导师姓名： 宁光 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： guangning@medmail.com.cn
邮编： 200025 邮箱地址： guangning@medmail.com.cn

研究方向 (点击浏览详细信息)
内分泌代谢病的临床和基础研究

社会任职
Journal of Endocrinology(3.586)/Journal of Molecular Endocrinology(3.6) 副主编
Endocrine Reviews(20)/Nature Reviews Endocrinology(9.8) Member of Advisory Board
中国医师协会内分泌代谢医师分会 会长
国际内分泌学会（International Society of Endocrinology） 执行委员
中华医学会内分泌分会 前任主委；
Journal of Diabetes(SCI收录) 主编
《中华内分泌代谢杂志》 总编

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 2型糖尿病双重缺陷的机制及干预研究 国家自然科学基金（创新研究群体） 2017-01~2019-12 525万元 课题负责人
** Menin在非酒精性脂肪肝所致肝脏纤维化进程中的作用机制及干预研究 国家自然科学基金（重点） 2016-01~2020-12 274万元 课题负责人
2015CB553600 中国人代谢综合征的分子营养机制及干预研究 973项目 2015-01~2019-08 3600万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang X, Jiang L, Shan A, Su Y, Cheng Y, Song D, Ji H, Ning G （通讯作者）, Wang W, Cao Y. Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. EBioMedicine 2018 10: 10.1016/j.ebiom.2018.09.051
Jieli Lu, Weiqing Wang, Mian Li, Yufang Bi, Yu Xu, Lulu Chen, Jiajun Zhao, Yiming Mu, Ralph A. DeFronzo, Guang Ning. （通讯作者） Associations of Hemoglobin A1c With Cardiovascular Disease and Mortality in Chinese Adults With Diabetes Journal of American College of Cardiology 2018 72 (24): 3224-3231
Cao Y, Zhou W, Li L, Wang J, Gao Z, Jiang Y, Jiang X, Shan A, Bailey MH, Huang KL, Sun SQ, McLellan MD, Niu B, Wang W, Ding L, Ning G. （通讯作者） Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types. Cell Research 2018 28 (5): 601-604
Bi Y, Wang L, Xu Y, Jiang Y, He J, Zhang M, Zhou M, Li Y, Xu M, Lu J, Wang T, Ding L, Dai M, Zhang D, Chen CS, Lai S, Wang W, Wang L, Ning G （通讯作者） 2012 China Noncommunicable Disease and Risk Factor Surveillance in Migrant Workers Study Group. Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study. Lancet Diabetes Endocrinol 2016 4 (2): 125-135.
Lu J, Bi Y, Ning G. （通讯作者） Curbing the obesity epidemic in China Lancet Diabetes Endocrinol 2016 4 (6): 470-471
Bi Y, Wang W, Xu M, Wang T, Lu J, Xu Y, Dai M, Chen Y, Zhang D, Sun W, Ding L, Chen Y, Huang X, Lin L, Qi L, Lai S, Ning G. （通讯作者） Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism. J Clin Endocrinol Metab 2016 101 (1): 143-150
Xu M, Huang Y, Xie L, Peng K, Ding L, Lin L, Wang P, Hao M, Chen Y, Sun Y, Qi L, Wang W, Ning G （通讯作者）, Bi Y. Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis. Diabetes. 2016 65 (6) :1731-1740
Yufang Bi, Yong Jiang, Jiang He, Yu Xu, Limin Wang, Min Xu, Mei Zhang, Yichong Li, Tiange Wang, Meng Dai, Jieli Lu, Mian Li, Chung-shiuan Chen, Shenghan Lai, Weiqing Wang, Linhong Wang, Guang Ning. （通讯作者） Status of Cardiovascular Health in Chinese Adults Journal of the American College of Cardiology 2015 65 (10): 1013-1025.
Zhou M, Astell-Burt T, Bi Y, Feng X, Jiang Y, Li Y, Page A, Wang L, Xu Y, Wang L, Zhao W, Guang Ning. （通讯作者） Geographical variation in diabetes prevalence and detection in china: multilevel spatial analysis of 98,058 adults Diabetes Care. 2015 38: 72-81
Yifei Zhang, Chunxiu Hu, Jie Hong, Jun Zeng, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hog Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning （通讯作者）, Guowang Xu. Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with Type 2 diabetes and coronary artery diseases. Diabetes Care 2014 37: 2804-2812.
