刘玲 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：医学院
联系方式：lliu@tongji.edu.cn
课题组链接：https://mednew.tongji.edu.cn/ktz/Group.aspx?id=3063
研究方向
主要任职
科研业绩

神经定向分化调控机制
Mechanism of patterning of human forebrain




同济大学转化医学高等研究院研究员。复旦大学博士毕业，在美国威斯康辛大学麦迪逊分校病毒研究所，HHMI从事博士后研究。
国家自然基金项目评审专家；BMC Cancer，Spandidos Publications 审稿专家。
Professor of translational medicine of the institute for Advanced Study in Tongji University.
Graduated from Fudan University. Postdoctoral research at UW-Madison, HHMI.
Expert reviewer of The National Natural Science Foundation of China.
Peer reviewer of the journal of BMC Cancer and Spandidos Publications.


主要从事神经定向分化调控机制的研究。研究人胚胎干细胞定向分化时不同转录因子所起的信号调节作用。揭示了人脑背腹侧化，及大脑皮层分化发育的重要转录因子（Scientific Reports, Cerebral Cortex, Stem Cell reports）。阐明病毒非结构蛋白在宿主细胞中形成病毒复制工厂所依赖的氨基酸结构（Plos Pathogens）；病毒攻击宿主细胞其基因介导的天然免疫机制等（Immunology）等杂志上。
Our major aim is to study the mechanism of patterning of human forebrain. Specify the differential functions derived from divergent transcriptional signals ruled in the neuronal patterning and development spatiotemporally. We have published papers uncovered several key genes function in the dorsal-ventral patterning and neural ectoderm differentiation (Scientific Resports, Cerebral Cortex, Stem Cell reports). Other publications involved that nicely imaged the small peptide of a viral non-structure protein in formation of the viral replication complex in host cell (Plos Pathogens) and the initiation mechanism of the innate immunity against the viral DNA (Immunology).
承担的项目：
国家重大科学研究计划（973项目），神经分化各阶段细胞命运决定的调控网络研究及转化应用骨干；
包括国家自然科学基金青年科学基金项目1项，**, TGFbeta信号非依赖Smad3核定位的机制与功能研究, 负责人；
上海市科技人才计划项目:基于编程和重编程的神经细胞的获取与应用研究，骨干。
发表的代表性文章：
1.Liu Z, Hui Y, Shi L, Chen Zh, Xu X, Liu L*, and Zhang X*. Efficient CRISPR/Cas9-mediated versatile, predictable and donor-free gene knockout in human pluripotent stem cells. Stem Cell Reports,2016, Accepted, ( *Co-Correspondence)
2.Chi L, Fan B, Zhang K , Du Y, Liu L, Fang Y, Chen Z, Ren X, Xu X, Jiang C, Li S, Ma L, Gao L, Liu L* ,and Zhang X* Directed differentiation of regional ventral neuroprogenitors and related neuronal subtypes from human pluripotent stem cells. Stem Cell Reports, 2016, Revised, （*Co-Correspondence)
3.Lv K, Chen Z, Zhang X, Zhang Q,* and Liu L*. Selective enrichment of CD133+/SOX2+ glioblastoma stem cells through adherent culture. (Oncology Letters, 2016, Accepted. *Correspondence)
4.Chi L, Fan B, Feng D, Chen Z, Liu Z, Hui Y, Xu X, Ma L, Fang Y, Zhang Q, Jin G, Liu L*, Guan F, Zhang X*. The Dorsoventral Patterning of Human Forebrain Follows an Activation/Transformation Model. Cereb Cortex. 2016, May 25. *Correspondence
5.Liu L*, Liu X, Ren X, Tian Y, Chen Z, Xu X, Du Y, Jiang C, Fang Y, Liu Z, Fan B, Zhang Q, Jin G, Yang X, Zhang X.Smad2 and Smad3 have differential sensitivity in relaying TGF??signaling and inversely regulate early lineage specification. Scientific Reports. 2016, 6, 21602.
6.Liu Z, Chi L, Fang Y, Liu L* and Zhang X-Q*. Specific expression pattern of a novel Otx2 splicing variant during neural differentiation. Gene. 2013，523(1):33-8. (*Co-Correspondence)
7.Liu L, Westler WM, den Boon JA, Wang X, Diaz A, Steinberg HA, AhlquistP. An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function. PLoS Pathog. 2009 Mar;5(3):e**.
8.Liu L, Zhou X, Liu H, Xiang L, Yuan Z. CpG motif acts as a 'danger signal' and provides a T helper type 1-biased microenvironment for DNA vaccination. Immunology. 2005 Jun;115(2):223-30.
9.Liu L, Zhou X, Shi J, Xie X, Yuan Z. Toll-like receptor-9 induced by physical trauma mediates release of cytokinesfollowing exposure to CpG motif in mouse skin. Immunology. 2003 Nov;110(3):341-7. (Commented on the same issue)