张青锋 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：医学院
联系方式：qfzhangsh@aliyun.com
课题组链接：https://mednew.tongji.edu.cn/ktz/Group.aspx?id=31
研究方向
主要任职
科研业绩

疟疾等感染性疾病病原体与宿主相互作用及其致病机制研究，以及相关的药物和疫苗等转化医学研究。


同济大学医学院，教授，博士生导师，“热带病与转化研究”课题组组长（PI）；同济大学高等研究院，兼职研究员；同济大学医学院附属东方医院转化医学中心，课题组长。


从事疟疾等重要传染性疾病防治相关的基础和应用研究，主要致力于恶性疟原虫等病原体免疫逃避和致病机制研究，以及相关的抗疟疾药物和疫苗研制等。主要研究成果包括：在国际上首次揭示了致死型疟疾的关键调控因子PfRNase II及其作用机制；揭示了疟疾主要致病基因家族(var基因)的新调控途径；揭示了var基因表达特征与疟疾临床表现之间的相关性等等，相关研究成果陆续发表于Nature, Cell Host & Microbe，PNAS，J Immunology等国际权威期刊上。目前在研项目包括国家自然科学基金面上项目、国家自然科学基金传染病领域国际合作项目、中央高校基本科研业务费专项资金项目等。学术任职：F1000 Associate Faculty Member (Microbiology)，
Cellular Microbiology等专业期刊审稿人。
近年代表性论文：
Zhang Q*, Scherf A*. RNase II: A new player enters the game. RNA Biology. 2015 Apr 18:0. (* Corresponding author)
Zhang Q*, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A*. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature, 2014，513(7518):431-5. (* Corresponding author)
Zhang Y, Yan H, Wei G, Han S, Huang Y, Zhang Q*, Pan W*. Distinctive origin and spread route of pyrimethamine-resistant Plasmodium falciparum in southern China. Antimicrob Agents Chemother. 2014, 58(1):237-46. (* Corresponding author)
Cheng Q, Zhang Q, Xu X, Yin L, Sun L, Lin X, Dong C, Pan W. MAPK Phosphotase 5 Deficiency Contributes to Protection against Blood-Stage Plasmodium yoelii 17XL Infection in Mice. J Immunol. 2014, 192 (8):3686-96.
Siegel TN, Hon CC, Zhang Q, Lopez-Rubio JJ, Scheidig-Benatar C, Martins RM, Sismeiro O, Coppée JY, Scherf A. Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum. BMC Genomics. 2014, 15(1):150.
Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature. 2013, 499(7457):223-7.
Qingfeng Zhang, Yufu Huang, Yilong Zhang, Xiaonan Fang, Aurelie Claes, Magalie Duchateau, Abdelkader Namane, Jose-Juan Lopez-Rubio, Weiqing Pan, and Artur Scherf. A Critical Role of Perinuclear Filamentous Actin in Spatial Repositioning and Mutually Exclusive Expression of Virulence Genes in Malaria Parasites. Cell Host & Microbe. 2011, 10(5):451-63.
Zhang Q, Zhang Y, Huang Y, Xue X, Yan H, Sun X, Wang J, McCutchan TF, Pan W. From in vivo to in vitro: dynamic analysis of Plasmodium falciparum var gene expression patterns of patient isolates during adaptation to culture. PLoS One. 2011, 6 (6):e20591.
Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A.Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc Natl Acad Sci U S A. 2010;107(34):15117-22.