Yanan Cao, Minghui He, Zhibo Gao, Ying Peng, Yanli Li, Lin Li, Weiwei Zhou, Xiangchun Li, Xu Zhong, Yiming Lei, Tingwei Su, Hang Wang, Yiran Jiang, Lin Yang, Wei Wei, Xu Yang, Xiuli Jiang, Li Liu, Juan He, Junna Ye, Qing Wei, Yingrui Li, Weiqing Wang, Jun Wang, and Guang Ning （通讯作者） Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing's Syndrome. Science. 2014 344; 6186: 913-917
Maigeng Zhou, Thomas Astell-Burt, Yufang Bi, Xiaoqi Feng, Yong Jiang, Yichong Li, Andrew Page, Limin Wang, Yu Xu, Lihong Wang, Wenhua Zhao, Guang Ning. （通讯作者） Geographical Variation in Diabetes Prevalence and Detection in China: Multilevel Spatial Analysis of 98,058 Adults. Diabetes Care. 2014 37:DOI: 10.2337/dc14-1100
Zhang Y, Guang Ning. （通讯作者） Diabetes: Young-onset type 2 diabetes mellitus-a challenge for Asia. Nat Rev Endocrinol 2014 Dec; 10 (12): 703-704.
Xiuli Jiang, Yanan Cao, Feng Li, Yutong Su, Yanli Li, Ying Peng, Yulong Cheng, Changxian Zhang, Weiqing Wang, Guang Ning. （通讯作者） Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours Nature Communication 2014 DOI: 10.1038/ncomms6809
Lu Y, Ma Z, Zhang Z, Xiong X, Wang X, Zhang H, Shi G, Xia X, Guang Ning （通讯作者）, Li X. Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice. Gut 2014 63: 170-178
Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J, Wang W, Guang Ning. （通讯作者） Berberine activates thermogenesis in white and brown adipose tissue. Nature Communication. 2014 Nov 25; 5: 5493.
Yan Lu, Xing Liu, Yang Jiao, Xuelian Xiong, E Wang, Xiaolin Wang, Zhijian Zhang, Huijie Zhang, Lingling Pan, Youfei Guan, Dongsheng Cai, Guang Ning （通讯作者）, and Xiaoying Li. Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα. The Journal of Clinical Investigation. 2014 124 (8): 3501-3513
Wang T, Li M, Chen B, Xu M, Xu Y, Huang Y, Lu J, Chen Y, Wang W, Li X, Liu Y, Bi Y, Lai S, Ning G. （通讯作者） Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab. 2012 97(2): E223-7.
Li M, Xu Y, Xu M, Ma L, Wang Liu Y, Dai M, Chen Y, Lu J, Liu J, Bi Y, Ning G. （通讯作者） Association between Nonalcoholic Fatty Liver Disease (NAFLD) and Osteoporotic Fracture in Middle-Aged and Elderly Chinese. J Clin Endocrinol Metab 2012
Zhang H, Li W, Wang Q, Wang X, Li F, Zhang C, Wu L, Long H, Liu Y, Li X, Luo M, Li G, Ning G. （通讯作者） Glucose-mediated repression of menin promotes pancreatic β-cell proliferation. Endocrinology. 2012 153(2): 602-11.
Liu R, Ma X, Xu L, Wang D, Jiang X, Zhu W, Cui B, Ning G （通讯作者）, Lin D, Wang S. Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients. J Clin Endocrinol Metab 2012
Li M, Bi Y, Qi L, Wang T, Xu M, Huang Y, Xu Y, Chen Y, Lu J, Wang W, Ning G. （通讯作者） Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults. Kidney Int 2012 81(11): 1131-9.
Zhang H, Li W, Wang Q, Wang X, Li F, Zhang C, Wu L, Long H, Liu Y, Li X, Luo M, Li G （通讯作者）, Ning G. Glucose-mediated repression of menin promotes pancreatic β-cell proliferation. Endocrinology. 2012 153(2): 602-11.
Li M, Bi Y, Qi L, Wang T, Xu M, Huang Y, Xu Y, Chen Y, Lu J, Wang W, Ning G. Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults. Kidney Int 2012 81(11): 1131-9.
