导师姓名： 王铸钢 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市黄浦区瑞金二路197号23号楼瑞金医院实验医学研究中心
邮编： 200025 邮箱地址： zhugang.wang@163.com

研究方向 (点击浏览详细信息)
利用遗传工程小鼠模型研究人类疾病致病或发病相关基因功能，解析疾病发病机制

社会任职
中国遗传学会理事
医学基因组学国家重点实验室副主任
上海南方模式生物研究中心主任
上海遗传学会副理事长
瑞金医院实验医学研究中心主任

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 三种睾丸特异性丝氨酸蛋白酶家族成员的生理功能研究 国家自然科学基金重点项目 2015-01~2019-12 320万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Cui X, Ma B, Wang Y, Chen Y, Shen C, Kuang Y, Fei J, Lu L, Wang Z. （通讯作者） Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels Front Med. 2019 13(1):104-111.
Xu WY, Shen Y, Zhu H, Gao J, Zhang C, Tang L, Lu SY, Shen CL, Zhang HX, Li Z, Meng P, Wan YH, Fei J, Wang ZG. （通讯作者） 2-Aminoadipic acid protects against obesity and diabetes. J Endocrinol. 2019 Epub
Liu J, Tang LY, Wang YG, Lu SY, Zhang EN, Wang ZG （通讯作者）, Zhang HX Identification of MAVS as a Novel Risk Factor for the Development of Osteoarthritis Aging Dis. 2018 1;9(1):40-50
Xiyi Wang, Chunling Shen, Xuejiao Chen, Jinjin Wang, Xiaofang Cui, Yicheng Wang, Hongxin Zhang, Lingyun Tang, Shunyuan Lu, Jian Fei, Zhugang Wang （通讯作者） Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice. Acta Biochim Biophys Sin 2018 50(10):984-995.
Xuan Shang, Chunling Shen, Jianbing Liu, Lingyun Tang, Hongxin Zhang, Yicheng Wang, Wenting Wu, Jun Chi, Hua Zhuang, Jian Fei, Zhugang Wang （通讯作者） Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding Cell Mol Life Sci 2018 75(23):4371-4384.
Wang-Yang Xu, Houbao Zhu, Yan Shen, Ying-Han Wan, Xiao-Die Tu, Wen-Ting Wu, Lingyun Tang, Hong-Xin Zhang, Shun-Yuan Lu, Xiao-Long Jin, Ying Kuang, Jian Fei, Zhu-Gang Wang （通讯作者） DHTKD1 deficiency causes Charcot-Marie-Tooth disease in mice Molecular and Cellular Biology 2018 14;38(13). pii: e00085-18
Mao YL, Shen CL, Zhou T, Ma BT, Tang LY, Wu WT, Zhang HX, Lu HL, Xu WX, Wang ZG. （通讯作者） Ablation of Tacr2 in mice leads to gastric emptying disturbance. Neurogastroenterol Motil. 2017 29(11): e13117
Cui X, Dang S, Wang Y, Chen Y, Zhou J, Shen C, Kuang Y, Fei J, Lu L, Wang Z. （通讯作者） Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice. Toxicol Lett. 2017 265:17-22.
Tang L, Wu X, Zhang H, Lu S, Wu M, Shen C, Chen X, Wang Y, Wang W, Shen Y, Gu M, Ding X, Jin X, Fei J, Wang Z. （通讯作者） A point mutation in Fgf9 impedes joint interzone formation leading to Multiple Synostoses Syndrome Hum Mol Genet. 2017 26(7):1280-1293.
Ma B, Zhu J, Tan J, Mao Y, Tang L, Shen C, Zhang H, Kuang Y, Fei J, Yang X, Wang Z. （通讯作者） Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway. Am J Cancer Res. 2017 7(3):433-447.
