袁健 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：同济大学附属东方医院
联系方式：yuanjian229@hotmail.com
课题组链接：
研究方向
主要任职
科研业绩

DNA 损伤修复与肿瘤/DNA damage repair and tumorigenesis
袁健，研究员，同济大学硕士和博士生导师，任国家自然科学基金函评专家，美国癌症联合会（AACR ）会员。致力于肿瘤发生及肿瘤耐药分子机制研究，原创性阐明多个肿瘤抑制因子在肿瘤发生及耐药中的关键作用，对于妇科肿瘤如乳腺癌及卵巢癌的精准基因诊断及耐药建立一系列检测体系。相关工作发表在国际顶级期刊Cell，Molecular Cell，Nature Communications, Science Advances，Genes & Development，EMBO J，JCB等杂志。入选国家自然科学基金委优秀青年人才计划，教育部新世纪人才计划及上海市科委浦江人才计划。担任国家自然科学基金重大项目子课题负责人，科技部973计划子课题负责人以及国家自然科学基金重大研究计划项目负责人。并先后获得国家自然科学基金面上项目，青年项目资助。
作为项目负责人主持国家自然科学基金重大项目1项，国家重大研究计划1项，国家自然科学基金优秀青年项目1项，国家自然科学基金面上项目2项，青年项目1项，教育部人才计划1项，科技部973子课题1项，省部级课题2项。
代表性研究论文如下：
1.Jian Yuan , Kuntian Luo, Lizhi Zhang, John C Cheville, Zhenkun Lou. USP10 regulates p53 localization and stability by deubiquitinating p53, Cell. 2010 Feb 5;140(3):384-396.(IF:36.216，第一作者)
2.Wootae Kim , Fei Zhao, Rentian Wu , Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou*, Jian Yuan*. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.Nat Commun (2019) 10:5304.(IF:12.123，通讯作者)
3.Qin Zhou#, Jinzhou Huang#, Chao Zhang#, Fei Zhao, Wootae Kim,Xinyi Tu,Yong Zhang, Somaira Nowsheen, Qian Zhu,Min Deng, Yuping Chen,Bo Qin,Kuntian Luo, Baohua Liu, Zhenkun Lou,Robert W. Mutter* ,Jian Yuan*.The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair.Nat Commun(2020) 11:2639 (IF:12.123，通讯作者)
4.Yuping Chen# , Jinhuan Wu# , Guang Liang , Guohe Geng , Fei Zhao , Ping Yin , Somaira Nowsheen , Chengming Wu , Yunhui Li , Lei Li , Wootae Kim , Qin Zhou , Jinzhou Huang , Jiaqi Liu , Chao Zhang , Guijie Guo , Min Deng , Xinyi Tu , Xiumei Gao , Zhongmin Liu , Yihan Chen , Zhenkun Lou , Kuntian Luo , Jian Yuan*. CHK2-FOXK axis promotes transcriptional control of autophagy programs, Sci Adv. 2020 Jan 1;6(1): eaax5819. (IF:12.8，通讯作者)
5.Yunhui Li#, Kuntian Luo#, Yujiao Yin, Chenming Wu, Min Deng , Lei Li, Yuping Chen, Somaira Nowsheen , Zhenkun Lou , Jian Yuan*. USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response, Nat Commun. 2017 Jun 1;8:15752. (IF:12.123，通讯作者)
6.Kuntian Luo#, Yunhui Li#, Yujiao Yin, Lei Li, Chenming Wu, Yuping Chen, Somaira Nowsheen , Qi Hu , Lizhi Zhang , Zhenkun Lou , Jian Yuan*. USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling, EMBO J, 2017 May 15;36(10):1434-1446. (IF:9.79，通讯作者)
7.Chenming Wu, Kuntian Luo, Fei Zhao, Ping Yin , Ying Song , Min Deng, Jinzhou Huang , Yuping Chen, Lei Li, SeungBaek Lee, JungJin Kim , Qin Zhou, Xinyi Tu, Somaira Nowsheen, Qifeng Luo, Xiumei Gao, Zhenkun Lou*, Zhongmin Liu*, Jian Yuan*. USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization, Cell Death Differ, 2018 Nov;25(10):1855-1869. (IF:8.08，通讯作者)
