姓名：蔡彦宁 性别：男 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：生物节律与神经系统疾病相关性及其机制研究 电子信箱：yanningcai@hotmail.com


社会任职
1. 中国神经科学学会会员
2. Regular member of Asian and Pacific Society for neuroscience
3. Tissue & cell 审稿人
4. Transfusion medicine 审稿人
5. Neurological research 审稿人
6. 中国药理学会会员
7. Italian Ministry for Education University and Research (MIUR) 评审人
8. Chronobiology international 审稿人
9. 中国睡眠研究会生物节律专业委员会常委
10. 中华医学会老年医学分会老年基础医学学组委员
11. 中国人类遗传资源管理专家组成员
12. 中国医药生物技术协会生物诊断技术分会生物诊断新技术与新材料专业学组委员
13. 北京神经内科学会基础与转化医学分会委员
14. 中国研究型医院学会临床数据与样本资源库专业委员会委员
个人简历
1. 199109-199506:南开大学 本科
2. 199509-200006:中科院上海生化所 硕博联读
3. 200007-200111:德国汉堡马普细胞和结构生物学研究所 博士后
4. 200112-200510:首都医科大学宣武医院 助理研究员
5. 200510-201110:首都医科大学宣武医院 副研究员
6. 201110-:首都医科大学宣武医院 研究员
7. 201604-:首都医科大学宣武医院 教授
重要学术论文
1. Wang X, Sun Y, Li T, Cai Y, Han Y#. .Amyloid-β as a Blood Biomarker for Alzheimer's Disease: A Review of Recent Literature. . J Alzheimers Dis.. 2020,73(3):819-832.SCI
2. Gao H, Liu M, Zhao Z, Yang C, Zhu L, Cai Y*, Yang Y*, Hu Z*..Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease by the Plasma and Serum Amyloid-beta 42 Assay through Highly Sensitive Peptoid Nanosheet Sensor.. ACS Appl Mater Interfaces.. 2020,12(8):9693-9700.SCI
3. Mao W#, Zhao C#, Ding H, Liang K, Xue J, Chan P, Cai Y*..Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients. . Neuroscience letters. 2018,668:115-119.SCI
4. Wen M, Jiang X, She H, Han C, Pei Z, Cai Y*, Zhang T*.The Per2 polymorphism rs** is associated with the risk of stroke in a Chinese population.. Biological Rhythm Research. 2015,46（4）:545-551.SCI
5. Gao J, Yang C, Ding H, Zhang Y, Xue J, Cai Y*.2,2,2-Trichloroethanol lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells. Biochem Biophys Res Commun. 2015,462:239-244.SCI
6. Gu Z,Wang B, Zhang YB, Ding H, Zhang Y, Yu J, Gu M, Piu C, Cai Y* .Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese. Sci. Rep. 2015,5:15891.SCI
7. Song Y, Ding H, Yang J, Lin Q, Xue J, Zhang Y, Chan P, Cai Y*..Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients. Neuroscience letters. 2014,569:85-88.SCI
8. Wang C, Cai Y, Gu Z, Ma J, Zheng Z, Tang BS, Xu Y, Zhou Y, Feng T, Wang T, Chen SD, Chan P*; Chinese Parkinson Study Group.Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals.. Neurobiol Aging. 2014,35(3):725.e1-e6.SCI
