姓名：于顺 性别：男 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：帕金森病的发病机理、新的诊断标记物和防治对策 电子信箱：yushun103@hotmail.com


社会任职
1. 中国神经科学会会员，北京神经科学会会员，APSN会员，Neuroscience Letter, Movement Disorder审稿人
个人简历
1. 198408-198608:吉林省龙井市卫生职工中专 助教
2. 198907-198906:延边医学院 硕士
3. 198907-199010:延边医学院 生理学教研室助教
4. 199011-199309:延边医学院 生理学教研室讲师
5. 199310-199803:日本滋贺医科大学神经生物学研究中心 博士
6. 199804-200008:军事医学科学院基础医学研究所神经生物学研究室 博士后
7. 200204-200303:美国圣路易斯华盛顿大学神经病学研究室 访问
8. 200501-201005:首都医科大学低氧医学研究所 研究员、副所长
9. 201310-201405:首都医科大学脑重大疾病研究院帕金森病研究所 教授、副所长
重要学术论文
1. Li XR#, Yang W, Li X, Chen M, Liu C, Li J, Yu S*.lpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys. Neurosci Lett. 2020,716:134640.SCI
2. Li X#, Yang W, Li X, Li XR, Song Q, Sun L, Lin D, Chen ZG, Wang C*, Yu S*.Phosphorylated alpha-synuclein in red blood cells as a potential diagnostic biomarker for multiple system atrophy: A pilot study. Parkinson's Disease. 2020,2020:**.SCI
3. Li X#, Yang W#, Li X, Chen M, Liu C, Yu S*.Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys. Neurosci Lett. 2018,662:276-282.SCI
4. Li X#, Yang W#, Li X, Chen M, Liu C, Yu S* .Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys. Neurosci Lett. 2018,662:276-282.SCI
5. Yang W, Li X, Li X, Li X, Yu S*.Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains. Oncotarget. 2016,7 (7):7441-7454.SCI
6. Chen M, Yang W, Li X, Li X, Wang P, Yue F, Yang H, Chan P, Yu S*.Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains. Oncotarget. 2016,7 (8):8466-8480.SCI
7. Chen M, Wang T, Yue F, Li X, Wang P, Li Y, Chan P, Yu S*.Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral alpha-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys. Neuroscience. 2015,286:383-392.SCI
8. Chen Y, Yang W, Li X, Li X, Yang H, Xu Z, Yu S*.α-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca (2+) influx upon NMDA stimulation. Neuroscience. 2015,300:297-306.SCI
9. Liu G, Chen M, Mi N, Yang W, Li X, Wang P, Yin N, Li Y, Yue F, Chan P, Yu S*.Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in agingmonkey brains. Neurobiology of Aging. 2015,36 (9):2649-2659.SCI
10. Yu S, Chan P*.Role of alpha-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease. Essays Biochem. 2014,56(1）:125-135.SCI
11. Cheng F, Li X, Li Y, Wang C, Wang T, Liu G, Baskys A, Uéda K, Chan P, Yu S*.α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death.. J Neurochem. . 2011,119:815-825.SCI
12. 贾春松，李昕，李尧华，刘光伟，殷娟娟，吴燕川，于顺*.缺血/再灌注大鼠脑和血浆中alpha-突触核蛋白含量的变化. 首都医科大学学报. 2010,31（3）:368-372.核心期刊
13. Cheng F, Vivacqua G, Yu S*.The role of alpha-synuclein in neurotransmission and synaptic plasticity. J Chem Neuroanat.. 2010,42:242-248.SCI
