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基本信息 The basic information
姓名: 段佳林

学院: 医学研究院


学历: 博士研究生毕业

学位: 医学博士


职称: 副教授

职务:


学科:


邮箱: dogson1989@163.com

电话: **




工作经历 Work Experience
2021/1-至今，西北工业大学，医学研究院，副教授
2017/9-2020/12，第四军医大学，第一附属医院药学部，主管药师
2011/7 -2017/8，第四军医大学，第一附属医院药学部，药师





教育经历 Education Experience
2017/9-2020/7，西北大学，中药药理专业，博士研究生，导师：乔博灵
2014/9-2017/7，陕西中医药大学，中药药理专业，硕士研究生，导师：张恩户
2007/9-2011/7，蚌埠医学院，药学系，学士





招生信息 Admission Information
招生专业：
硕士研究生：分子药理学、基础药理学、中药药理学


研究方向：
心脑血管保护药物筛选和作用机制研究
* 欢迎具有基础医学、药学、中药学等学习背景的同学和从业者报考硕士研究生。



荣誉获奖 Awards Information
段佳林（1/7），太白楤木皂苷药理学研究及应用，2017年陕西省第三届研究生创新成果奖一等奖，2017
段佳林（4/9），秦巴山区特产药材太白楤木药理学研究及应用，2016年陕西省科技进步奖二等奖，2016
段佳林，2016年春季共青团中央中国光华科技基金会医学奖学金，共青团中央中国光华科技基金会，2016





科学研究 Scientific Research
研究简介：

主要从事心脑血管治疗药效物质筛选及作用机制研究，结合地域优势，揭示了陕西特产药材太白楤木皂苷中的活性成分竹节参皂苷IVa对糖尿病心肌病及糖尿病脑病的的治疗作用，参与申请国家发明专利4项。目前发表论文43篇，其中SCI收录30篇，第一或共同第一作者26篇，IF>5分7篇（按当年影响因子计）；获得2016年陕西省科技进步奖二等奖（第四）和2017年陕西省第三届研究生创新成果奖一等奖；研究论文获得全国活性氧生物学效应专委会学术会议优秀论文一等奖、2015中国药学大会暨第十五届中国药师周优秀论文二等奖等学术奖项。
承担项目：
国家自然科学基金青年项目，**，秦巴太白楤木皂苷调控Apelin13/Akt/Sox2通路促神经血管新生治疗缺血性脑卒中的机制研究，2020.1-2022.12，21万元，主持





