姓名：张愚 性别：男 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：干细胞生物学特性及临床应用 电子信箱：yaz@bjsap.org


社会任职
1. Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) Council Member
2. 中国神经科学学会 理事
3. 中国干细胞产学研盟会 理事
4. 中国细胞生物学会干细胞分会 理事
个人简历
1. 2001-2015:首都医科大学宣武医院细胞治疗中心 主任
重要学术论文
1. Shuyan Wang1,2,3,*, Chunlin Zou4,*, Linlin Fu1, Bin Wang1, Jing An1, Gongru Song1, Jianyu Wu1, Xihe Tang1,Mo Li1, Jian Zhang4, Feng Yue5, Chengyun Zheng6, Piu Chan3,5, Y Alex Zhang1*, Zhiguo Chen1,2,3*.Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model. Cell Discovery. 2015,2015 May 26;1:15012.SCI
2. Wu J, Sheng C, Liu Z, Jia W, Wang B, Li M, Fu L, ren Z, An J, Sang L, Song G, Wu Y, Xu Y, Wang S, Chen Z, Zhou Q, Zhang YA..Lmx1a enhances the effect of iNSCs in a PD model. Stem Cell Res.. 2015,2015,14(1):1-9.SCI
3. Chen Z* Zhang YA*.Introduction to the special topic "stem cells and regenerative medicine". Sci China Life Sci.. 2014,2014 ;57(6):561- 3.SCI
4. Zou C, Wang J, Wang S, Huang F, Ren Z, Chen Z, Zhang YA..Monkeys with Different doses of StreptozotocinCharacterization of Induction of Diabetes in Juvenile Cynomolgus .. SCIENCE CHINA Life Sciences.. 2012,2012;55(3):210-8.SCI
5. Ren Z, Zhang YA*, Chen Z..Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.. Exp Cell Res. 2012,318(5):435-40.SCI
6. Zou C, Chou BK, Dowey SN, Tsang K, Huang X, Liu CF, Smith C, Yen J, Mali P, Zhang YA*, Cheng L, Ye Z.Efficient Derivation and Genetic Modifications of Human Pluripotent Stem Cells on Engineered Human Feeder Cell Lines.. Stem Cells Dev. 2012,2011;504(3):285-9.SCI
7. Ren Z, Wang J, Zou C, Guan Y, Zhang YA*.Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging.. Sci China Life Sci. 2011,54(11):981-7.SCI
8. Ren Z, Wang J, Zhu W, Guan Y, Zou C, Chen Z, Zhang YA*.Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro.. Exp Cell Res. 2011,317(20):2950-7.SCI
9. Wang S, Ren P, Li X, Guan Y, Zhang YA*.17β-estradiol protects dopaminergic neurons in organotypic slice of mesencephalon by MAPK-mediated activation of anti-apoptosis gene BCL2.. J Mol Neurosci. 2011,45(2):236-45.SCI
10. Du Q, Guan Y, Ji H, Chen Z, Zhang YA*.Effect of monolayer cells on sphere cells--two types of cells that emerge during the neural differentiation of mouse embryonic stem cells.. Neurosci Lett. 2011,504(3):285-9.SCI
11. Zhang Y, Ren Z, Zou C, Wang S, Luo B, Li F, Liu S, Zhang YA*.Insulin-producing cells from human pancreatic islet-derived progenitor cells following transplantation in mice.. Cell Biol Int. 2011,35(5):483-90.SCI
12. Ren Z, Wang J, Zou C, Guan Y, Zhang YA*.Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys.. Sci China Life Sci. 2010,53(5):563-72.SCI
13. Ren Z, Zou C, Ji H, Zhang YA*.Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha.. Cell Biol Int. 2010,34(5):523-30.SCI
14. Ren Z, Wang S, Zhang Y, Zou C, Zhang YA*.Improving infection efficiency of adult cynomolgus monkey mesenchymal stem cells with lentiviral vectors.. Sheng Wu Gong Cheng Xue Bao. 2010,26(6):789-95.SCI
15. Wang Y, Guan Y, Wang F, Huang A, Wang S, Zhang YA*.Bmi-1 regulates self-renewal, proliferation and senescence of human fetal neural stem cells in vitro.. Neurosci Lett. 2010,476(2):74-8.SCI
