姓名：王朝东 性别：男 职称：主任医师、教授 招生院所：附属宣武医院 招生类型：科学与专业学位(博) 科学与专业学位(硕) 招生专业：神经病学(博) 神经病学(硕) 研究方向名称：神经遗传性疾病、帕金森病的分子遗传学基础和发病机制 电子信箱：cdongwang01@126.com


社会任职
1. 北京市医学会遗传学分会委员
2. 北京市医学会帕金森病和运动障碍分会委员
3. 中国医师协会老年医学分会 委员
4. 中国优生科学协会 理事
5. 中国老年保健协会脑保健专业委员会 副主任委员
个人简历
1. 199109-199607:赣南医学院 本科学习
2. 199608-199908:福建省三明市第二医院 住院医师
3. 199909-200207:福建医科大学 硕士研究生
4. 200208-200211:福建省三明市第二医院 住院医师
5. 200212-200303:美国哈佛大学医学院 访问
6. 200304-200512:美国哥伦比亚大学医学院 访问
7. 200604-200807:江西省人民医院 主治医师
8. 200808-201207:福建省三明市第一医院 副主任医师、科副主任
9. 200809-201107:首都医科大学 博士研究生
10. 201208-201312:福建省三明市第一医院 副主任医师、副院长
11. 201401-201603:福建省三明市第一医院 主任医师、副院长
12. 201603-:首都医科大学宣武医院 主任医师
13. 201702-:首都医科大学宣武医院 国家老年疾病临床医学研究中心办公室主任（兼）
重要学术论文
1. Ji S, Wang C, Qiao H, Gu Z, Gan-Or Z, Fon EA, Chan P..Decreased Penetrance of Parkinson's Disease in Elderly Carriers of Glucocerebrosidase Gene L444P/R Mutations: A Community-Based 10-Year Longitudinal Study.. Movement Disorders. 2020,【未填写卷（期）】:【未填写起止页码】.SCI
2. Li XY, Yang W, Li X, Li XR, Li W, Song Q, Sun L, Lin F, Chen Z, Wang C*, Yu S*..Phosphorylated Alpha-Synuclein in Red Blood Cells as a Potential Diagnostic Biomarker for Multiple System Atrophy: A Pilot Study. Parkinson's Disease. 2020,【未填写卷（期）】:【未填写起止页码】.SCI
3. Xianling Wang, Yanhui Yang, Xuying Li, Cunjiang Li* ，Chaodong Wang*.Distinct clinical, neuroimaging and genetic profiles of late-onset cobalamin C defects(cb1C): a report of 16 Chinese cases . Orphanet Journal of Rare Diseases. 2019,14（1）:109（1-9）.SCI
4. Yang Song, Feng Lin, Cheng-hui Ye, Huaping Huang, Xuying Li Xiaoli Yao, Yanming Xu, Chaodong Wang .Rare,low frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 2019,87:138.e1-138.e6.SCI
5. Ren ZL, Wang CD, Wang T, et al..Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.. Acta Pharmacol Sin.. 2018,40(4:441-450.SCI
6. Liu SY,Zheng Z, Gu Z, WangCD et al..Prevalence of pre-diagnostic symptoms did not differ between LRRK2-related , GBA-related and idiopathic patients with Parkinson's disease.. Parkinsonism and Related Disorders. 2018,57:72-76.SCI
7. Mi TM, Mao W, Cai YN, Yang CX, Wang CD, Xu EH, Zhang H, Chan P*.Primary familial brain calcifications linked with a novel SLC20A2 gene mutation in a Chinese family.. J Neurogenet.. 2017,13:1-4.SCI
8. Dan XJ, Wang CD, ZhangJ, Gu Z, Zhou Y, Ma J, Chan P*..Association between common genetic risk variants and depression inParkinson's disease: A dPD study in Chinese.. Parkinsonism and Related Disorders. 2016,33:122-126.SCI
9. H Dong, L Tian, R Li, C Pei, Y Fu, X Dong, F Xia, C Wang, W Li, X Guo, C Gu, B Li, A Liu, H Ren, C Wang* and H Xu*.IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy . Oncogene. 2015,34(42):5363-71.SCI
10. Wang S, WAng B, Pan N, Fu L, Wang C, Song G, An J, Liu Z, Zhu W, Guan Y, Xu ZQ, CHan P, Chen Z, ZHang YA. .Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons,. Sci Rep. 2015,5:9232.SCI
11. Wang C, Xu Y, Feng X, Ma J, Xie S, Zhang Y, Tang BS, Chan P.Linkage analysis and whole-exome sequencing exclude extra mutations responsible for the parkinsonian phenotype of spinocerebellar ataxia-2 . Neurobiology of Aging. 2015,36(1):545.e1-7.SCI