学术成果 Academic Achievements
(1)Jialin Duan^#, Jia Cui^#, Zhifu Yang^#, Chao Guo^#, Jinyi Cao^#, Miaomiao Xi, Yan Weng, Ying Yin, Yanhua Wang, Guo Wei, Boling Qiao^*, Aidong Wen^* Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling. Journal of Neuroinflammation, 2019, 16(1):24.
(2)Jialin Duan^#, Jia Cui^#, Hongnan Zheng^#, Miaomiao Xi^#, Chao Guo^#,Yan Weng,Ying Yin, Guo Wei, Jinyi Cao, Yanhua Wang, Aidong W^en*, and Boling Qiao^*. Aralia taibaiensis Protects against I/R-Induced Brain CellInjury through the Akt/SIRT1/FOXO3a Pathway. Oxidative Medicine and Cellular Longevity, 2019, **.
(3)Chao Guo^#, Junrong Zhu^#, Jingwen Wang^#, Jialin Duan^#, Shanbo Ma^#, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen^*, Yingdong Zhang^*. Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson’s disease. Aging (Albany NY). 2019; 11:9424-9441.
(4)Fei Li^#, Jialin Duan^#, Meina Zhao^#, Shaojie Huang^#, Fei Mu, Jing Su, Kedi Liu, Yang Pan, Xinming Lu, Jing Li, Peifeng Wei^*, Miaomiao Xi^*, Aidong Wen^*. A network pharmacology approach to reveal the protective mechanism of Salvia miltiorrhiza-Dalbergia odorifera coupled-herbs on coronary heart disease. Sci Rep 9, 19343 (2019)
(5)YanWeng, JingwenWang, ZhifuYang, MiaomiaoXi, JialinDuan, ChaoGuo, YingYin, RyosukeSegawa, TakahiroMoriya, TakayukiYonezawa, Byung YoonChacJe-TaeWoo, AidongWen^*, NoriyasuHirasawa^*. A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes.Cell Signal. 2019, pii: S0898-6568(19)30008-7.
(6)Rui Lin^#,Jialin Duan^#, Fei Mu^#, Haixu Bian, Meina Zhao, Min Zhou, Yao Li, Aidong Wen, Yong Yang^*, Miaomiao Xi^*. Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. Int J Mol Med. 2018, 42(5):2628-2640.
(7)Haixu Bian^#, Qiaoli Yang^#, Tao Ma^#, Wei Li^#,Jialin Duan^#, Guo Wei, Xiaoxiao Wu, Fei Mu, Rui Lin, Aidong Wen^*, Miaomiao Xi^*.Beneficial effects of extracts from Lucilia sericata maggots on burn wounds in rats.Mol Med Rep. 2017, 16(5):7213-7220.
(8)YingYin^#, JialinDuan^#, ChaoGuo^#, GuoWei^#, YanhuaWang, YueGuan, FeiMu, MinnaYao, MiaomiaoXi^*, AidongWen^*.Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis.Eur J Pharmacol. 2017, 814:274-282.
(9)Fei Mu^#, Jialin Duan^#, Haixu Bian, Ying Yin, Yanrong Zhu, Guo Wei, Yue Guan, Yanhua Wang, Chao Guo, Aidong Wen, Yong Yang^*, Miaomiao Xi^*. Cardioprotective effects and mechanism of Radix Salviae miltiorrhizae and Lignum Dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury.Mol Med Rep. 2017, 16(2):1759-1770.
(10) Chao Guo^#, Yongyuan Ma^#, Shanbo Ma^#, Fei Mu^#, Jiao Deng, Jialin Duan, Lize Xiong, Ying Yin, Yanhua Wang, Miaomaio Xi^*,Aidong Wen^*.The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury.Sci Rep. 2017, 8;7(1):3039.
(11) Jialin Duan^#, Yue Guan^#, Fei Mu^#, Chao Guo^#, Enhu Zhang^#, Ying Yin, Guo Wei, Yanrong Zhu, Jia Cui, Jinyi Cao, Yan Weng, Yanhua Wang, Miaomiao Xi^*, Aidong Wen^*.Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017, 7:41491.
(12) Chao Guo^#, Shiquan Wang^#, Jialin Duan^#, Na Jia^#, Yanrong Zhu, Yi Ding, Yue Guan, Guo Wei, Ying Yin, Miaomaio Xi^*, Aidong Wen^*. Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway.Mol Neurobio2017 , 54(2):833-845.
