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基本信息 The basic information
姓名: 张瑞雪

学院: 医学研究院


学历: 博士研究生毕业

学位: 理学博士


职称: 副教授

职务:


学科: 药学


邮箱: zhangruixue@nwpu.edu.cn




招生信息 Admission Information
招生类型
硕士研究生、本科三或四年级学生
请将个人简历(CV)、个人陈述（personal statement)以及成绩单发送至zhangruixue@nwpu.edu.cn
招生背景

药学、化学工程、材料科学、分子生物学、有机化学、基础医学
招生录取联系方式

西北工业大学医学研究院
网页：https://imr.nwpu.edu.cn/index.htm
地址：陕西省西安市友谊西路127号，710072；



教育教学 Education And Teaching
1、本科专业核心课程
《分子生物》、《分子生物学实验》
2、研究生课程
《高等药剂学》、《肿瘤纳米医疗的应用研究进展》
3、国际合作交流课程
多伦多大学Leslie Dan 药学院制药科研实践2018年、2018微信版、2019年、2019微信版



科学研究 Scientific Research

张瑞雪副教授长期致力于研究基于纳米技术的递药体系。通过理性筛选及组合脂质材料、食品工业改良蛋白及多糖，设计构建具有生物相容性可降解的稳定纳米药物载体和制剂，以适用于不同给药途径，从而解决生物制药分类系统中药物在预防和治疗慢性、复发性疾病的问题。目前，研究集中在针对消化系统疾病及生理特点，评估可用于增强药物生物利用率、降低药物毒性，具有修复功能的纳米药物。研究内容主要包括：a)具有协同效应的联合纳米药物的可控释放；b) 脂质和生物聚合物纳米材料在代谢动力、细胞和分子水平的作用机制；c) 提高药物生物利用率的递送方案。
张瑞雪副教授持续在医药学门类期刊发表科研论文，包括Journal of Controlled Release, Nanomedicine-Nanotechnology Biology and Medicine, Nanoscale, Advanced Functional Materials, Nature communications等。2016年同时获得具有国际声望的药物递送奖-CSPS Gattefossé Canada Lipid-based Drug Delivery Award和国家留学基金委颁发的全球500名国家优秀留学生奖。目前主持国家自然科学基金1项、合作主持陕西省重点研发项目1项、国家外国文教专家项目1项。已结题西北工业大学科研部中央高校基础科研基金2项，参与加拿大国立卫生研究院（CIHR）与加拿大乳腺癌基金会（CBCF）研发计划课题2项。



Left: Polymer-lipid hybrid nanoparitcles (PLN) deliver drugs with various properties to their nanoscale targets. Reproduced fromZhang et al.,Nanoscale, 9 (2017) 1334-1355, with permission from the Royal Society of Chemistry. Right:Nanocarriers for ratio-metric delivery of synergisitic drug combination for cancer treatment.ReproducedfromZhang et al.,Journal of Controlled Release, 240(2016) 489-503, with permission from Elsevier. B.V.



学术成果 Academic Achievements
^# 并列第一作者；^* 通讯作者

2021年


2020年
- Chong Chen, Cheng Zhang, Rui Xue Zhang, Xingrong Ju, Rong He, Zhigao Wang*, Enzyme-catalyzed acylation improves Gel Properties of Rapeseed Protein Isolates, J. Sci. Food Agric., 2020. 100, 4182-4189. Link


2019年
- Hujing Lu, Yaguang Li, Sepideh Pakpour, Sufang Wang, Qingxia Wei, Zhenhong Pan, Junhong Liu, Junjun She, Huaixing Cang*, Rui Xue Zhang*, Dose Effects of Orally Administering Spirulina Suspension on Colonic Microbiota in Healthy Mice, Front. Cell. Infect. MI., 2019. 9, 243-256. Link
- Yaguang Li, Junhong Liu, Gaixia Liu, Zhenhong Pan, Mingxia Zhang, Yao Ma, Qingxia Wei, Hongping Xia, Rui Xue Zhang*, Junjun She*, Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch, J. Vis. Exp., 2019. 150, e59921-e59931. Link
- Zhigao Wang, Rui Xue Zhang, Cheng Zhang, Caixia Dai, Xingrong Ju*, Rong He*, Fabrication of Stable and Self-assembling Rapeseed Protein Nanogel for Hydrophobic Curcumin Delivery, J. Agric. Food Chem., 2019. 67, 887-894. Link
- Ting Huyan, Yongyong Du, Dandan Dong, Qi Li,Rui Xue Zhang, Jiancheng Yang, Zhouqi Yang, Jingbao Li*, Peng Shang*, Osteoclast-derived Exosomes Inhibit Osteogenic Differentiation Through Wnt/β-catenin Signaling Pathway in Simulated Microgravity Model,Acta Astronaut., 2019. 154: 140-152. Link


2018年
- Zhigao Wang^#, Rui Xue Zhang^#, Tian Zhang, Chunsheng He, Rong He, Xingrong Ju*, Xiao Yu Wu*, In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer, ACS Appl. Mater. Interfaces, 2018. 10(48): 41056-41069. Link

