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基本信息 The basic information
姓名: 柴芸

学院: 医学研究院


学历: 博士研究生毕业

学位: 理学博士


职称: 讲师（高校）

职务:


学科: 药学





工作经历 Work Experience
2019/11-至今：西北工业大学, 医学研究院, 助理教授
2017/06-2019/10：国家药品监督管理局药品审评中心，审评员
2014/06-2017/06：中国医学科学院医药生物技术研究所，副研究员
2011/03-2014/03： 美国佐治亚州立大学，博士后，合作导师: W. David Wilson & David W. Boykin
2010/09-2014/06：中国医学科学院医药生物技术研究所，助理研究员





教育教学 Education And Teaching
2005/09-2010/07，清华大学北京协和医学院，微生物与生化药学，博士，导师：郭慧元
2001/09-2005/07，中南大学湘雅医学院，药学，学士





科学研究 Scientific Research



学术成果 Academic Achievements
代表性项目：
1）国家十二五“重大新药创制”科技重大专项-耐药结核病药物自主创新及评价关键技术子课题，项目名称：新型抗结核候选药物IMB-TS1及同系物成药性研究（2015.01-2018.12）；主持
2）北京协和医学院“协和青年教师项目”，项目名称：”超级”阿司匹林衍生物的设计，合成与抗肿瘤作用研究（2014.09-2015.09），主持；
3）中国医学科学院医药生物技术研究所中央级公益性科研院所基本科研业务专项，项目名称：含有噬铁素结构片段的喹诺酮衍生物设计，合成与抗革兰阴性菌作用研究（2014.06-2015.06），主持；
4）美国NIH，项目名称：Heterocycle Cation Recognition of the DNA Minor Groove，参与；
代表性论文：
[1] Zhang, J.^#, Shen, W. Y. ^#, Li, X. N., Chai, Y.,* Li, S. J., Lv, K., Guo, H. Y. and Liu, M. L.* Synthesis and antitumor activity of 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. Molecules, 2016, 21(12), 1674. (IF:2.465)
[2] Harika, N. K., Paul, A., Stroeva, E., Chai, Y., Boykin, D. W., Germann, M. W., and Wilson, W. D. Imino proton NMR guides the reprogramming of AT specific minor groove binders for mixed base pair recognition. Nucleic Acids Res., 2016, 44(10), 4519-4527.
[3] Wang, C. L., Xia, G. M., Liu, X., Zhang, R., Chai, Y., Zhang, J., Li, X. N., Yang, Y., Wang, J., Liu, M. L.Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety. Bioorg Med Chem Lett., 2016, 26(9), 2355-2359.
[4] Paul, A., Chai, Y., Boykin, D. W., and Wilson, W. D. Understanding mixed sequence dna recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidines. Biochemistry, 2015, 54(2), 577-587.
[5] Paul, A., Nanjunda, R., Kumar, A., Laughlin, S., Nhili, R., Depauw, S., Deuser, S. S., Chai, Y., Chaudhary, A. S., David-Cordonnier, M. H., Boykin, D. W., and Wilson, W. D. Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair. Bioorg Med Chem Lett., 2015, 25(21), 4927-4932.
[6] Chai, Y., Paul, A., Boykin, D. W., and Wilson, W. D. Design and synthesis of heterocyclic cations for specific DNA recognition: from at-rich to mixed-base-pair DNA sequences. Journal of Organic Chemistry, 2014, 79(3), 852-866. (As Featured Article, this work has been highlighted in ChemInform 2014, 45). (IF:4.638)
[7] Chai, Y., Munde, M., Kumar, A., Mickelson, L., Lin, S., Campbell, N. H., Banerjee, M., Akay, S., Liu, Z. Y., Farahat, A. A., Nhili, R., Depauw, S., David-Cordonnier, M. H., Neidle, S., Wilson, W. D., and Boykin, D. W. Structure dependent binding of arylimidamides to the DNA minor groove. ChemBioChem. 2014, 15(1), 68-79. (IF:3.74)
[8] Wang, S., Chai, Y., Babu, B., Satam, V., Lee, M., and Wilson, W. D. Conformational modulation of dna by polyamide binding: structural effects of f-ImPyIm based derivatives on 5’-ACGCGT-3’. Journal of Molecular Recognition, 2013, 26(8), 331-340.
[9] Liu, Y., Chai, Y., Kumar, A., Tidwell, R. R., Boykin, D. W., and Wilson, W. D. Designed compounds for recognition of 10 base pairs of DNA with two at binding sites. Journal of the American Chemical Society, 2012, 134(11), 5290-5299. (IF:10.677)
[10] Feng, L. S., Liu, M. L., Wang, S., Chai, Y., Li, S. J., and Guo, H. Y. Synthesis and in vitro antimycobacterial activity of moxifloxacin methylene and ethylene isatin derivatives. Chemical Research in Chinese Universities, 2012, 28(1), 61-66.
[11] Chai, Y. ^#, Liu, M. L. ^#, Lv, K., Feng, L. S., Li, S. J., Sun, L. Y., Wang, S., and Guo, H. Y. Synthesis and in vitro antibacterial activity of a series of novel gatifloxacin derivatives. European Journal of Medicinal Chemistry, 2011, 46(9), 4267-4273. (IF:3.193)
