Qingzhi Gao——Professor
Nationality:
CHINA
Phone:
Email:
qingzhi@tju.edu.cn
Office:
Room A609, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
K-1596-2015
Group weblink
Education Experience
1994 Ph. D. Nagoya University, JP
1994-1999 Postdoctoral Stanford University, USA
Professional Experience
1994-2001 Research Scientist Tokyo, JAPAN
1999-2000 Postdoctoral fellow Stanford University, California, USA
2001-2009 Senior Research Scientist XenoPort, Inc. California, USA
2009-2015 Professor Tianjin University, Tianjin, CHINA
2010-2015 Director Tianjin Key Laboratory
Research Area
The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.
Honors and Awards
Patents
Highlighted Publications
Qian Mi, Yuru Ma, Ran Liu, Xiangqian Gao, Pengxing Liu, Yi Mi, Xuegang Fu, and QingzhiGao*, 2-Deoxyglucose Conjugated Platinum (II) Complexes for Targeted Therapy: Design, Synthesis, and Antitumor Activity. Journal of Biomolecular Structure & Dynamics, 2015, 30,1-12.
Hong Li, Xiangqian Gao, Ran Liu, Yu Wang, Menghua Zhang, Zheng Fu, Yi Mi, Yiqiang Wang, Zhi Yao, Qingzhi Gao*, Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. European Journal of Medicinal Chemistry, 2015, 101, 400-408.
Liu, P.; Lu, Y.; Li, H.; Gao, X.; Liu, R.; Zhang-Negrerie, D.; Shi, Y.; Wang, Y.; Wang, S.; Gao, Q. Highly Water-soluble Platinum(II) Complex as GLUT Substrate for Targeted Therapy: Improved Anticancer Efficacy and Ttransporter-mediated Cytotoxic Properties. Chem. Commun. 2013, 49, 2421.
Lu, Y.; Gao, X.; Wu, M.; Zhang-Negrerie, D.; Gao, Q. Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy. Mini-Rev in Med. Chem. 2011, 11, 611.
Qingzhi Gao, Q.; Yang, L.; Zhu, Y. Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Current. Comput-Aided Drug Design 2010, 6, 37.
Ye, Y.; Wei, J.; Dai, X.; Gao, Q. Computational Studies of the Binding Modes of A2A Adenosine Receptor Antagonists. Amino Acids 2008, 35, 389.
Wei, J.; Wang, S.; Gao, S.; Dai X.; Qingzhi Gao, Q. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists. J. Chem. Inf. Model 2007, 47, 613.
ResearcherID Publications
Year Title Author(s) Source Volume
2008 Computational studies of the binding modes of A(2A) adenosine receptor antagonists Ye, Y.; Wei, J.; Dai, X.; et al. Amino Acids 35
2009 Molecular docking study of A(3) adenosine receptor antagonists and pharmacophore-based drug design Wei, Jing; Li, Hui; Qu, Wanlu; et al. Neurochemistry International 55
2009 Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I: Comprehensive Understanding of the SAR of alpha-Amino Acid Boronates Zhu, Yongqiang; Zhao, Xin; Zhu, Xinrong; et al. Journal of Medicinal Chemistry 52
2009 A three-dimensional pharmacophore model for RXR alpha agonists Dong, Aiguo; Huo, Junfeng; Gao, Qingzhi; et al. Journal of Molecular Structure 920
2009 3D-pharmacophore model for RXR gamma agonists Dong, Aiguo; Wei, Jing; Gao, Qingzhi Neurochemistry International 54
2010 Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Gao, Qingzhi; Yang, Lulu; Zhu, Yongqiang Current Computer-Aided Drug Design 6
2010 3D-QSAR study of corticotropin-releasing factor 1 antagonists and pharmacophore-based drug design Ye, Yingda; Liao, Qinghua; Wei, Jing; et al. Neurochemistry International 56
2010 3D Pharmacophore Based Virtual Screening of A(2A) Adenosine Receptor Antagonists Wei, Jing; Qu, Wanlu; Ye, Yingda; et al. Protein and Peptide Letters 17
2011 Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy Lu, Y. -H.; Gao, X. -Q.; Wu, M.; et al. Mini-Reviews in Medicinal Chemistry 11
2011 Docking and Molecular Dynamics Study on the Inhibitory Activity of Novel Inhibitors on Epidermal Growth Factor Receptor (EGFR) Liao, Qing-Hua; Gao, Qing-Zhi; Wei, Jing; et al. Medicinal Chemistry 7
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天津大学药学院导师教师师资介绍简介-Qingzhi Gao——Professor
本站小编 Free考研考试/2020-09-13
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