导师姓名： 毕宇芳 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200025 邮箱地址： byf10784@rjh.com.cn

研究方向 (点击浏览详细信息)
2型糖尿病等代谢性疾病的临床诊治与研究

社会任职
中华预防医学会慢性病预防与控制分会，委员
《Biomedical and Environmental Sciences》，编委
上海交通大学医学院附属瑞金医院青年联合会，副会长
中华医学会内分泌学分会，委员
上海市医学会内分泌学分会，副主任委员
《中华内分泌代谢杂志》，编委
《Journal of Diabetes》，编委
《诊断学理论与实践》，副主编

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** LGR4基因变异和性别的交互作用促进肥胖发生的作用机制研究 国家自然科学基金委员会面上项目 2020-01~2023-12 59万元 课题负责人
18XD** 2型糖尿病遗传与环境危险因素的交互作用 上海市优秀学术带头人 2018-05~2021-04 40万元 课题负责人
2016YFC** 2型糖尿病高风险的早期识别与适宜切点研究 国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项 2016-09~2020-12 635万元 课题负责人
运动干预在中澳糖尿病前期和新发糖尿病中对代谢表型组的影响 国家自然科学基金委 2016-01~2020-12 291万元 课题负责人
** 环境内分泌干扰物双酚A致代谢紊乱的作用机制研究 国家自然科学基金委 2015-01~2018-12 80万元 课题负责人
** 内分泌代谢性疾病 国家自然科学基金优秀青年项目 2013-01~2015-12 100万元 课题负责人
** ACTH依赖性库欣综合征的糖皮质激素抵抗机制及干预治疗 国家自然科学基金 2009-01~2011-12 31万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ruizhi Zheng#, Yu Xu#, Weiqing Wang, Guang Ning*, Yufang Bi* （通讯作者） Spatial transmission of COVID-19 via public and private transportation in China Travel Med Infect Dis . 2020 34:101626
Zhuojun Xin#, Yuanyue Zhu#, Shuangyuan Wang#, Shanshan Liu, Min Xu, Tiange Wang, Jieli Lu, Yuhong Chen, Zhiyun Zhao, Weiqing Wang, Guang Ning, Yufang Bi* （通讯作者）, Yu Xu*, Mian Li* Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non-invasive score Liver Int . 2020 40(4):806-814
Chanjuan Deng #, Jingya Niu #, Liping Xuan, Wen Zhu, Huajie Dai, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi* （通讯作者）, Min Xu*, Tiange Wang* Association of QTc Interval with Risk of Cardiovascular Diseases and Related Vascular Traits: A Prospective and Longitudinal Analysis Glob Heart . 2020 15(1):13
Chunyan Hu#, Yiming Mu#, Qin Wan#, Yingfen Qin#, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Lulu Chen, Jiajun Zhao, Jieli Lu, Lin Lin, Mian Li, Rui Du, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Donghui Li, Yufang Bi* （通讯作者）, Weiqing Wang, Guang Ning, REACTION Study Group Association between birth weight and diabetes: Role of body mass index and lifestyle in later life J Diabetes . 2020 12(1):10-20
Yuqing Zhang#, Shushu Wang#, Linlin Zhang, Feiye Zhou, Kecheng Zhu, Qin Zhu, Qianqian Liu, Yun Liu, Lei Jiang, Guang Ning, Yufang Bi* （通讯作者）, Libin Zhou*, Xiao Wang* Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling Theranostics . 2020 10(16):7351-7368
Yanan Cao#, Lin Li#, Min Xu#, Zhimin Feng, Xiaohui Sun, Jieli Lu, Yu Xu, Peina Du, Tiange Wang, Ruying Hu, Zhen Ye, Lixin Shi, Xulei Tang, Li Yan, Zhengnan Gao, Gang Chen, Yinfei Zhang, Lulu Chen, Guang Ning*, Yufang Bi* （通讯作者）, Weiqing Wang*, ChinaMAP Consortium The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals Cell Res . 2020 Online ahead of print.
