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基本信息 The basic information
姓名: 戴亮亮

学院: 医学研究院


学历: 博士研究生毕业

学位: 工学博士


职称: 副教授

职务:


学科: 生物医学工程,材料科学与工程,药学


邮箱: liangliangdai@nwpu.edu.cn




工作经历 Work Experience
2018/07-至今： 西北工业大学，医学研究院，副教授，硕士生导师



教育经历 Education Experience
2015/09-2018/06重庆大学，生物医学工程专业，博士，导师：蔡开勇
2012/09-2015/06重庆大学，生物学专业，硕士，导师：蔡开勇









招生信息 Admission Information
招生专业：
硕士研究生：药学、生物材料与纳米医药、纳米药物控释系统与肿瘤治疗、医学生物技术
研究方向：
1）生物功能性纳米药物递送系统的构建与抗肿瘤效应评价；
2）功能纳米控释系统介导肿瘤生物/免疫治疗的机制研究；
3）肿瘤微环境的分子调控干预策略。
*欢迎具有材料、力学、生物学、化学、高分子、医学等背景的同学报考研究生！



科学研究 Scientific Research
戴亮亮教授（orcid.org/0000-0002-2041-9357）一直从事构建生物功能性纳米药物递送系统及提高恶性肿瘤治疗效果的研究。近 5 年，在ACS Nano, Advanced Functional Materials, Advanced Science, Chemistry of Materials, Biomaterials, ACS Applied Materials & Interfaces, Nanoscale等本领域TOP期刊发表SCI论文30余篇。影响因子IF大于10的5篇，大于5的10篇，ESI高被引用论文1篇，热点论文1篇，H指数18，SCI引用900余次。在功能性纳米药物递送系统的构建与抗肿瘤疗效评价等研究领域具有一定的工作基础。2018年7月加入西北工业大学医学研究院工作。





荣誉获奖 Awards Information
2020年，入选陕西省高校科协青年人才托举计划
2021年，入选西北工业大学“翱翔新星”



学术成果 Academic Achievements
代表性论文：
[1]Liangliang Dai,Xiang Li, Mengjiao Yao, Peiyun Niu, Xichen Yuan, Ke Li, Maowen Chen, Zengxiang Fu, Xianglong Duan,Haibin Liu, Kaiyong Cai*, Hui Yang*.Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy.Biomaterials. 2020, 241, 119901. (IF: 10.317)
[2] ZhangYuan, Chuanchuan Lin, Liangliang Dai*, Ye He, Jinwei Hu, Kun Xu, Bailong Tao, Peng Liu*, Kaiyong Cai*. Near‐infrared light‐activatable dual‐action nanoparticle combats the established biofilms of methicillin‐resistant staphylococcus aureus and its accompanying inflammation.Small. 2021, **. (IF: 11.459)
[3]Ke Li, Lu Lu, Chencheng Xue, Ju Liu, Ye He, Jun Zhou, Zengzilu Xia, Liangliang Dai,*Kaiyong Cai*.Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale. 2020, 12, 130-144. (IF: 6.895，HCP)
[4]Liangliang Dai, Xiang Li, Xianglong Duan, Menghuan Li, Peiyun Niu, Huiyun Xu, Kaiyong Cai, Hui Yang. A pH/ROS cascade-responsive charge-reversal nanosystem with self-amplified drug release for synergistic oxidation-chemotherapy. Advanced Science. 2019, 6, **. (IF: 15.84)
[5]Liangliang Dai, Ke Li, Menghuan Li, Xiaojing Zhao, Zhong Luo, Lu Lu, Yanfeng Luo, Kaiyong Cai.Size/Charge changeable acidity‐responsive micelleplex for photodynamic‐improved PD‐L1 immunotherapy with enhanced tumorpenetration.Advanced Functional Materials. 2018, 28,**. (IF: 16.836)
[6]Liangliang Dai, Ruisi Cai, Menghuan Li, Zhong Luo, Yonglin Yu, Weizhen Chen, Xinkun Shen, Yuxia Pei, Xiaojing Zhao, Kaiyong Cai. Dual-targeted cascade-responsive prodrug micelle system for tumor therapy in vivo.Chemistry of Materials. 2017,29, 6976-6992.(IF: 9.567)
[7]Liangliang Dai, Yonglin Yu, Zhong Luo, Menghuan Li, Weizhen Chen, Xinkun Shen, Feng Chen, Qiang Sun, Qingfeng Zhang, Hao Gu, Kaiyong Cai.Photosensitizer enhanced disassembly of amphiphilic micelle for ROS-response targeted tumor therapy in vivo.Biomaterials. 2016, 104,1-17.(IF: 10.317)
[8]Liangliang Dai, Qingfeng Zhang, Jinghua Li, Xinkun Shen, Caiyun Mu, Kaiyong Cai.Dendrimerlike mesoporous silica nanoparticles as pH-responsive nanocontainers for targeted drug delivery and bioimaging.ACS Applied Materials &Interfaces.2015, 7, 7357-7372.(IF: 8.758)
[9]Liangliang Dai, Junjie Liu, Zhong Luo, Menghuan Li, Kaiyong Cai.Tumor therapy: Targeted drug delivery systems. Journal of Materials Chemistry B. 2016, 4. 6758-6772. (IF: 5.344)
[10]Liangliang Dai, Qingfeng Zhang, Xinkun Shen, Qiang Sun, Caiyun Mu, Hao Gu, Kaiyong Cai. A pH-responsive nanocontainer based on hydrazone-bearing hollow silica nanoparticles for targeted tumor therapy.Journal of Materials Chemistry B. 2016, 4, 4594-4604.(IF: 5.344)
[11]Liangliang Dai, Qingfeng Zhang, Hao Gu, Kaiyong Cai. Facile synthesis of yolk-shell silica nanoparticles for targeted tumor therapy.Journal of Materials Chemistry B. 2015, 3,8303-8313. (IF: 5.344,Hot Paper)
[12]Liangliang Dai, Jinghua Li, Beilu Zhang, Junjie Liu, Zhong Luo, Kaiyong Cai. Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo.Langmuir. 2014, 3, 7867-7877.(IF: 3.557)
[13]戴亮亮，刘军杰，周骏，罗忠，蔡开勇。响应性纳米药物递送系统构建及肿瘤治疗研究[J]，医用生物力学，2019年S1期







代表性项目：
1）主持国家自然科学基金青年科学基金项目，功能化MOF纳米反应器“双重饥饿”肿瘤治疗及机制研究（2021.01-2023.12）；
2）主持陕西省高校科协青年人才托举计划，程序性胶束控释系统化疗/肿瘤免疫联合治疗研究（2021.01-2022.12）；

3）主持陕西省自然科学基金青年项目，自增强药物释放胶束控释系统的构建及抑瘤机制研究（2019.01-2020.12）；
4）主持中央高校基本科研业务费，具有电荷反转/自增强药物释放特性的胶束递送系统构建及抗肿瘤机制研究（2018.01-2020.12）；



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