导师姓名： 徐敏 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师：
联系方式： **
邮编： 200025 邮箱地址： della.xumin@163.com

研究方向 (点击浏览详细信息)
2型糖尿病临床及流行病学研究

社会任职
Editorial Board Member, Food & Nutrition: Current Research.
上海市医学会糖尿病学专科分会代谢病学组委员
中华糖尿病学会胰岛Beta细胞学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于队列和饮食-运动干预的肠道菌群相关代谢物与老年人 心血管健康的关联和机制研究 国家自然基金委员会 2020-01~2022-12 90万元 课题负责人
2018YFC** 糖尿病临床研究数据采集标准、交换机制及应用研究 国家重点研发计划“重大慢性非传染性疾病防控研究”专项“重大慢病流行病学监测大数据平台构建和关键技术研究”项目 2018-07~2020-12 250万元 课题负责人
** 视黄醇结合蛋白-4在白色脂肪棕色化及体重调节中的作用及机制研究 国家自然科学基金面上项目 2018-01~2021-12 54万元 课题负责人
00-000 基于新型生物大数据的糖尿病防治路径及推广应用 上海市科委 2017-07~2020-06 150万元 课题负责人
SHDC** 2型糖尿病预警模型开发及推广应用 上海申康医院发展中心 2016-11~2019-11 15万元 课题负责人
000-00 SMC-晨星优秀青年教师（A类计划） 上海交通大学 2016-09~2019-08 30万元 课题负责人
2016YFC** 环境、行为及生物危险因素对 2 型糖尿病发生发展影响的研究 国家重点研发计划课题 2016-07~2020-12 117万元 课题参与人
2015BAI12B14 中国成人糖尿病的发病危险因素、动态监测及综合防治 国家科技支撑计划 2015-04~2017-12 939万元 课题参与人
** 谷氨酰胺酰基环化酶同工酶（QPCTL）在脂肪发育及体重调节中的作用及机制研究 国家自然基金委，面上项目 2015-01~2018-12 73万元 课题负责人
** 临床专职科研 上海交通大学医学院“高原高峰计划” 2015-01~2017-12 100万元 课题负责人
14PJD024 肥胖及糖代谢相关遗传变异位点与环境因素交互作用的研究 上海市浦江人才计划项目 2014-09~2016-08 20万元 课题负责人
** 锌转运蛋白8基因（SLC30A8）pre-mRNA选择性剪接的影响机制 国家自然基金委，面上项目 2013-01~2016-12 65万元 课题负责人
2011-293 新的脂肪因子SFRP5在胰岛素抵抗及相关代谢异常中的作用研究 上海市卫生局局级课题 2012-01~2014-12 3万元 课题负责人
2012AA02A509 2型糖尿病冠心病早期诊治的分子分型标记物研究 国家高技术研究发展计划（863计划） 2012-01~2015-12 189万元 课题参与人
000-00 新的脂肪因子SFRP5在胰岛素抵抗及相关代谢异常中的作用研究 院级课题，优秀青年教师 2011-08~2013-07 2万元 课题负责人
** 锌转运蛋白－8基因(SLC30A8)影响胰岛β细胞功能研究 国家自然基金委，青年项目 2009-01~2011-12 21万元 课题负责人
08ZR** 锌转运蛋白－8基因(SLC30A8)影响胰岛β细胞功能研究 上海市科委，自然科学基金 2008-08~2010-09 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Deng C, Niu J, Xuan L, Zhu W, Dai H, Zhao Z, Li M, Lu J, Xu Y, Chen Y, Wang W, Ning G, Bi Y, Xu M （通讯作者）, Wang T. 2020 Feb 10; Association of QTc Interval with Risk of Cardiovascular Diseases and Related Vascular Traits: A Prospective and Longitudinal Analysis. Glob Heart. 2020 15(1):13.
Li M, Xu Y, Wan Q, Shen F, Xu M （共同第一作者）, Zhao Z, Lu J, Gao Z, Chen G, Wang T, Xu Y, Zhao J, Chen L, Shi L, Hu R, Ye Z, Tang X, Su Q, Qin G, Wang G, Luo Z, Qin Y, Huo Y, Li Q, Zhang Y, Chen Y, Liu C, Mu Y, Wang Y, Wu S, Yang T, Chen L, Yu X, Yan L, Deng H, Ning G, Bi Y, Wang W. Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study. Diabetes Care. 2020 43(8):1929-1936.