Jieli Lu#, Jiang He#, Mian Li#, Xulei Tang#, Ruying Hu#, Lixin Shi, Qing Su, Kui Peng, Min Xu, Yu Xu, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Guijun Qin, Qin Wan, Gang Chen, Meng Dai, Di Zhang, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Rui Du, Di Cheng, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Zachary T Bloomgarden, Lulu Chen*, Jiajun Zhao*, Yiming Mu*, Guang Ning*, Weiqing Wang*, Yufang Bi* （通讯作者）, 4C Study Group Predictive Value of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults Diabetes Care 2019 42(8):1539-1548
Wang Long#, Li Mian#, Zhao Zhiyun#, Xu Min, Lu Jieli, Wang Tiange, Chen Yuhong, Wang Shuangyuan, Dai Meng, Hou Yanan, Wu Xueyan, Ma Lina, Li Lin, Liu Shanshan, Wang Weiqing, Xu Yu*, Bi Yufang* （通讯作者）, Ning Guang*. Ideal cardiovascular health is inversely associated with non-alcoholic fatty liver disease: a prospective analysis. Am J Med. 2018 pii: S0002-9343(18)30734-4.
Wang Tiange#, Zhao Zhiyun#, Xu Yu#, Qi Lu#, Xu Min, Lu Jieli, Li Min, Chen Yuhong, Dai Meng, Zhao Wenhua, Ning Guang, Wang Weiqing, Bi Yufang*. （通讯作者） Insulin Resistance and β-Cell Dysfunction in Relation to Cardiometabolic Risk Patterns. J Clin Endocrinol Metab. 2018 103(6):2207-2215
Lu Jieli#, Wang Limin#, Li Mian#, Xu Yu#, Jiang Yong, Wang Weiqing, Li Jianhong, Mi Shengquan, Zhang Mei, Li Yichong, Wang Tiange, Xu Min, Zhao Zhiyun, Dai Meng, Lai Shenghan, Zhao Wenhua*, Wang Linhong*, Bi Yufang* （通讯作者）, Ning Guang*; 2010 China Noncommunicable Disease Surveillance Group. Metabolic Syndrome among Adults in China - The 2010 China Noncommunicable Disease Surveillance. J Clin Endocrinol Metab. 2017 102(2):507-515
Ding Lin#, Xu Yu#, Wang Limin#, Xu Min#, Jiang Yong, Zhang Mei, Li Yichong, Lu Jieli, Wang Tiange, Dai Meng, Zhang Di, Wang Weiqing, Zhao Wenhua, Wang Linhong, Bi Yufang* （通讯作者）, Ning Guang; 2010 China Non-communicable Disease Surveillance Group. The cardiometabolic risk profile of Chinese adults with diabetes: A nationwide cross-sectional survey. J Diabetes Complications. 2017 31(1):43-52
Bi Yufang# （共同第一作者）, Wang Weiqing#, Xu Min#, Wang Tiange#, Lu Jjieli, Xu Yu, Dai Meng, Chen Yuhong, Zhang Di, Sun Wanwan, Ding Lin, Chen Ying, Huang Xiaolin, Lin Lin, Qi Lu, Lai Shenghan, Ning Guang. Diabetes genetic risk score modifies effect of bisphenol A exposure on deterioration in glucose metabolism. J Clin Endocrinol Metab 2016 101(1):143-50
Xu Yu#, Zhao Wenhua#, Wang Weiqing#, Bi Yufang# （共同第一作者）, Li Jianhong#, Mi Shengquan# , Xu M, Lu J, Wang T, Li M, Wang Z, Jiang Y, Wang L, Wang L, Dai M, Zhang D, Lai S, Ning G; 2010 China Noncommunicable Disease Surveillance Group. Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults. J Diabetes 2016 8(3):378-86
Ding Lin, Xu Yu, Wang Limin, Jiang Yong, Zhang Mei, Li Yichong, Lu Jieli, Xu Min, Wang Tiange, Li Mian, Zhao Zhiyun, Dai Meng, Wang Weiqing, Zhao Wenhua, Wang Linhong, Bi Yufang* （通讯作者）, Ning Guang; 2010 China Non-communicable Disease Surveillance Group. Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey. Biomed Environ Sci. 2016 29(9):619-627
