山东理工大学农业工程与食品科学学院导师教师简介-张怀渊

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教师信息

	张怀渊		男		1987 年 04 月
	讲师		无		群众
		食品科学与工程
		食品科学
		硕士研究生导师
		山东省生态农业泰山产业人才团队核心成员

起止时间		学校		专业		学位	学历
2011.09-2015.01		江南大学		食品科学		博士	博士研究生
2008.09-2011.06		中南大学		生物化学与分子生物学		硕士	硕士研究生
2004.09-2008.06		中南大学		生物科学		学士	本科

起止时间		单位					职务/职称
2015.07-今		山东理工大学-农业工程与食品科学学院					讲师



本科生课程：食品工程原理、80 学时食品工程原理课程设计、32 学时研究生课程：脂质生物化学、32 学时

研究方向 1. 微生物油脂研究 2. 食品生物技术 3.食品发酵工程

1. 山东省自然科学基金博士基金，ZR**0098，柠檬酸转运蛋白在耶氏解脂酵母油脂积累中的作用机制研究，2018/03-2020/12，9 万元，在研，主持

2. 国家自然科学基金面上项目，**，AMPD、AMPK 对产脂真菌卷枝毛霉脂质积累的协同调控作用及其分子机制，2020/01-2023/12，58 万元，在研，参加

3. 国家自然科学基金面上项目，**，柠檬酸转运体系在产脂真菌卷枝毛霉油脂积累中的作用及机制研究，2017/01-2020/12，62 万元，在研，参加

4. 山东省泰山产业领军人才项目，卷枝毛霉细胞工厂高效转化秸秆生产伽马-亚麻酸、十八碳四烯酸技术开发，2017/01-2021/12，300 万元，在研，参加

5. 国家自然科学基金面上项目，**，高山被孢霉ω-6/ω-3 脂肪酸代谢流调控“分子开关”的分子改造及其机制研究，2013/01-2016/12，77 万元，已结题，参加

6.863 计划子课题，2012AA022105C，功能性脂质生物合成微生物基因组及分子改造，2012/11-2015/12，

50 万元，已结题，参加

7. 国家自然科学基金面上项目，**，人类 AUTOTAXIN 催化 LPA∕ｃPA 生成的"分子开关"调控机理，2011/01-2013/12，35 万元，已结题，参加

一、论文

1. Huaiyuan Zhang#, Xinxin Kang#, Na Xiao, Meng Gao,Yanlei Zhao, Yuanda Song*. Intracellular Expression of Vitreoscilla Hemoglobin Improves LipidProduction in Yarrowia lipolytica. Lett Appl Microbiol. 2019 Mar;68(3):248-257.

2. ZhangLuning#, Zhang Huaiyuan#, Song Yuanda. Identification and Characterizationof Diacylglycerol Acyltransferase from Oleaginous Fungus Mucor circinelloides. J Agric Food Chem. 2018,24;66(3):674-681.( Co-first author)

3. Huaiyuan Zhang#, Yongshuang Zhou, Haiqin Chen, YongQ. Chen and Yuanda Song.Enhanced Fatty Acid Production in Escherichia coli by Over-Expression of NADPHGenerating Enzymes. American Journal of Biochemistry and Biotechnology 2017, 13(4): 167.175

4. Zhang Huaiyuan#, Wu Chao, Wu Qingyu,Dai Junbiao*, Song Yuanda*. MetabolicFlux Analysis of Lipid Biosynthesis in the YeastYarrowia lipolytica Using13C-Labled Glucose and Gas Chromatography-Mass Spectrometry. PLoS One. 2016 Jul 25;11(7):e**.

5. Mo Qiuyan#,Zhang Huaiyuan#, Liu Qin, TangXin, Zhao Lina, Zan Xinyi, Song Yuanda*.Enhancing nosiheptide production in Streptomyces actuosus byheterologous expression of haemoprotein from Sinorhizobium meliloti. Lett ApplMicrobiol. 2016 Jun;62(6):480-7. (co-firstauthor)

6. Huaiyuan Zhang#, Luning Zhang, Haiqin Chen, Yong Q. Chen, Colin Ratledge, Yuanda Song*, Wei Chen*. Regulatory properties of malic enzyme in theoleaginous yeast, Yarrowia lipolytica,and its non-involvement in lipid accumulation. Biotechnology Letters (2013) 35:2091–2098.

