姓名：刘光慧 性别：男 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：老年医学(博) 老年医学(硕) 研究方向名称：基于多能干细胞的疾病研究和精准治疗 电子信箱：lujing_0203@aliyun.com


社会任职
1. 中国细胞生物学会衰老细胞生物学分会会长
2. 中国老年学和老年医学学会抗衰老分会主任委员
3. 中国生物物理学会衰老生物学分会副理事长兼秘书长
4. 中国老年医学学会基础与转化医学分会副会长
5. Protein-Cell杂志副主编
6. stem cell research & therapy杂志副主编
7. Aging Cell杂志编委任职
8. Cell reports杂志编委任职
个人简历
1. 199709-200206:北京大学医学部 学习
2. 200209-200706:中国科学院生物物理研究所 学习
3. 200707-200909:美国斯克利普斯（Scripps）研究所 任职
4. 200909-201209:美国索尔克（Salk）生物学研究所 任职
5. 201210-201905:中国科学院生物物理研究所 任职
6. 201905-:中国科学院动物研究所 任职
重要学术论文
1. Zhang W, Qu J, Liu GH*, Belmonte JC*. The Aging Epigenome and its Rejuvenation.. Nat Rev Mol Cell Biol. . 2020,21(3):137-150.SCI
2. Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y，Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*.Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-mediated Gene Correction.. Protein Cell. 2020,11(1):1-22.SCI
3. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*.Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. . Cell. 2020,180(5):984-1001.SCI
4. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Jing Qu*, Tang F*, Liu GH*.Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. . Cell. 2020,180(3):585-600.SCI
5. Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*.Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging.. Protein Cell. 2019,10(6):417-435.SCI
6. Song M, Belmonte JCI*, Liu GH*..Age-related cardiopathies gene editing. . Aging (Albany NY). 2019,11(5):1327-1328.SCI
7. He X, Song M, Qu J, Guo Y, Cao H, Sun R*, Liu GH*, Shen Y*, Major Program Expert Group..Basic and Translational Aging Research in China: Present and Future.. Protein Cell. 2019,10(7):476-484.SCI
8. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Liu GH*, Qu J*.Telomere-Dependent and Telomere-Independent Roles of RAP1 in Regulating Human Stem Cell Homeostasis. . Protein Cell. 2019,10(9):649-667.SCI
9. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw R, Esteban CR, Benner C, Nakagawa H, Garcia PG, Delicado EN, Castells A, Campistol JM, Liu GH*, Belmonte JC*.Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway.. Protein Cell. 2019,10(7):485-495.SCI
10. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J*.Low-dose quercetin positively regulates mouse healthspan. . Protein Cell. 2019,10(10):770-775.SCI
11. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*.Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells.. Protein Cell. 2019,10(4):249-271.SCI
12. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*.Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis.. Cell Reports. 2019,26(13):3643-3656.SCI
13. Cheng F, Wang S, Song M, Liu Z, Liu P, Chan P, Wang Y, Wang L, Zhang W*, Qu J*, Liu GH*.DJ-1 is dispensable for human stem cell homeostasis. . Protein Cell. 2019,10(11):846-853.SCI
14. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*.Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis.. PLoS Biology. 2019,17(4):e**.SCI
15. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*.FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. . Cell Stem Cell. 2019, 24(3):447-461.SCI
16. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J*, Liu GH*.Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. . Nat Commun.. 2019,10(1):3329.SCI
17. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*.Metformin alleviates human cellular aging by upregulating the ER peroxidase GPx7. . Aging Cell. 2018,17(4):e12765.SCI
18. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*.ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. . Cell Discovery. 2018,4:2.SCI
19. Wang ZH, Li HY, Qu J*, Zhang W*, Liu GH*.Premature Aging Disorders: Mechanisms and Potential Therapeutic Interventions. . Prog. Biochem. Biophys.. 2018,45(9):926-934.核心期刊
20. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Belmonte JC*, Liu GH*.Differential stem cell aging kinetics in Hutchinson–Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018,9(4):333–350.SCI
21. Wang S, Wu J*, Liu GH*. First stem cell transplantation to regenerate human lung. Protein Cell. 2018,9（3）:244–245.SCI
22. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*.SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.. Nature. 2018,560(7720):661-665.SCI
23. Ren R, Belmonte JC*, Liu GH* .Adenine base editing to mimic or correct disease mutations in rodents. . Protein Cell. 2018,9(9):752-753.SCI
24. Zhang W, Song M, Qu J*, Liu GH*.Epigenetic Modifications in Cardiovascular Aging and Diseases. . Circ Res.. 2018,123(7):773-786.SCI
25. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.. Protein Cell. 2017,8(5):365-378.SCI
26. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J*, Tang F*, Liu GH*.Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding.. Cell Res.. 2017,27(9):1178-1181.SCI
27. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*.Visualization of aging-associated chromatin alterations with an engineered TALE system.. Cell Res.. 2017,27(4):483-504.SCI
28. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J*, Zhang W*, Liu GH*.Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.. Protein Cell. 2016,7(7):478-488.SCI
29. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC*, Qu J*, Liu GH*.Modeling Xeroderma Pigmentosum associated neurological pathologies with patients-derived iPSCs.. Protein Cell. 2016,7(3):210-221.SCI
30. Guo J, Fang W, Sun L, Lu Y, Dou L, Huang X, Sun M, Qu J*, Liu GH*, Li J*.Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1.. Oncotarget. 2016,14;7(24):36207-36219.SCI
31. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.. Cell Res.. 2016,26(2):190-205.SCI
32. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*.Repression of the antioxidant NRF2 pathway in premature aging.. Cell. 2016,165(6):1361-1374.SCI
33. Deng L, Ren R, Wu J, Suzuki K, Belmonte JC*, Liu GH*. .CRISPR/Cas9 and TALE: Beyond cut and paste.. Protein Cell. 2015,6(3):157-159.SCI
34. Wang L, Wu J, Fang W, Liu GH*, Belmonte JC*.Regenerative medicine: Targeted genome editing in vivo.. Cell Res.. 2015,25:271-272.SCI
35. Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban C,Yu X, Yang Z, Li J, Wang X, Belmonte JC, Liu GH*, Yi F*, Qu J*..A widely adaptable approachto generate integration-free iPSCs from non-invasively acquired human somatic cells.. Protein Cell. 2015,6(5):386-389.SCI
36. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J*, Tang F*, Liu GH*.PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype.. Nat Commun.. 2015,6:10068.SCI
37. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JC*.A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.. Science. 2015,348(6239):1160-1163.SCI
主编或副主编的著作/译著
重要奖项
1. 国家“-科技创新领军人才” 国家“-科技创新领军人才” 国家级 2019
2. 普洛麦格创新奖 普洛麦格创新奖 国家级-学会 2019
3. 顾孝诚讲座奖 顾孝诚讲座奖 国家级 2019
4. 药明康德生命化学研究奖 药明康德生命化学研究奖 国家级 2019
5. 干细胞研究创新奖 干细胞研究创新奖 国家级 2019
6. 中源协和生命医学创新突破奖 中源协和生命医学创新突破奖 国家级 2019
7. 中国生命科学十大进展 中国生命科学十大进展 国家级 2018
8. 谈家桢生命科学创新奖 谈家桢生命科学创新奖 国家级 2018
9. 中国青年科技奖（特别奖） 中国青年科技奖（特别奖） 国家级 2018
10. 中青年科技创新领军人才 中青年科技创新领军人才 国家级 2018
11. 首届老年医学杰出贡献奖 首届老年医学杰出贡献奖 国家级-学会 2017
12. 中国细胞生物学会青年研究员奖 中国细胞生物学会青年研究员奖 国家级-学会 2017
13. 树兰医学青年奖 树兰医学青年奖 国家级 2017
14. 人类干细胞衰老的分子基础研究 北京市科学技术二等奖 省市级 2017
15. 中国科学院青年科学家奖 中国科学院青年科学家奖 国家级 2017
16. 首都十大疾病科技攻关创新型科技进展奖 首都十大疾病科技攻关创新型科技进展奖 省市级 2016
17. 国家基金 国家基金 国家级 2016
18. 干细胞青年研究员奖 干细胞青年研究员奖 国家级-学会 2015
19. 大挑战2015青年科学家奖 大挑战2015青年科学家奖 国家级 2015
20. 贝时璋青年生物物理学家奖 贝时璋青年生物物理学家奖 国家级-学会 2013
21. 中组部青年 中组部青年 国家级 2012
22. 国家优秀青年基金 国家优秀青年基金 国家级 2012