Bi Yufang, Wang Limin, Xu Yu, Jiang Yong, He Jiang, Zhang Mei, Zhou Maigeng, Li Yichong, Xu Min, Lu Jieli, Wang Tiange, Ding Lin, Dai Meng, Zhang Di, Chen Chung Shiuan, Lai Shenghan,Wang Weiqing,Wang Linhong,Ning Guang. Diabetes-related metabolic risk factorsin internal migrant workers in China: a national surveillance study Lancet diabetes & endocrinology 2016 4(2): 125~135
Xu Min#, Yufang Bi# （共同第一作者）,, Huang Ya#, Xie Lan#, Hao Mingli, Zhao Zhiyun, Xu Yu, Lu Jieli, Chen Yuhong, Sun Yimin, Qi Lu, Wang Weiqing, Ning Guang. Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study. EBioMedicine. 2016 6:162-70
Yang Minglan, Chen Maopei, Wang Jiqiu, Xu Min, Sun Jichao, Ding Lin, Lv Xiaofei, Ma Qinyun, Bi Yufang* （通讯作者）, Liu Ruixin, Hong Jie, Ning Guang. Bisphenol A Promotes Adiposity and Inflammation in a Nonmonotonic Dose-response Way in 5-week-old Male and Female C57BL/6J Mice Fed a Low-calorie Diet. Endocrinology. 2016 157(6):2333-45
Xu Min, Huang Ya, Xie Lan, Peng Kui, Ding Lin, Lin Lin, Wang Po, Hao Mingli, Chen Yuhong, Sun Yimin, Qi Lu, Wang Weiqing, Ning Guang, Bi Yufang （通讯作者） Diabetes and Risk of Arterial Stiffness: a Mendelian Randomization Analysis， Diabetes 2016 65(6): 1731~1740
Xu Min#, Lv Xiaofei#, Xie Lan#, Huang Xiaolin, Huang Ya, Chen Ying, Peng Kui, Wang Po, Wang Weiqing, Qi Lu, Bi Yufang* （通讯作者）, Sun Yimin, Ning Guang. Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis. Diabetologia. 2016 59(2):307-15
Bi Y*, Wang W, Xu M, Wang T, Lu J, Xu Y, Dai M, Chen Y, Zhang D, Sun W, Ding L, Chen Y, Huang X, Lin L, Qi L, Lai S, Ning G. Diabetes genetic risk score modifies effect of bisphenol A exposure on deterioration in glucose metabolism. J Clin Endocrinol Metab 2015 jc**.
Bi Y*, Jiang Y, He J, Xu Y, Wang L, Xu M, Zhang M, Li Y, Wang T, Dai M, Lu J, Li M, Chen CS, Lai S, Wang W, Wang L, Ning G; 2010 China Noncommunicable Disease Surveillance Group. Status of cardiovascular health in Chinese adults. J Am Coll Cardiol. 2015 65(10):1013-1025.
Chen Y#, Xu M#, Wang T, Sun J, Sun W, Xu B, Huang X, Xu Y, Lu J, Li X, Wang W, Bi Y* （通讯作者）, Ning G. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease. Atherosclerosis 2015 241(1):145-50.
Lin Ding#, An Song#, Meng Dai#, Min Xu, Wanwan Sun, Baihui Xu, Jichao Sun, Tiange Wang, Yu Xu, Jieli Lu, Weiqing Wang, Yufang Bi* （通讯作者）, Guang Ning. Serum lipoprotein (a) concentrations are inversely associated with type 2 diabetes, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population. Journal of Lipid Research. 2015 56(4):920-6
Maigeng Zhou#, Thomas Astell-Burt#, Yufang Bi# （共同第一作者）, Xiaoqi Feng, Yong Jiang, Yichong Li, Andrew Page, Limin Wang, Yu Xu, Linhong Wang*, Wenhua Zhao*, and Guang Ning*. Geographical variation in diabetes prevalence and detection in China: Multilevel Spatial Analysis of 98,058 Adults. Diabetes Care. 2015 38(1):72-81.
Huang X#, Xu M#, Chen Y, Peng K, Huang Y, Wang P, Ding L, Lin L, Xu Y, Chen Y, Lu J, Wang W, Bi Y* （通讯作者）, Ning G. Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese. Medicine (Baltimore) 2015 94(40):e1682.
