姓名：陈志国 性别：男 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：干细胞与再生医学：通过细胞治疗干预神经退行性疾病，如帕金森病，脊髓损伤，ALS等；同时进行疾病机制研究。 电子信箱：chenzhiguo@gmail.com


社会任职
1. 中国神经科学学会神经干细胞和组织工程分会 委员
2. 国际神经修复协会 理事
个人简历
1. 199509-199907:南开大学 学士
2. 199909-200409:卡罗琳斯卡医学院（瑞典） 博士
3. 200410-201010:斯坦福大学（美国） 博士后
4. 201003-201306:首都医科大学宣武医院 特聘专家
5. 201011-201210:斯坦福大学（美国） 访问助理教授
6. 201306-:首都医科大学宣武医院 副主任、主任
重要学术论文
1. Deqiang Han , Wei Zheng , Xueyao Wang and Zhiguo Chen*.Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease.. Frontiers in Cellular Neuroscience. 2020,14(45):1-10.SCI
2. Heng Chi , Yunqian Guan , Fengyan Li , and Zhiguo Chen*.The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinson’s Disease Model.. Cell Transplantation.. 2019, 28(1S): 87S–99S.SCI
3. Liu S, Chen Z*. Employing endogenous NSCs to promote recovery of spinal cord injury. . Stem Cell International. 2019,2019:**.SCI
4. Zhongfeng Liu, Xuan Wang, Kewen Jiang, Y. Alex Zhang*, Zhiguo Chen*.TNF-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells.. Aging and Disease.. 2019,10(6):1207-1220.SCI
5. Yu Zhao#, Zhongfeng Liu#, Xuan Wang#, Huantong Wu, Jianping Zhang, Junfang Yang, Fayou Zhang, Lining Liu, Jiafu Long, Peihua Lu, and Zhiguo Chen*. .Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies.. Clinical Cancer Research. 2019,【未填写卷（期）】:5595-5607.SCI
6. Zheng W, Chen Z*. .Generation of induced neural stem cells from peripheral mononuclear cells and differentiation toward DA neuron precursors for transplantation studies. . JoVE. 2019,149:【未填写起止页码】.SCI
7. Wei Zheng, Qian Li, Chao Zhao, Yuwei Da, Hong-Liang Zhang*, Zhiguo Chen*.Differentiation of Glial Cells from hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy. . Front. Cell. Neurosci.. 2018,12:239.SCI
8. Shuyan Wang#, Zhongfeng Liu#, Yanxia Ye#, Bingnan Li, Tiantian Liu, Weiqi Zhang, Guang-Hui Liu, Y. Alex Zhang, Jing Qu*, Dawei Xu*, Zhiguo Chen*.Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. . Cell Death and Disease. 2018,9(9):923.SCI
9. Yanpeng Yuan, Xihe Tang, Yun-Fei Bai, Shuyan Wang, Jing An, Yanchuan Wu, Zhi-Qing David Xu, Y. Alex Zhang*, Zhiguo Chen*..Dopaminergic neurons differentiated from human blood-derived induced neural stem cells show efficacy in a mouse Parkinson’s disease model. . Theranostics. 2018,8(17):4679-4694.SCI
10. Yunqian Guan#, Xiaobo Li#, Wenxiu Yu#, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen*..Intravenous transplantation of mesenchymal stem cells reduces the number of infiltrated Ly6C+ cells but enhances the proportions positive for BDNF, TNF-1 and IL-1 in the infarct cortices of dMCAO rats.. Stem Cell International. 2018,2018:**.SCI
11. Li M, Wang Y, Zhang J, Cao Z, Wang S, Zheng W, Li Q, Zheng T, Wang X, Xu Q, Chen Z*..Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials.. J Biomater Sci Polym Ed. . 2018,29(17):2168-2186.SCI
12. Xihe Tang a,b,c, Shuyan Wang a,b,c, Yunfei Bai d, Jianyu Wu a, Linlin Fu a, Mo Li a, Qunyuan Xub,Zhi-Qing David Xu d, Y. Alex Zhanga,c*,, Zhiguo Chen a,b,c,**.Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors. Stem Cell Research. 2016,16 (2016): 236–242.SCI
13. Da Y*, Wang W, Liu Z, Chen H, Di L, Previch L, Chen Z*.Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease.. Neurological Research. . 2016,38(10):897-902.SCI
14. Li P#, Li M#, Tang X, Wang S, Zhang YA*, Chen Z*..Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2.. Sci China Life Sci. . 2016,59(11):1131-1138.SCI
15. Chen Z*, Zhang YA*. Cell therapy for macular degeneration – first phase I/II pluripotent stem cell-based clinical trial shows promise. . Sci China Life Sci.. 2015,58(1):119-20.SCI
16. 2.Wang S, Wang B, Pan N, Fu L, Wang C, Song G, An J, Liu Z, Zhu W, Guan Y, Xu ZQD, Chan P, Chen Z*, Zhang YA.Differentiation of human induced pluripotent stem cells to functional Purkinje neurons. . Scientific Reports. 2015,5:9232.SCI
17. 38.Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH*.PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. . Nature Communications.. 2015,6:10068.SCI
18. 36.Wang S, Zou C, Fu L, Wang B, An J, Song G, Wu J, Tang X, Li M, Zhang J, Yue F, Zheng C, Chan P, Zhang YA, Chen Z*.Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model.. Cell Discovery. 2015,1:15012.SCI
19. Chen Z*, Zhang Y*.Introduction to the special topic "stem cells and regenerative medicine".. Sci China Life Sci. . 2014,57(6):561-3.SCI
20. Ren Z, Wang J, Wang S, Zou C, Li X, Guan Y, Chen Z *, Zhang YA *.Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys.. Scientific Reports.. 2013,3:2786.SCI
21. Chen Z*，Palmer TD*.Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis.. Brain Behav Immun.. 2013,30:45-53.SCI
22. Sheng C#, Zheng Q#, Wu J#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*，Zhou Q*.Direct Reprogramming of Sertoli Cells into Multipotent Neural Stem Cells by Defined Factors.. Cell Research. 2012,22(1):208-18.SCI
23. Sheng C#, Zheng Q#, Wu J#, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Zhao XY, Wang L, Chen Z*，Zhou Q*.Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors.. Cell Research. 2012,22(4):769-72.SCI
24. Ren Z, Zhang YA*, Chen Z*.Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.. Exp Cell Res. 2012,318(5):435-440.SCI
25. Ren Z, Wang J, Zhu W, Guan Y, Zou C, Chen Z*, Zhang YA*.Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro.. Exp Cell Res.. 2011,317(20):2950-7.SCI
26. Chen Z*, Phillips LK, Gould E, Campisi J, Lee SW, Ormerod BK, Zwierzchoniewska M, Martinez O, Palmer TD*.MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts.. PLoS ONE. 2011,(3):e14787.SCI
主编或副主编的著作/译著
重要奖项
1. “帕金森病的发病机制、预警和干预研究” 北京市科学技术一等奖 省级 2015