导师姓名： 陆洁莉 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师：
联系方式： 瑞金二路197号33舍224
邮编： 200025 邮箱地址： Jielilu@hotmail.com

研究方向 (点击浏览详细信息)
糖脂代谢异常的发病机制及人群队列研究

社会任职
《中华内分泌代谢杂志》通讯编委
上海医学会糖尿病分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
20XD** 2型糖尿病的预警模型及早期干预研究 上海市科学技术委员会 优秀学术带头人（青年） 2020-06~2023-06 40万元 课题负责人
** 肝细胞因子Sparcl1调控机体胰岛素敏感性的作用及机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 强化饮食和运动干预对新诊断2型糖尿病患者血糖控制的疗效评估 上海市科学技术委员会西医先导项目 2019-03~2022-03 20万元 课题负责人
高峰高原计划（研究型医师） 中国2型糖尿病及其并发症发病危险因素分析及潜在代谢标志物研究 上海交通大学医学院 2019-01~2021-12 100万元 课题负责人
上海医药发展基金会青年研究项目 中国成人糖尿病与肿瘤风险的相关性研究：多中心、前瞻性人群研究 上海医药发展基金会青年研究项目 2018-01~2020-12 50万元 课题负责人
** Leupaxin调控LXR转录活性及肝脏脂代谢的机制研究 国家自然科学基金面上项目 2017-01~2020-12 58万元 课题负责人
2016YFC** 儿童青少年糖尿病危险因素及分型诊断研究 国家重点研发计划 2016-07~2020-12 125万元 课题负责人
科技部课题 糖尿病注册研究 科技部 2015-06~2017-12 498.59万元 子课题负责人
晨星计划 晨星计划 上海交通大学医学院 2014-06~2016-08 36万元 课题负责人
** MafB调控肝脏ChREBP转录致非酒精性脂肪肝病的机制研究 国家自然基金面上项目 2014-01~2017-12 70万元 课题负责人
** Foxa2在胰岛细胞转分化过程中的作用及机制研究 国家自然基金面上项目 2012-01~2015-12 58万元 课题负责人
XYQ** 胰岛细胞增殖的动物模型 上海市卫生局新优青计划 2011-11~2016-11 60万元 课题负责人
10PJ** 胰岛细胞增殖机制研究 浦江人才计划 2010-06~2012-06 20万元 课题负责人
胰岛细胞再生的动物模型 上海市科委实验动物模型专项课题 2010-03~2012-03 15万元 课题负责人
C140406 MafB在胰岛β细胞增殖调控中的作用及其机制研究 国家自然基金，青年科学基金项目 2010-01~2012-12 20万元 课题负责人
** MafB促进胰岛细胞增殖作用及机制研究 国家自然基金青年项目 2010-01~2012-12 19万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jieli Lu （通讯作者）, Mian Li, Yu Xu, Yufang Bi, Yingfen Qin, Qiang Li , Tiange Wang, Ruying Hu, Lixin Shi, Qing Su, Min Xu, Zhiyun Zhao, Yuhong Chen, Xuefeng Yu, Li Yan, Rui Du, Chunyan Hu, Guijun Qin, Qin Wan, Gang Chen, Meng Dai, Di Zhang, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Yanan Huo, Zhen Ye, Xulei Tang, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Zachary T Bloomgarden, Lulu Chen, Jiajun Zhao, Yiming Mu, Guang Nin, Weiqing Wang, 4C Study Group Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study Diabetes Care 2020 43(8):1902-1909
Qi H, Hu C, Wang S, Zhang Y, Du R, Zhang J, Lin L, Wang T, Zhao Z, Li M, Xu Y, Xu M, Bi Y, Wang W, Chen Y, Lu J （通讯作者） Early life famine exposure, adulthood obesity patterns and the risk of nonalcoholic fatty liver disease Liver Int 2020 doi: 10.1111/liv.14572.
Du R, Zheng R, Xu Y, Zhu Y, Yu X, Li M, Tang X, Hu R, Su Q, Wang T, Zhao Z, Xu M, Chen Y, Shi L, Wan Q, Chen G, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Chen L, Zhao J, Mu Y, Li D, Qin G, Wang W, Ning G, Yan L, Bi Y, Lu J （通讯作者）, REACTION Study Group Early-Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study J Am Heart Assoc 2020 9(7):e014175. doi: 10.1161/JAHA.119.014175.
