导师姓名： 王计秋 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市瑞金二路197号11号楼922室
邮编： 200025 邮箱地址： jiqiuwang@163.com

研究方向 (点击浏览详细信息)
肥胖症的发病机制与临床干预研究

社会任职
教育部“****奖励计划”青年****
国家自然科学基金委“优秀青年”(小****)
上海市优秀学术/技术带头人（上海市学带）
Front Endocrinol 特邀主编（Guest Editor-in-Chief）

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
20XD** 青少年肥胖病的发病机制与干预研究 2020年度优秀学术技术带头人计划（上海市科委） 2020-08~2022-07 40万元 课题负责人
** 性别决定关键基因调控能量平衡与糖脂代谢的机制研 究 重大研究计划-培育项目 2020-01~2020-12 92万元 课题负责人
** R-Spondins/LGR4 通路调控能量平衡与糖脂代谢的机制研究 上海交通大学医学院 “临床专职科研队伍”（第二轮） 2020-01~2022-12 100万元 课题负责人
2019-08 Jiangnan Diet Intervention Study 上海市医药卫生发展基金会与赛诺菲（中国）联合“糖尿病临床研究项目” 2019-09~2020-08 20万元 课题负责人
** 构建多种动物模型探究经典Wnt信号通路参与肥胖症发生和脂肪棕色化的分子机制 上海市科委（科技专项经费） 2019-06~2022-03 40万元 课题负责人
SQ2018YFC130289 肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究 国家重点研发计划“重大慢病防控研究” 2019-01~2021-12 250万元 子课题负责人
2018BR01 Wnt信号通路与肥胖发生 上海市优秀学科带头人 2018-07~2021-06 45万元 课题负责人
** LGR4/Wnt/beta-catenin信号通路与肥胖发生 上海交通大学医学院高原高峰计划 2016-07~2019-06 100万元 课题负责人
** 肥胖症发病机制 国家自然科学基金-优秀青年项目 2016-01~2018-01 150万元 课题负责人
** NPC1促进中国青少年肥胖发生的遗传与机制研究 国家自然科学基金-面上项目 2016-01~2019-12 59.6万元 课题负责人
** LGR4调节米色脂肪前体细胞定向分化机制及肥胖治疗应用 国家自然科学基金-面上项目 2014-01~2017-12 61万元 课题负责人
** GPR48在昼夜节律异常与能量代谢紊乱中的作用 国家自然科学基金-青年科学基金项目 2012-01~2012-12 14万元 课题负责人
** G蛋白偶联受体家族成员GPR48在能量平衡与肥胖发生中的作用研究 国家自然科学基金-重点项目 2011-01~2014-12 240万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Lingxia Ye, Weiqiong Gu, Yufei Chen, Xuelin Li, Juan Shi, Ankang Lv, Jingfen Hu, Ru Zhang, Ruixin Liu, Jie Hong, Jiqiu Wang* （通讯作者）, Yifei Zhang*. The impact of shift work on glycemic characteristics assessed by CGM and its association with metabolic indices in non-diabetic subjects Acta Diabetol 2020 57(1):53-61
Ajun Geng#, Ting Wu#, Cheguo Cai#, Wenqian Song, Jiqiu Wang, Qing Cissy Yu , Yi Arial Zeng* A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling Elife 2020 doi: 10.7554/eLife.56434
Chunkai Huang, Daopeng Dai, Hongyang Xie, Zhenbing Zhu, Jian Hu, Min Su, Mingyao Liu, Lin Lu , Weifeng Shen, Guang Ning, Jiqiu Wang* （通讯作者）, Ruiyan Zhang*, Xiaoxiang Yan* Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair Cir Res 2020 10.1161/CIRCRESAHA.119.315807
Jiqiu Wang, Xu Lin, Zachary T. Bloomgarden, Guang Ning* The Jiangnan diet, a healthy diet pattern for Chinese J Diabetes 2020 2020;1–7
Maopei Chen, Peng Lu, Qinyun Ma, Yanan Cao, Na Chen, Wen Li, Shaoqian Zhao, Banru Chen, Juan Shi, Yingkai Sun, Hongbin Shen, Liangdan Sun, Juan Shen, Qijun Liao, Yifei Zhang, Jie Hong, Weiqiong Gu, Ruixin Liu*, Guang Ning*, Weiqing Wang*, Jiqiu Wang* （通讯作者） CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes Sci Adv 2020 6(2):eaax9605
Yang He#, Ruixin Liu#, Mingting Zhu, Wenbin Shen, Jing Xie, Zhiyin Zhang, Na Chen, Chang Shan, Xin zhi Guo, Yide Lu, Bei Tao, Lihao Sun, Hongyan Zhao, Rui Guo, Biao Li, Simin Liu, Guang Ning*, Jiqiu Wang* （通讯作者）, Jianmin Liu* The browning of white adipose tissue and body weight loss in primary hyperparathyroidism EBioMedicine 2019 Feb;40:56-66
Xuemin Gong#, Yunfeng Li#, Jie Luo#, Jiqiu Wang# （共同第一作者）, Jian Wei#, Juqiong Wang, Ting Xiao, Chang Xie, Jie Hong, Guang Ning, Xiongjie Shi, Boliang Li, Wei Qi*, Baoliang Song* Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance Nat Met 2019 doi.org/10.1038/s42255-019-0065-4