14. 李昕，程芙蓉，李尧华，王玉兰，张燕莉，于顺*.alpha-突触核蛋白对N-甲基-D-天门冬氨酸所致细胞毒性作用的影响. 首都医科大学学报. 2010,31(6):726-731.核心期刊
15. 程芙蓉，李昕，殷娟娟，李尧华，王玉兰，张燕莉，于顺*.alpha-突触核蛋白促进多巴胺能神经细胞表面NMDA受体的内在化. 首都医科大学学报. 2010,31(6):737-741.核心期刊
16. 程芙蓉，李昕，殷娟娟，李尧华，王玉兰，于顺*.过氧化氢和帕金森病患者血清促进alpha-突触核蛋白向线粒体与细胞核转运. 首都医科大学学报. 2010,31(6):732-736.核心期刊
17. 殷娟娟，Giorgio Vivaqua,李昕，刘光伟，李尧华，于顺*.α-突触核蛋白在大鼠脊髓的表达. 首都医科大学学报. 2009,30（5）:584-589.核心期刊
18. 李雁，殷娟娟，李昕，吴燕川，刘光伟，李尧华，于顺*.帕金森病患者血清对α-突出核蛋白寡聚体形成的促进作用. 首都医科大学学报. 2009,30（5）:590-592.核心期刊
19. 刘光伟，王鹏，李尧华，李昕，何欣，于顺*.alpha-突触核蛋白促进大鼠原代培养神经元突起生长. 首都医科大学学报. 2009,30（5）:607-610.核心期刊
20. 2.Vivaqua G, Yin JJ, Casini A, Li X, Li YH, Este LD, Chan P, Yu S*.Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies. Neuroscience. 2009,158(4):1478-1487.SCI
21. 谢胜男，李昕，李尧华，刘耀波，于顺*.急性重复低氧对小鼠脑组织血氧饱和度、线粒体功能以及ATP水平的影响. 中国病理生理杂志. 2008,24(4):755-758.核心期刊
22. 刘光伟，殷娟娟，李昕，谢胜男，李尧华，于顺*.alpha-突触核蛋白对线粒体复合体I活性的调控作用. 基础医学与临床. 2008,28(9):925-929.核心期刊
23. Yu S, Zhao T, Guo M, Fang HX, Ma JX, Ding AS, Wang FZ, Chan P, Fan M.Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes.. Brain Research. 2008,1211C:22-29.SCI
24. 3.Zhang L, Zhang CY, Cai Q, Chan P, Uéda K, Yu S*,Yang H*.Semi-quantitive analysis of a-synuclein in subcellular compartments of rat brain neurons: an immunoelectron microscopic study using ultra-small golds as probes. Brain Research. 2008,1244:40-52.SCI
25. Yu S, Li X, Liu GW, Han JY, Zhang CY, Li YH, Xu SL, Liu C, Gao YP, Yang H, Ueda K, Chan P*.Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience. 2007,145:539-555.SCI
26. 殷娟娟，韩俊燕，李昕，李尧华，刘耀波，于顺*.α-突触核蛋白的促细胞增殖作用依赖于其NAC区和C-端的氨基酸序列. 首都医科大学学报. 2007,28(3):345-349.核心期刊
27. Yu S*, Ueda K, Chan P.alpha-Synuclein and dopamine metabolism. Molecular Neurobiology. 2005,31(1-3):243-254.SCI
28. Lu GW*, Yu S, Li RH, Cui XY, Gao CY.Hypoxic preconditioning: A novel intrinsic cytoprotective strategy. Molecular Neurobiology. 2005,31(1-3):255-271.SCI
29. Ichinose T, Yu S (共同第一作者), Wang XQ, Yu SP*.Ca2+-independent but voltage/activity-dependent regulation of NMDA receptor-mediated outward K+ current. Journal of Physiology (London). 2003,551 (2):403-417.SCI
30. Yu S, Fan M*, Zhao T, Ding AS, Wang FZ.CoCl(2)-induced enhancement of glucose transport activity in mediating hypoxic tolerance in cultured hippocampal neurons. Acta Physiologia Sinica. 2002,54（6):508-512.无
31. Yu S, Zhao T, Fan M*, Tooyama I, Kimura H, Renda TG..Production of monoclonal antibody to [D-Ala2] deltorphin I and its immunocytochemical . Peptides. 2000,21:1657-1662.SCI
主编或副主编的著作/译著
重要奖项
1. 帕金森病的发病机制、预警和干预研究 北京市科学技术奖 1 201512
2. 低氧预适应的基础研究和应用前景 中华医学科技奖 3 201112