Chen XJ, Wang XY, Tang LY, Wang JJ, Shen CL, Liu JB, Lu SY, Zhang HX, Kuang Y, Fei J, Wang ZG （通讯作者） Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mic Am J Med Genet B Neuropsychiatr Gene 2017 174(8):828-838
Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG （通讯作者） Lacking of palladin leads to multiple cellular events changes which contribute to NTD Neural Dev 2017 12(1):4
Zhu H, Xu WY, Hu Z, Zhang H, Shen Y, Lu S, Wei C, Wang ZG. （通讯作者） RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J Exp Clin Cancer Res. 2017 36(1):2.
Cui XF, Dang SY, Wang Y, Chen Y, Zhou J, Shen CL, Kuang Y, Fei J, Lu LG, Wang ZG （通讯作者） Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice Toxicol Lett 2017 4;265:17-22
Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z. （通讯作者） Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017 149:1-8.
Liu J, Shen C, Fan W, Chen Y, Zhang A, Feng Y, Li Z, Kuang Y, Wang Z. （通讯作者） Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. Acta Biochim Biophys Sin (Shanghai) 2016 48(11):1058-1065.
Shen C, Wang J, Zhuang H, Liu J, Wang X, Chen X, Wu Z, Wu W, Wu Y, Sun Y, Yan H, Fei J, Kuang Y, Wang Z. （通讯作者） Establishment, characterization, and application of pAcr-SP-NTP-EGFP transgenic mice in visualizing the oviduct-migrating ability of sperm from Prss37-null mice. Acta Biochim Biophys Sin (Shanghai). 2015 47(6):466-73.
Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG. （通讯作者） Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. World J Gastroenterol. 2014 20(2):498-508
Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z. （通讯作者） DHTKD1 is essential for mitochondrial biogenesis and function maintenance. FEBS Letters 2013 587(21):3587-3592
Shen C, Kuang Y, Liu J, Feng J, Chen X, Wu W, Chi J, Tang L, Wang Y, Fei J, Wang Z. （通讯作者） Prss37 is required for male fertility in the mouse. Biol Reprod. 2013 88(5):123
Wang JJ, Zhang LL, Zhang HX, Shen CL, Lu SY, Kuang Y, Wan YH, Wang WG, Yan HM, Dang SY, Fei J, Jin XL, Wang ZG. （通讯作者） Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Cell Death Dis. 2013 4:e853
Zhu H, Xu W, Zhang HX, Liu J, Xu H, Lu S, Dang S, Kuang Y, Jin X, Wang Z. （通讯作者） Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation. Biochem Biophys Res Commun. 2013 438(1):97-102
Chen Y, Ni YY, Liu J, Lu JW, Wang F, Wu XL, Gu MM, Lu ZY, Wang ZG （通讯作者）, Ren ZH. Dopamine receptor 3 might be an essential molecule in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. BMC Neurosci 2013 14:76
Wang JJ, Kuang Y, Zhang LL, Shen CL, Wang L, Lu SY, Lu XB, Fei J, Gu MM, Wang ZG. （通讯作者） Phenotypic correction and stable expression of factor VIII in hemophilia A mice by embryonic stem cell therapy. Genet Mol Res 2013 12(2):1511-1521
Zhang HX, Liu ZX, Sun YP, Zhu J, Lu SY, Liu XS, Huang QH, Xie YY, Zhu HB, Dang SY, Chen HF, Zheng GY, Li YX, Kuang Y, Fei J, Chen SJ, Chen Z, Wang ZG （通讯作者） Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA. Proc Natl Acad Sci USA. 2013 110(16), 6459-6464
Wangyang Xu, Mingmin Gu, Lianhua Sun, Wenting Guo, Houbao Zhu, Jianfang Ma, Wentao Yuan, Ying Kuang, Baojun Ji, Xiaolin Wu, Yan Chen, Hongxin Zhang, Futing Sun, Wei Huang, Lei Huang, Shengdi Chen, Zhugang Wang. （通讯作者） A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. AJHG 2012 91(6):1-7