16. Wu D, Zou C, Yue F, Li X, Li S, Zhang YA*.The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca fascicularis) monkeys.. J Med Primatol. 2009,38(1):15-22.SCI
17. 王淑艳，任萍，谢淑，朱宛宛，王旸，关云谦，张愚*.含GDNF基因的慢病毒载体的构建和其在人胚胎神经肝细胞中的表达. 生物工程学报. 2008,24(12):2061-2067.核心期刊
18. 李宁，朱宝长，朱宛宛，王淑艳，任萍，关云谦，张愚*.慢病毒介导绿色荧光蛋白转染人胚胎干细胞及其培养. 基础医学与临床. 2008,28(10):1083-1087.核心期刊
19. Ning Li, Yanning Cai*, Xanli Zhang, Piu Chan, Xiaohong Zou, Shengli Xu, Yu Alex Zhang.Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts. Biochemical and Biophysical Research Communications. 2008,377:1179-1184.SCI
20. Zou Hui, Nie Xiu-hong, Zhang Yi, Hu Mu, Zhang Yu Alex*.Effect of basic fibroblast growth factor on the proliferation, migration and phenotypic modulation of airway smooth muscle cells. Chin Med J. 2008,121(5):424-429.SCI
21. P.M.Suen, C.Zou, Y.A.zhang, T.K.Lau, J.chan, K.M.Yao, P.S.Leung*.PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. The International Journal of Biochemistry & Cell Biology. 2008,40(4):789-803.SCI
22. 朱宛宛，王淑艳，吴迪，徐艳玲，付琳琳，关云谦，张愚*.胰酶和IV型胶原酶在人胚胎干细胞传代中的作用特点. 首都医科大学学报. 2008,29(4):445-450.核心期刊
23. 任萍，关云谦，徐艳玲，张愚*.皮层神经发生的分子调控机制. 生理科学进展. 2007,38(2):174-176.核心期刊
24. Betty Ying Zhou, Zhaohui Ye, Guibin Chen, Zhi gang Peter Gao, Yu A. Zhang，Linzhao Cheng*.Inducible and reversible transgene expression in human stem cells after efficient and stable gene transfer. stem cells. 2007,25:779-789.SCI
25. Xiao-Bo Li, Yun-Qian Guan, Ping Ren, Wan-Wan Zhu, Yang Wang, Piu Chan, Xin-Sheng Ding, Y. Alex Zhang*.The tropism of embryoid body cells for glioma cells. Neuroreport. 2007,18(17):1821-1825.SCI
26. 任萍，王淑艳，关云谦，徐艳玲，张愚*.OTX1基因慢病毒载体的构建及过表达研究. 中国生物工程杂志. 2007,27:16-21.核心期刊
27. 任萍，关云谦，张愚*.人胚皮层神经干细胞培养方法的探讨. 分子细胞生物学报. 2007,40:79-83.核心期刊
28. 任萍，张愚*.脑片培养在神经科学中的应用. 中华神经医学杂志. 2006,5(11):1178-1179.核心期刊
29. 岳峰，陈彪，曾思恩，易德桥，张愚*. 食蟹猴年龄相关的运动功能减退及其与纹状体多巴胺转运体的关系；. 中华神经科杂志； . 2006,39:776-780.核心期刊
30. 吴迪，岳峰，关云谦，张愚*.食蟹猴脑室下区成体神经前体细胞培养及鉴定. 中华神经医学杂志;. 2006,5:555-558.核心期刊
31. 孙鹏，董恺，董朝轩，张愚*.人胚额叶皮层和海马干细胞的自主分化研究. 中华神经外科杂志；. 2006,22:620-623.核心期刊
32. 董朝轩，关云谦，张愚*.雌激素与神经系统发育. 生理科学进展. 2006,27(2):149-152.核心期刊
33. Feng Yue,Sien Zeng,Deqiao Yi,Y. Alex Zhang*, Piu Chan.Biological properties of neural progenitor cells isolated from the hippocampus of adult cynomolgus monkeys.. Chin Med J (Engl). 2006,119(2):110-116.SCI
34. Chunlin Zou, Po Man Suen, Ying Zhang, Zeyu Wang, Piu Chan,Po Sing Leung, Y. Alex Zhang *.Isolation and in vitro characterization of pancreatic progenitor cells from the islets of diabetic monkey models.. Int J Biochem Cell Biol. 2006,38(5-6):973-984.SCI
35. 董恺，张愚*.一种新的将神经球分散为单细胞悬液的方法. 首都医科大学学报； . 2006,27:620-622.核心期刊
36. zhang YA,Okada A ,Lew CH and McCnnell SK..Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Molecular Cellular Neuroscience . 2002,19:430-446.SCI
37. Zhang* YA, Weimann JM, Levin ME, Devine, WP, Brulet, P and McConnell . Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets.. Neuron. 1999,24:819-831.SCI
主编或副主编的著作/译著
重要奖项
1. 帕金森病的发病机制、预警和干预研究 北京市科学技术一等奖 北京市科学技术奖 2015
2. 北京市卫生系统高层次卫生技术人才 北京市级人选 2008
3. 新世纪优秀人才支持计划 教育部科技司 2005
4. 新世纪百千万人才工程 北京市级人选 2004
5. NATIONAL RESEARCH SERVICE AWARD National Institutes of Health，American 1998
6. Damon Runyon-Walter Winchell Postdoctoral Fellowshi Cancer Research Fund,American 1994