导师姓名： 黄秋花 专业代码： 071000
性别： 女 专业名称： 生物学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海交通大学医学院附属瑞金医院血液学研究所，上海瑞金二路197号11号楼807室
邮编： 200025 邮箱地址： qiuhua_huang@126.com

研究方向 (点击浏览详细信息)
造血干细胞及血液系统疾病相关基因及表观因子的功能研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 组蛋白H3K36三甲基转移酶Setd2在小鼠MDS形成过程中的分子机制研究 国家自然科学基金面上项目 2019-01~2022-12 55万元 课题参与人
** 利用Setd2小鼠模型研究H3K36me3修饰异常的白血病的病理与治疗机制 国家自然基金面上项目 2017-01~2020-12 57万元 课题负责人
** H3K36组蛋白甲基转移酶SETD2及其截断突变体在造血过程中的作用机理研究 国家自然科学基金青年项目 2016-01~2018-12 18万元 课题参与人
2013CB966801 重编程造血细胞的基础与临床应用研究 科技部国家重大科学研究计划 2013-01~2017-08 900万元 课题参与人
** 用小鼠模型研究 GATA-2 L359V 突变对造血调控的影响 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
** HYPB低倍体剂量不足在造血干细胞老化中的作用 国家自然科学基金面上项目 2010-01~2012-12 30万元 课题负责人
NCET-09-0541 新世纪优秀人才支持计划 教育部 2010-01~2012-12 50万元 课题负责人
2009CB825604 染色质修饰异化在血液肿瘤中的作用机制 973前沿项目课题 2009-01~2013-12 348万元 课题负责人
** 利用模式生物进行组蛋白H3-K36甲基转移酶HYPB基因的表观遗传学功能研究 国家自然科学基金面上项目 2007-01~2009-12 26万元 课题负责人
** 一个新的组蛋白H3甲基转移酶的研究 国家自然科学基金面上项目 2004-01~2006-12 19万元 课题负责人
** CD34+细胞中新发现的锌指蛋白的功能研究 国家自然基金青年科学基金项目 2003-01~2005-12 21万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang MM#, Liu N#, Zhang YL#, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L*, Huang QH* （通讯作者）, Sun XJ* Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation. Leukemia 2019 33(7):1822-1827
Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, Sun XJ. Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc Natl Acad Sci USA 2019 116(3):890-899
Yu SH, Zhu KY, Zhang F, Wang J, Yuan H, Chen Y, Jin Y, Dong M, Wang L, Jia XE, Gao L, Dong ZW, Ren CG, Chen LT, Huang QH, Deng M, Zon LI, Zhou Y, Zhu J, Xu PF, Liu TX. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta Gene Regul Mech. 2018 1861(2):106-116
Yuanliang Zhang, Jiewen Sun, Yinyin Xie, Yan Zhou, Jiachun Song, Aining Xu, Ping Liu, Zhu Chen, Saijuan Chen, Xiaojian Sun, Qiuhua Huang. （通讯作者） Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation. Cell Research 2018 28:476-490
Sun HM, Chen XL, Chen XJ, Liu J, Ma L, Wu HY, Huang QH, Xi XD, Yin T, Zhu J, Chen Z, Chen SJ. Palladin regulates phagocytosis by enabling timely actin polymerization and depolymerization. J Immunol. 2017 199(5):1817-1826
Zhang X#, Chen X#, Liu J#, Xu X, Zhang Y, Ruan Z, Xie Y, Huang Q* （通讯作者）, Yin T*, Chen Z, Chen S* Palladin is a novel microtubule-associated protein responsible for spindle orientation. Sci Rep. 2017 7(1):11806
Yang LS, Zhang XJ, Xie YY, Sun XJ, Zhao R, Huang QH. （通讯作者） SUMOylated MAFB promotes colorectal cancer tumorigenesis. Oncotarget. 2016 7(50):83488-83501.
Jia XE, Ma K, Xu T, Gao L, Wu S, Fu C, Zhang W, Wang Z, Liu K, Dong M, Jing C, Ren C, Dong Z, Chen Y, Jin Y, Huang Q, Chang X, Deng M, Li L, Luo L, Zhu J, Dang Y, Chang HC, Zon LI, Zhou Y, Chen S, Pan W. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction Cell Res. 2015 25(8):946-62
Peng X, Dong M, Ma L, Jia XE, Mao J, Jin C, Chen Y, Gao L, Liu X, Ma K, Wang L, Du T, Jin Y, Huang Q, Li K, Zon LI, Liu T, Deng M, Zhou Y, Xi X, Zhou Y, Chen S. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease Leukemia 2015 29(12):2355-65
Xie Y, Zhang Y, Jiang L, Zhang M, Chen Z, Liu D, Huang Q. （通讯作者） Disabled homolog 2 is required for migration and invasion of prostate cancer cells. Front Med. 2015 9 (3): 312-321
Zhang W, Zhang L, Chen YX, Xie YY, Zou YF, Zhang MJ, Gao YH, Liu Y, Zhao Q, Huang QH, Chen N Identification of Nestin as a Urinary Biomarker for Acute Kidney Injury. Am J Nephrol. 2014 39(2):110-121
谢树高,谢银银,张元亮,黄秋花 （通讯作者） miR-145 靶向调控DAB2 对前列腺癌PC3 细胞迁移和侵袭能力的影响 《遗传》 2014 36(1):50-7
Du TT, Xu PF, Dong ZW, Fan HB, Jin Y, Dong M, Chen Y, Pan WJ, Ren RB, Liu TX, Deng M, Huang QH （通讯作者） Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1 Dev Biol. 2014 392(2):233-44
Zhang Y, Xie S, Zhou Y, Xie Y, Liu P, Sun M, Xiao H, Jin Y, Sun X, Chen Z, Huang Q （通讯作者）, Chen S. H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation towards endoderm. Cell Rep. 2014 8(6):1989-2002
杨林森,张元亮,黄秋花 （通讯作者） 组蛋白H3K36甲基化与疾病 《生命的化学》 2013 33(5):543-548
Zhang HX, Liu ZX, Sun YP, Zhu J, Lu SY, Liu XS, Huang QH, Xie YY, Zhu HB, Dang SY, Chen HF, Zheng GY, Li YX, Kuang Y, Fei J, Chen SJ, Chen Z, Wang ZG. Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA PNAS 2013 110(16):6459-64.
