Lei Chen——Associate Professor
Nationality:
CHINA

Phone:


Email:
chenlei@tju.edu.cn

Office:
Room 412-2, Building 24, Tianjin University

School:
School of Pharmaceutical Science and Technology

ResearcherID:
K-2114-2015

Group weblink








Education Experience
2003-2006 Ph. D. Applied Chemistry Tianjin University, CN

Professional Experience
2006- Associate Professor SPST,Tianjin Univ.
2013-2014 Visiting Scholar UCSB,USA

Research Area
The research of the Chen group is focused on synthesis of biomaterials and development ofmodern separation and analysis technology. In particular, efforts include a) development of different methods to control the morphology and pore structure of the HPLC stationary phase, b) design mixed-mode chromatography (MMC)according tothestructure of analytesand investigation into their mechanism, and c) exploitation of magnetic separation technology in the purification of biological samples. Additionally, efforts are extended towards chiral analysis of pharmacological compounds, including synthesis of chiral stationary phase of HPLC, and optimization of separation and identification methods in HPLC and LC-MS.



Honors and Awards

Patents
Wan Q.H., Huo Z.X, Chen L., A preparation method for monodispersed porous silica microspheres. 2020-3-31, Chinese, ZL 5.5
Chen L., Jiang Y.T., Wan Q.H. Porous organic-inorganic hybridization silicon microsphere preparation method. 2017-5-10, Chinese, ZL 2015 1 **.X
Chen L., Jia G.Y., Wan Q.H. Method for preparing monodisperse hybrid silica gel microspheres through self-hydrolysis of methoxy-organosilane. 2017-7-28, Chinese, ZL 2015 1 **.9
Wan Q.H., Chen L., Zhang Z.C., Li W.B. A preparation method for ferromagnetic porous silica microspheres. 2003-7-21, Chinese, ZL 03 1 30422.2
Wan Q.H., Chen L., Li W.B., Zhang Z.C. A preparation method for ferromagnetic urea-formaldehyde resin. 2003-7-21, Chinese, ZL 03 1 30423.0

Highlighted Publications
Z.X. Huo, Q.H. Wan, L. Chen*, Energy-efficient and environment-friendly method to prepare monodispersed silica stationary phases for simultaneous separation of compound drugs. J. Chromatogr. A. 1618 (2020) 460866.
Z.X. Huo, L. Chen*, Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres. J. Sep. Sci. 2020, 43:389-397.
F. Zhang, L.Chen*, Synthesis of octyl-quaternary ammonium mixed-mode stationary phase by vapor deposition approach and its application in compound preparation separation. Chromatographia. 2019, 82:1437-1447.
M. Chen, L. Chen*, A novel high hydrothermal stability amino-functionalized stationary phase prepared by a vapour deposition method. Anal. Methods. 2018,10:1538-1546.
Z. X. Huo, Q. H. Wan, L. Chen*, Synthesis and evaluation of porous polymethylsisesquioxane microspheres as low silano activity chromatographic stationary phase for basic compound separation. J. Chromatogr. A. 2018, 1553:90-100.

ResearcherID Publications
Year Title Author(s) Source Volume
2016 Monitoring structural evolution of organosilicate species during sol-gel processes by electrospray ionization mass spectrometry Li, Jun; Chen, Lei Rapid Communications in Mass Spectrometry 30
2012 Preparation of a magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples Wang, Xianhua; Fang, Qiuxue; Liu, Shipeng; et al. Analytical and Bioanalytical Chemistry 404
2012 Restricted access magnetic materials prepared by dual surface modification for selective extraction of therapeutic drugs from biological fluids Wang, Yu; Wang, Yuxia; Chen, Lei; et al. Journal of Magnetism and Magnetic Materials 324
2012 The application of pseudo template molecularly imprinted polymer to the solid-phase extraction of cyromazine and its metabolic melamine from egg and milk Wang, Xianhua; Fang, Qiuxue; Liu, Shipeng; et al. Journal of Separation Science 35
2011 Field-flow fractionation of magnetic particles in a cyclic magnetic field Bi, Yanping; Pan, Xiaoxia; Chen, Lei; et al. Journal of Chromatography a 1218
2010 Templated synthesis of monodisperse mesoporous maghemite/silica microspheres for magnetic separation of genomic DNA Chen, Feng; Shi, Ruobing; Xue, Yun; et al. Journal of Magnetism and Magnetic Materials 322
2009 Endcapping of Octadecyl Bonded Silica by Atomic Layer Deposition for Separation of Basic Compounds Guo Zhi-Qiang; Chen Lei; Wan Qian-Hong Chinese Journal of Analytical Chemistry 37
2009 Magnetically immobilized frits for the preparation of packed columns used in capillary electrochromatography Wang, Hongling; Cao, Jingjing; Bi, Yanping; et al. Journal of Chromatography a 1216
2009 Preparation of magnetite-loaded silica microspheres for solid-phase extraction of genomic DNA from soy-based foodstuffs Shi, Ruobing; Wang, Yucong; Hu, Yunli; et al. Journal of Chromatography a 1216
2009 Separation of Dihydroergotoxine on Polar Embedded Reversed-Phase Stationary Phase Guo Zhi-Qiang; Xu Dan; Wan Qian-Hong; et al. Chinese Journal of Analytical Chemistry 37