摘要/Abstract

摘要： SUMO 化修饰是一个动态可逆的过程，需要特异性连接酶参与，其逆反应（去 SUMO 化）则是由一组 SUMO 特异性蛋白酶（SUMO-specific proteases，SENPs）参与的催化解离。SUMO 化修饰的靶蛋白分子与机体的发育、疾病，特别是肿瘤、代谢、炎症与免疫等密切相关，且 SENPs 在 SUMO 蛋白的加工成熟和靶蛋白去 SUMO 化修饰中发挥重要作用。该文就 SENPs 家族蛋白在肿瘤发生发展中的作用和机制进行综述。
关键词: SUMO, SUMO 特异性蛋白酶, 肿瘤
Abstract:
SUMOylation is a dynamically reversible process that needs to be modified by a specific ligase, while its inverse reaction deSUMOylation is catalyzed by a group of SUMO-specific proteases (SENPs). SUMO-modified target protein molecules are closely related to development and disease, especially tumor, metabolism, inflammation and immunity. SENPs play an important role in SUMO protein maturation and deSUMOylation. This review discussed the functions of SENPs in the development and progression of tumors and related mechanisms.
Key words: SUMO, SUMO-specific proteases (SENPs), tumor


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