解端阳 特聘研究员
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：医学院
联系方式：Xieduanyang@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

心脏电生理及心律失常基础研究 Basic research on Cardiac electrophysiology and Arrhythmias
同济大学医学院，心律失常教育部重点实验室，特聘研究员，博导； Distinguished Research Fellow, Doctoral Supervisor, Medicine School of Tongji University, Key Laboratory of Arrhythmias of the Ministry of Education of China
研究方向:
1.利用谱系示踪、多组学分析、光遗传学、光学标测等手段在介观层面鉴定心脏的细胞学构成及心脏细胞间通讯的分子本质；
2.利用单细胞测序、单分子荧光追踪、膜片钳、钙成像等探索心脏特定细胞亚群的电生理学特性及其分子本质；
3.探索心律的分子本源及心律失常的分子机制。
在研课题：
1.国自然面上项目**；m6A识别蛋白Ythdf2调控离子通道mRNA甲基化介导心房颤动发生的机制研究； 55万； 主持；
2.国自然青年科学基金项目**；冷诱导RNA结合蛋白CIRBP转录后调控心房颤动发生的机制研究； 21万；主持；
3.中央高校基本科研业务费；冷诱导RNA结合蛋白对心脏异位节律形成的作用及机制研究； 20万；主持。
科研成果：
1. Duanyang Xie, Li Geng, Ke Xiong, Tingting Zhao, Shuo Wang, Jinfeng Xue, Cheng Wang, Guanghua Wang, Zhiqiang Feng, Huixing Zhou, Yini Li, Li Li, Yi Liu, Zhigang Xue, Jian Yang, Honghui Ma, Dandan Liang, and Yi-Han Chen. Cold-inducible RNA-binding protein prevents an excessive heart rate response to stress by targeting phosphodiesterase. Circulation Research. 2020；
2. Jun Li, Duanyang Xie, Jian Huang, Fei Lv, Dan Shi, Yi Liu, Lin Li, Geng Li, Yahan Wu, Dandan Liang, Yi-Han Chen. Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels. Circulation Research. 2015；
3. Duanyang Xie, Li Geng, Shuo Wang, Ke Xiong, Tingting Zhao, Guanghua Wang, Zhiqiang Feng, Fei Lv, Cheng Wang, Dandan Liang, Dan Shi, Xiue Ma, Yi Liu, JianYang, Chao Zhang, Yi-Han Chen. Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels. Heart Rhythm. 2020；
4. Li Geng, Shuo Wang, Fulei Zhang, Ke Xiong, Jian Huang, Tingting Zhao, Dan Shi, Fei Lv, Li Li, Dandan Liang, Yingyu Cui, Yi Liu, Duanyang Xie#, Yi-Han Chen#. SNX17 (Sorting Nexin 17) Mediates Atrial Fibrillation Onset Through Endocytic Trafficking of the Kv1.5 (Potassium Voltage-Gated Channel Subfamily A Member 5) Channel，Circulation, Arrhy and Electro. 2019；
5. Lei Yao; Duanyang Xie; Li Geng; Dan Shi; Jian Huang; Yufei Wu; Fei Lv; Dandan Liang; Li Li; Yi Liu ; Jun Li; Yi-Han Chen. Electrotonic Myofibroblast-to-REEP5 Acts as A Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function. J Am Heart Assoc. 2018；
6. Li J, Li C, Liang D, Lv F, Yuan T, The E, Ma X, Wu Y, Zhen L, Xie D, Wang S, Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L, Lin L, Peng L, Cui J, Zhu W, Chen Y-H. LRP6 acts as a scaffold protein in cardiac gap junction assembly. Nat Commun. 2016；
7. Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen Y-H. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. J Cell Mol Med. 2014；
8. Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen Y-H. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Res. 2014.