8.Lei Li#, Tongzheng Liu#, Yunhui Li, Chenming Wu, Kuntian Luo, Yujiao Yin, Yuping Chen, Somaira Nowsheen, Jinhuan Wu, Zhenkun Lou*, Jian Yuan*. The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization. Oncogene, 2018 May;37(18):2422-2431. (IF:6.634，通讯作者)
9.Jinhuan Wu#, Yuping Chen#, Guohe Geng , Lei Li, Ping Yin, Somaira Nowsheen, Yunhui Li, Chenming Wu, Jiaqi Liu , Fei Zhao, Wootae Kim, Qin Zhou, Jinzhou Huang, Guijie Guo, Chao Zhang, Xinyi Tu, Xiumei Gao, Zhenkun Lou*, Kuntian Luo*, Haixuan Qiao*, Jian Yuan*. USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2. Cancer Lett, 2019 May 1;449:114-124. (IF:6.508，通讯作者)
10.Tongzheng Liu, Jia Yu, Min Deng, Yujiao Yin, Haoxing Zhang, Kuntian Luo, Bo Qin, Yunhui Li,Chenming Wu, Tao Ren, Yang Han, Peng Yin, JungJin Kim, SeungBaek Lee, Jing Lin, Lizhi Zhang, Jun Zhang, Somaira Nowsheen, Liewei Wang, Judy Boughey, Matthew P. Goetz, Jian Yuan*, Zhenkun Lou*. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nature Communications,2017 Jan 9;8:13923. (IF:11.878，并列通讯作者)
11.Kuntian Luo#, Lei Li#, Yunhui Li, Chenming Wu, Yujiao Yin, Yuping Chen, Min Deng,Somaira Nowsheen, Jian Yuan* , Zhenkun Lou*. A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination. Genes & Development.2016 Dec; 30:1–15. (IF:10.042，并列通讯作者)
12.Kuntian Luo, Min Deng, Yunhui Li, Chenming Wu, Ziwen Xu, Jian Yuan*, Zhenkun Lou*. CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase. Nucleic Acids Research, 2015,43(11) 5465–75. (IF:11.147，并列通讯作者)
13.Tongzheng Liu, Yi-hui Lin, Wenchuan Leng, Sung Yun Jung, Haoxing Zhang, Min Deng, Debra Evans, Yunhui Li, Kuntian Luo, Bo Qin, Jun Qin, Jian Yuan*, Zhenkun Lou*. A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint. Mol Cell.2014, 56(5): 681–95. (IF:14.548，并列通讯作者)
14.Jian Yuan *, Kuntian Luo, Min Deng, Yunhui Li, Ping Yin, Bowen Gao,Yuan Fang, Puqiang Wu, Tongzheng Liu and Zhenkun Lou*. HERC2-USP20 axis regulates DNA damage checkpoint through Claspin. Nucleic Acids Research, 42(21): 13110–13121. (IF:11.147，第一作者并列通讯作者)
15.Bo Qin，Bowen Gao，Jia Yu，Jian Yuan*，Zhenkun Lou*. Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G2/M Checkpoint through the Aurora A Cofactor Bora Protein，Journal of Biological Chemistry，2013,288（22）：16139~16144. (IF:4.106，并列通讯作者)
16.Jian Yuan*, Kuntian Luo, Tongzheng Liu, Zhenkun Lou*. Regulation of SIRT1 activity by genotoxic stress, Genes & Development,2012, 26(8):791~796. (IF:10.042，第一作者并列通讯作者)
17.Luo K, Zhang H, Wang L, Yuan J*, Lou Z*. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J ,2012,31(13):3008-3019. (IF:11.227，并列通讯作者)
18.Luo K*, Yuan J#, Lou Z*. Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response. J Biol Chem.2011, 286(32):28192-9. (IF:4.106，并列第一作者)