相册


基本信息 The basic information
姓名: 王万河

学院: 医学研究院


学历: 博士研究生毕业

学位: 哲学博士


职称: 副教授

职务:


学科: 药学,化学


邮箱: wanhewang1988@hotmail.com




工作经历 Work Experience
2019/12-至今 西北工业大学医学研究院 副教授
2014/10-2015/11 香港浸会大学 科研助理




教育经历 Education Experience
2015/12-2019/09 香港浸会大学 化学 哲学博士
2017/08-2017/08 Monash University（澳大利亚） 海外交流计划

2011/09-2014/06 吉林大学 药物化学 医学硕士
2007/09-2011/07 昆明理工大学 制药工程 工程学士



综合介绍 General Introduction
本课题组的研究围绕（1）有机过渡金属配合物类探针开发；（2）有机过渡金属配合物（铱（III）、铑（III）类）药物开发；（3）天然产物的虚拟药物筛选几个方面展开。目前，课题组负责人（https://scholar.google.com.hk/citations?user=0HgBuSEAAAAJ&hl=en）已在Angewandte Chemie International Edition, Chemical Science, Analytical Chemistry等知名国际期刊上发表SCI论文40余篇，以及申请专利2项（其中一项为PCT），其中以第一作者、共同一作发表20余篇（7篇被选为封面或封底文章），H-Index为20，单篇最高被引次数达100余次，总被引次数达1100余次。



学术成果 Academic Achievements
代表性成果：
After 2020

[1] W. Wang, K.-J. Wu, K. Vellaisamy, C.-H. Leung*, D.-L. Ma*. "Peptide-conjugated long-lived theranostic imaging toolbox fortargeting GRPr in cancer and immune cells ". Angew. Chem. Int. Ed., 2020, 59, 17897. (Impact factor: 12.959, Inside cover, 化学一区)
[2] W. Wang, T.-L. Yung, S.-S. Cheng, F. Chen, J.-B. Liu, C.-H. Leung, D.-L. Ma*. “A long-lived luminogenic iridium(III) complex for acetylacetone detection in environmental samples” Sens. Actuator B-Chem., 2020, 321, 128486. (Impact factor: 7.100, 化学一区)
[3] G.-J. Yang, W. Wang (co-first author), P.-M. Lei, C.-H. Leung*, D.-L. Ma*. "A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy". Int. J. Biol. Macromol., 2020, 164, 3204. (Impact factor: 5.162, 医学二区)
[4] S.-S. Cheng, G.-J. Yang, W. Wang, C.-H. Leung*, D.-L. Ma*. "The design and development of covalent protein-protein interaction inhibitors for cancer treatment". J Hematol Oncol., 2020, 13, 26. (Impact factor: 11.059, 医学一区)
[5] C. Wu, K.-J. Wu, J.-B. Liu, W. Wang, C.-H. Leung*, D.-L. Ma*. "Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect". Chem. Sci., 2020, DOI:10.1039/D0SC04576D. (Impact factor: 9.346, Front cover, 化学一区)
[6] K.-J. Wu, W. Wang, H.-M. David Wang, C.-H. Leung*, D.-L. Ma*. "Interfering with S100B-effector protein interactions for cancer therapy". Drug Discov. Today, 2020, 25, 1754. (Impact factor: 7.321, 医学二区)


Before 2020

[1] G.-J. Yang, W. Wang (co-first author), W.-F. S. Mok, C. Wu, Y.-K. B. Law, X.-M. Miao, K.-J. Wu, H.-J. Zhong, C.-Y. Wong, K.-W. V. Wong*, D.-L. Ma*, C.-H. Leung*. "Selective inhibition of lysine-specific demethylase 5A (KDM5A) using a rhodium(III) complex for triple-negative breast cancer therapy". Angew. Chem. Int. Ed., 2018, 57, 13091. (Impact factor: 12.959, Inside back cover, 化学一区)
[2] W. Wang, K. Vellaisamy, G. Li, C. Wu, C.-N. Ko, C.-H. Leung*, D.-L. Ma*. "Development of a long-lived luminescence probe for visualizing β-galactosidase in ovarian carcinoma cells". Anal. Chem., 2017, 89, 11679. (Impact factor: 6.785, 化学一区)
[3] W. Wang, Z. Mao, M. Wang, L.-J. Liu, D. W. J. Kwong, C.-H. Leung, D.-L. Ma*. “A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al³⁺ ions” Chem. Commun., 2016, 52, 3611. (Impact factor: 5.996, Inside front cover, 化学一区，高被引文章)
[4] L.-J. Liu, W. Wang (co-first author), S.-Y. Huang, Y. Hong, G. Li, S. Lin, J. Tian, Z. Cai, H.-M. D. Wang, D.-L. Ma*, C.-H. Leung. “Inhibition of the ras/raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound” Chem. Sci., 2017, 8, 4756. (Impact factor: 9.346, Inside back cover, 化学一区)