9. Zhang L, Lin QL, Lu L, Yang CC, Li YL, Sun FL, Wang DH, Cai YN*, Li L*..Tissue-specific modification of clock methylation in aging mice. Eur Rev Med Pharmacol Sci. 2013,17(14):1874-1880.SCI
10. Zhang L, Ding H, Wang D, Zhang Y, Baskys A, Chan P, Zhong Y, Cai Y*. .Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson’s disease in Han Chinese population. . Plos one. 2013,8 :e70935.SCI
11. 林庆玲,蔡彦宁*,袁艳鹏,左晓虹.小鼠外周组织时钟基因启动子区甲基化分析. 基础医学与临床. 2012,32(10）:1118-1125.核心期刊
12. Lin Q, Ding H, Yuan Y, Cai Y*. Promoter methylation in eight clock genes examined with methylation-specific polymerase chain reaction. Biological Rhythm Research. 2012,43（4）:341-350.SCI
13. Zhang L, Lin Q, Ding H, Wang D, Cai Y*.Promoter methylation of seven clock genes in total leukocytes from different-aged healthy subjects. Biological Rhythm Research. 2012,43（6）:631-637.SCI
14. Mazzoccoli G*, Francavilla M, Giuliani F, Aucella F, Vinciguerra M, Pazienza V, Piepoli A, Benegiamo G, Liu S, Cai Y.Clock gene expression in mouse kidney and testis: analysis of periodical and dynamical patterns.. J Biol Regul Homeost Agents. 2012,26（2）:303-311.SCI
15. Mazzoccoli G*, Cai Y, Liu S, Francavilla M, Giuliani F, Piepoli A, Pazienza V, Vinciguerra M, Yamamoto T, Takumi T.REV-ERBalpha and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge. J Biol Regul Homeost Agents. 2012,26（2）:265-276.SCI
16. Wang C, Cai Y, Zheng Z, Tang BS, Xu Y, Wang T, Ma J, Chen SD, Langston JW, Tanner CM, Chan P*，the Chinese Parkinson Study Group (CPSG).The Chinese Parkinson Study Group (CPSG).Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants. Parkinsonism Relat Disord. 2012,18:958-963.SCI
17. Yanning Cai, Hui Ding, Zhuqin Gu, Jinghong Ma, Piu Chan*..Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson’s disease in a Chinese population.. Neuroscience letters. 2011,498 (2):124-126.SCI
18. 林庆玲，蔡彦宁*，袁艳鹏，左晓虹，陈彪.帕金森病患者外周血白细胞中时钟基因Bmal1和Bmal2的表达. 中华行为医学与脑科学. 2011,20（7):586-588.核心期刊
19. 林庆玲, 蔡彦宁*, 丁晖, 顾朱勤, 马敬红, 陈彪..中国人群pitx3基因多态性与晚发散发性帕金森病的相关研究.. 首都医科大学学报. 2011,32(6):764-766.核心期刊
20. Mazzoccoli G*, Sothern RB, Greco A, Pazienza V, Vinciguerra M, Liu S, Cai Y. .Time-Related Dynamics of Variation in Core Clock Gene Expression Levels in Tissues Relevant to the Immune System.. International Journal of Immunopathology and Pharmacology.. 2011,24(4):869-879.SCI
