基本信息

姓名：
郭欣
性别：
女
出生日期
1983.04


工作单位
山东大学公共卫生学院营养与食品卫生学系
职称：
副研究员

Email：
xguo@sdu.edu.cn

电话：


地址：
济南市文化西路44号山东大学趵突泉校区

个人空间




?个人简介

郭欣，女，美国德克萨斯州A&M大学（TEXAS A&M UNIVERSITY）营养学博士，现为山东大学公共卫生学院副研究员。长期从事代谢，慢性炎症，肥胖病，糖尿病等代谢疾病方面的工作研究。近五年在Circulation，Journal of Biological Chemistry （JBC），PLoS ONE，Arteriosclerosis Thrombosis and Vascular Biology（ATVB），Journal of Nutritional Biochemistry，Scientific Report等杂志上正式发表SCI论文12篇，其中第一作者4篇、第三作者4篇，每篇论文的影响因子在3-17之间；同时作为Scientific Reports、PLOS One、Journal of Cellular and Molecular Medicine、Journal of Nutrition & Food Sciences、Journal of Cell Science & Therapy 五个期刊的审稿人。另外于2013年7月获美国注册营养师执照、2013年10月获德克萨斯州注册营养师执照。

?教育经历

2004年6月，江西师范大学，生物工程，学士学位。
2007年6月，中国科学技术大学，生物化学与分子生物学，硕士学位。
2013年5月，美国德克萨斯州农工大学（Texas A&M University），营养学，博士学位。

?工作经历

2013年7月-2016年3月，美国德克萨斯州农工大学（Texas A&M University）农学院营养与食品科学系，博士后研究助理。
2016年3月-2017年8月，美国贝勒医学院儿童营养研究中心，助理研究员。
2017年9月至今，山东大学公共卫生学院营养与食品卫生学系，副研究员。

?学术任职

美国营养和饮食学会会员(Academy of Nutrition and Dietetics)

?研究领域

肥胖症，糖尿病，心血管疾病等代谢疾病

?在研项目

山东大学基本科研业务费项目2017TB0028, 2017.09-2019.12, 肥胖症中生物节律失调与脂肪组织炎症反应的关系, 15万元

?主要发表论文[20篇以内]

