郭春源 副研究员-高研院
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：无
博士招生专业：无
所在院系：附属皮肤病医院
联系方式：chunyuanguo@aliyun.com
课题组链接：
研究方向
主要任职
科研业绩

表观遗传学在疾病中的作用及机制研究:
(1)急性肾损伤向慢性肾脏病转化，
（2）银屑病，
（3）特异性皮炎。
Epigenetic regulation in human diseases：
(1)AKI-to-CKD transition,
(2)Psoriasis,
(3) Atopic dermatitis.
2017年获美国奥古斯塔大学佐治亚医学院细胞生物学与解剖学专业博士学位，在美国从事多年表观遗传学基础研究。2019年被同济大学附属皮肤病医院（上海市皮肤病医院）聘用为副研究员，2020年被同济大学转化医学院高等研究院聘为副研究员, 同年取得同济大学医学院硕士研究生导师资格。
In 2017, Dr. Guo received a doctorate degree in Cellular Biology and Anatomy from Medical College of Georgia at Augusta University, Georgia. Dr. Guo’s research interest is focused on epigenetic regulation. In 2019, Dr. Guo was hired by Shanghai Skin Disease Hospital as Associate Research Fellow, and in 2020, was appointed as Associate Research Fellow (Associate Professor) by Tongji University Institute for Advanced Study and Master
近5年共发表SCI论文10余篇，其中，以第一作者发表单篇影响因子最高为20.711。
科研基金：国家自然科学基金青年项目，**，Klotho DNA甲基化在急性肾损伤向慢性肾脏病转化过程中的作用及机制的研究，2020/01-2022/12，22万，主持。
代表性著作：
（1）Guo C#, Dong G, Liang X, Dong Z*. Epigenetic regulation in AKI and repair: mechanisms and therapeutic implications. Nat Rev Nephrol 15(4):220-239, 2019；
（2）Guo C#, Pei L, Xiao X, Wei Q, Chen JK, Ding HF, Huang S, Fan G, Shi H, and Dong Z*. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8. Kidney Int 92(5): 1194-1205, 2017；
（3）Guo C#, Wei Q, Su Y, and Dong Z*. SUMOylation occurs in acute kidney injury and plays a cytoprotective role. Biochim Biophys Acta 1852(3): 482-489, 2015；
（4）Yu Z#, Gong Y, Cui L, Hu Y, Zhou Q, Chen Z, Yu Y, Chen Y, Xu P, Zhang X, Guo C, Shi Y*. High-throughput transcriptome and pathogenesis analysis of clinical psoriasis. J Dermatol Sci 98(2):109-118, 2020；
（5）Xiang X#, Guo C, Tang C, Cai J, Dong Z*. Epigenetic regulation in kidney toxicity: insights from cisplatin nephrotoxicity. Semin Nephrol 39(2):152-158, 2019；
（6） Yao Y#, Martin C, Yin C, Guo C, Dong Z, Zhou L*, and Mi QS*. Micro RNAs are required for Langerhans cell, skin and lung resident macrophage ontogeny. J Allergy Clin Immunol 142(3):976-978.e2, 2018.