21. Yanning Cai, Hui Ding, Zhuqin Gu, Andrius Baskys, Jinghong Ma, Piu Chan*..PITX3 polymorphism is not associated with Parkinson’s disease in a Chinese population.. Neuroscience letters. 2011,505(3):260-262.SCI
22. 袁艳鹏，关云谦，林庆玲，薛金花，蔡彦宁*.反转录巢式多重聚合酶链式反应体系检测单细胞中时钟基因表达. 首都医科大学学报. 2011,32(3):365-370.核心期刊
23. 左晓虹, 刘姝, 林庆玲, 李宁, 陈彪, 蔡彦宁*.启动子区E-box以及周围CpG岛的甲基化与基因节律性表达的关系.. 首都医科大学学报. 2011,32(6):781-786..核心期刊
24. 林庆玲,蔡彦宁*,丁晖,顾朱勤,马敬红,陈彪..帕金森病患者时钟基因启动子区甲基化分析.. 首都医科大学学报. 2011,32(6):767-770.核心期刊
25. Hui Ding, Shu Liu, Yanpeng Yuan, Qingling Lin, Piu Chan, Yanning Cai*.Decreased expression of Bmal2 in patients with Parkinson’s disease. . Neuroscience letters. 2011,499 (3):186-188.SCI
26. Yanning Cai, Yanpeng Yuan, Qingling Lin, Piu Chan*. .Allele-specific-extension allows for base-pair neutral homozygotes to be discriminated by highresolution melting of small amplicons.. Analytical Biochemistry.. 2010,406(1):29-33..SCI
27. Yanning Cai, Shu Liu, Robert Sothern, Shengli Xu, Piu Chan*..Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease.. European Journal of Neurology. 2010,17:550–554..SCI
28. 畅怡, 聂秀红*, 蔡彦宁, 曹若瑾, 冯明..脓毒血症对大鼠膈肌Glut-1和Glut-4 mRNA表达的影响.. 首都医科大学学报. 2010,31（5）:544-547..核心期刊
29. 袁艳鹏,林庆玲,左晓虹*,蔡彦宁..基于等位基因特异性引物延伸的高分辨率熔解曲线基因分型方法的建立.. 首都医科大学学报.. 2010,31(6):742-747..核心期刊
30. 袁艳鹏,柴玉鑫,蔡彦宁*..昼夜节律紊乱与心脑血管疾病.. 国际心血管病杂志.. 2010,37(5):292-294..核心期刊
31. 左晓虹, 蔡彦宁*, 李宁, 张燕莉, 陈彪..视交叉上核脑片诱导NIH/3T3成纤维细胞中分子时钟的节律性表达.. 中华行为医学与脑科学杂志.. 2010,19 (1):15-17..核心期刊
32. Yanning Cai, Hui Ding, Ning Li, Yuxin Chai, Yanli Zhang, Piu Chan*..Oscillation development for neurotransmitter-related genes in the mouse striatum.. Neuroreport.. 2010,21(2) :79-83..SCI
33. 畅怡,聂秀红*,曹若瑾,蔡彦宁, 冯明..增龄对大鼠膈肌Glut-1和Glut-4 mRNA表达的影响.. 中国比较医学杂志.. 2010,20(8):15-17..核心期刊
34. 刘姝，蔡彦宁*，陈彪..C57 BL/6J小鼠肝脏中mPer1基因CpG岛甲基化分析.. 中国现代医学杂志.. 2009,19(12):1813-1816.核心期刊
35. 左晓虹，蔡彦宁*，李宁，于顺，张燕莉，陈彪..视交叉上核脑片与NIH/3T3成纤维细胞共培养模型的建立.. 首都医科大学学报.. 2009,30(5):601-606.核心期刊
36. 丁晖，蔡彦宁*，王玲玲，柴玉鑫，张燕莉，陈彪..小鼠纹状体中神经递质相关基因表达的节律性波动.. 首都医科大学学报.. 2009,30(5) :580-583.核心期刊
37. 施晓耕,蔡彦宁, 陈彪,林健雯,黄如训*..人工寒潮对RHR外周血白细胞基因表达谱的影响.. 四川医学.. 2009,30(8:1175-1177.核心期刊
38. Yanning Cai, Shu Liu, Ninig Li, Shengli Xu, Yanli Zhang, Piu Chan*.Postnatal ontogenesis of molecular clock in mouse striatum.. Brain Research. 2009,1264:33-38.SCI
39. 左晓虹，蔡彦宁*，于顺，刘姝，陈彪.MPTP对C57BL/6J小鼠脑时钟基因mPer1 mRNA表达的影响. 首都医科大学学报. 2009,30（1）:76-79.核心期刊
40. 左晓虹,蔡彦宁*,李宁,刘姝,张燕莉,陈彪..小鼠纹状体时钟基因表达的生后发育.. 中华行为医学与脑科学杂志.. 2009,18(5):385-387.核心期刊
