姓 名
曾涛

性别
男

职称
教授 (博士研究生导师)

职务


电话


电子邮件
zengtao@sdu.edu.cn

通信地址
山东省济南市文化西路44号

最高学位
博士







学术简历
2005年6月毕业于山东大学，获医学学士学位；同年7月推免为山东大学毒理学硕博连读研究生，2010年6月获医学博士学位，并留校工作。2011年1月-2014年9月，任山东大学公共卫生学院讲师；2018年10月-2019年9月，美国UniversityofArizonaDonnaZhang实验室访问****；2014年9月-2019年8月，任山东大学公共卫生学院副教授；2019年9月-至今，山东大学公共卫生学院教授
研究方向
肝脏毒理学：环境/职业有害因素的肝脏毒性的分子机制及防治研究。（1）以氧化应激和肝脏巨噬细胞极化调控为研究切入点，探讨自噬、Nrf-2以及巨噬细胞极化在化学性肝损伤发病中的作用；（2）天然活性产物对化学性肝损伤的保护作用及其机制
学术/社会兼职
中国毒理学会会员；中华预防医学会卫生毒理学分会青年委员；中国诱变剂学会致突变分会青年委员；山东省预防医学会卫生毒理学分会委员；欧洲自由基学会（Society of free radical-Europe）会员；国家自然科学基金函审专家；山东省自然科学基金结题评审专家；BLDE University journal of health science、世界胃肠病学杂志编委；Toxicology Mechanisms and Methods、Frontiers in Pharmacology等杂志特邀审稿人；Toxicology、Food and Chemical Toxicology、BBAMolecular Basis of Disease、Molecular Nutrition and Food Research等杂志审稿人。
承担的主要研究课题
[1].Nrf-2信号通路活化和枯否细胞极化调控在二烯丙基二硫（DADS）拮抗酒精性肝病中的作用 （**）国家自然科学基金面上项目 2019.01-2022.12
[2].基于MAPK信号通路研究酒精性脂肪肝发病中PPAR-α抑制的分子机制 （**） 国家自然科学基金面上项目 2015.01-2018.12
[3].Kupffer细胞极化调控在酒精性肝病发病及防治中的作用 （2017GSF18122） 山东省重点研发计划 2017.09-2019.12
[4].酒精性脂肪肝发病的分子机制及干预研究(2011WLJH52）山东大学青年****未来计划2015.07-2020.06
[5].细胞色素P4502E1在酒精性脂肪肝发病中的作用及分子机制 (**) 国家自然科学基金青年基金 2012.1-2014.12
[6].PI3K/Akt信号通路在酒精性脂肪肝发病中的作用 (064）教育部博士点基金 2011.12-2015.12
[7].二烯丙基二硫化物拮抗酒精性肝损伤及Nrf2/HO-1介导的保护机制(ZR2011HQ026) 山东省自然科学基金青年基金 2011.7-2014.7
[8].自噬溶酶体途径在酒精性脂肪肝发病中的作用() 中国博士后基金特别资助(第四批)
[9].酒精性肝损伤发病的分子机制及其干预研究() 中国博士后基金面上项目(第48批)
[10].细胞色素P4502E1活化在酒精性脂肪肝发病中的作用研究() 山东省博士后创新项目基金
代表性学术论文 (2012年--至今)
[1].Zhao, H.J., Li, M.J., Zhang, M.P., et al., 2019. Allyl methyl trisulfide protected against acetaminophen (paracetamol)-induced hepatotoxicity by suppressing CYP2E1 and activating Nrf2 in mouse liver. Food & function 10, 2244-2253.通讯作者
[2].Yang, R., Guan, M.J., Zhao, N., et al., 2019. Roles of extrahepatic lipolysis and the disturbance of hepatic fatty acid metabolism in TNF-alpha -induced hepatic steatosis. Toxicology 411, 172-180. 通讯作者
[3].Li, M.J., Zeng, T., 2019. The deleterious effects of N,N-dimethylformamide on liver: A mini-review. Chem Biol Interact 298, 129-136. 通讯作者
[4].Zeng, T., Zhang, C.L., Zhao, N., et al., 2018. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Redox Biol 14, 295-304. 第一作者/通讯作者
[5].Zhao, N., Guo, F.F., Xie, K.Q., et al., 2018. Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease. Cell Mol Life Sci 75, 3143-3157. 通讯作者
[6].Zhao, N., Guan, M.J., Li, M.J., et al., 2018. Effects of garlic-derived lipid soluble organosulfur compounds on hematological parameters in mice. Journal of functional foods 46, 85-89. 通讯作者
[7].Guan, M.J., Zhao, N., Xie, K.Q., et al., 2018. Hepatoprotective effects of garlic against ethanol-induced liver injury: A mini-review. Food Chem Toxicol 111, 467-473. 通讯作者
[8].Zhao, Y.Y., Yang, R., Xiao, M., et al., 2017. Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues. Toxicology 390, 53-60 通讯作者
[9].Zeng T., C.-L. Zhang, M. Xiao, et al., Critical roles of Kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials. Frontiers in Immunology, 2016. 7: p. 538.
[10].Wang, Y., Zhao, Y., Li, M., Yu, S. and Zeng, T. 2016. Docosahexaenoic acid supplementation failed to attenuate chronic alcoholic fatty liver in mice. Acta Biochim Biophys Sin (Shanghai) 48, 482-484. (Corresponding author)
[11].Zeng, T., Zhao, Y.Y. and Xie, K.Q. 2016. Does Intestinal Microbiota Protect Mice Against Acute/Binge Drinking-Induced Liver Injury? Alcohol Clin Exp Res 40, 1788-1790.
