研究生导师介绍姓名：喻启桂性别:男院系：检验医学院、生命科学学院行政职务：专业技术职称：教授任职年月：从事专业1：免疫学从事专业2：导师类别：博士生导师(学术型)最后学历：最后学位：博士任硕导年月：2011任博导年月：2011是否院士：否是否国务院学科评议组成员：否毕业院校：第四军医大学毕业专业：毕业时间：1995办公电话：(317)274-2391E-mail：andyu@iupui.edu在职信息：在岗◇本人从事的主要研究方向的特点、意义及其水平:现就职于美国印第安纳大学医学院微生物与免疫系。主要研究艾滋病的免疫疗法，以及艾滋病与丙型肝炎病毒等其它顽固性病毒在临床和免疫学上的相互作用。2009年获比尔及梅琳达-盖茨基金会资助。DescriptionandsummaryofresearchfocusofthelaboratoryThereasonsforthefailureoftheimmunesystemtocontrolHIVinfection,andtheresultingimmunodeficiency,remainunclear.InfectionwithHIVischaracterizedbybothcontinualvirusreplicationandavigorousimmuneresponse.AntibodiesareelicitedearlyininfectionandaregenerallyvigorousatallstagesofHIVinfection.However,theseantibodiesareunabletoclearvirusparticlesandinfectedcellsbyactionsofthecomplementsystem,phagocytesorkillercells.Similarly,HIVinfectionisassociatedwithanextremelyvigorousvirus-specificcytotoxicT-lymphocyte(CTL)response,butHIVdiseaseultimatelyprogresses.Dr.Yu'slaboratoryisinterestedinunderstandingthemolecularmechanismsbywhichHIV/HIV-infectedcellsprovideresistancetoantibody-dependentcomplement-mediatedvirotoxicity/cytotoxicity,andbywhichthecontinuouspresenceoftheviralantigen(s)rendersvirus-specificTcellstobecomedysfunctional.ThemajorareasofDr.Yu'scurrentresearchare:(1)EradicationofHIVreservoirs.WehaveinvestigatedtheabrogationofcomplementcontrolproteinfunctiontofacilitateHIV-specificantibodiesinpatientplasmatolyzethecomplement-resistantHIVvirions.WeareusingthisstrategytokillHIV-infectedcellsthroughcomplement-mediatedcelllysisinordertoeradicateHIVreservoirs.(2)Novelstrategiestoaidinvaccinedesigntoenhancecellularimmunitytopersistentvirusinfectioninimmunocompromisedhostsandagedindividuals.WehaveincorporatedtheTNFsuperfamilymoleculesincludingCD40L,RANKL,andOx40L,pivotalcostimulatorymoleculesforimmuneresponses,intopoxvirusvectorsinordertotesttheiradjuvantactivityinenhancingimmunogenicityofpoxvirus-basedHIVvaccines.Co-immunizationofregularmicewithCD40L-expressingpoxvirusandpoxvirus-basedHIVvaccinesaugmentedHIV-1specificCTLresponsesintermsoffrequency,polyfunctionalityandIL-7receptoralphachainexpression.WeareparticularlyinterestinginexploringtheadjuvantactivityoftheseconstructsinenhancingimmunogenicityofHIVvaccinesinCD4+Tcell-deficientoragedmurinemodels.(3)ClinicalandimmunologicalinteractionbetweenHIVandHCV.WeareinterestingtoinvestigatewhyHIVcoinfectionisassociatedwithenhancedHCVreplication,increasedhepaticinflammationandfibrosis,andmorerapidprogressiontocirrhosisandend-stageliverdisease.
Honors
1991ScienceandTechnologyAwardfromChineseArmy.
1992SilverPrizein92’BeijingInternationalExhibitionofInventions.
1994ProvincialScienceandTechnologyAwardfromShanxiProvinceofChina.
1995-1997UNDP/WorldBank/WHOSpecialProgramforResearchandTraininginTropicalDiseases(TDR)Award(M22/181/157ID950385).
1996-1998ChineseNationalNaturalandScientificFoundationAward(ID39570807).
1996-1998ChineseNationalNaturalandScientificFoundationAward(ID39500132).
2001-2003FellowshipAwardfromtheOntarioHIVTreatmentNetwork,Canada.
2005-2007JuniorInvestigatorDevelopmentAwardfromtheOntarioHIVTreatmentNetwork,Canada.
2006JuniorFacultyTravelAwardfromtheUniversityofHawaiiatManoa.
2006-2007IdeaNetworksforBiomedicalResearchExcellentMiniGrantfromUniversityofHawaii.
2006-2008NewInvestigatorAwardfromCenterforAIDSResearchatUniversityofWashington.
2008AAIJuniorFacultyTravelAwardfromtheAmericanAssociationofImmunologists.
2006-2008MedicalResearchAwardfromHawaiiCommunityFoundation.