吴婧,吴博,张元亮,谢银银,黄秋花 （通讯作者） GATA-2过表达对小鼠胎肝造血干细胞功能的影响 《中国实验血液学杂志》 2013 21(4):999-1004
周雁,黄秋花 （通讯作者） 白血病细胞中不同启动子驱动外源基因表达的能力差异分析 《遗传》 2011 33(8):879-885
Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Xue LQ, Shen M, Liu W, Xie F, Yang SY, Wang HF, Shi JY, Sun WW, Du WH, Zuo CL, Shi JX, Liu BL, Guo CC, Zhan M, Gu ZH, Zhang XN, Sun F, Wang ZQ, Song ZY, Zou CY, Sun WH, Guo T, Cao HM, Ma JH, Han B, Li P, Jiang H, Huang QH, Liang L, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Chen Z, Chen JL, Chen SJ, Huang W, Song HD. A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet. 2011 43(9):897-901
Chen YX, Li Y, Wang WM, Zhang W, Chen XN, Xie YY, Lu J, Huang QH, Chen N. Phosphoproteomic study of human tubular epithelial cell in response to transforming growth factor-beta-1-induced epithelial-to-mesenchymal transition. Am J Nephrol. 2010 31(1):24-35
Zhang XW, Yan XJ, Zhou ZR, Yang FF, Wu ZY, Sun HB, Liang WX, Song AX, Lallemand-Breitenbach V, Jeanne M, Zhang QY, Yang HY, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, de Thé H, Chen SJ, Chen Z. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 2010 328(5975):240-3
Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z, Chen SJ. As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. PNAS 2010 107(50):21683-8
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH （通讯作者）, Chen SJ, Chen Z. Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling Proc Natl Acad Sci U S A. 2010 107(7):2956-61
Cheung WK, Yang PH, Huang QH, Chen Z, Chen SJ, Lin MC, Kung HF Identification of protein domains required for makorin-2-mediated neurogenesis inhibition in Xenopus embryos. Biochem Biophys Res Commun. 2010 394(1):18-23
Fu YF, Du TT, Dong M, Zhu KY, Jing CB, Zhang Y, Wang L, Fan HB, Chen Y, Jin Y, Yue GP, Chen SJ, Chen Z, Huang QH, Jing Q, Deng M, Liu TX. Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. Blood 2009 113(6):1340-9
Zhang QY, Mao JH, Liu P, Huang QH （共同第一作者）, Lu J, Xie YY, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 106(9):3378-83
Du TT, Fu YF, Dong M, Wang L, Fan HB, Chen Y, Jin Y, Chen SJ, Chen Z, Deng M, Huang QH （通讯作者）, Liu TX. Experimental validation and complexity of miRNA-mRNA target interaction during zebrafish primitive erythropoiesis. Biochem Biophys Res Commun. 2009 381(4):688-93
Zhang SJ, Ma LY, Huang QH （共同第一作者）, Li G, Gu BW, Gao XD, Shi JY, Wang YY, Gao L, Cai X, Ren RB, Zhu J, Chen Z, ChenSJ. Gain of Function Mutation of GATA-2 in Acute Myeloid Transformation of Chronic Myeloid Leukemia. Proc Natl Acad Sci U S A. 2008 105(6):2076-81
Zhang NN, Shen SH, Jiang LJ, Zhang W, Zhang HX, Sun YP, Li XY, Huang QH, Ge BX, Chen SJ, Wang ZG, Chen Z, Zhu J. RIG-I plays a critical role in negatively regulating granulocytic proliferation. PNAS 2008 105(30):10553-8.
杜婷婷, 黄秋花 （通讯作者） 组蛋白赖氨酸甲基化在表观遗传调控中的作用 《遗传》 2007 29(4):387-92
Zheng PZ, Wang KK, Zhang QY, Huang QH （共同第一作者）, Du YZ, Zhang QH, Xiao DK, Shen SH, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z, Zhang J. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A 2005 102(21):7653-8
Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH （通讯作者）, Chen Z. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem. 2005 280(42):35261-71
Xiao HS, Huang QH （共同第一作者）, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ, Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG, Zhang X. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A 2002 99(12):8360-5
Hu RM, Han ZG, Song HD, Peng YD, Huang QH （共同第一作者）, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A 2000 97(17):9543-8
Gu J, Zhang QH, Huang QH （共同第一作者）, Ren SX, Wu XY, Ye M, Huang CH, Fu G, Zhou J, Niu C, Han ZG, Chen SJ, Chen Z. Gene expression in CD34 (+) cells from normal bone marrow and leukemic origins. Hematol J. 2000 1(3):206-17