(13) GuoWei^#, YingYin^#, JialinDuan^#, ChaoGuo, YanrongZhu, YanhuaWang, MiaomiaoXi^*, AidongWen^*. Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1α cascade.Biomed Pharmacother. 2017, 88:409-420.
(14) Fei Mu^#, Jialin Duan^#, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen^*, Miaomiao Xi^*.Metabonomic Strategy to the Evaluation of Chinese Medicine Salvia miltiorrhiza and Dalbergia odorifera Interfering Myocardial Ischemia/Reperfusion Injury in Rats.Rejuvenation Res. 2017. doi: 10.1089/rej.2016.1884.
(15) Naping Hu^#, Jialin Duan^#, Huihui Li^#, Yanhua Wang^#, Fang Wang^#, Jianjie Chu, Jin Sun, Meiyou Liu, Chao Wang, Chengtao Lu^*, Aidong Wen^*. Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition. PLoS One. 2016, 11(4):e**.
(16) Jialin Duan^#, Ying Yin^#, Jia Cui^#, Jiajia Yan^#, Yanrong Zhu^#, Yue Guan, Guo Wei, Yan Weng, Xiaoxiao Wu, Chao Guo, Yanhua Wang, Miaomiao Xi^*, Aidong Wen^*.Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3 β Pathway In Vivo and In Vitro. Mol Neurobio 2016, 53(1):728-43.
(17) Jialin Duan^#, Ying Yin^#, Guo Wei^#, Jia Cui^#, Enhu Zhang^#, Yue Guan, Jiajia Yan, Chao Guo, Yanrong Zhu, Fei Mu, Yan Weng, Yanhua Wang, Xiaoxiao Wu, Miaomiao Xi^*, Aidong Wen^*. Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway.Sci Rep. 2015, 5:18123.
(18) Jialin Duan ^#, Guo Wei ^#, Chao Guo^#, Jia Cui ^#, Jiajia Yan ^#, Ying Yin, Yue Guan, Yan Weng, Yanrong Zhu, Xiaoxiao Wu, Yanhua Wang, Miaomiao Xi^*, Aaidong Wen^*. Aralia taibaiensis Protects Cardiac Myocytes against High Glucose-Induced Oxidative Stress and Apoptosis.Am J Chin Med. 2015, 43(6):1159-1175.
(19) JiaCui^#, MiaomiaoXi^#, YuwenLi^#, JialinDuan^#, LeiWang^#, YanWeng, NaJia, ShanshanCao, RuiliLi, ChaoWang, ChaoZhao, YinWu^*, AiDongWen^*. Characterization of Chikusetsu saponin IVa -induced insulin secretion in pancreatic β-cells. J Ethnopharmacol. 2015, 164:334-9.
(20) Jiajia Yan^#,Jialin Duan^#, Xiaoxiao Wu^#, Chao Guo, Ying Yin, Yanrong Zhu, Tianxin Hu, Guo Wei, Aidong Wen^*, Miaomiao Xi^*.Total saponins from Aralia taibaiensis protect against myocardial ischemia/reperfusion injury through AMPK pathway.Int J Mol Med. 2015, 36(6):1538-46.
(21) Yue Guan^#, Yan Cheng^#, Ying Yin^#, Jialin Duan^#, Guo Wei^#, Yan Weng, Chao Guo, Yanrong Zhu, Yanhua Wang, Miaomiao Xi^*, Aidong Wen^*. A novel animal model of impaired glucose tolerance induced by the interaction of vitamin E deficiency and (60)Co radiation.Biomed Res Int. 2015, 2015:457246.
(22) ChaoGuo^#, YingYin^#, JialinDuan^#, YanrongZhu^#, JiajiaYan, GuoWei, YueGuan, XiaoxiaoWu, YanhuaWang, MiaomaioXi^*, AidongWen^*. Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats.Phytomedicine. 2015, 22(2):283-9.
(23) Yue Guan ^#, Xiaoxiao Wu ^#, Jialin Duan^#, Ying Yin, Chao Guo, Guo Wei, Yanhua Wang, Yanrong Zhu, Yan Weng, Miaomiao Xi^*, Aidong Wen ^*. Effects and Mechanism of Combination of Rhein and Danshensu in the Treatment of Chronic Kidney Disease.Am J Chin Med. 2015, 43(7):1381-400.
(24) YanWeng^#, LuYu^#, JiaCui^#, YanRongZhu^#, ChaoGuo^#, GuoWei, JiaLinDuan, YingYin, YueGuan, YanhuaWang, ZhiFuYang, MiaomiaoXi^*, AidongWen^*. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. Journal of Ethnopharmacology, 2014, 152(3):553-560.
