 8, 1441–1445.
Wen Shi and Huimin Ma*. Spectroscopic probes with changeable π-conjugated systems. Chem. Commun., 2012, 48, 8732–8744.
Wen Shi*, Xiaohua Li, and Huimin Ma*. A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells. Angew. Chem. Int. Ed., 2012, 51, 6432–6435.
Yanchao Song, Wen Shi, Wei Chen, Xiaohau Li and Huimin Ma*. Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells.J. Mater. Chem., 2012, 22, 12568–12573.
Suming Chen, Wei Chen, Wen Shi, and Huimin Ma*, Spectroscopic response of ferrocene derivatives bearing a BODIPY moiety to water: new dissociation reaction, Chem. Eur. J., 2012, 18, 925-930.
Wei Chen, Zhao Li, Wen Shi, and Huimin Ma*, A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation, Chem. Commun., 2012, 48, 2809-2811.
Yangyang Zhang, Wei Chen, Duan Feng, Wen Shi*, Xiaohua Li, and Huimin Ma*, A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging, Analyst , 2012, 137, 716-721.
Chengdong Sun, Wen Shi, Yanchao Song, Wei Chen and Huimin Ma*, An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide, Chem. Commun., 2011, 47, 8638-8640.
Duan Feng, Yangyang Zhang, Tingting Feng, Wen Shi, Xiaohua Li and Huimin Ma*, A graphene oxide–peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2, Chem. Commun., 2011 , 47, 10680-10682.
Wei Chen, Wen Shi, Zhao Li, Huimin Ma*, Yang Liu, Jinghua Zhang, Qingjun Liu, Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine -6G spirolactam based on consecutive chemical reactions, Anal. Chim. Acta, 2011, 708(1-2), 84-88.
Jinxin Lu, Chengdong Sun, Wei Chen, Huimin Ma*, Wen Shi, Xiaohua Li*, Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe Catalyst, Talanta, 2011, 83, 1050-1056.
Yangyang Zhang, Wen Shi, Duan Feng, Huimin Ma*, Yan Liang, Jianru Zuo, Application of rhodamine B thiolactone to fluorescence imaging of Hg2+ in Arabidopsis thaliana, Sensors Actuat. B-Chem., 2011, 153(1), 261-265.
Jia Jia and Ma HuiMin*, A water-soluble fluorescence resonance energy transfer probe for hypochlorous acid and its application to cell imaging, Chinese Sci. Bull., 2011 , 56(31), 3266-3272.
Ma HuiMin*, Bio-spectroscopic sensing, Chinese Sci. Bull., 2011, 56(31), 3233.
Sun Chengdong, Chen Jianming Ma Huimin*, Liu Yang, Zhang Jinghua and Liu Qingjun, A new Cu2+-induced color reaction of a rhodamine derivative N-(3-carboxy)acryloyl rhodamine B hydrazide, Sci. China Chem. , 2011, 54(7), 1107-1114.
Su-Ming Chen, Jin-Xin Lu, Cheng-Dong Sun and Hui-Min Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010 , 135, 577-582.
Jia Jia, Wei Chen, Hui-Min Ma*, Ke Wang and Chuan Zhao, Use of a rhodamine-based bifunctional probe in N-terminal specific labeling of thermomyces lanuginosus xylanase, Molecular BioSystems, 2010 , 6, 1829-1833.
Duan Feng, Yang-Yang Zhang, Wen Shi, Xiao-Hua Li and Hui-Min Ma*, A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, Chem. Commun., 2010 , 46, 9203-9205.
Jia Jia, Ke Wang, Wen Shi, Suming Chen, Xiaohua Li, Huimin Ma*, Rhodamine B piperazinoacetohydrazine a water-soluble spectroscopic reagent for pyruvic acid labeling, Chem. Eur. J., 2010, 16(22), 6638-6643.
Wen Shi, Shuna Sun, Xiaohua Li and Huimin Ma*, Imaging different interactions of mercury and silver with live cells by a designed fluorescence probe rhodamine B selenolactone, Inorg. Chem., 2010 49(3) 1206-1210.