Xu B#, Dai M#, Li M, Sun K, Zhang J, Wang T, Sun J, Chen Y, Xu M, Lu J, Bi Y*. （通讯作者） Low-grade albuminuria is associated with peripheral artery disease in Chinese diabetic patients. Atherosclerosis 2014 232(2):285-288
Lu J#, Bi Y# （共同第一作者）, Wang T#, Wang W, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Qin G, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Deng H, Yu X, Shen F, Chen L, Zhao L, Dai M, Xu M, Xu Y, Chen Y, Lai S, Ning G. The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population Results of the REACTION study Int J Cardiol 2014 172(2):388-94
Sun J#, Zhang Y#, Xu B, Lv X, Ding L, Chen Y, Sun W, Lu J, Xu M, Bi Y* （通讯作者）, Ning G. Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosis. J Diabetes. 2014 6(5):409-416
Xu Y#, Bi Y# （共同第一作者）, Li M, Wang T, Sun K, Xu M, Lu J, Yu Y, Li X, Lai S, Wang W, Ning G. Significant Coronary Stenosis in Asymptomatic Chinese With Different Glycemic Status. Diabetes Care 2013 36(6):1687-94.
Xu B#, Sun J#, Deng X, Huang X, Sun W, Xu Y, Xu M, Lu J, Bi Y*. （通讯作者） Low serum magnesium level is associated with microalbuminuria in chinese diabetic patients. Int J Endocrinol. 2013 2013:580685
Xu Y#, Wang L#, He J#, Bi Y# （共同第一作者）, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W*, Zhao W*, Ning G*; 2010 China Noncommunicable Disease Surveillance Group. Prevalence and control of diabetes in Chinese adults. JAMA. 2013 310(9):948-959.
Li Mian, Bi Yufang （共同第一作者）, Qi Lu, Wang Tiange, Xu Min, Huang Yun, Xu Yu, Chen Yuhong, Lu Jieli, Li Xiaoying, Wang Weiqing, Ning Guang. Association of Bisphenol A Exposure with Low-Grade Albuminuria in Chinese Adults. Kidney International. 2012 81(11):1131-9.
Wang Tiange, Li Mian, Chen Bin, Xu Min, Xu Yu, Huang Yun, Lu Jieli, Chen Yuhong, Wang Weiqing, Li Xiaoying, Liu Yu, *Bi Yufang （通讯作者）, Lai Shenghan, Ning Guang. Urinary BPA Concentration Associates with Obesity and Insulin Resistance. Journal of Clinical Endocrinology and Metabolism. 2012 97(2):223-227.
Li Mian, Xu Yu, Xu Min, Ma Lingying, Wang Tiange, Liu Yu, Dai Meng, Chen Yuhong, Lu Jieli, Liu Jianmin, *Bi Yufang （通讯作者）, Ning Guang. Association between Non-alcoholic Fatty Liver Disease (NAFLD) and Osteoporotic Fracture in Middle-aged and Elderly Chinese. Journal of Clinical Endocrinology and Metabolism. 2012 97(6):2033-2038.
Huang Yun, Chen Yuhong, Xu Min, Gu Weiqiong, *Bi Yufang （通讯作者）, Li Xiaoying, Ning Guang. Low-grade albuminuria is associated with carotid intima-media thickness in Chinese type 2 diabetic patients. Journal of Clinical Endocrinology and Metabolism. 2010 95(11):5122-5128.
BI Yufang, GAO Runlin, PATEL Anushka, SU Steve, GAO Wei, HU Dayi, HUANG Dejia, KONG Lingzhi, QI Wenhang, WU Yangfeng, YANG Yuejin, TURNBULL Fiona, on behalf of the CPACS Investigators. Evidence-based medication use among Chinese patients with acute coronary syndromes at the time of hospital discharge and one year after hospitalisation: results from the CPACS study. American Heart Journal 2009 157:509-516
Bi YF, Liu RX, Ye L, Fang H, Li X, Wang W, Zhang J, Wang KK, Jiang L, Su T,Chen ZY, Ning G. Gene expression profiles of thymic neuroendocrine tumors(carcinoids) with ectopic ACTH syndrome reveal novel molecular mechanism. Endocrine Related Cancer. 2009 16(4):1273-1282
Chen Y, Huang Y, Li X, Xu M, Bi Y （通讯作者）, Zhang Y, Gu W, Ning G. Association of arterial stiffness with HbA1c in 1,000 type 2 diabetic patients with or without hypertension. ENDOCRINE 2009 36(2):262-267
BI Yu-fang, Zhao Lie-bin, LI Xiao-ying, WANG Wei-qing, SUN Shou-yue, CHEN Yu-hong, HONG Jie, SU Ting-wei, LIU Jian-min, NING Guang. A 2-way cross-over, open-labeled trial to compare efficacy and safety of insulin Aspart and Novolin R delivered with CSII in 21 Chinese diabetic patients. Chinese Medical Journal 2007 120(19):1700-1703