范礼强^1,2, 郑关超², 吴海燕², 郭萌萌², 卢霞¹, 李玉¹, 谭志军^2,3
1.江苏海洋大学测绘与海洋信息学院, 江苏 连云港 222005;2.农业农村部水产品质量安全检测与评价重点实验室, 中国水产科学研究院黄海水产研究所, 山东 青岛 266071;3.青岛海洋科学与技术试点国家实验室, 山东 青岛 266237

摘要:
麻痹性贝类毒素（paralytic shellfish toxins，PSTs）能够导致贝类、鱼类等海洋生物染毒或死亡，危害海洋生态安全及人类健康。其中，贻贝具有强蓄积性特点，在国外可作为PSTs的指示性生物。近年来，我国因食用贻贝造成多起PSTs中毒事件成为安全关注重点，因此急需弄清其风险形成机理。本文通过综述我国近海贻贝等贝类中PSTs的风险程度、贻贝对不同产毒藻来源的PSTs的蓄积作用，分析环境因子对于蓄积代谢的影响，深入挖掘贻贝蓄积代谢特异性。进而聚焦贻贝代谢阶段的表达调控过程、影响因素、转化作用及方式等。未来应侧重于摸清我国目标区域贻贝等海洋贝类中PSTs基础风险规律和变化过程，并据此建立区域性PSTs风险防控技术，提高我国贻贝中PSTs风险的主动防控能力，对于保障消费者健康和海洋生态安全具有积极意义。
关键词:贻贝蓄积代谢免疫风险评价
DOI：10.11759/hykx20201102003
分类号:S917
基金项目:国家重点研发计划项目（2017YFC1600701）；国家自然科学基金面上项目（31772075，32072329）；2019江苏省研究生科研创新项目（KYCX19_2282）

Research progress on the accumulation and metabolism of paralytic shellfish toxin in mussels
FAN Li-qiang^1,2, ZHENG Guan-chao², WU Hai-yan², GUO Meng-meng², LU Xia¹, LI Yu¹, TAN Zhi-jun^2,3
1.School of Geomatics and Marine Information, Jiangsu Ocean University, Lianyungang 222005, China;2.Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, P. R. China, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China;3.Pilot National Laboratory for Marine Science and Technology(Qingdao), Qingdao 266237, China
Abstract:
Poisoning with paralysis shellfish toxins (PSTs) can cause death in shellfish, other fish, and other marine organisms as well as hamper the marine ecology and human health. Mussels are highly accumulative and serve as indicators of PSTs in foreign countries. In recent years, several cases of PST poisoning by mussel consumption in China have become the focus of safety attention. Therefore, understanding the mechanism of risk formation is essential and urgent. This study evaluates the risk degree of PSTs in offshore mussels and other shellfishes in China and the accumulation effect of mussels on PSTs from different toxigenic alga sources, analyzes the influence of environmental factors on the accumulation and metabolism, and explores in depth the specificity of mussel accumulation and metabolism. Furthermore, focusing on the expression regulation process of the mussel metabolic stage, our study clarifies the influencing factors, transformation functions, and modes. In future studies, we aim to focus on understanding the basic risk rule and change process of PSTs in mussels as well as other marine shellfish in certain target areas of China and establish regional risk prevention and control technology for active prevention and control of PST risk in mussels of China. This will contribute positively and significantly toward protecting consumer health and the marine ecology.
Key words:musselsaccumulation and metabolismimmunerisk assessment





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