Xiaohua Li*, Wen Shi, Suming Chen, Jia Jia, Huimin Ma* and Otto S. Wolfbeis, A near-infrared fluorescent probe for monitoring tyrosinase activity, Chem. Commun., 2010, 46, 2560-2562.
Suming Chen, Jinxin Lu, Chengdong Sun, Huimin Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010, 135, 577-582.
Ke Wang, Wen Shi, Jia Jia, Suming Chen, Huimin Ma.* Characterization of 2-phenylbenzo[g]quinoxaline derivatives as viscosity-sensitive fluorescent probes,Talanta, 2009, 77, 1795-1799.
Xinqi Chen, Jia Jia, Huimin Ma*, Shujuan Wang and Xiaochun Wang. Characterization of rhodamine B hydroxylamide as a highly selective and sensitive fluorescence probe for Cu(II), Anal. Chim. Acta, 2009, 632, 9-14.
Suming Chen, Xiaohua Li, Huimin Ma*. New approach for local structure analysis of tyrosine domain in proteins by using site-specific and polarity-sensitive fluorescent probe. ChemBioChem, 2009, 10, 1200-1207.
Shujuan Wang, Xiaochun Wang, Wen Shi, Ke Wang, Huimin Ma.* Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe. Biochim. Biophys, Acta. Proteins and Proteomics, 2008, 1784, 415-422.
Wen Shi and Huimin Ma*. Rhodamine B thiolactone: a simple chemosensor for Hg2+ in aqueous media,Chem. Commun., 2008, 1856-1858.
Shuna Sun, Zhijuan Bao, Huimin Ma*, Deqing Zhang, Xiaoping Zheng. Singlet oxygen generation from the decomposition of α-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase, Biochemistry, 2007, 46, 6668-6673.
Zhijuan Bao, Shujuan Wang, Wen Shi, Suying Dong and Huimin Ma.* Selective modification of Trp 19 in β-lactoglobulin by a new diazo fluorescence probe, J. Proteome Res., 2007, 6, 3835-3841.
Suying Dong, Zhenwen Zhao, Huimin Ma.* Characterization of local polarity and hydrophobic binding sites of beta-lactoglobulin by using N-terminal specific fluorescence labeling J. Proteome Res. 2006, 5, 26-31.
Zhijuan Bao, Shuna Sun, Jun Li, Xinqi Chen, Suying Dong and Huimin Ma*, Direct identification of tryptophan in a mixture of amino acids by the naked eye, Angew. Chem. Int. Ed., 2006, 45, 6723-6725.
Suying Dong, Huimin Ma*, Xuejun Duan, Xinqi Chen, Jun Li. Detection of local polarity of a-lactalbumin by N-terminal specific labeling with a new tailor-made fluorescent probe, J. Proteome Res., 2005, 4, 161-166.
Xuejun Duan, Zhen Zhao, Jianping Ye, Huimin Ma* Andong Xia* Guoqiang Yang Chihchen Wang*. Donor-donor energy-migration measurements of dimeric DsbC labeled at its N-terminal amines with fluorescent probes: a study of protein unfolding, Angew. Chem. Int. Ed., 2004, 43, 4216-4219.
Xiaohua Li, Guanxin Zhang, Huimin Ma* Deqing Zhang*, Jun Li and Daoben Zhu.* 45-Dimethylthio-4'-[2-(9-anthryloxy)ethylthio]tetrathiafulvalene a highly selective and sensitive chemiluminescence probe for singlet oxygen, J. Am. Chem. Soc., 2004, 126, 11543-11548.
Lihua Nie, Huimin Ma*, Xiaohua Li, Ming Sun, Shaoxiang Xiong. Recognition of thymine by a triazine fluorescent probe through intermolecular multiple hydrogen bonding, Biopolymers(Biospectroscopy) , 2003, 72, 274-281.