Cao Y, Li L, Xu M （共同第一作者）, Feng Z, Sun X, Lu J, Xu Y, Du P, Wang T, Hu R, Ye Z, Shi L, Tang X, Yan L, Gao Z, Chen G, Zhang Y, Chen L, Ning G, Bi Y, Wang W; ChinaMAP Consortium. The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals. Cell Res. 2020 10.1038/s41422-020-0322-9.
Wang T, Lu J, Shi L, Chen G, Xu M （共同第一作者）, Xu Y, Su Q, Mu Y, Chen L, Hu R, Tang X, Yu X, Li M, Zhao Z, Chen Y, Yan L, Qin G, Wan Q, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Zhao J, Lai S, Bi Y, DeFronzo RA, Wang W, Ning G; China Cardiometabolic Disease and Cancer Cohort Study Group. Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet Diabetes Endocrinol. 2020 8(2):115-124.
Xuan L, Wang T, Dai H, Wang B, Xiang J, Wang S, Lin H, Li M, Zhao Z, Lu J, Chen Y, Xu Y, Wang W, Xu M （通讯作者）, Bi Y, Ning G. Serum lipoprotein (a) associates with a higher risk of reduced renal function: a prospective investigation J Lipid Res 2020 0(0):00-00
Zhu W, Wang S, Dai H, Xuan L, Deng C, Wang T, Zhao Z, Li M, Lu J, Xu Y, Chen Y, Wang W, Bi Y, Xu M （通讯作者）, Ning G. Serum total bile acids associate with risk of incident type 2 diabetes and longitudinal changes in glucose-related metabolic traits. J Diabetes. 2020 12(8):616-625.
Zhang Y, Peng K, Liu J, Chen X, Wang T, Li M, Chen Y, Xu Y, Lu J, Bi Y, Wang W, Ning G, Xu M. （通讯作者） Carotid intima-media thickness and plagues are associated with indicators of peripheral artery diseases in patients with diabetes. Diabetes Res Clin Pract 2018 144(10):245-251
Xuan L, Hou Y, Wang T, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Qi L, Wang W, Bi Y, Xu M. （通讯作者） Association of branched chain amino acids related variant rs** with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese. Acta Diabetol 2018 55(9):901-908
Wang T, Xu M, Bi Y, Ning G. Interplay between diet and genetic susceptibility in obesity and related traits. Front Med 2018 12(6):601-607
Xuan L, Zhao Z, Jia X, Hou Y, Wang T, Li M, Lu J, Xu Y, Chen Y, Qi L, Wang W, Bi Y, Xu M. （通讯作者） Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis. Front Med 2018 12(6):678-687
Ding L, Xu Y, Wang L, Xu M （共同第一作者）, et al. The cardiometabolic risk profile of Chinese adults with diabetes: A nationwide cross-sectional survey. J Diabetes Complications. 2017 31(1):43-52
Hao M, Ding L, Xuan L, Wang T, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Wang W, Bi Y, Xu M （通讯作者）, Ning G Urinary bisphenol A concentration and the risk of central obesity in Chinese adults: A prospective study. J Diabetes. 2017 xx(xx):xx-xx
Bi Y, Wang W, Xu M （共同第一作者）, et al. Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism. J Clin Endocrinol Metab. 2016 101(1):143-50.
Xu M, Bi Y, Huang Y, Xie L, Hao M, Zhao Z, Xu Y, Lu J, Chen Y, Sun Y, Qi L, Wang W, Ning G. Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study. EBioMedicine. 2016 6:162-70.
Xu M, Huang Y, Xie L, Peng K, Ding L, Lin L, Wang P, Hao M, Chen Y, Sun Y, Qi L, Wang W, Ning G, Bi Y. Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis. Diabetes. 2016 65(6):1731-40
Wang T, Xu Y, Xu M （共同第一作者）, Ning G, Lu J, Dai M, Xu B, Sun J, Sun W, Lai S, Bi Y, Wang W. Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study. Am J Epidemiol. 2016 184(4):295-301.
Huang Y, Xu M （共同第一作者）, Xie L, Wang T, Huang X, Lv X, Chen Y, Ding L, Lin L, Wang W, Bi Y, Sun Y, Zhang Y, Ning G. Obesity and peripheral arterial disease: A Mendelian Randomization analysis. Atherosclerosis. 2016 247:218-24
Bi Y, Wang L, Xu Y, Jiang Y, He J, Zhang M, Zhou M, Li Y, Xu M, Lu J, Wang T, Ding L, Dai M, Zhang D, Chen CS, Lai S, Wang W, Wang L, Ning G; 2012 China Noncommunicable Disease and Risk Factor Surveillance in Migrant Workers Study Group. Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study. Lancet Diabetes Endocrinol. 2016 4(2):125-35.