Zhou M, Jing S, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H. Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance Diabetes 2019 68(9):1730-1746
Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang* （通讯作者）, Xizhi Guo*. Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization. Nat Commun 2019 10(1):5070
Ma X, Feng D, Lu Y, Sun N, Wang J, Xu L Novel Strategies Targeting Obesity and Metabolic Diseases Front Physiol 2019 29;10:668
Lishu Yue#, Wenjun Zhao#, Dongmei Wang#, Meiyao Meng, Ying Zheng, Yu Li, Jin Qiu, Jian Yu, Yang Yan, Peng Lu, Youmin Sun, Jie Fu, Jiqiu Wang, Qiang Zhang, Lingyan Xu*, Xinran Ma* Silver nanoparticles inhibit beige fat function and promote adiposity Mol Metab 2019 Apr;22:1-11
Tianshi Wang#,*, Ying Cao#, Quan Zheng, Jun Tu, Wei Zhou, Jianli He, Jie Zhong, Yalan Chen, Jiqiu Wang, Rong Cai, Yong Zuo, Bo Wei, Qiuju Fan, Jie Yang, Yicheng Wu, Jing Yi, Dali Li, Mingyao Liu, Chuangui Wang, Aiwu Zhou, Yu Li, Xuefeng Wu, Wen Yang, Y. Eugene Chin, Guoqiang Chen, Jinke Cheng*. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism Mol Cell 2019 75(4):823-834.e5
Qianqian Lv#, Yuying Yang, Sheng Jia, Shaoqian Zhao, Bin Gu, Peng Lu, Yang He, Ruixin Liu, Jiqiu Wang, Guang Ning*, Qinyun Ma* SRC1 Deficiency in Hypothalamic Arcuate Nucleus Increases Appetite and Body Weight J Mol Endocrinol 2018 doi: 10.1530/JME-18-0075
Xuhao Zhi, Jiqiu Wang, Peng Lu, Jue Jia, Hongbin She*, Guang Ning* AdipoCount: A New Software for Automatic Adipocyte Counting Front Physiol 2018 20;9:85
Na Chen, Jiqiu Wang （通讯作者） Wnt/β-Catenin Signaling and Obesity Front Physiol 2018 17;9:792
Dandan Zhao, Shaoqian Zhao, Xiao Wang, Mingbo Su, Wen Liu, Qinyun Ma, Jie Hong, Weiqiong Gu, Jingya Li, Ruixin Liu, Guang Ning, Jiqiu Wang* （通讯作者）, Yifei Zhang* Clinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels (Hyperglipemia) in a Dipeptidyl Peptidase IV Mutation Carrier Front Endocrinol (Lausanne) 2018 5;9:62
Yingkai Sun#, Rui Wang#, Shaoqian Zhao, Wen Li, Wen Liu, Linyun Tang, Zhugang Wang, Weiqing Wang, Ruixin Liu, Guang Ning, Jiqiu Wang* （通讯作者）, Jie Hong* FGF9 inhibits browning program of white adipocytes and associates with human obesity J Mol Endocrinol 2018 doi: 10.1530/JME-18-0151
Ruixin Liu#, Jie Hong#, Xiaoqiang Xu#, Qiang Feng#, Dongya Zhang#, Yanyun Gu#, Juan Shi, Shaoqian Zhao, Wen Liu, Xiaokai Wang, Huihua Xia, Zhipeng Liu, Bin Cui, Peiwen Liang, Liuqing Xi, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Xinjie Zhao, Wanyu Li, Huijue Jia, Zhou Lan, Fengyu Li, Rui Wang, Yingkai Sun, Minglan Yang, Yuxin Shen, Zhuye Jie, Junhua Li, Xiaomin Chen, Huanzi Zhong, Hailiang Xie, Yifei Zhang, Weiqiong Gu, Xiaxing Deng, Baiyong Shen,Xun Xu, Huanming Yang, Guowang Xu, Yufang Bi, Shenghan Lai, Jian Wang, Lu Qi, Lise Madsen, Jiqiu Wang, Guang Ning*, Karsten Kristiansen*, Weiqing Wang* Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention Nature Medicine 2017 doi: 10.1038/nm.4358
