研究生导师介绍姓名：侯陵性别:男院系：眼视光学院行政职务：副主任专业技术职称：研究员任职年月：从事专业1：眼科学从事专业2：遗传学导师类别：博士生导师(学术型)最后学历：最后学位：博士任硕导年月：2008任博导年月：2008是否院士：否是否国务院学科评议组成员：否毕业院校：IndianaUniversity毕业专业：071008发育生物学毕业时间：办公电话：88067931E-mail：lhou88@yahoo.cn在职信息：在岗◇本人从事的主要研究方向的特点、意义及其水平:◇学术团体任职情况:美国国家卫生研究院NIH客座研究员,中国遗传咨询网专家委员会成员，ISRNDevelopmentalBiology国际学术杂志编委主要研究方向：发育遗传学/发育生物学/细胞生物学/功能基因组学◇近五年在国内外核心期刊上发表学术论文情况:论文题目刊物名称刊物国家收录情况卷期排名Allele-specificgeneticinteractionsbetweenMitfandKitaffectmelanocytedevelopmentPigmentCell&MelanomaRes国外SCI(2010)23:441-447.通讯作者AllroadsleadtomelanocytesPigmentCell&MelanomaRes国外SCI(2010)23:290-291.通讯作者Transcriptionalandsignalingregulationinneuralcreststemcell-derivedmelanocytedevelopmentCellResearch国外SCI(2008)18:1163-1176通讯作者InterspeciesdifferenceintheregulationofneuralcrestdevelopmentbySOX10andMITFPNASUSA国外SCI103:9081-9085通讯作者ThesecretedmetalloproteaseADAMTS20isrequiredformelanoblastsurvivalPLoSGenetics国外SCI4(2):e1000003第二GeneticevidencedoesnotsupportdirectregulationofEDNRBbySox10inmigratoryneuralcrestandthemelanocytelineageMechanismsofDevelopment国外SCI123:124-134第二Cell-autonomousandcellnon-autonomoussignalingthroughendothelinreceptor-BduringmelanocytedevelopmentDevelopment国外SCI131:3239-3247.通讯作者ComplementationofmelanocytedevelopmentinSOX10mutantneuralcrestusinglineage-directedgenetransferDevelopmentalDynamics国外SCI229(1):54-62.第一Spotlightonspottedmice:areviewofwhitespottingmousemutantsandassociatedhumandisordersPigmentCellRes国外SCI17:215-234.第二MitfandTfe3,twomembersoftheMitf-TfefamilyofbHLH-Ziptranscriptionfactors,haveimportantbutfunctionallyredundantrolesinosteoclastdevelopmentPNASUSA国外SCI99:4477-4482.第四AnalysisofSox10functioninneuralcrest-derivedmelanocytedevelopment:Sox10-dependenttranscriptionalcontrolofdopachrometautomeraseDevelopmentalBiology国外SCI237:245-257.第三Signalingandtranscriptionregulationinneuralcrest-derivedmelanocytelineage:interactionbetweenKitandMitfDevelopment国外SCI127:5391-5402第一Effectsoflocaltissueenvironmentonthedifferentiationofneuralcrestcells,withspecialreferencetounderstandingthespatialdistributionofpigmentcellsPigmentCellRes国外SCI12:81-88.通讯作者Identificationofanewformofdeath-associatedproteinkinasethatpromotescellsurvivalJBiolChem国外SCI276:39667-78.第三220-and130-kDaMLCKshavedistincttissuedistributionsandintracellularlocalizationpatternsAmJPhysiolCellPhysiol国外SCI282(3):C451-60.第三Characterizationandsubcellularlocalizationofhumanpmel17/silver,a100-kDa(pre)melanosomalmembraneproteinassociatedwithDHICAconvertingactivityJ.Invest.Dermatol国外SCI106:605-611.第二Lungcellsproduceamelanization-stimulatingactivitythatpromotemelanocyticdifferentiationofavianneuralcrestcellsPigmentCellRes国外SCI8:113-119.第一AsensitizedmutagenesisscreenidentifiesmodifiersofSox10neurocristopathiesHunanMolecularGenetics国外SCI17:2118-31.第四Microphthalmia-associatedtranscriptionfactoractsthroughPEDFtoregulateRPEcellmigrationExpCellRes国外SCI(2011)Nov19(Epub)通讯作者◇出版专著教材情况(注：在书名后注明教材或专著):名称类别出版单位日期排名Mitf-amatteroflifeanddeathforthedevelopingmelanocytes.In:Melanocytesandmelanomas:Theprogressiontomalignancy专著HumanaPress2006-01-01第二TheGeneticRegulationofPigmentCellDevelopmen.InNeuralCrestInductionandDifferentiation.专著AdvExpMedBiol2006-01-01第二TheroleofMicrophthalmiainpigmentcelldevelopment.In:MechanismsofSuntanning.专著MartinDunitzPublication.2002-01-01第二◇成果获奖情况:成果名称颁奖部门等级完成日期证书号排名

◇近五完成的科研项目:项目名称任务来源完成形式完成日期鉴定验收单位主要结论排名6.利用Ednrb突变小鼠研究神经嵴干细胞发育分化相关的分子和细胞机理论文国家自然科学基金尚无主持人神经嵴干细胞衍生的黑色素细胞发育分化的信号传递途径及其调控机制论文浙江省人事厅尚无主持人
◇目前承担的主要项目:项目名称及下达编号项目类别项目来源起讫时间科研经费(万元)本人承担任务转录因子MITF调控眼视网膜色素上皮细胞增殖与分化的机理研究2012.06-2016.0631主持人SOX10调控神经嵴干细胞衍生的黑色素细胞分化与发育的作用机理研究2012.01-2015.1255主持人转录因子MITF调控神经嵴干细胞衍生系增殖与分化的作用机理研究2010.01－2012.1230主持人MITF调控眼色素细胞发育与疾病的机理研究2009.01-2012.127主持人色素细胞的发育遗传及相关疾病调控机理2010-2015200主持人