Huang X, Ding L, Peng K, Lin L, Wang T, Zhao Z, Xu Y, Lu J, Chen Y, Wang W, Bi Y, Ning G, Xu M. （通讯作者） Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation. J Transl Med. 2016 14(1):336-336
Xu M, Lv X, Xie L, et al. Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis. Diabetologia. 2016 59(2):307-15.
Huang X, Xu M （共同第一作者）, Chen Y, et al. Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese. Medicine (Baltimore). 2015 94(40):e1682.
Zhou Y, Zhao L, Wang T, Hong J, Zhang J, Xu B, Huang X, Xu M （通讯作者）, Bi Y. Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population. J Atheroscler Thromb. 2015 Oct 1. [Epub ahead of print] 2015 00-00
Wang T, Xu Y, Xu M （共同第一作者）, et al. Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study. Cardiovasc Diabetol. 2015 14:28.
He M, Xu M （共同第一作者）, Zhang B,et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 24(6):1791-800.
Xu M, Zhou Y, Xu B,et al. The associations of smoking and alcohol consumption with impaired β cell function in Chinese men. J Diabetes. 2015 2015 May 19. doi: 10.1111/1753-0407.12314. [Epub ahead of print]
Xu M, Huang T, Lee AW, et al. Ready-to-Eat Cereal Consumption with Total and Cause-Specific Mortality: Prospective Analysis of 367,442 Individuals. J Am Coll Nutr. 2015 23:1-7
Chen Y, Xu M （共同第一作者）, Wang T, et al. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease. Atherosclerosis. 2015 241(1):145-150.
Wang T, Xu M （共同第一作者）, Xu Y, et al. Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study. Medicine (Baltimore). 2015 94(43):e1814
Xu M （通讯作者）, Ng SS, Bray GA, et al. Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial. J Nutr. 2015 145(6):1289-94.
Sun JC, Xu M （共同第一作者）, Lu JL, et al; the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal (REACTION) Study group. Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults. Diabet Med. 2015 32(7):935-43
Sun JC, Huang XL, Deng XR, Lv XF, Lu JL, Chen YH, Bi YF, Wang WQ, Xu M （通讯作者）, Ning G. Elevated resting heart rate is associated with dyslipidemia in middle-aged and elderly Chinese. Biomed Environ Sci. 2014 27(8):601-5.
Xu M,Qi L. Chapter40: Genetics of central obesity. In: Ronald Watson, editors. Nutrition in and Prevention and Treatment of Abdominal Obesity. Elsevier; 2014 p. 471-485
Zhou Y, Ye L, Wang T, Hong J, Bi Y, Zhang J, Xu B, Sun J, Huang X, Xu M. （通讯作者） Free triiodothyronine concentrations are inversely associated with microalbuminuria. Int J Endocrinol. 2014 2014:959781.
Xu M, Bi Y, Cui B,et al. The new perspectives on genetic studies of type 2 diabetes and thyroid diseases. Curr Genomics. 2013 14(1):33-48.
Xu M, Bi Y, Chen Y, et al. Increased C-reactive protein associates with elevated carotid intima-media thickness in Chinese adults with normal low density lipoprotein cholesterol levels. J Atheroscler Thromb. 2013 20(6):575-84.
Xu M, Qi Q, Liang J, et al. Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. Circulation. 2013 127(12):1283-9.
Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, …, Ning G; 2010 China Noncommunicable Disease Surveillance Group. Prevalence and control of diabetes in Chinese adults. JAMA. 2013 310(9):948-59.
Cui B, Zhu X, Xu M （共同第一作者）, et al. 2011;6(7): A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. PLoS One. 2011 e22353.
Xu Y, Zhao Z, Li X, Bi Y, Xu M （通讯作者）, Ning G. Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population. Endocrine. 2011 39(2):175-81.
Ning G, Bi Y, Wang T, Xu M, et al. Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis. Ann Intern Med. 2011 155(6):368-74.
Li M, Xu M* （共同第一作者）, Bi Y, et al. Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly chinese with normal glucose tolerance. Diabetes Care. 2010 33(11):2462-4.
Xu M, Bi Y, Xu Y, et al. Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One. 2010 5(11):e14022.
Xu M （共同第一作者）, Li XY, Wang JG, et al. Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Diabetologia. 2009 52(8):1511-9.
Xiang J, Li XY, Xu M （共同第一作者）,et al. Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab. 2008 93(10):4107-12.
Xu M, Li X, Wang JG, et al. Glucose and lipid metabolism in relation to novel polymorphisms in the 5'-AMP-activated protein kinase gamma2 gene in Chinese. Mol Genet Metab. 2005 86(3):372-8.