黄莺 副教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：医学院
联系方式：yinghuang@tongji.edu.cn
课题组链接：http://202.120.165.73/ktz/Group.aspx?id=47
研究方向
主要任职
科研业绩

认知记忆的神经环路、神经可塑性机制及认知障碍性疾病:
神经可塑性是脑内学习记忆在神经元之间突触层面的重要机制，而神经网络的同步性活动参与不同神经元集群的信息编码和整合，是更为宏观层面的脑认知功能的神经基础。神经可塑性的损害和网络同步性异常将导致认知记忆功能的障碍及疾病。我们的研究主要集中在神经可塑性（LTP，LTD等）调控的细胞机制、网络同步性活动（gamma, theta oscillation等）中不同种类神经元放电的pattern 和timing等在认知和认知障碍中的作用，包括运用转基因动物模型进行行为学研究，以及运用电生理，形态学，生化等方法进行机制探讨。
Mechanisms of Neuronal Circuit & Neuroplasticity in Memory and Cognitive Disorders：
Neuroplasticity is one of the most important mechanisms on the synaptic level of learning and memory in the brain. Network synchronized activities are essential for binding neuronal assemblies in the brain and underlying various cognitive processes and memory. The impairment in neuroplasticity or network synchrony participates in the pathophysiology in some cognitive dysfunctions and diseases. Using transgenic animal models and investigations by behavioral analysis, electrophysiology, optogenetics, morphological and molecular biological methods, I aim to decipher the cellular and synaptic mechanisms underlying neuroplasticity (LTP, LTD) as well as firing pattern and timing of different subtypes of neurons in network activities (gamma, theta oscillation) and their involvement in memory and cognitive disorders.



同济大学医学院副教授，硕/博士生导师，神经环路与神经可塑性课题组组长
Associate Professor of Tongji University, School of Medicine
Master's/Ph.D Supervisor
PI of Laboratory of Neuronal Circuit & Neuroplasticity



主持和参与多项国家自然科学基金重点项目和面上项目，上海市自然科学基金项目，以及与国际制药公司的合作课题。近年来发表SCI论文十余篇，以通讯作者在Cerebral Cortex, Experimental Neurology等杂志上发表论文。
代表性论文（*通讯作者）：
1. Huang Y*, Yoon K, Ko H, Jiao S, Ito W, Wu JY, Yung WH, Lu B, Morozov A. 5-HT3a receptors modulate hippocampal gamma oscillations by regulating synchrony of parvalbumin-positive interneurons. Cerebral Cortex. 2016 26(2):576-585.

2. Huang L, Yang XJ, Huang Y, Sun EY, Sun M. Ketamine Protects Gamma Oscillations by Inhibiting Hippocampal LTD. PLoS One. 2016 (in press).

3. Yu Y, Cao DQ, Xu HY, Sun M, Huang ZL, Yung WH, Lu N, Huang Y*. 5-HT3A receptors are required in long-term depression and AMPA receptor internalization. Neuroscience. 2014. 278:105-112.

4. Huang Y, Wang JJ, Yung WH*. Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. Cerebellum. 2013,12(3):328-330.

5. Huang Y*, Ko H, Cheung ZH, Yung KK, Yao T, Wang JJ, Morozov A, Ke Y, Ip NY, Yung WH*. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental Neurology.2012, 233(2):791-798.

6. Huang Y, Morozov A*. Hippocampal deletion of BDNF gene attenuates Gamma oscillations in area CA1 by up-regulating 5-HT3 receptor. PLoS ONE. 2011, 6(1): e16480.

7. Huang Y, Huang YL, Lai B, Zheng P, Zhu YC, Yao T*. Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high voltage-activated calcium current. Neuroscience2007; 147:334-341.

8. Huang Y, Huang YL, Zhang S, Zhu YC, Yao T*. Estradiol acutely attenuates glutamate-induced calcium overload in primarily cultured rat hippocampal neurons through a membrane receptor-dependent mechanism. Brain Research.2004; 1026: 254-260.

9. Zhang S, Huang Y, Yao T*. Estrogen stimulates the release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway. Acta Pharmacologica Sinica. 2005; 26: 171-176.

10. He Y, Huang Y, Zhou L, Lu LM, Zhu YC, Yao T*. All-trans retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts. Acta Pharmacologica Sinica. 2006;27:423-429.