Tiange Wang, Jieli Lu （共同第一作者）, Lixin Shi, Gang Chen, Min Xu, Yu Xu, Qing Su, Yiming Mu, Lulu Chen, Ruying Hu, Xulei Tang, Xuefeng Yu, Mian Li, Zhiyun Zhao, Yuhong Chen, Li Yan , Guijun Qin, Qin Wan, Meng Dai, Di Zhang, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yufang Bi, Ralph A DeFronzo, Weiqing Wang, Guang Ning, China Cardiometabolic Disease and Cancer Cohort Study Group Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study Lancet Diabetes Endocrinol 2020 8(2):115-124.
Li M, Xu Y, Wan Q, Shen F, Xu M, Zhao Z, Lu J （共同第一作者）, Gao Z, Chen G, Wang T, Xu Y, Zhao J, Chen L, Shi L, Hu R, Ye Z, Tang X, Su Q, Qin G, Wang G, Luo Z, Qin Y, Huo Y, Li Q, Zhang Y, Chen Y, Liu C, Mu Y, Wang Y, Wu S, Yang T, Chen L, Yu X, Yan L, Deng H, Ning G, Bi Y, Wang W. Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study Diabetes Care 2020 43(8):1929-1936
Cao Y, Li L, Xu M, Feng Z, Sun X, Lu J （共同第一作者）, Xu Y, Du P, Wang T, Hu R, Ye Z, Shi L, Tang X, Yan L, Gao Z, Chen G, Zhang Y, Chen L, Ning G, Bi Y, Wang W; ChinaMAP Consortium. The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals Cell Res 2020 doi: 10.1038/s41422-020-0322-9.
Hu C, Zhang Y, Wang S, Lin L, Peng K, Du R, Qi H, Zhang J, Wang T, Zhao Z, Li M, Xu Y, Xu M, Li D, Bi Y, Wang W, Chen Y, Lu J. （通讯作者） Association of bedtime with the risk of non-alcoholic fatty liver disease among middle-aged and elderly Chinese adults with pre-diabetes and diabetes Diabetes Metab Res Rev 2020 doi: 10.1002/dmrr.3322.
Wu XY, Lin L, Qi HY, DU R, Hu CY, Ma LN, Peng K, Li M, Xu Y, Xu M, Chen YH, Lu JL* （通讯作者）, Bi YF, Wang WQ, Ning G. Association between Lipoprotein (a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort. Biomed Environ Sci 2019 32(7):477-485
Lu J, Lam SM, Wan Q, Shi L, Huo Y, Chen L, Tang X, Li B, Wu X, Peng K, Li M, Wang S, Xu Y, Xu M, Bi Y, Ning G, Shui G, Wang W. High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults Diabetes Care 2019 42(11):2117-2126.
Ma LN, DU R, Cheng D, Lin L, Wu XY, Hu CY, Dai M, Xu Y, Xu M, Jiang L, Li M, Lu JL* （通讯作者）, Bi YF, Wang WQ, Ning G. Serum Alanine Aminotransferase Is Associated with Metabolic Syndrome and 10-year Risk of Cardiovascular Disease Biomed Environ Sci 2019 32(2):121-125
Du R, Wu X, Peng K, Lin L, Li M, Xu Y, Xu M, Chen Y, Li D, Lu J* （通讯作者）, Bi Y, Wang W, Guang N. Serum apolipoprotein B is associated with increased risk of metabolic syndrome among middle-aged and elderly Chinese: a cross-sectional and prospective cohort study J Diabetes 2019 DOI: 10.1111/1753-0407.12904
Wang T*, Lu J* （共同第一作者）, Su Q*, Chen Y*, Bi Y, Mu Y, Chen L, Hu R, Tang X, Yu X, Li M, Xu M, Xu Y, Zhao Z, Yan L, Qin G, Wan Q, Chen G, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Li D, Lai S, Bloomgarden ZT, Shi L, Ning G, Zhao J, Wang W; 4C Study Group Ideal Cardiovascular Health Metrics and Major Cardiovascular Events in Patients With Prediabetes and Diabetes JAMA Cardiol 2019 DOI: 10.1001/jamacardio.2019.2499
Wu X, Du R, Hu C, Cheng D, Ma L, Li M, Xu Y, Xu M, Chen Y, Li D, Bi Y, Wang W, Ning G, Lu J*. （通讯作者） Resting heart rate is associated with metabolic syndrome and predicted 10-year risk of cardiovascular disease: a cross-sectional study. J Diabetes 2019 DOI: 10.1111/1753-0407.12927
Zhang J, Du R, Peng K, Wu X, Hu C, Li M, Xu Y, Xu M, Wang S, Bi Y, Wang W, Lu J （通讯作者）, Chen Y. Serum lipoprotein (a) is associated with increased risk of stroke in Chinese adults: A prospective study Atherosclerosis 2019 289:8-13.