Zhang LL, Wang JJ, Liu Y, Lu XB, Kuang Y, Wan YH, Chen Y, Yan HM, Fei J, Wang ZG. （通讯作者） GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Neuroscience 2011 196:203-214
Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, Kawano T, Wang X, Cao Z, Wang Z （通讯作者）, Huang L. MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13. Laboratory Investigation 2011 91(5):778-787
Yuan Li, Haiying Yi, Yixin Yao, Xiaodong Liao, Yiqun Xie, Jie Yang, Zheng Yan, Long Wang, Shunyuan Lu, Ying Kuang, Mingmin Gu, Jian Fei, Zhugang Wang （通讯作者）, Lei Huang. The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-catenin. PLOS ONE 2011 6(4):e19102
Xue-song Liu, Xu-dong Zhao, Xiao-xing Wang, Yi-xin Yao, Liang-liang Zhang, Run-zhe Shu, Wei-hua Ren, Ying Huang, Lei Huang, Ming-min Gu, Ying Kuang, Long Wang, Shun-yuan Lu, Jun Chi, Jing-sheng Fen, Yi-fei Wang, Jian Fei, Wei Dai, Zhu-gang Wang. （通讯作者） Germinal cell aplasia in Kif18a mutant male mice due to impaired chromosome congression and dysregulated BubR1 and CENP-E. Gene & Cancer 2010 1(1): 26-39
Run-Zhe Shu, Feng Zhang, Fang Wang , De-Chun Feng, Xi-Hua Li, Wei-Hua Ren, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Lei Huang, Zhu-Gang Wang. （通讯作者） Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. Laboratory Investigation 2009 89(9):1043-52
Feng Zhang, Run-zhe Shu, Xiao-lin Wu, Xiao-ping Zhao, De-chun Feng, Long Wang, Shun-yuan Lu, Qiao-ling Liu, You-gui Xiang, Jian Fei, Lei Huang, Zhu-gang Wang. （通讯作者） Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice. Toxicology Letters 2009 188(3):201-207
Xiao-lin Wu, Ming-min Gu, Lei Huang, Xue-song Liu, Hong-xin Zhang, Xiao-yi Ding, Jian-qiang Xu, Bin Cui, Long Wang, Shun-yuan Lu, Xiao-yi Chen, Hai-guo Zhang, Wei Huang, Wen-tao Yuan, Jiang-ming Yang, Qun Gu, Jian Fei, Zhu Chen, Zhi-min Yuan, Zhu-Gang Wan （通讯作者） Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. AJHG 2009 85(1):53-63
Ling Kong, Lei Sun, Hong-xin Zhang, Qin Liu, Ye Liu, Lin-hua Qin, Guo-jun Shi, Jun-Hao Hu, A-jing Xu, Yue-Ping Sun, Dang-sheng Li, Yu-Fang Shi, Jing-Wu Zang, Jiang Zhu, Zhu Chen, Zhu-Gang Wang （通讯作者）, Bao-Xue Ge. An Essential Role for RIG-I in Toll-like Receptor-Stimulated Phagocytosis. CELL HOST & MICROBE 2009 6(2):150-161
Jin Hou,Pin Wang,Li Lin, Xing-guang Liu, Feng Ma, Hua-zhang An, Zhu-gang Wang （通讯作者）, and Xue-tao Cao. MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2. Journal of Immunology 2009 183(3):2150-2158
Run-Zhe Shu, Feng Zhang, Xue-Song Liu, Chun-Liang Li, Long Wang, Yi-Lin Tai, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Ying Jin, Ming-Min Gu, Lei Huang, Xiao-Fen Pang, Zhu-Gang Wang. （通讯作者） Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice. PLoS ONE 2009 4(9):e6916
Nan-Nan Zhang, Shu-Hong Shen, Lin-Jia Jiang, Wu Zhang, Hong-Xin Zhang, Yue-Ping Sun, Xian-Yang Li, Qiu-Hua Huang, Bao-Xue Ge, Sai-Juan Chen, Zhu-Gang Wang （通讯作者）, Zhu Chen, and Jiang Zhu. RIG-I plays a critical role in negatively regulatinggranulocytic proliferation. PNAS 2008 105(30):10553-10558
Gan Y, Zhao X, Hu J, Wang ZG （通讯作者）, Zhao XT. HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality. CELL DEATH AND DIFFERENTIATION 2008 15(9):1481-1490