Robert P. Borris ——Professor
Nationality:
USA

Phone:


Email:
rborris@tju.edu.cn

Office:
Room A206, Building 24, Tianjin University

School:
School of Pharmaceutical Science and Technology

ResearcherID:
K-1095-2015

Group weblink








Education Experience
1970-1974 Bachelor of Science Biology Loyola University, Chicago, USA
1975-1977 Bachelor of Science Pharmacy University of Illinois Medical Center, Chicago, US
1977-1981 Doctor of Philosophy Pharmacognosy University of Illinois Medical Center, Chicago, US
1981-1982 Postdoctoral Natural Products Chemistry University of Zuruich, Zurich, CH

Professional Experience
2007-2013 Associate Dean for Research and Associate Professo College of Phaermacy, University of Hawaii at Hilo
2007-2007 Vice President, Botanical Science and Regulation Council for Responsible Nutrition
2001-2005 Senior Investigator Merck Research Laboratories, Dept of Natural Products Chemistry
1993-2000 Senior Research Fellow Merck Research Laboratories, Dept. of Natural Products Chemistry
1987-1993 Research Fellow Merck Research Laboratories, Dept. of Natural Products Chemistry
1983-1987 Senior Research Chemist Merck Research Laboratories, Dept. of Natural Products Chemistry
1982-1983 Assistant Professor of Pharmacogbnosy Rutgers University
1978-1980 Registered Pharmacist Meyer Drugs, Chicago
2014- Professor Tianjin university

Research Area
The research of the Borris groups involves a) Validation of traditional medical practices, b) Discovery of novel biologically active natural products, c) Natural products used as dietary supplements, d) Phytochemical systematics, e) Application of NMR spectrometry to the structure determination of natural products, and f) Applications of high performance centrifugal partition chromatography to the isolation of biologically active natural products and other organic compounds.





Honors and Awards
National Merit Scholarship (USA) 1970 - 1974
Illinois State Scholarship 1970 - 1974
Phi Sigma Tau Honor Society
Rho Chi Pharmaceutical Honor Society
Phi Kappa Phi Honor Society
American Foundation for Pharmaceutical Education Fellowship 1979 - 1981
Dorothea H. Fleming Student Research Fellowship 1980 - 1981.
Helmut Legerlotz Postdoctoral Research Fellowship 1981 - 1982.
Fellow, Linnean Society of London (elected 1995)
President, American Society of Pharmacognosy 1997-1998
Board of Directors, Institute for Triple Helix Innovation, Honolulu, HI, 2009 - 2013

Patents
Monaghan, R. L., Sigal, N. H., Kaplan, L., Byrne, K. M., Borris, R. P., Dumont, F. J., Garrity, G. M., and Zink, D. L.(1989)Fermentation of Novel Immunosuppressant Agents by Streptomyces hygroscopicus ascomyceticus.European Patent EP 323,865.
Borris, R. P., Burg, R. W., Hensens, O. D., Huang, L., Kelemen, L., and Mochales, S. (1989)Manufacture of Sterol Inhibitors of Testosterone 5-Alpha Reductase with Gliocladium.U. S. Patent 4,814,324.
Borris, R. P., Wicker, L. S., Zink, D. L., and Lien, T. H. (1990)Novel Immunosuppressant Compound.European Patent EP 358,508
Borris, R. P., Lam, Y. K. T., and Koupal, L. (1993).Preparation of Antimigraine Alkyl Indole Derivative with Penicillium daleae.U.S. Patent 5,233,050.
Kaplan, L., Borris, R. P., Byrne, K. M., Wicker, L. S., and Zink, D. L. (1995)Microbial Immunoregulant.U.S. Patent 5,431,896
Kaplan, L., Borris, R. P., Byrne, K. M., Wicker, L. S., and Zink, D. L. (1995)Immunosuppressant L-687819 and its manufacture with Streptomyces.European Patent EP 388,153