7. Huaiyuan Zhang#, Luning Zhang, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*,Colin Ratledge. Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expresssion of ATP:citrate lyase from Mus musculus.Journal of biotechnology. (2014) 192:78-84.

8. Khan MAK, Yang J, Hussain SA, Zhang Huaiyuan, Liang L, GarreV, Song Yuanda*. Construction of DGLA producing cell factory by geneticmodification of Mucor circinelloides. Microb Cell Fact. 2019 Apr 3;18(1):64.

9. Khan MAK, Yang J, Hussain SA, Zhang Huaiyuan, Garre V, SongYuanda*. Genetic Modification ofMucor circinelloides to Construct Stearidonic Acid Producing Cell Factory. Int J Mol Sci. 2019 Apr 4;20(7).

pii: E1683. 10. Hussain SA, Hameed A, Khan MAK, Zhang Y, Zhang Huaiyuan, Garre V, Song Yuanda. Engineering of Fatty Acid Synthases (FASs) to Boost the Production of Medium-Chain Fatty Acids (MCFAs) in Mucor circinelloides. Int J Mol Sci. 2019 Feb 12;20(3). pii: E786. 11. Zhang Yao, Luan Xxiao, Zhang Huaiyuan, Garre V, Song Yuanda, Ratledge Colin. Improved γ-linolenic acid production in Mucor circinelloides by homologous overexpressing of delta-12 and delta-6 desaturases. Microb Cell Fact. 2017 Jun 21;16(1):113. 12. Zhao Lina, Zhang Huaiyuan, Wang L, Chen H, Chen YQ, Chen W, Song Yuanda. (13)C-metabolic flux analysis of lipid accumulation in the oleaginous fungus Mucor circinelloides. Bioresour Technol. 2015 Dec;197:23-9. 13. Onivogui G, Diaby M, Chen X, Zhang Huaiyuan, Kargbo MR, Song Yuanda. Antibacterial and antifungal activities of various solvent extracts from the leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used as traditional medicine in Guinea. J Ethnopharmacol. 2015, 20;168:287-90. 14. Mingxuan Wang, Jianxin Chen, Huaiyuan Zhang, Yuanda Song. Molecular switch that controls the flux of linoleic acid into n-6 or n-3 polyunsaturated fatty acids in microorganisms. American Journal of Biochemistry and Biotechnology 2014, 10 (2): 105-115. 15. Gbago Onivogui, Huaiyuan Zhang, Erasto Mlyuka, Mohamed Diaby, Yuanda Song. Chemical Composition, Nutritional Properties and Antioxidant Activity of Monkey Apple (Anisophyllea laurina R. Br. ex Sabine). Journal of Food and Nutrition Research, 2014, 2(6), 281-287. 16. Xin Tang, Huaiyuan Zhang, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song. Effects of 20 standard amino acids on the growth, total fatty acids production and γ-linolenic acid yield in Mucor circinelloides. Current Microbiology, 2014, 69(6):899-908. 17. Jiayu Yang, Xinjie Hu, Huaiyuan Zhang, Haiqin Chen, M’balu.R.Kargbo, Jianxin Zhao, Yuanda Song, Yong Q. Chen, Hao Zhang, Wei Chen. Expression, Purification and Characterization of NADP+-dependent Malic Enzyme from the Oleaginous Fungus Mortierella alpina. Applied Biochemistry and Biotechnology, 2014 173(7):1849-57. 18. 唐文佳, 张怀渊, 陈卫, 宋元达, 柠檬酸在产油酵母油脂积累过程中的中心作用, 食品科学, 2013, 34(19): 326-329 19. Mousumi Tania, Md. Asaduzzaman Khan, Huaiyuan Zhang, Jinhua Li, Yuanda Song. Autotaxin: A protein with two faces. Biochemical and Biophysical Research Communications, 2010, 401: 493-497. 20.张怀渊, 宋元达, 酯交换反应在制备生物柴油上的应用, 中国工程科学, 2010, 12(1): 24-29.



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