Zhuangzhuang Zhao
Mingxue Gu
Xinghua Feng
Haoxing Xu
1 Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China;
2 The Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Funds: The authors are supported by NIH Grants (NS062792, AR060837 and DK115471) and funds from the Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals.
Received Date: 2017-12-29
Rev Recd Date:2018-02-05
Abstract
Abstract
Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life, ranging from cell proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of this regulation is the compartmentalization of Ca2+ in various cytoplasmic organelles that act as intracellular Ca2+ stores. Whereas Ca2+ release from the large-volume Ca2+ stores, such as the endoplasmic reticulum (ER) and Golgi apparatus, are preferred for signal transduction, Ca2+ release from the small-volume individual vesicular stores that are dispersed throughout the cell, such as lysosomes, may be more useful in local regulation, such as membrane fusion and individualized vesicular movements. Conceivably, these two types of Ca2+ stores may be established, maintained or refilled via distinct mechanisms. ER stores are refilled through sustained Ca2+ influx at ER-plasma membrane (PM) membrane contact sites (MCSs). In this review, we discuss the release and refilling mechanisms of intracellular small vesicular Ca2+ stores, with a special focus on lysosomes. Recent imaging studies of Ca2+ release and organelle MCSs suggest that Ca2+ exchange may occur between two types of stores, such that the small stores acquire Ca2+ from the large stores via ER-vesicle MCSs. Hence vesicular stores like lysosomes may be viewed as secondary Ca2+ stores in the cell.Keywords: Ca2+ stores,
lysosomes,
vesicles,
refilling,
organelle membrane contact sites (MCSs)
PDF全文下载地址:
http://www.protein-cell.org/article/exportPdf?id=dfe2f22b-9d99-4910-9587-e38b59589966&language=en