[12].Zhao, Y.Y., Xiao, M., Zhang, C.L., Xie, K.Q. and Zeng, T. 2016. Associations between the tumor necrosis factor-alpha gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease: A meta-analysis. Clin Res Hepatol Gastroenterol 40, 428-439. (Corresponding author)
[13].Chen YY, Zhang CL, Zhao XL, Xie KQ, Zeng T. Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. Chem Biol Interact.2014, 222C:18-26. (Corresponding author)
[14].Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ.CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway. PLoS One. 2014, 9(6):e98658.
[15].Zeng T, Zhang CL, Zhao XL, Xie KQ. Pentoxifylline for the treatment of nonalcoholic fatty liver disease: a meta-analysis of randomized double-blind, placebo-controlled studies. Eur J Gastroenterol Hepatol. 2014, 26(6):646-53.
[16].Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. Biochim Biophys Acta, 2013, 1830: 4848-4859.
[17].Zeng T, Zhang CL, Zhao XL, Xie KQ. The roles of garlic on the lipid parameters: a systematic review of the literature. Crit Rev Food Sci Nutr, 2013, 53: 215-230
[18].Zeng T, Zhang CL, Han XY, Zhao S, Xie KQ. Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol, 2013, 25, 1183-1189.
[19].Zeng T, Li Y, Zhang CL, Yu LH, Zhu ZP, Zhao XL, Xie KQ. Garlic oil suppressed the hematological disorders induced by chemotherapy and radiotherapy in tumor-bearing mice. J Food Sci, 2013, 78: H936-942.
[20].Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis. PloS one, 2013, 8:e54188.
[21].Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology, 2012, 296:56-66.
[22].Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1. Food Chem Toxicol, 2012, 50:485-491
[23].Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles. J Sci Food Agric, 2012, 92:1892-1902
[24].Guo FF, Xie Q, An RF, Zeng T, Zhou W. The CD14--159C/T polymorphisms and the risks of tuberculosis: a meta-analysis. Infect Genet Evol. 2013, 18:277-83. (corresponding author)
[25].Zeng T, Xie KQ. The differential modulation on cytochrome P450 enzymes by garlic components. Food Reviews International.2010, 26(4):353-363.
[26].Yin HY, Guo Y, Song FY, Zeng T, Xie KQ. Toxicokinetic study of pyrrole adducts and its potential application for biological monitoring of 2,5-hexanedione subacute exposure.Int Arch Occup Environ Health. 2014, 87(6):655-62.
[27].Zhang CL, Zeng T, Zhao XL, Xie KQ. Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes.Int J Biol Sci. 2013, 9(3):237-45.
[28].Chen J, Zeng T, Zhao X, Xie K, Bi Y, Zhong Z, Zhao X. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. Food Chem Toxicol. 2013, 57:330-7.
[29].Zhong Z, Zeng T, Xie K, Zhang C, Chen J, Bi Y, Zhao X.Elevation of 4-hydroxynonenal and malondialdehyde modified protein levels in cerebral cortex with cognitive dysfunction in rats exposed to 1-bromopropane.Toxicology. 2013, 306:16-23.
[30].Song F, Han X, Zeng T, Zhang C, Zou C, Xie K.Changes in beclin-1 and micro-calpain expression in tri-ortho-cresyl phosphate-induced delayed neuropathy.Toxicol Lett. 2012, 210(3):276-84.
代表性著作（章节）
Zeng T and Xie KQ. “Chapter 19: Cytochrome P4502E1 GenePolymorphisms and the Risks of Ethanol-Induced Health Problems in Alcoholics”.In: “Molecular Aspects of Alcohol and Nutrition, 1st Edition” edited by VinoodB. Patel; Publisher: ElsevierScience; 11 Nov 2015
重要奖项
（1）2011年山东省毒理学会青年毒理学工作者一等奖
（2）2011年山东省研究生优秀科技创新成果二等奖
（3）2008年获得山东大学研究生校长奖学金