2009AAIJuniorFacultyTravelAwardfromtheAmericanAssociationofImmunologists.◇学术团体任职情况:◇近五年在国内外核心期刊上发表学术论文情况:论文题目刊物名称刊物国家收录情况卷期排名CooperationofTNFfamilymembersCD40ligand,receptoractivatorofNF-kappaBligand,andTNF-alphaintheactivationofdendriticcellsandtheexpansionofviralspecificCD8+TcellmemoryresponJImmunol.国外SCI2003Feb15;170(4)FirstauthorTheroleofthep38mitogen-activatedproteinkinase,extracellularsignal-regulatedkinase,andphosphoinositide-3-OHkinasesignaltransductionpathwaysinCD40ligand-induceddendriticcellactivatJImmunol国外SCI2004May15;172(10)FirstauthorOX40ligationofCD4+Tcellsenhancesvirus-specificCD8+TcellmemoryresponsesindependentlyofIL-2andCD4+Tregulatorycellinhibition.JImmunol国外SCI2006Feb15;176(4)FirstauthorWhycan'ttheimmunesystemcontrolHIV-1?DefiningHIV-1-specificCD4+Tcellimmunityinordertodevelopstrategiestoenhanceviralimmunity.ImmunolRes.国外SCI2006;35(1-2)SecondauthorComparativeanalysisoftropismbetweencanarypox(ALVAC)andvacciniavirusesrevealsamorerestrictedandpreferentialtropismofALVACforhumancellsofthemonocyticlineage.Vaccine国外SCI2006Sep29;24(40-41)FirstauthorCEACAM1(CD66a)promoteshumanmonocytesurvivalviaaphosphatidylinositol3-kinase-andAKT-dependentpathway.JBiolChem国外SCI2006Dec22;281(51)FirstauthorCD40Lexpressedfromthecanarypoxvector,ALVAC,canboostimmunogenicityofHIV-1canarypoxvaccineinmiceandenhancetheinvitroexpansionofviralspecificCD8+TcellmemoryresponsesfromHIVVaccine国外SCI2008Jul29;26(32)SecondauthorRoleofcellsignalinginpoxvirus-mediatedforeigngeneexpressioninmammaliancells.Vaccine国外SCI2009;27(22)CorrespondingauthorThegoodandevilofcomplementactivationinHIV-1infectionCellMolImmunol国外SCI2010；7FirstauthorDirecteffectsofHIV-1Tatproteinonexcitabilityandsurvivalofprimarydorsalrootganglionneurons:possiblecontributiontoHIV-1-associatedpainPLoSONE国外SCI2011,6(9)CorrespondingauthorCD59incorporationprotectshepatitisCvirusfromcomplement-mediateddestruction.Hepatology国外SCI2011Sep19.doiCorrespondingauthorAhigh-affinityinhibitorofhumanCD59enhancesantibody-dependentcomplement-mediatedvirolysisofHIV-1TheJournalofImmunology国外SCI2010;184Secondauthor◇出版专著教材情况(注：在书名后注明教材或专著):名称类别出版单位日期排名ViralApplicationofGFP专著HumanaPressInc2009-01-01◇成果获奖情况:成果名称颁奖部门等级完成日期证书号排名MedicalResearchAwardfromHawaiiCommunityFoundation其他其他00001AAIJuniorFacultyTravelAwardfromtheAmericanAssociationofImmunologists其他其他00001NewInvestigatorAwardfromCenterforAIDSResearchatUniversityofWashington其他其他00001IdeaNetworksforBiomedicalResearchExcellentMiniGrantfromUniversityofHawaii.其他其他00001JuniorInvestigatorDevelopmentAwardfromtheOntarioHIVTreatmentNetwork,Canada其他其他00001AAIJuniorFacultyTravelAwardfromtheAmericanAssociationofImmunologists其他其他00001JuniorFacultyTravelAwardfromtheUniversityofHawaiiatManoa.其他其他00001

◇近五完成的科研项目:项目名称任务来源完成形式完成日期鉴定验收单位主要结论排名BAADAAD19-03-R-0017/2.52BiologicalRamanandopticalimagingprogram:detectingbioagentsandbiomarkers论文TheUSDepartmentofDefenseThisprojectistouseRamanandopticalimagingsystemtorapidlyandaccuratelydetectbioagents.共同主持W81XWH-07-2-0073AdvancedTechnologiesaddressingAsia-PacificInfectiousDiseases论文TheUSArmyMedicalResearchProgramThisprojectistodevelopadvancedtechnologiestoaddressAsia-Pacificinfectiousdiseases.共同主持AI27757DevelopmentofmolecularadjuvantsfortherapeuticHIV-1vaccines论文CenterforAIDSResearch(CFAR)attheUniversityofWashingtonThisprojectistotestCD40LadjuvantactivityinenhancingimmunogenicityofHIV-1vaccinesinmic主持GenerationsolubletrimericmouseCD40ligand论文INBREThisprojectistogeneratebioactiveCD40LtrimerstobeusedasmolecularadjuvantsforHIVvaccin主持ID#:20061466BiologicalactivityofmouseCD40LtrimerinactivationofHIV-1gag-loadedDCs论文HawaiiCommunityFoundationThemajorgoalofthisprojectistotestthebiologicalactivityoftrimericmouseCD40ligandine主持
◇目前承担的主要项目:项目名称及下达编号项目类别项目来源起讫时间科研经费(万元)本人承担任务HCV病毒颗粒通过劫持CD59抵抗补体介导的溶解作用的分子机制2012.01-2014.1222第二探讨淋球菌抑制树突细胞功能及降低HIV-1CD8T细胞记忆反应的机理2013.01-2015.1230课题指导恢复HIV-1中和抗体和非中和抗体的抗感染功能的研究2011.01-2013.1210课题指导