(25) Jialin Duan^#, Jingwen Wang^#, Yue Guan^#, Ying Yin^#, Guo Wei^#, Jia Cui, Dan Zhou, Yanrong Zhu, Wei Quan, Miaomiao Xi^*, Aidong Wen^*. Protective effects of Safflor yellow A on anoxia/reoxygenation injury in neonatal rat cardiomyocytes. Acta Pharmacologica Sinica. 2013, 34(4):487-95.
(26) YingYin^#, YueGuan^#, JialinDuan^#, GuoWei^#, YanrongZhu, WeiQuan, ChaoGuo, DanZhou, YanhuaWang, MiaomiaoXi^*, AidongWen^*. Cardioprotective effect of Danshensu against myocardialischemia/reperfusion injury and inhibits apoptosis of H9c2cardiomyocytes via Akt and ERK1/2 phosphorylation. European Journal of Pharmacology. 2013, 699(1-3):219-26.
(27) Guo Wei^#, Yue Guan^#, Ying Yin^#, Jialin Duan^#, Dan Zhou, Yanrong Zhu, Wei Quan, Miaomiao Xi^*, Aidong Wen^*. Anti-in？ammatory Effect of Protocatechuic Aldehyde on Myocardial Ischemia/Reperfusion InjuryIn Vivo and In Vitro. Inflammation. 2013, 36(3):592-602.
(28) JiaCui^#, YuwenLi^#, NaJia^#, XiaomeiSong, JialinDuan, YanWeng, YueGuan, DanZhou, LeiWang, MiaomiaoXi^*, AidongWen^*. The effects of eleven plants traditionally used in China on the insulin secretion of βTC3 cells and identification of the active ingredients. Life sci. 2013, 2(92): 131-136.
(29) NaJia^#, WeiChu^#, YuwenLi^#, LikunDing,JialinDuan, JiaCui, ShanshanCao, ChaoZhao,YinWu^*, AidongWen^*. Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats.J Ethnopharmacol. 2016, 189:1-9.
(30) Yue Guan^#, Ying Yin^#, Yanrong Zhu^#, Chao Guo^#, Guo Wei, Jialin Duan, Yanhua Wang, Dan Zhou, Wei Quan, Yan Weng, Miaomiao Xi^*, Aidong Wen^*. Dissection of mechanisms of a chinese medicinal formula: danhong injection therapy for myocardial ischemia/reperfusion injury in vivo and in vitro.Evidence-based complementary and alternative medicine : eCAM, 2013, 2013(8):972370.
(31) 段佳林，奚苗苗，牟菲，蔺瑞，赵美娜，卫国，文爱东，张恩户^*. 紫铆花素通过调节AMPK/GSK-3β信号通路抑制心肌缺血再灌注损伤. 现代生物医学进展, 2017, 17(14):2616-2621.
(32) 卫国, 殷英, 段佳林, 梁凌飞, 文爱东^*. 丹红注射液中5种主要活性成分促血管新生作用研究. 现代生物医学进展, 2017, 17(17):3230-3233.
(33) 卫国, 段佳林, 殷英, 王艳华，文爱东^*. 丹参素和羟基红花黄色素A促血管新生及抗大鼠心肌梗死作用研究. 时珍国医国药, 2016(11):2576-2578.
(34) 蔺瑞, 段佳林, 牟菲, 边海旭, 赵美娜, 文爱东, 奚苗苗^*. 丹参主要活性成分体内代谢途径及产物研究进展. 中国新药杂志, 2017(19):2271-2277.
(35) 赵美娜, 段佳林, 牟菲,蔺瑞, 奚苗苗^*. 液质联用技术检测脂肪酸的研究进展. 中国新药杂志, 2017(19):2278-2284.
(36) 牟菲，段佳林，边海旭，蔺瑞，尚沛津，朱志会，文爱东，奚苗苗^*. 降香水提物和挥发油对心肌缺血/再灌注损伤大鼠预防作用的代谢组学研究. 中国药理学通报, 2016, 32(10):1377-1382.
(37) 奚苗苗, 段佳林, 郭超,关月，殷英，朱艳荣，卫国，王艳华，翁琰，文爱东^*. EBL、CBL、PBL综合教学法在药事管理学教学中的应用. 药学教育, 2016, 32(2):43-46.
(38) 王艳华, 段佳林, 卫国,朱艳荣，殷英，郭超，关月，奚苗苗，文爱东，翁琰*. 脂溶性蟾毒配基的纯化工艺研究. 中国民族民间医药, 2016, 25(13):15-17.
(39) 殷英, 卫国, 王艳华, 牟菲，段佳林，郭超，关月，朱艳荣，奚苗苗，文爱东^*. 丹红注射液促进心梗模型大鼠缺血心肌血管新生. 中成药, 2016, 38(9):1893-1897.
(40) 关月, 卫国, 段佳林,殷英，郭超，朱艳荣，王艳华，奚苗苗，文爱东^*. 心肌缺血/再灌注的保护机制RISK信号通路的影响因素. 中国新药杂志, 2016(19):2211-2217.
(41) 牟菲，段佳林，文爱东，奚苗苗^*. 代谢组学在中药治疗冠心病的药效物质及作用机制研究中的应用. 中国新药杂志. 2015, 19: 2197-2202.
(42) 闫佳佳，伍晓晓，段佳林，文爱东，奚苗苗^*. 楤木皂苷对大鼠心肌缺血/再灌注损伤的保护作用.现代生物医学进展. 2015, 15: 2829-2832.
(43) 伍晓晓, 卫国, 关月, 闫佳佳，段佳林，殷英，郭超，朱艳荣，奚苗苗，文爱东^*. 大黄酸和迷迭香酸单用及配伍对慢性肾脏疾病的保护作用研究. 现代生物医学进展, 2015, 15(13):2432-2435.
(44) 刘维, 奚苗苗, 孙静, 李锐，张艳妮，王安辉，段佳林，刘俊，周新民，尹芳，董旭旸，刘芳娥^*. 应用自配口腔护理液防治重型肝炎病人口腔感染的效果研究. 护理研究, 2015(6):711-713.
(45) 翁琰，张玲琴，卫国，段佳林，关月，奚苗苗，文爱东^*. 太白楤木根皮的质量标准研究. 时珍国医国药. 2014, 2: 263-264.
(46) 段佳林, 杨静, 曹军, 卫国, 昌翠, 奚苗苗, 吴寅, 沈敏, 文爱东^*. 癫痫患者血清与唾液中卡马西平浓度的相关性研究.中国药房. 2011, 37(22): 3483-3485.





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