[12] Chai, Y., Wang, J., Liu, M. L., Yi, H., Sun, L. Y., You, X. F., and Guo, H. Y. Design, synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl) fluoroquinolone derivatives. Bioorganic & Medicinal Chemistry Letters, 2011, 21(11), 3377-3380. (IF:2.661)
[13] Arafa, R. K., Wenzler, T., Brun, R., Chai, Y., and Wilson, W. D. Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European Journal of Medicinal Chemistry, 2011, 46(12), 5852-5860.
[14] Wang, J. X., Zhang, Y. B., Liu, M. L., Wang, B., Chai, Y., Li, S. J., and Guo, H. Y. Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-4-amino-4-methylpiperidin -1-yl)flroroquinolone derivatives. European Journal of Medicinal Chemistry, 2011, 46(6), 2421-2426.
[15] Feng, L. S., Liu, M. L., Zhang, S., Chai, Y., Wang, B., Zhang, Y. B., Lv, K., Guan, Y., Guo, H. Y., and Xiao, C. L. Synthesis and in vitro antimycobacterial activity of 8-OCH3 ciprofloxacin methylene and ethylene isatin derivatives. European Journal of Medicinal Chemistry, 2011, 46(1), 341-348.
[16] Feng, L. S., Liu, M. L., Wang, S., Chai, Y., Lv, K., Shan, G. Z., Cao, J., Li, S. J., and Guo, H. Y. Synthesis of naphthyridone derivatives containing 8-alkoxyimino-1,6-dizaspiro[3.4] octane scaffolds. Tetrahedron, 2011, 67(43), 8264-8270.
[17] Chai, Y., Liu, M. L., Wang, B., You, X. F., Feng, L. S., Zhang, Y. B., Cao, J., and Guo, H. Y. Synthesis and in vitro antibacterial activity of novel fluoroquinolone derivatives containing substituted piperidines. Bioorganic & Medicinal Chemistry Letters, 2010, 20(17), 5195-5198. (IF:2.65)
[18] Wan, Z. L., Chai, Y., Liu, M. L., Guo, H. Y., and Sun, L. Y. Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-methyl-3-methylaminopiperidin-1-yl)quinolones. Yao Xue Xue Bao, 2010, 45(7), 860-868.
[19] Wang, J. X., Guo, Q., Chai, Y., Feng, L. S., Guo, H. Y., and Liu, M. L. Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperdin-1-yl)quinolone derivatives. Chinese Chemical Letters, 2010, 21(1), 55-58.
[20] Guo, Q., Feng, L. S., Liu, M. L., Zhang, Y. B., Chai, Y., Lv, K., Guo, H. Y., and Han, L. Y. Synthesis and in vitro antibacterial activity of fluoroquinolone derivatives containing 3-(N '-alkoxycarbamimidoyl)-4-(alkoxyimino) pyrrolidines. European Journal of Medicinal Chemistry, 2010, 45(11), 5498-5506.
[21] Feng, L. S., Liu, M. L., Wang, B., Chai, Y., Hao, X. Q., Meng, S., and Guo, H. Y. Synthesis and in vitro antimycobacterial activity of balofloxacin ethyleneisatin derivatives. European Journal of Medicinal Chemistry, 2010, 45(8), 3407-3412.
[22] Chai, Y. ^#, Wan, Z. L. ^#, Wang, B., Guo, H. Y., and Liu, M. L. (2009) Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives. European Journal of Medicinal Chemistry, 2009, 44(10), 4063-4069. (IF:3.269)
[23] Chai, Y., Wan, Z. L., Guo, H. Y., and Liu, M. L. (2009) tert-Butyl 3-carbamoyl-4-methoxy imino-3-methylpiperidine-1-carboxylate. Acta Crystallographica Section E Structure Reports Online, 2009, E65, o282. (IF:0.411)
[24] Wan, Z. L., Chai, Y., Liu, M. L., and Guo, H. Y. Improved synthesis of a gemiflo- xacin intermediate 4-(aminomethyl)pyrrolidin-3-one-O-methyloxime dihydrochlorIde. Chinese Journal of Medicinal Chemistry, 2009, 19, 109-111.
[25] Guo, Q., Chai, Y., Zhang, Y. B., Li, S. J., and Liu, M. L. Synthesis of a cefozopran intermediate (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid. Chinese Journal of Medicinal Chemistry, 2009, 19, 188-190.
[26] Chai, Y., Liu, B. Q., and Guo, H. Y. Recent advances in the study of structural modification and pharmacological activity of quinolones. Chinese Journal of New Drugs, 2007, 16, 1068-1074.