41. 李宁，刘姝，蔡彦宁*，陈彪..C57小鼠胸腺和睾丸中mPer1基因启动子区CpGs甲基化分析.. 首都师范大学学报（自然科学版).. 2009,30(3):33-37.核心期刊
42. Yanning Cai, Shu Liu S, Robert Sothern, Ning Li, Yunqian Guan, Piu Chan*..Epigenetic analysis of mPer1 promoter in peripheral tissues.. Biological Rhythm Research.. 2009,40(6) :445-453..SCI
43. Ning Li, Yanning Cai*, Xiaohong Zuo, Shengli Xu, Yanli Zhang, Piu Chan, Yu Alex Zhang.Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts.. Biochemical and Biophysical Research Communications. 2008,377(4):1179-84.SCI
44. Haifeng Wei,Yanning Cai,Jin Chu,Chunyang Li,Lin Li*.Temporal Gene expression profile in hippocampus of mouse treated with D-galactose. Cellular and Molecular Neurobiology. 2008,28(5):781-794.SCI
45. 蔡彦宁,温玫,刘姝,陈彪*.MPTP作用下小鼠黑质和纹状体中不同时期基因表达变化. 首都医科大学学报. 2007,28（5）:592-595.核心期刊
46. 刘姝, 蔡彦宁*, 谢淑, 关云谦, 陈彪.C57小鼠周围组织时钟基因表达特点的研究. 基础医学与临床. 2007,27（12）:1305-1308.核心期刊
47. Shu Liu, Yanning Cai*, Robert B. Sothern, Yunqian Guan, and Piu Chan.Chronobiological Analysis of Circadian Patterns in Transcription of Seven Key Clock Genes in Six Peripheral Tissues in Mice. Chronobiology international. 2007,24（5）:793-820.SCI
48. 丁晖， 蔡彦宁， 温玫，陈彪*.基因芯片检测灵芝提取物对白细胞中免疫相关基因表达的影响. 中国组织工程和临床康复. 2007,11(33):6954-6956.核心期刊
49. 谢淑，蔡彦宁，关云谦，武文琪，徐艳玲，张愚，陈彪*.时钟基因在胚胎干细胞分化为神经元过程中的表达特征. 中华医学杂志. 2007,87(45) :3203-3207.核心期刊
50. 蔡彦宁，左晓虹，刘姝，谢淑，温玫，陈彪*.Per1和Per2基因实时荧光定量聚合酶链反应检测方法的建立. 中国医学科学院学报. 2006,28(6):780.核心期刊
51. 关云谦，蔡彦宁*，谢淑，朱宛宛，徐艳玲，张愚，陈彪.利用巢式聚合酶链反应检测单个胚胎小体细胞中时钟基因的表达. 基础医学与临床. 2006,26(12):1313-1318.核心期刊
52. 蔡彦宁，左晓虹，刘姝，谢淑，温玫，陈彪*.利用荧光定量聚合酶链反应检测小鼠纹状体中Per1基因的表达规律. 首都医科大学学报. 2006,27(1):63-65.核心期刊
53. 温玫,蔡彦宁,田娜,刘桓,陈彪*.成纤维细胞生长因子受体3基因荧光定量聚合酶链反应检测方法的建立. 中华检验医学杂志. 2005,28(5):499-500.核心期刊
54. 刘姝,蔡彦宁,冯秀丽,温玫,左晓虹,陈彪*.改进竞争性RT-PCR法在定量PER1基因表达中的应用. 基础医学与临床. 2005,25(5):409-413.核心期刊
55. 蔡彦宁,温玫,张愚,陈彪*.帕金森病患者尾状核中基因表达谱的研究. 中华医学杂志. 2004,84(14):1191-1193.核心期刊
56. 蔡彦宁，温玫，左晓虹，田娜，陈彪*.帕金森病患者尾状核中基因表达谱的研究. 中国临床康复. 2004,8(28):6068-6070.核心期刊
57. Yanning Cai, Qing Zhou, Yuying Kong, Mei Li, Benoit Viollet, Youhua Xie, Yuan Wang*.LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication. Cell Research. 2003,13(6):451-458.SCI
58. Yanning Cai,Mei Li,Qing Zhou,Yuying Kong, Yuan Wang*.hB1F and HNF1 work synergistically in the regulation of the function of HBV EN II. Chinese Science Bulletin. 2001,46(2):133-135.SCI
主编或副主编的著作/译著
重要奖项
1. 帕金森病及运动障碍疾病的分子诊断与功能影像研究 中华医学科技奖 二等奖 201701
2. 帕金森病的发病机制、预警和干预研究 北京市科学技术奖 一等奖 201512