姓名：严君 性别：女 职称：教授 招生院所：脑重大疾病研究院 招生类型：科学学位(博) 科学学位(硕) 招生专业：免疫学(博) 免疫学(硕) 研究方向名称：肿瘤免疫学 电子信箱：yanjun@ccmu.edu.cn


社会任职
1. 美国癌症研究协会会员
2. 美国免疫协会会员
3. Immunology & Cell Biology杂志审稿人
4. Neoplasma杂志审稿人
5. Cancer Grrowth and Metastasis杂志审稿人
6. Endocrine, Metabolic & Immune Disorders-Drug Targets杂志审稿人
7. 中国天然药物杂志审稿人
8. Indian Journal of Cancer杂志审稿人
个人简历
1. 199709-200206:中国药科大学 本科
2. 200301-200408:中国医学科学院北京协和医学院药物研究所 研究助理
3. 200409-200906:中国医学科学院北京协和医学院药物研究所 博士
4. 200907-201206:北京伟峰益民科技有限公司 研发主管
5. 201207-201709:美国德州大学MD安德森癌症中心 博士后
6. 201710-201911:美国德州大学MD安德森癌症中心 研究科学家
重要学术论文
1. Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R. Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S. Watowich, Amy B. Heimberger, Shulin Li*.FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nature Communications. 2019,10(448):1-15.SCI
2. K. Latha#, Jun Yan#, Yuhui Yang, L. V Gressot, Ling-Yuan Kong, G. Manyam, R. Ezhilarasan, Qianghu Wang, E. P Sulman, R E. Davis, Suyun Huang, G. N Fuller, A.Rao, A. B Heimberger, Shulin Li*, G. Rao*.The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma. JNCI: Journal of the National Cancer Institute. 2019,111(3):292- 300.SCI
3. Hyangsoon Noh, Qingnan Zhao, Jun Yan, Ling-Yuan Kong, Konrad Gabrusiewicz, Sungguan Hong, Xueqing Xia, Amy B. Heimberger, Shulin Li*.Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells. Cancer Letters. 2018,433:176-185.SCI
4. Abhisek Mitra, Jun Yan, Xueqing Xia, Shouhao Zhou, Jian Chen, Lopa Mishra, Shulin Li*.IL6-Mediated Inflammatory Loop Reprograms Normal to Epithelial-Mesenchymal Transition(+) Metastatic Cancer Stem Cells in Preneoplastic Liver of Transforming Growth Factor Beta-Deficient beta 2-Spectrin(+/-) Mice. Hepatology. 2017,65(4):1222-1236.SCI
5. Hyangsoon Noh, Jun Yan, Sungguan Hong, Ling-Yuan Kong, Konrad Gabrusiewicz, Xueqing Xia, Amy B Heimberger, Shulin Li*.Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells. Oncotarget. 2016,7(44):72021-72032.
6. Jiemiao Hu#, Jun Yan#, Ganesh Rao#, Khatri Latha, Willem W Overwijk, Amy B Heimberge r, Shulin Li*.The Duality of Fgl2-Secreted Immune Checkpoint Regulator Versus Membrane- Associated Procoagulant: Therapeutic Potential and Implications. International Reviews of Immunology. 2016,35(4):325- 339.SCI
7. Jun Yan, Abhisek Mitra, Jiemiao Hu, Jeffery J Cutrera, Xueqing Xia, Thomas Doetschman, Mihai Gagea, Lopa Mishra, Shulin Li*.Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Journal of Hepatology. 2016,64(5):1128- 1136.SCI
8. Jun Yan, Ling-Yuan Kong, Jiemiao Hu, Konrad Gabrusiewic z, Denada Dibra, Xueqing Xia, Amy B Heimberger, Shulin Li*.FGL2 as a Multimodality Regulator of Tumor -Mediated Immune Suppression and Therapeutic Target in Gliomas. JNCI: Journal of the National Cancer Institute. 2015,107 (8):1-10.SCI
9. Fang Hua#, Ke Li#, Jiao-Jiao Yu#, Xiao-Xi Lv, Jun Yan, Xiao-Wei Zhang, Wei Sun, Heng Lin, Shuang Shang, Feng Wang, Bing Cui, Rong Mu, Bo Huang, Jian-Dong Jiang, Zhuo-Wei Hu*.TRB3 links insulin /IGF to tumour promotion by interacting with p62 and impeding autophagic/ proteasomal degradations. Nature Communications. 2015,6(1):1-16.SCI
10. Jun Yan, Song Li, Shulin Li*.The role of the liver in sepsis. International Reviews of Immunology. 2014,33(6):498-510.SCI
11. Abhisek Mitra, Arun Satelli, Jun Yan, Xia Xueqing, Mihai Gagea, Christopher A Hunter, Lopa Mishra, Shulin Li*.IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2Drae1 interaction between NKT and activated hepatic stellate cells in mice. Hepatology. 2014,60(6):2027-2039.SCI
12. Dan Du#, Jun Yan#, Jinhong Ren#, Haining Lv, Yong Li, Song Xu, Yadan Wang, Shuanggang Ma, Jing Qu, Weibin Tang, Zhuowei Hu*, Shishan Yu*.Synthesis, Biological Evaluation, and Molecular Modeling of Glycyrrhizin Derivatives as Potent High- Mobility Group Box -1 Inhibitors with Anti- Heart Failure Activity in Vivo. Journal of Medicinal Chemistry. 2013,56(1):97-108.SCI
13. Heng Lin, Jun Yan, Ziyan Wang, Fang Hua, Jiaojiao Yu, Wei Sun, Ke Li, Hong Liu, Hongzhen Yang, Qi Lv, Jianfei Xue, Zhuo- Wei Hu*.Loss of Immunity- Supported Senescence Enhances Susceptibility to Hepatocellular Carcinogenesis and Progression in Toll-Like Receptor 2-Deficient Murine Model. Hepatology. 2013,57(1):171-182.SCI
14. Ziyan Wang, Jun Yan, Heng Lin, Fang Hua, Xiaoxing Wang, Hanzhi Liu, Xiaoxi Lv, Jiaojiao Yu, Su Mi, Jiaping Wang, Zhuo- Wei Hu*.TLR4 activity protects against hepatocellular tumorigenesis and progression through regulating the expression of DNA repair protein ku70. Hepatology. 2013,57(5):1869-1881.SCI
15. Jun Yan#, Fang Hua#, Han -zhi Liu, Hongzheng Yang, Zhuo-wei Hu*.Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice. Acta Pharmacol Sinica. 2012,33(4):503-512.SCI
16. Jun Yan, Zi-Yan Wang, Hong-Zhen Yang, Han-Zhi Liu, Su Mi, Xiao-Xi Lv, Xiao-Ming Fu, Hui-Min Yan, Xiao-Wei Zhang, Qi-Min Zhan, Zhuo-Wei Hu*.Timing is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1- Mediated Activation of Autophagy. PLOS ONE. 2011,6(9):1-13.SCI
主编或副主编的著作/译著
重要奖项
1. TLRs介导的免疫-自噬调节纤维化和肿瘤发生发展的机制及药靶发现 中华医学科技奖 三等奖 201701
2. TLRs介导的免疫-自噬调节纤维化和肿瘤发生发展的机制及药靶发现 北京市科学技术奖 三等奖 201611