12. Wang C, Chan P*..Clinicogenetics pf Parkinson's disease: a drawing but not completed picture.. Neuroimmunology and Neuroinflammation. 2014,1(3):115-126.SCI
13. Dan X, Wang C, Ma J, Feng X, Wang T, Zheng Z, Chan P..MAPT IVS1+124 C>G modifies risk of LRRK2 G2385 R for Parkinson's disease in Chinese.. Neurobiology of aging. 2014,35(7):1780.e7-1780.e10.SCI
14. Wang C#, Wang C#, Dong H#, Wu XM, Wang C, Xia F, Li G, Jia X, He S, Jiang X, Li H, Xu H..Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier. Molecular Immunology. 2013,53(1-2）:43-51.SCI
15. Wang C, Feng X, Xie S, Gu Z, Chan P.Exonic sequencing revealed no causative mutation in the BST1 gene in patients with Parkinson's disease. Neurobiology of Aging. 2013,34(11):2695.e9-2695.e10.SCI
16. Wang C, Xu Y, Feng X, Ma J, Xie S, Zhang Y, Tang BS, Chan P.Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals . Neurobiology of Aging. 2013,35(3):725.e1-6.SCI
17. Wu T, Wang C, Wang J, Hallett M, Zang Y, Chan P..Preclinical and clinical neural network changes in SCA2 parkinsonism. Parkinsonism & Related Disorders. 2012,【未填写卷（期）】:【未填写起止页码】.SCI
18. Wang C, Cai Y, Zheng Z, Tang B-S, Xu Y, Wang T, Ma J, Chen SD,Langston JW, Tanner CM, Chan P, the Chinese Parkinson Study Group (CPSG).Penetrance of LRRK2 G2385R and RMB 628PDF in modified by common PD-associated genetic variants. Parkinsonism & Related Disorders. 2012,8:958-963.SCI
19. He S#, Wang C#,Dong H, Xia F, Zhou H, Jiang X, Pei C, Ren H, Li H, Li R, Xu H..Immune-related GTPase1 (IRGM1) regulates neuronal autophagy in a mouse model of stroke. Autophagy. 2012,8(11):1621-7.SCI
20. Liu J, Zhou Y, Wang C, et al.Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2(LRRK2) for Parkinson's disease. Parkinsonism & Related Disorders. 2012,18(2):140-3.SCI
21. Yao J, Du H, Yan S, Fang H, Wang C, Lue L-F, Guo L, et al.Inhibition of Amyloid-β(Aβ) peptide-binding alcohol dehydrogenase-Aβ interaction reduces Aβ accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Neuroscience. 2011,31(6):2313-20.SCI
22. Li N, Zhu F, Gao F, Wang Q, Wang X, Li H, Ma C, Sun W, Xu W, Wang C#, Zhang L#..Blockade of CD28 by a synthetical peptoid inhibits T-cell proliferation and attenuates graft-versus-host disease. Cellular & Molecular Immunology. 2010,7(2):133-42.SCI
23. Wang C, Ma H, Feng X, Xie S, Chan P..Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson's disease in Chinese: an independent pathogenic role. Brain Research. 2010,1358:30-8.SCI
24. Wu XM#, Wang#, Zhang KN, Lin AY et al.Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations. Multiple Sclerosis Journal. 2009,15(12):1422-30.SCI
25. Wang C, Zhang KN, Wu XM, et al.Balo's disease showing benign clinical course and co-existence with multiple sclerosis-like lesions in Chinese. Multiple Sclerosis Journal. 2008,14(3):418-24.SCI
26. Rastogi D, Wang C, Mal X, et al.Antigen-Specific immune response to influence vaccine in Utero. The Journal of clinical investigation. 2007,117(6):1637-46.SCI
主编或副主编的著作/译著
1.
重要奖项
1. 多发性硬化的临床和遗传学研究与应用 2011年度江西省科技进步 三等奖 2011
2. 2011年度福建医科大学优秀教师奖 2011
3. 2011年度福建省医德标兵 2011
4. 帕金森及运动障碍性疾病的分子诊断和功能影像研究 2016年度中华医学科技奖二等奖 二等奖
5. 帕金森的发病机制,预警和干预研究 2015年度北京市科学技术奖一等奖 一等奖