Ming Sun, Dihua Shangguan, Huimin Ma*, Lihua Nie, Xiaohua Li, Shaoxiang Xiong Guoquan Liu Wolfram Thiemann. Simple Pb(II) fluorescent probe based on the Pb(II)-catalyzed hydrolysis of phosphodiester, Biopolymers(Biospectroscopy), 2003, 72, 413-420.
Hui-Min Ma*, Zhi-Hua Wang, Mei-Hong Su. New triazine spectroscopic reagent for separation of DL-amino acids by micellar electrokinetic chromatography, J. Chromatogr. A, 2002, 955, 125-131.
Huimin Ma*, Ute Jarzak and Wolfram Thiemann*, In situ fluorescent labeling of highly volatile methylamine with 8-(46-dichloro-135- triazinoxy)quinoline, New J. Chem., 2001, 25, 872-874.
Huimin Ma*, Jens Wohlers, Uwe Meierhenrich, Axel Bernecker, Vera Suling, Wolfram Thiemann*, Analysis of oxidative degradation products of 246- trichlorophenol treated with air ions, Anal. Chem., 2001, 73, 3506-3510.
Meihong Su, Yong Liu, Huimin Ma*, Quanli Ma, Zhihua Wang, Junlin Yang and Meixiang Wang*, 19-Dihydro-3-phenyl-4H-pyrazolo[34-b]quinolin-4-one a novel fluorescent probe for extreme pH measurement, Chem. Commun., 2001, 960-961.
组内照片
Professor
Prof. Huimin Ma
Contact us
Address: No.2 1st North Street, Zhongguancun, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Tel: +86-
E-mail: mahm@iccas.ac.cn
Introduction
Our research group mainly focuses on the development of spectroscopic probes and their bioanalytical applications. In the past 20 years, we proposed many new strategies for designing excellent spectroscopic probes, and developed a series of spectroscopic probes for various analytes by utilizing specific chemical reactions. These include: water-soluble polymeric chromogenic reagents for metal ions; triazine-based spectroscopic probes for N-terminal labeling and local structural analyses of proteins; spectroscopic probes with cleavable active bonds for reactive oxygen species and enzymes; highly selective spectroscopic sensing and imaging systems for amino acids, intracellular pH, hydrogen sulfide, etc.
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我室在硝基还原酶和细胞缺氧的检测方面取得新进展 图片新闻 14-4-29 下午4:29 已批准 活体分析-马会民-史文
《Chemical Reviews》报道我室在光学探针设计策略方面的系统研究成果 图片新闻 14-4-29 下午4:22 已批准 活体分析-马会民-史文
组内照片 组内照片 14-4-29 下午3:24 已批准 活体分析-马会民-史文
已发表论文 已发表论文 14-4-29 下午3:06 已批准 活体分析-马会民-史文
研究方向 研究领域 14-4-29 下午3:03 已批准 活体分析-马会民-史文
已毕业研究生 已毕业研究生 14-4-29 下午2:55 已批准 活体分析-马会民-史文
在读研究生 在读研究生 14-4-29 下午2:53 已批准 活体分析-马会民-史文
史文 副研究员 课题组职工 14-4-29 下午2:46 已批准 活体分析-马会民-史文
李晓花 副研究员 课题组职工 14-4-29 下午2:44 已批准 活体分析-马会民-史文
马会民研究员中文简介 马会民研究员简介 14-4-29 下午2:39 已批准 活体分析-马会民-史文
联系我们 联系我们 14-4-29 下午2:35 已批准 活体分析-马会民-史文
课题组中文简介 课题组简介 14-4-29 下午2:30 已批准 活体分析-马会民-史文
马会民研究员 马会民研究员头像 14-4-29 下午2:27 已批准 活体分析-马会民-史文
Research
Our research interests are: spectroscopic probes and sensing analysis; biospectroscopy and selective detection; biochemical analysis; molecular recognition.
1. Spectroscopic analytical reagents and their bioanalytical applications: to develop novel spectroscopic (including chromogenic, fluorescent, and chemiluminescent) probes and use them for the analysis and imaging of biochemical substances.