1. Guo, X., Shu, C., Zheng, J., Li, H., Pei, Y., Woo, S., Xu, H., Botchlett, R., Qi, T., Guo, T., Zhao, J., Cai, Y., Hu, X., Zhao, Y., Huo, Y., Li, P., Wu, C. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Scientific Report. 2017, 7(1): 6355.
2. Mo, Q., Salley, J., Roshan, T., Baer, L., May, F., Jaehning, E., Lehing, A., Guo, X., Tong, Q., Nuotio-Antar, A., Shamsi, F., Tseng, Y., Stanford, K., Chen, M. Identification and characterization of a supraclavicular brown adipose tissue in mice. Journal of Clinical Investigation Insight. 2017 June 2nd.
3. Botchlett, R., Woo, S., Liu, M., Pei, Y., Guo, X., Li, H., Wu, C. Nutritional approaches for managing obesity-associated metabolic diseases. Journal of Endocrinology. 2017, 233 (3) :R145.
4. Botchlett, R., Li, H., Guo, X., Qi, T., Zhao, J., Zheng, J., Woo, S., Pei, Y., Liu, M., Hu, X., Chen, G., Guo, T., Li, Q., Xiao, X., Huo, Y., and Wu, C. Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells. Scientific Report. 2016, 6 :28963.
5. Guo, T., Woo, S., Guo, X., Li, H., Zheng, J., Botchlett, R., Liu, M., Pei, Y., Xu, H., Cai, Y., Li. X., Li, Q., Xiao, X., Huo, Y., and Wu, C. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity. Scientific Report, 2016, Mar 3;6:22612.
6. Xu, H., Li, H., Woo, S., Kim, S., Shende, V. R., Neuendorff, N., Guo, X., Guo, T., Qi, T., Pei, Y., Zhao, Y., Hu, X., Zhao, J., Chen, L., Chen, L., Ji, J., Alaniz, R.C., Earnest, D.J., Wu, C. Myeloid cell-specific disruption of Period 1 and Period 2 exacerbates diet-induced inflammation and insulin resistance. J Biol Chem, 2014; 289 (23): 16374-16388.
7. Xu, Y., An, X., Guo, X., Habtetsion, T., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R., Fulton, D., Su, Y., Hoda, M. N., Zhou, G., Wu, C., Huo, Y. Endothelial PFKFB3 plays a critical role in angiogenesis. ATVB, 2014; 34 (6): 1231-1239.
8. Woo, S., Xu, H., Li, H., Zhao, Y., Hu, X., Zhao, J., Guo, X., Guo, T., Botchlett, R., Qi, T., Huo, Y., Wu, C. Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in Diet-Induced Obesity. PLoS ONE, 2014; 9 (3), e91111.
9. Chen, Y., Mu, P., He, S., Tang, X., Guo, X., Li, H., Xu, H., Woo, S., Qian, X., Zeng, L., Wu C. Gly482Ser mutation impairs the effects of peroxisome proliferator–activated receptor γ coactivator-1α on decreasing fat deposition and stimulating phosphoenolpyruvate carboxykinase expression in hepatocytes. Nutrition Research. 2013; 33 (4): 332-339.
10. Li, H., Guo, X. (co-first author, equal contribution), Xu, H., Woo, S., Halim V., Morgan C., Wu, C. A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis J Nutr Biochem. 2013; 24 (6): 1153-1158.
11. Guo, X., Li, H., Xu, H., Halim, V., Thomas, L.N., Woo, S., Huo, Y., Chen, Y. U., Sturino, J.M., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response. J Nutr Biochem, 2013; 24 (5): 770-775.
12. Guo, X., Li, H., Xu, H., Woo, S., Dong, H., Lu, F., Lange, A.J., Wu, C. Glycolysis in the control of blood glucose homeostasis (Invited Review). Acta Pharmaceutica Sincia, 2012; 2:358-367.
13. Guo X., Li H., Xu H., Halim V., Zhang W., Wang H., Ong K.T., Woo S.L., Walzem R.L., Mashek D.G., Dong H., Lu F., Wei L., Huo Y, and Wu C. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice. PLoS ONE, 2012; 7:e39286. PMCID: PMC**.
14. Huo, Y., Guo, X. (co-first author, equal contribution), Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y., Ong, K.T., Woo, S., Chapkin, R.S, Mashek,D.G., Chen, Y., Dong, H., Lu, F., Wei, L., Wu. C. Targeted overexpression of inducible 6-Phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory response. J Biol Chem, 2012; 287(25): 21492-21500.
15. Zhuang, G.., Meng, C. (co-first author, equal contribution), Guo, X., Xu, H., Wang, G., Li, H., and Wu, C., Zhou, B. A Novel Regulator of Macrophage Activation miR-223 in Obesity-Associated Adipose Tissue Inflammation. Circulation, 2012; 125(23): 2892–2903.
16. Guo, X., Huo, Y., Xu, K., Li, H., Zhang, W., Wang, H., Zhang, J., Lange, A.J., Chen, Y.E., and Wu, C. Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of rosiglitazone in mice. J Biol Chem, 2010; 285: 23711-23720.
17. Huo, Y., Guo, X., Li, H., Wang, H., Zhang, W., Wang, Y., Zhou, H., Gao, Z., Telang, S., Chesney, J., Chen, Y.E., Ye, J., Chapkin, R.S., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem, 2010; 285: 3713-3721.
18. Chen, Y.P., Shen, Y.Y., Guo, X. (co-first author, equal contribution), Zhang, C.S., Yang, W.J., Ma, M.L., Liu, S., Zhang, M.B., and Wen, L.P. Transdermal protein delivery by a coadministered peptide identified via phage display. Nature Biotechnology, 2006; 455-460.

?已获奖项

1. Outstanding Graduate Award in Nutrition, Texas A&M University, 2013
2. NFSC Award in Excellence for Graduate Research Assistant, Texas A&M University, 2012

学术活动（近五年）

1. 郭欣，Regulation of Gene Activation May Become a Potential Strategy to Prevent and Treat Nutrition-related Diseases，东湖论坛, 2016. 武汉，中国
2. Guo, X., Guo, T., Li, H., Pei, Y., Xu, H., Qi, Ting., Hu, X., Zhao, Y., Zhao, J., Wu, C. Temporal effects pf Peroxisome Proliferator-activated Receptor γ (PPARγ) activation on macrophage inflammatory responses. Experimental Biology, 2014. San Diego, CA