Liu JM, Ma LY, Bi YF, Xu Y, Huang Y, Xu M, Zhao HY, Sun LH, Tao B, Li XY, Wang WQ, Ning G. （通讯作者） A population-based study examining calcaneus quantitative ultrasound and its optimal cut-points to discriminate osteoporotic fractures among 9352 Chinese women and men. J Clin Endocrinol Metab 2012 97(3): 800-9.
Wang J, Li X, Ke Y, Lu Y, Wang F, Fan N, Sun H, Zhang H, Liu R, Yang J, Ye L, Liu M, Ning G. （通讯作者） GPR48 increases mineralocorticoid receptor gene expression. J Am Soc Nephrol 2012 23(2): 281-93.
Guang Ning, Yufang Bi, Tiange Wang, Min Xu, Yu Xu, Yun Huang, Xiaoying Li, Weiqing Wang, Yuhong Chen, Yaohua Wu, Jianing Hou, Aiyun Song,Yu Liu, Mian Li, Shenghan Lai. Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults. A cross-sectional analysis. Ann Intern Med 2011 155: 368-74.
L Zhou, X Wang, Y Yang, L Wu, F Li, R Zhang, G Yuan, N Wang, M Chen, and G Ning. （通讯作者） Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes. Biochim Biophys Acta 2011 1812: 527-535.
Liu R, Liu D, Trink E, Bojdani E, Ning G （通讯作者）, Xing M The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway. J Clin Endocrinol Metab 2011 96: E577-E585.
Huang Y, Bi Y, Wang W, Xu M, Xu Y, Li M, Wang T, Chen Y, Li X, Ning G. （通讯作者） Glycated hemoglobin a1c, fasting plasma glucose, and two-hour postchallenge plasma glucose levels in relation to carotid intima-media thickness in chinese with normal glucose tolerance. J Clin Endocrinol Metab 2011 96(9): E1461-5
Xu L, Ma X, Wang Y, Li X, Qi Y, Cui B, Li X, Ning G （通讯作者）, Wang S. The expression and pathophysiological role of osteopontin in graves' disease. J Clin Endocrinol Metab 2011 96(11): E1866-70.
Mian Li, Min Xu, Yufang Bi, Aiyun Song, Yu Liu, Xiaoying Li, and Guang Ning. （通讯作者） Association between Higher Serum Fetuin-A Concentrations and Abnormal Albuminuria in Middle-aged and Elderly Chinese with Normal Glucose Tolerance. Diabetes Care 2010 33(11): 2462-2464.
Xiaoying Li, Yan Lu, Haiyan Sun, Jiqiu Wang, Jun Yang, Huijie Zhang, Nengguang Fan, Jia Xu, Jinjing Jiang, Ruya Liu, Dali Li, Mingyao Liu, Guang Ning （通讯作者） G protein-coupled receptor 48 upregulates estrogen receptor α expression via cAMP/PKA signaling in the male reproductive tract. Development. 2010 137: 151-157.
Li N, Liu R, Zhang H, Yang J, Sun S, Zhang M, Liu Y, Lu Y, Wang W, Mu Y, Ning G （通讯作者）, Li X. Seven Novel DAX1 Mutations with Loss of Function Identified in Chinese Patients with Congenital Adrenal Hypoplasia. J Clin Endocrinol Metab 2010 95: E104 - E111.
Huang Y, Chen Y, Xu M, Gu W, Bi Y, Li X, Ning G. （通讯作者） Low-Grade Albuminuria Is Associated with Carotid Intima-Media Thickness in Chinese Type 2 Diabetic Patients. J Clin Endocrinol Metab 2010 95: 5122-5128.
Huang Y, Chen Y, Xu M, Gu W, Bi Y, Li X, Ning G. （通讯作者） Low-Grade Albuminuria Is Associated with Carotid Intima-Media Thickness in Chinese Type 2 Diabetic Patients. J Clin Endocrinol Metab 2010 95: 5122-5128.
Liu JM, Zhang MJ, Zhao L, Cui B, Li ZB, Zhao HY, Sun LH, Tao B, Li M, Ning G. （通讯作者） Analysis of Recently Identified Osteoporosis Susceptibility Genes in Han Chinese Women. J Clin Endocrinol Metab 2010 95: E112-E120.
Jiang J, Li N, Wang X, Lu Y, Bi Y, Wang W, Li X, Ning G. （通讯作者） Aberrant Expression and Modification of Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors Involved in the Pathogenesis of Tumoral Cortisol Resistance. Endocrinology. 2010 151(8): 3697-3705.