2. Fundamental studies on molecular spectroscopy.
3. Biospectroscopy and selective detection.
4. To develop the test kits or test papers for clinical and biological applications.
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Professor
Faculties
Professor
Prof. Dr. Huimin Ma
Education
1979-1983, B.S., Department of Chemistry, Shandong University;
1986, M.S., Institute of Chemistry, Chinese Academy of Sciences (ICCAS);
1987-1990, Ph.D., ICCAS.
Employments
1986-1987, Assistant Researcher, Institute of Semiconductors, Chinese Academy of Sciences;
1990-1992, Postdoctoral Researcher, Department of Chemistry, Wuhan University;
1992 –1999, Associate Professor, ICCAS;
1999 – present, Professor, ICCAS;
(1996-1997, Research Fellow of the Alexander von Humboldt Foundation, Bremen University, Germany).
Awards/Honors and Appointments
2005, National Science Fund for Distinguished Young Scholars from NSF of China;
2006, the 1st-grade Award from CAIA (China Associationfor Instrumental Analysis);
2010, the 2nd-grade Award of Science and Technology from Beijing Municipal Government;
Permanent member of Chinese Chemical Society;
Member of International Programme Committee, the 9th International Conference on Methods and Applications of Fluorescence Spectroscopy, Imaging and Probes (MAF 9);
Member of the editorial board of several chemical and biological journals, such as Journal of Analytical Science, Current Chemical Biology, Spectroscopy and Spectral Analysis,ISRN Spectroscopy, Chinese Science Bulletin, Chinese Journal of Analytical Chemistry, and so on.
Group members
Professor
Faculties
Professor
Prof. Dr. Huimin Ma
Education
1979-1983, B.S., Department of Chemistry, Shandong University;
1986, M.S., Institute of Chemistry, Chinese Academy of Sciences (ICCAS);
1987-1990, Ph.D., ICCAS.
Employments
1986-1987, Assistant Researcher, Institute of Semiconductors, Chinese Academy of Sciences;
1990-1992, Postdoctoral Researcher, Department of Chemistry, Wuhan University;
1992 –1999, Associate Professor, ICCAS;
1999 – present, Professor, ICCAS;
(1996-1997, Research Fellow of the Alexander von Humboldt Foundation, Bremen University, Germany).
Awards/Honors and Appointments
2005, National Science Fund for Distinguished Young Scholars from NSF of China;
2006, the 1st-grade Award from CAIA (China Associationfor Instrumental Analysis);
2010, the 2nd-grade Award of Science and Technology from Beijing Municipal Government;
Permanent member of Chinese Chemical Society;
Member of International Programme Committee, the 9th International Conference on Methods and Applications of Fluorescence Spectroscopy, Imaging and Probes (MAF 9);
Member of the editorial board of several chemical and biological journals, such as Journal of Analytical Science, Current Chemical Biology, Spectroscopy and Spectral Analysis,ISRN Spectroscopy, Chinese Science Bulletin, Chinese Journal of Analytical Chemistry, and so on.
Group members
Professor
Faculties
Associate professor
Dr Xiaohua Li, Associate professor
Education
1995.09–2001.07 M.S.and B.S,Major in Analytical Chemistry, Northwest University, Xi’an, China
2001.09–2004.07 Ph.D., Major in Chemistry Chemistry. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Research Experiences
2004.12–2006.09 Postdoctoral Associate,Emory University, Department of Chemistry, Atlanta, USA
2006.10–2008.09 Postdoctoral Associate,University of Regensburg, Institute of Analytical Chemistry, Chemo- and Biosensors, Regensburg, Germany
2008.10 – Present Associate Professor, Institute of chemistry, Chinese Academy of Sciences.