Highlighted Publications
Lange, I., Moschny, J., Tamanyan, K., Khutsishvili, M., Atha, D., Borris, R.P., and Koomoa, D.L. Scrophularia orientalis Extract Induces Calcium Signaling and Apoptosis in Neuroblastoma Cells. Int. J. Oncology, 2016, 48, 1608-1616.
Showman, A., Baker, J.D., Linares, C., Naeole, C.K., Borris, R.P., Johnston, E., Konanui, J., and Turner, H. Contemporary Pacific and Western Perspectives on ‘Awa Toxicology. Fitoterapia, 2015, 100, 56-67.
Lange, I., Moschny, J., Kerimov, V.M., Khutsishvili, M. Atha, D., Borris, R.P., and Koomoa, D.L. Juniper extracts regulate calcium signaling pathways and induce apoptosis in neuroblastoma cells. J. Pharm. Pharm.Scien. 2015, 1 (1) 1-7.
Clark, B.R., Pramanick, S., Arancon, N., and Borris, R.P. Unusual Flavonoid Glycosides from the Hawaiian Tree Metrosideros polymorpha. Nat. Prod. Commun., 2015, 10 (6) 925-928.
Shimoda, L.M.N., Showman, A., Baker, J.D., Lange, I., Koomoa-Lange, D., Borris, R.P., and Turner, H. Differential Regulation of Calcium Signaling Pathways by Components of Piper methysticum (‘Awa) Phytotherapy Research, 2014, 29, 582-590.
Clark, B.R., Bliss, B.J., Suzuki, J.Y., and Borris, R.P. Chemotaxonomy of Hawaiian Anthurium Cultivars Based on Multivariate Analysis of Phenolic Components. J. Agric. Food Chem. 2014, 62(46) 11323-11334.
Ul-Haq, I.; Youn, U.-J.; Chai, X.-Y.; Park, E. J.; Kondratyuk, T. P.; Simmons, C. J.; Borris, R. P.; Mirza, B.; Pezzuto, J. M.; Chang, L. C. Biologically active Withanolides from Withania coagulans. J. Nat. Prod. 2013, 76, 22.
Youn, U.-J.; Park, E.-J.; Kondratyuk, T. P.; Simmons, C. J.;Borris, R. P.; Tanamatayarat, P.; Wongwiwatthananukit, S.; Toyama, O.; Songsak, T.; Pezzuto, J. M.; Chang, L. C. Anti-inflammatory Sesquiterpene Lactones from the Flower of Vernonia cinerea. Bioorg. Med. Chem. Lett. 2012, 22, 5559.
Clark, B. R.; Suzuki, J. Y.; Bliss, B. R.; and Borris, R. P. Flavone C-glycosides from Anthurium andreanum. Nat. Prod. Commun. 2012, 7, 747.
Jayasuriya, H.; Herath, K. B.; Ondeyka, J. G.; Guan, Z.; Borris, R. P.; Tiwari, S.; de Jong, W.; Chavez, F.; Moss, J.; Stevenson, D. W.; Beck, H. T.; Slattery, M.; Zamora, N.; Schulman, M.; Ali, A.; Sharma, N.; MacNaul, K.; Hayes, N.; Menke, J. G.; Singh, S. B. Diterpenoid, Steroid and Triterpenoid Agonists of Liver X Receptors from Diversified Terrestrial Plants and Marine Sources. J. Nat. Prod. 2005, 68, 1247.
Herath, K.; Jayasuriya, H.; Ondeyka, J. G.; Guan, Z.; Borris, R. P.; Stijfhoorn, E.; Stevenson, D.; Wang, J.; Sharma, N.; MacNaul, K.; Menke, J. G.; Ali, A.; Schulman, M. J.; Singh, S. B. Guttiferone I, a New Prenylated Benzophenone from Garcinia humilis as a Liver X Receptor Ligand. J. Nat. Prod. 2005, 68, 617.

ResearcherID Publications
Year Title Author(s) Source Volume
2015 Contemporary Pacific and Western perspectives on ’awa (Piper methysticum) toxicology Showman, Angelique F.; Baker, Jonathan D.; Linares, Christina; et al. Fitoterapia 100
2015 Differential Regulation of Calcium Signalling Pathways by Components of Piper methysticum (’Awa) Shimoda, L. M. N.; Showman, A.; Baker, J. D.; et al. Phytotherapy Research 29
2015 Juniper Extracts Regulate Calcium Signaling Pathways and Induce Apoptosis in Neurioblastoma Cells Lange, I.; Moschny, J; Kerimov, V.M.; et al. Journal of Pharma and Pharmaceutical Science 1
2015 Unusual Flavonoid Glycosides from the Hawaiian Tree Metrosideros polymorpha Clark, Benjamin R.; Pramanick, Swapan; Arancon, Norman; et al. Natural Product Communications 10
2014 Chemotaxonomy of Hawaiian Anthurium Cultivars Based on Multivariate Analysis of Phenolic Metabolites Clark, Benjamin R.; Bliss, Barbara J.; Suzuki, Jon Y.; et al. Journal of Agricultural and Food Chemistry 62
2014 Herbicidin Congeners, Undecose Nucleosides from an Organic Extract of Streptomyces sp L-9-10 Chai, Xingyun; Youn, Ui Joung; Sun, Dianqing; et al. Journal of Natural Products 77
2013 Biologically Active Withanolides from Withania coagulans Ihsan-ul-Haq; Youn, Ui Joung; Chai, Xingyun; et al. Journal of Natural Products 76
2012 Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea Youn, Ui Joung; Park, Eun-Jung; Kondratyuk, Tamara P.; et al. Bioorganic & Medicinal Chemistry Letters 22
2012 Flavone C-glycosides from Anthurium andraeanum Clark, Benjamin R.; Suzuki, Jon Y.; Bliss, Barbara J.; et al. Natural Product Communications 7
2012 PHYTOCHEMICAL STUDY OF THE NATIVE HAWAIIAN PLANT, METROSIDEROS POLYMORPHA Pramanick, Swapan; Clark, Benjamin R.; Arancon, Norman Q.; et al. Pharmaceutical Biology 50