[5] K. Vellaisamy, G. Li, W. Wang (co-first author), C.-H. Leung,* D.-L. Ma*. “A long-lived peptide-conjugated iridium(III) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2” Chem. Sci., 2018, 9, 8171. (Impact factor: 9.346, Front cover, 化学一区)
[6] W. Wang, C. Yang, S. Lin, K. Vellaisamy, G. Li, W. Tan, C.-H. Leung, D.-L. Ma*. “First synthesis of an oridonin-conjugated iridium(III) complex for the intracellular tracking of NF-κB in living cells” Chem. Eur. J., 2017, 23, 4929. (Impact factor: 4.857, 化学二区)
[7] W. Wang, C. Yang, G. Li, Y.-C. Tse, C.-H. Leung, D.-L. Ma*. “An iridium(III) complex-based chemosensor for the detection of thiourea in living cells” Sens. Actuator B-Chem., 2017, 251, 374. (Impact factor: 7.100, 化学一区)
[8] W. Wang, C. Wu, C. Yang, G. Li, Q.-B. Han, S. Li, M.-Y. Lee, C.-H. Leung, D.-L. Ma*. "A dual-functional luminescent probe for imaging H₂S in living zebrafish and discrimination hypoxic cells from normoxic cells". Sens. Actuator B-Chem., 2018, 255, 1953. (Impact factor: 7.100, 化学一区)
[9] W. Wang, L. Lu, C. K.-J. Wu, J. Liu, C.-H. Leung, C.-Y. Wong, D.-L. Ma*. "Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells". Sens. Actuator B-Chem., 2019, 288, 392. (Impact factor: 7.100, 化学一区)

[10] C. Yang, W. Wang (co-first author), J. Liang, G. Li, K. Vellaisamy, C.-Y. Wong, D.-L. Ma*, C.-H. Leung. “A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells” J. Med. Chem., 2017, 60, 2597. (Impact factor: 6.205, 医学一区)


代表性专利：
[1] 喹唑啉类化合物、其中间体、制备方法、药物组合物和应用, 柏旭, 余建鑫, 王万河, 张永, 郑连友, 夏广新, 张春玲, 王余吉, 周倩, 张大鹏（CNA）, 2017/01/11.
[2] Quinazoline compound, intermediate, preparation method, pharmaceutical composition and uses thereof, 柏旭, 余建鑫, 王万河, 张永, 郑连友, 夏广新, 张春玲, 王余吉, 周倩, 张大鹏（WOA1）, 2017/01/12.





荣誉获奖 Awards Information
2017 中国分析测试协会科学技术三等奖（中国分析测试协会）
2017 亚坤内地研究生奖学金计划（香港浸会大学）




招生信息 Admission Information
课题组硕士研究方向：
A. 小分子荧光探针开发；

B. 有机金属配合物（铱、钌等）的发光机理研究及其探针开发；
C. 有机金属配合物（铱、钌、铑等）和生物大分子的作用方式研究及其抗癌药物开发；
D. 计算机辅助药物设计（ICM）及天然产物类药物发现。

硕士期间，课题组提供海外交流机会，表现优秀者，可推荐至海外高校攻读博士。



欢迎各位有志学子报考我院硕士研究生！
接受推免生

欢迎广大化学、药学背景的有志学子加入本课题组！
联系方式：wanhewang1988@hotmail.com/whwang0206@nwpu.edu.cn




学术活动 Professional Activities
2017 香港浸会大学研究生核心课程-科研技能专题讨论会 特邀嘉宾
2017 5^th MacroTrend Conference on Applied Science: Paris 2017会议口头报告"Iridium complex-based probe for visualizing β-galactosidase in ovarian carcinoma cells", 法国巴黎







English Version