Research Interests
1. Development of new functional luminescent probes and their applications in biochemical analysis；
2. Fluorescent labeling and structure-function relationship studies of biomolecules;
3. Design of molecular probes and fluorescent imaging analysis.
Associate professor
Dr Wen Shi, Associate professor
Education
2001.09–2005.06 M.S.,Chemistry, Wuhan University
2005.09–2010.06 Ph.D., Analytical Chemistry. Institute of Chemistry, Chinese Academy of Sciences
Research Experiences
2010.07–2013.07 Assistant Professor, Institute of chemistry, Chinese Academy of Sciences
2013.08–Present Associate Professor, Institute of chemistry, Chinese Academy of Sciences
Research Interests
Spectroscopic probes for biological/toxic substances
Selected publications
Xiaohua Li*, Xinghui Gao, Wen Shi, Huimin Ma*. Design strategies for water-soluble small molecular chromogenic and fluorogenic probes. Chem. Rev. 2014, 114, 590-659.
Yangyang Zhang, Wen Shi, Xiaohua Li, Huimin Ma*. Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal. Sci. Rep. 2013, 3, 2830.
Duan Feng, Yanchao Song, Wen Shi, Xiaohua Li, Huimin Ma*. Distinguishing folate-receptor-positive cells from folate-receptor-negative cells using a fluorescence off-on nanoprobe. Anal. chem. 2013, 85, 6530-6535.
Zhao Li, Xinghui Gao, Wen Shi, Xiaohua Li, Huimin Ma*. 7-((5-Nitrothiophen -2-yl)methoxy)-3H-phenoxazin-3 -one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase. Chem. Commun. 2013, 49, 5859-5861.
Qiongqiong Wan, Yanchao Song, Zhao Li, Xinghui Gao and Huimin Ma*. In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe. Chem. Commun., 2013, 49, 502–504.
Tingting Feng and Huimin Ma*. Fluorescence sensing of adenosine deaminase based on adenosine induced self-assembly of aptamer structures. Analyst, 2013, 138, 2438–2442.
Zhao Li, Xiaohua Li*, Xinghui Gao, Yangyang Zhang, Wen Shi, and Huimin Ma*. Nitroreductase detection and hypoxic tumor cell imaging by a designed sensitive and selective fluorescent probe, 7-[(5-nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one. Anal. Chem., 2013, 85, 3926–3932.
Tingting Feng, Duan Feng, Wen Shi, Xiaohua Li* and Huimin Ma*. A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen. Mol. BioSyst., 2012, 8, 1441–1445.
Wen Shi and Huimin Ma*. Spectroscopic probes with changeable π-conjugated systems. Chem. Commun., 2012, 48, 8732–8744.
Wen Shi*, Xiaohua Li, and Huimin Ma*. A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells. Angew. Chem. Int. Ed., 2012, 51, 6432–6435.
Yanchao Song, Wen Shi, Wei Chen, Xiaohau Li and Huimin Ma*. Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells.J. Mater. Chem., 2012, 22, 12568–12573.
Suming Chen, Wei Chen, Wen Shi, and Huimin Ma*, Spectroscopic response of ferrocene derivatives bearing a BODIPY moiety to water: new dissociation reaction, Chem. Eur. J., 2012, 18, 925-930.
Wei Chen, Zhao Li, Wen Shi, and Huimin Ma*, A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation, Chem. Commun., 2012, 48, 2809-2811.
Yangyang Zhang, Wei Chen, Duan Feng, Wen Shi*, Xiaohua Li, and Huimin Ma*, A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging, Analyst , 2012, 137, 716-721.
Chengdong Sun, Wen Shi, Yanchao Song, Wei Chen and Huimin Ma*, An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide, Chem. Commun., 2011, 47, 8638-8640.
Duan Feng, Yangyang Zhang, Tingting Feng, Wen Shi, Xiaohua Li and Huimin Ma*, A graphene oxide–peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2, Chem. Commun., 2011 , 47, 10680-10682.
Wei Chen, Wen Shi, Zhao Li, Huimin Ma*, Yang Liu, Jinghua Zhang, Qingjun Liu, Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine -6G spirolactam based on consecutive chemical reactions, Anal. Chim. Acta, 2011, 708(1-2), 84-88.
Jinxin Lu, Chengdong Sun, Wei Chen, Huimin Ma*, Wen Shi, Xiaohua Li*, Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe Catalyst, Talanta, 2011, 83, 1050-1056.