- Rui Xue Zhang, Jason Li,Tian Zhang, Mohammad A. Amini, Chunsheng He, Brian Lu, TaksimAhmed,HoYin Lip, Andrew M. Rauth, Xiao Yu Wu*, Importance of Integrating Nanotechnology with Pharmacology and Physiology for Innovative Drug Delivery and Therapy – An Illustration with Firsthand Examples,Acta. Pharmacol. Sin., 2018.39: 825-844. Link^{(2020年 Nature APS 杰出贡献论文奖)}



2017年
- Rui Xue Zhang^#, Lily YiLi^#, Jason Li, Zhengsong Xu, Azhar Z. Abbasi, Lucy Lin, Mohammad A. Amini, Weiyu Weng, Yu Sun, Andrew M. Rauth, XiaoYu Wu^*, Coordinating Bio-Interaction and Bio-Reaction of aNanocarrier Material and an Anticancer Drug to Overcome Membrane Rigidity andTarget Mitochondria in Multidrug-Resistant Cancer Cells, Adv. Funct. Mater., 2017, 27(39): 170. Link

- Rui Xue Zhang, TaksimAhmed, Lily Yi Li, Jason Li, Azhar Z. Abbasi, Xiao Yu Wu^*, Design ofNanocarriers for Nanoscale Drug Delivery to Enhance Cancer Treatment UsingHybrid Polymer and Lipid Building Blocks, Nanoscale, 2017, 9: 1334-1355.Link^{(2017年web of science 高被引)}
- Rui XueZhang, Tian Zhang, King Chen, Ji Cheng, Pairs Lai, Andrew M. Rauth, K. Sandy Pang, Xiao Yu Wu^*, Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-Bearing Mice,J. Vis. Exp., 2017. 128 (e56159): 1-13. Link



2016年
- Rui XueZhang, Ping Cai, Tian Zhang, King Chen, Jason Li, Ji Cheng, K. Sandy Pang, Hibret A. Adissu, Andrew M. Rauth, Xiao Yu Wu^*, Polymer-Lipid Hybrid Nanoparticles Synchronize Pharmacokinetics of Co-encapsulated Doxorubicin-Mitomycin C and Enable Their Spatiotemporal Co-delivery and Local Bioavailability in Breast Tumor,Nanomedicine-Nanotechnol., 2016, 12: 1279-1290. Link
- Rui XueZhang^#, Ho Lun Wong^#, Hui Yi Xue, June Young Eoh, Xiao Yu Wu^*, Nanomedicine of Synergistic Drug Combinations for Cancer Therapy - Strategies and Perspectives, J. Control. Release., 2016, 240: 489-503. Link^{(2019年web of science 高被引)}


2016年之前
- Adam J. Shuhendler^#, PreethyPrasad^#, Rui Xue Zhang^#, Mohammad A. Amini, Mei Sun, Peter P. Liu, Robert G. Bristow, Andrew M.Rauth, Xiao Yu Wu^*, Synergistic Nanoparticulate Drug CombinationOvercomes Multidrug Resistance, Increases Efficacy, and Reduced Cardiotoxicityin a Non-immunocompromised Breast Tumor Model. Mol. Pharmaceut., 2014, 11:2659-2674. Link
- Jan D. Huizinga^*, Ji-Hong Chen, Yong Fang Zhu, Andrew Pawelka, Ryan J. McGinn, Berj L. Bardakjian, Sean P. Parsons, Wolfgan A. Kunze, Richard You Wu, Premysl Bercik, Amir Khoshdel, Sifeng Chen, Sheng Yin, Qian Zhang, Yuanjie Yu, Qingmin Gao, Kongling Li, Xinghai Hu, Natalia Zarate, Phillip Collins, Marc Pistilli, Junling Ma,Rui Xue Zhang, David Chen, The Origin of Segmentation Motor Activity in the Intestine,Nat. Commun., 2014, 5: 3326-3337.Link

- Rui Xue Zhang, Xuan Yu Wang, David Chen,Jan D. Huizinga^*, Role of Interstitial Cells of Cajal in theGeneration and Modulation of Motor Activity Induced by CholinergicNeurotransmission in the Stomach, Neurogastroent. Motil., 2011, 23: e356-371. Link




团队信息 Team Information






教育经历 Education Experience
2009.09 - 2016.08 博士学位
加拿大，多伦多大学，药学院，制药科学专业
2007.09 - 2009.08 硕士学位
加拿大，麦克马斯特大学，医学院，医药科学专业
2003.09 - 2007.08 学士学位
加拿大，麦克马斯特大学，生命科学院，分子生物学专业




工作经历 Work Experience
2019.05 - 至今 副教授
中国，西北工业大学，医学研究院

2017.12 - 2019.04 副教授
中国，西北工业大学，生命学院
2016.09 - 2017.10 博士后

加拿大，多伦多大学，药学院，Xiao Yu (Shirley) Wu 教授课题组，Advanced Pharmaceuticsand Drug Delivery Laboratory
2010.01 - 2015.04教学助理 (本科生实验课程)
加拿大，多伦多大学，药学院，Christine Allen教授和 David Dubins 教授的药物分析系列课程
2007.09 - 2009.04教学助理 (本科生理论课程)
加拿大，麦克马斯特大学，医学院，护理部，人体生物化学
2006.05 - 2007.04科研助理
加拿大，麦克马斯特大学，生命科学院，Radley Gupta 教授课题组






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