Lu J*, He J*, Li M*, Tang X*, Hu R*, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Qin G, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Deng H, Yu X, Shen F, Chen L, Zhao L, Dai M, Xu M, Xu Y, Chen Y, Lai S, Li D, Bloomgarden Z, Chen L, Zhao J, Mu Y, Ning G, Wang W, Bi Y. Predictive Values of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults Diabetes Care 2019 42(8):1539-1548
Cheng D, Du R, Wu XY, Lin L, Peng K, Ma LN, Xu Y, Xu M, Chen YH, Bi YF, Wang WQ, Dai M, Lu JL* （通讯作者） Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes Biomed Environ Sci 2018 31(2):106-114
Lu J, Wang W, Li M, Bi Y, Xu Y, Chen L, Zhao J, Mu Y, DeFronzo RA, Ning G Associations of Hemoglobin A1c With Cardiovascular Disease and Mortality in Chinese Adults With Diabetes J Am Coll Cardiol 2018 72(24):3224-3225
Du R, Lin L, Cheng D, Xu Y, Xu M, Chen Y, Wang W, Bi Y, Li D, Lu J*. （通讯作者） Thiazolidinedione therapy and breast cancer risk in diabetic women: A systematic review and meta-analysis. Diabetes Metab Res Rev. Diabetes Metab Res Rev 2018 34(2)
Lin L, Peng K, Du R, Huang X, Sun W, Ding L, Wang P, Huang Y, Xu Y, Xu M, Chen Y, Bi Y, Wang W, Lu J. （通讯作者） High glomerular filtration rate is associated with arterial stiffness in Chinese population. J Hypertens 2017 35(2):385-391
Du R, Sun W, Lin L, Sun J, Peng K, Xu Y, Xu M, Chen Y, Bi Y, Wang W, Li D, Lu J （通讯作者） Serum CA 19-9 and risk of incident diabetes in middle-aged and elderly Chinese: a prospective cohort study. Acta Diabetol 2017 54(2):201-208
Wang P, DU R, Lin L, Ding L, Peng K, Xu Y, Xu M, Bi YF, Wang WQ, Ning G, Lu JL （通讯作者） Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants. Biomed Environ Sci 2017 30(2):128-133
Du R, Cheng D, Lin L, Sun J, Peng K, Xu Y, Xu M, Chen Y, Bi Y, Wang W, Lu J （通讯作者）, Ning G Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study. J Diabetes. 2017 [Epub ahead of print]
Lv X, Zhou W, Sun J, Lin R, Ding L, Xu M, Xu Y, Zhao Z, Chen Y, Bi Y, Lu J （通讯作者）, Wang W, Ning G Visceral adiposity is significantly associated with type 2 diabetes in middle-aged and elderly Chinese women: A cross-sectional study. J Diabetes. 2017 [Epub ahead of print]
Lu J, Wang L, Li M, Xu Y, Jiang Y, Wang W, Li J, Mi S, Zhang M, Li Y, Wang T, Xu M, Zhao Z, Dai M, Lai S, Zhao W, Wang L, Bi Y, Ning G Metabolic Syndrome Among Adults in China: The 2010 China Noncommunicable Disease Surveillance. J Clin Endocrinol Metab 2017 102(2):507-515
Bonnavion R, Teinturier R, Gherardi S, Leteurtre E, Yu R, Cordier-Bussat M, Du R, Pattou F, Vantyghem MC, Bertolino P, Lu J （通讯作者）, Zhang CX Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas. J Pathol 2017 242(1):90-101
Sun J*, Lu J* （共同第一作者）, Wang W#, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Yang T, Yan L, Wan Q, Wu S, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Xu M, Sun J, Bi Y, Lai S, Bloomgarden ZT, Li D, Ning G. Spouses of diabetic patients have higher prevalence of diabetes and cardiometabolic disorders. Am J Epide 2016 doi: 10.1093/aje/kwv330
Sun W*, Lu J* （共同第一作者）, Wu S, Bi Y, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Yang T, Yan L, Wan Q, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Wang T, Sun J, Xu M, Xu Y, Chen Y, Dai M, Zhang J, Zhang D, Lai S, Li D, Ning G, Wang W Association of insulin resistance with breast, ovarian, endometrial and cervical cancers in non-diabetic women. Am J Cancer Res 2016 6(10):2334-2344
Lu J , Mu Y, Su Q, Zhao J, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Qin G, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Deng H, Yu X, Shen F, Chen L, Zhao L, Dai M, Xu M, Xu Y, Chen Y, Lai S, Li D, Wang W, Ning G. Reduced Kidney Function is associated with Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results from the REACTION Study. J Am Heart Assoc. 2016 5(7),e003328