Yangyang Zhang, Wen Shi, Duan Feng, Huimin Ma*, Yan Liang, Jianru Zuo, Application of rhodamine B thiolactone to fluorescence imaging of Hg2+ in Arabidopsis thaliana, Sensors Actuat. B-Chem., 2011, 153(1), 261-265.
Jia Jia and Ma HuiMin*, A water-soluble fluorescence resonance energy transfer probe for hypochlorous acid and its application to cell imaging, Chinese Sci. Bull., 2011 , 56(31), 3266-3272.
Ma HuiMin*, Bio-spectroscopic sensing, Chinese Sci. Bull., 2011, 56(31), 3233.
Sun Chengdong, Chen Jianming Ma Huimin*, Liu Yang, Zhang Jinghua and Liu Qingjun, A new Cu2+-induced color reaction of a rhodamine derivative N-(3-carboxy)acryloyl rhodamine B hydrazide, Sci. China Chem. , 2011, 54(7), 1107-1114.
Su-Ming Chen, Jin-Xin Lu, Cheng-Dong Sun and Hui-Min Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010 , 135, 577-582.
Jia Jia, Wei Chen, Hui-Min Ma*, Ke Wang and Chuan Zhao, Use of a rhodamine-based bifunctional probe in N-terminal specific labeling of thermomyces lanuginosus xylanase, Molecular BioSystems, 2010 , 6, 1829-1833.
Duan Feng, Yang-Yang Zhang, Wen Shi, Xiao-Hua Li and Hui-Min Ma*, A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, Chem. Commun., 2010 , 46, 9203-9205.
Jia Jia, Ke Wang, Wen Shi, Suming Chen, Xiaohua Li, Huimin Ma*, Rhodamine B piperazinoacetohydrazine a water-soluble spectroscopic reagent for pyruvic acid labeling, Chem. Eur. J., 2010, 16(22), 6638-6643.
Wen Shi, Shuna Sun, Xiaohua Li and Huimin Ma*, Imaging different interactions of mercury and silver with live cells by a designed fluorescence probe rhodamine B selenolactone, Inorg. Chem., 2010 49(3) 1206-1210.
Xiaohua Li*, Wen Shi, Suming Chen, Jia Jia, Huimin Ma* and Otto S. Wolfbeis, A near-infrared fluorescent probe for monitoring tyrosinase activity, Chem. Commun., 2010, 46, 2560-2562.
Suming Chen, Jinxin Lu, Chengdong Sun, Huimin Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010, 135, 577-582.
Ke Wang, Wen Shi, Jia Jia, Suming Chen, Huimin Ma.* Characterization of 2-phenylbenzo[g]quinoxaline derivatives as viscosity-sensitive fluorescent probes,Talanta, 2009, 77, 1795-1799.
Xinqi Chen, Jia Jia, Huimin Ma*, Shujuan Wang and Xiaochun Wang. Characterization of rhodamine B hydroxylamide as a highly selective and sensitive fluorescence probe for Cu(II), Anal. Chim. Acta, 2009, 632, 9-14.
Suming Chen, Xiaohua Li, Huimin Ma*. New approach for local structure analysis of tyrosine domain in proteins by using site-specific and polarity-sensitive fluorescent probe. ChemBioChem, 2009, 10, 1200-1207.
Shujuan Wang, Xiaochun Wang, Wen Shi, Ke Wang, Huimin Ma.* Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe. Biochim. Biophys, Acta. Proteins and Proteomics, 2008, 1784, 415-422.
Wen Shi and Huimin Ma*. Rhodamine B thiolactone: a simple chemosensor for Hg2+ in aqueous media,Chem. Commun., 2008, 1856-1858.
Shuna Sun, Zhijuan Bao, Huimin Ma*, Deqing Zhang, Xiaoping Zheng. Singlet oxygen generation from the decomposition of α-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase, Biochemistry, 2007, 46, 6668-6673.
Zhijuan Bao, Shujuan Wang, Wen Shi, Suying Dong and Huimin Ma.* Selective modification of Trp 19 in β-lactoglobulin by a new diazo fluorescence probe, J. Proteome Res., 2007, 6, 3835-3841.
Suying Dong, Zhenwen Zhao, Huimin Ma.* Characterization of local polarity and hydrophobic binding sites of beta-lactoglobulin by using N-terminal specific fluorescence labeling J. Proteome Res. 2006, 5, 26-31.
Zhijuan Bao, Shuna Sun, Jun Li, Xinqi Chen, Suying Dong and Huimin Ma*, Direct identification of tryptophan in a mixture of amino acids by the naked eye, Angew. Chem. Int. Ed., 2006, 45, 6723-6725.
Suying Dong, Huimin Ma*, Xuejun Duan, Xinqi Chen, Jun Li. Detection of local polarity of a-lactalbumin by N-terminal specific labeling with a new tailor-made fluorescent probe, J. Proteome Res., 2005, 4, 161-166.
Xuejun Duan, Zhen Zhao, Jianping Ye, Huimin Ma* Andong Xia* Guoqiang Yang Chihchen Wang*. Donor-donor energy-migration measurements of dimeric DsbC labeled at its N-terminal amines with fluorescent probes: a study of protein unfolding, Angew. Chem. Int. Ed., 2004, 43, 4216-4219.
Xiaohua Li, Guanxin Zhang, Huimin Ma* Deqing Zhang*, Jun Li and Daoben Zhu.* 45-Dimethylthio-4'-[2-(9-anthryloxy)ethylthio]tetrathiafulvalene a highly selective and sensitive chemiluminescence probe for singlet oxygen, J. Am. Chem. Soc., 2004, 126, 11543-11548.
Lihua Nie, Huimin Ma*, Xiaohua Li, Ming Sun, Shaoxiang Xiong. Recognition of thymine by a triazine fluorescent probe through intermolecular multiple hydrogen bonding, Biopolymers(Biospectroscopy) , 2003, 72, 274-281.
Ming Sun, Dihua Shangguan, Huimin Ma*, Lihua Nie, Xiaohua Li, Shaoxiang Xiong Guoquan Liu Wolfram Thiemann. Simple Pb(II) fluorescent probe based on the Pb(II)-catalyzed hydrolysis of phosphodiester, Biopolymers(Biospectroscopy), 2003, 72, 413-420.
Hui-Min Ma*, Zhi-Hua Wang, Mei-Hong Su. New triazine spectroscopic reagent for separation of DL-amino acids by micellar electrokinetic chromatography, J. Chromatogr. A, 2002, 955, 125-131.
Huimin Ma*, Ute Jarzak and Wolfram Thiemann*, In situ fluorescent labeling of highly volatile methylamine with 8-(46-dichloro-135- triazinoxy)quinoline, New J. Chem., 2001, 25, 872-874.
Huimin Ma*, Jens Wohlers, Uwe Meierhenrich, Axel Bernecker, Vera Suling, Wolfram Thiemann*, Analysis of oxidative degradation products of 246- trichlorophenol treated with air ions, Anal. Chem., 2001, 73, 3506-3510.
Meihong Su, Yong Liu, Huimin Ma*, Quanli Ma, Zhihua Wang, Junlin Yang and Meixiang Wang*, 19-Dihydro-3-phenyl-4H-pyrazolo[34-b]quinolin-4-one a novel fluorescent probe for extreme pH measurement, Chem. Commun., 2001, 960-961.
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课题组负责人
马会民 研究员
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地址：北京市海淀区中关村北一街2号 中国科学院化学研究所
邮编：100190
Tel: 86-
Email: mahm@iccas.ac.cn
课题组简介
本课题组长期从事生物分子的光学探针与生化分析研究。先后发展了水溶性高分子类、三嗪类、含反应性桥联键等一系列光学探针，并利用特殊的化学反应建立了色氨酸、单线态氧的高选择性光学分析法；基于转氨反应发展了蛋白质N-末端定位标记与局部极性检测新方法等。
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