Lu J, Zhang J, Du R, Wang T, Xu M, Xu Y, Wang W, Bi Y, Li D, Chen Y, Ning G. Age at Menarche is Associated with the Prevalence of NAFLD Later in Life J Diabetes. 2016 doi: 10.1111/1753-0407.12379
Lu J, Bi Y, Ning G. Curbing the obesity epidemic in China Lancet Diabetes Endocrinol 2016 S2213-8587(16)30007-9
Lin L*, Lu J* （共同第一作者）, Huang X, Ding L, Huang Y, Wang P, Peng K, Zhang D, Xu Y, Xu M, Chen Y, Bi Y, Wang W, Xu Y. Nonalcoholic fatty liver disease is associated with low-grade albuminuria in Chinese adults. International Journal of Medicine 2016 pii: hcw070
Wang T*, Lu J* （共同第一作者）, Wang W, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Yang T, Yan L, Wan Q, Wu S, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Xu M, Sun J, Bi Y, Lai S, Bloomgarden ZT, Li D, Ning G. Sleep duration and snoring associate with hypertension and glycaemic control in patients with diabetes. Diabetic Medicine 2015 32(8):1001-1007
Bi Y*, Lu J* （共同第一作者）, Wang W, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Zhang J, Sun J, Dai M, Xu M, Xu Y, Chen Y, Lai S, Bloomgarden ZT, Li D, Ning G. Cohort profile: risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study. J Diabetes 2014 6(2):147-157
Deng X, Zhang Y, Wang T, Xu B, Sun J, Zhao L, Xu M, Chen Y, Wang W, Bi Y, Lu J （通讯作者） Serum calcium level is associated with brachial-ankle pulse wave velocity in middle-aged and elderly Chinese Biomed Environ Sci 2014 27(8):594-600
Lu J, Bi Y, Wang T, Wang W, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Qin G, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Deng H, Yu X, Shen F, Chen L, Zhao L, Dai M, Xu M, Xu Y, Chen Y, Lai S, Ning G*. The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population: Results of the REACTION study. Int J Cardiol 2014 172(2):388-394
Sun K*, Lu J* （共同第一作者）, Jiang Y, Xu M, Xu Y, Zhang J, Xu B, Sun J, Sun W, Ren C, Liu J, Wang W, Bi Y, Ning G. Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabolic disorders. Clin Endocrinol (Oxf). 2014 80(3):348-355
Chen Y*, Lu J* （共同第一作者）, Huang Y, Wang T, Xu Y, Xu M, Li M, Wang W, Li D, Bi Y, Ning G Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China J Clin Endocrinol Metab 2013 98(2):283-7
Liu Y*, Lu J* （共同第一作者）, Xu M, Xu Y, Li M, Wang T, Zhang J, Xu B, Sun J, Dai M, Bi Y, Wang W, Ning G. Association between history of abortion and nonalcoholic fatty liver disease in middle-aged and elderly Chinese women. Ann Epidemiol. 2013 23(3):119-123.
Bonnavion R, Jaafar R, Kerr-Conte J, Assade F, van Stralen E, Leteurtre E, Pouponnot C, Gargani S, Pattou F, Bertolino P, Lu J （通讯作者）, Zhang CX Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PLoS One 2013 27(8):7219-4
Wang T*, Lu J* （共同第一作者）, Li M, Chen B, Xu M, Xu Y, Huang Y, Chen Y, Wang W, Li X, Liu Y, Bi Y, Lai S, Ning G Urinary Bisphenol A Concentration and Thyroid Function in Chinese Adults. Epidemiology 2013 24(2):295-302
Wang T*, Lu J* （共同第一作者）, Xu M, Xu Y, Chen Y, Wang W, Liu Y, Bi Y, Ning G Circulating prolactin associates with diabetes and impaired glucose regulation: a population based study Diabetes Care 2013 36(7):1974-80
Lu J,Hamze Z, Bonnavion R, Herath N, Pouponnot C, Assade F, Fontanière S, Bertolino P, Cordier-Bussat M, Zhang CX Re-expression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse Oncogene 2012 31(31):3647-54
Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX alpha-cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development Gastroenterology 2010 138(5):1954-65