Ruixin Liu#, Yaoyu Zou#, Jie Hong#, Min Cao#, Bin Cui#, Huiwen Zhang, Maopei Chen, Juan Shi, Tinglu Ning, Shaoqian Zhao, Wen Liu, Hui Xiong, Cuijie Wei, Zhengqing Qiu, Weiqiong Gu, Yifei Zhang, Wanyu Li, Lin Miao, Yingkai Sun, Minglan Yang, Rui Wang, Qinyun Ma, Min Xu, Yu Xu, Tiange Wang, Kei-hang Katie Chan, Xianbo Zuo, Haoyan Chen, Lu Qi, Shenghan Lai, Shumin Duan, Baoliang Song, Yufang Bi, Simin Liu*, Weiqing Wang*, Guang Ning*, Jiqiu Wang* （通讯作者） Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity Diabetes 2017 66(4):935-947
Quan Zheng#, Ying Cao#, Yalan Chen, Jiqiu Wang, Qiuju Fan, Xian Huang, Yiping Wang, Tianshi Wang, Xiuzhi Wang, Jiao Ma, Jinke Cheng* Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1 J Mol Cell Biol 2017 10.1093/jmcb/mjx055
Yaoyu Zou#, Peng Lu#, Juan Shi, Wen Liu, Minglan Yang, Shaoqian Zhao, Na Chen, Maopei Chen, Yingkai Sun, Aibo Gao, Qingbo Chen, Zhiguo Zhang, Qinyun Ma, Tinglu Ning, Xiayang Ying, Jiabin Jin, Xiaxing Deng, Baiyong Shen, Yifei Zhang, Bo Yuan, Sophie Kauderer, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*, Weiqing Wang*, Weiqiong Gu*, Jiqiu Wang* （通讯作者） IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants Are Associated with Human Obesity Risk EBioMedicine 2017 24:64-75
Tingting Liu, Dongmei Liu, Yan Xuan, Lin Zhao, Lihao Sun, Diandian Zhao, Xiaofeng Wang, Yang He, XingZhi Guo, Rui Du, Jiqiu Wang, Jianmin Liu, Hongyan Zhao, Bei Tao The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years Bone Research 2017 4(5):17020
Rong Wu, Jianguang Sun, Jiqiu Wang, Binhua Li, Qingsong Liu, Guang Ning, Wanzhu Jin*, and Zengqiang Yuan* c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice Diabetologia 2017 60(5): 900-910
Tinglu Ning, Yaoyu Zou, Minglan Yang, Qianqian Lu, Maopei Chen, Wen Liu, Shaoqian Zhao, Yingkai Sun, Juan Shi, Qinyun Ma, Jie Hong, Ruixin Liu, Jiqiu Wang* （通讯作者）, Guang Ning* Genetic interaction of DGAT2 and FAAH in the development of human obesity Endocrine 2017 56(2):366-378
Wen Liu#, Shaoqian Zhao#, Jiqiu Wang# （共同第一作者）, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Jie Hong*, Ruixin Liu* Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice Mol Nutr Food Res 2017 10.1002/mnfr.
Rong Wu, Xiaomeng Liu Jianguang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Jiqiu Wang, Jianqing Ding, Donghao Li, John R Speakman, Guang Ning, Wanzhu Jin*, and Zengqiang Yuan* DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue Cell Discov 2017 3: 16054
Shaoqian Zhao#, Wen Liu#, Jiqiu Wang# （共同第一作者）, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Ruixin Liu*, Jie Hong* Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice J Mol Endocrinol 2017 58(1):1-14
Yaoyu Zou, Tinglu Ning, Juan Shi, Maopei Chen, Lin Ding, Ya Huang, Sophie Kauderer, Min Xu, Bin Cui, Yufang Bi, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*, Jiqiu Wang* （通讯作者） Association of a gain-of-function variant in LGR4 with central obesity Obesity 2017 25(1):252-260
Jian Luo, Zhengfeng Yang, Yu Ma, Zhiying Yue, Hongyu Lin, Guojun Qu, Jinping Huang,Wentao Dai, Chenghai Li, Chunbing Zheng, Leqin Xu, Huaqing Chen, Jiqiu Wang, Dali Li, Stefan Siwko, Josef M Penninger, Guang Ning, Jianru Xiao, Mingyao Liu LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption Nature Medicine 2016 22:539-546
Qinyun Ma#, Jianxia Fan#, Jiqiu Wang# （共同第一作者）, Shuai Yang, Qing Cong, Rui Wang, Qianqian Lv, Ruixin Liu, Guang Ning* High levels of CG attenuate insulin sensitivity and promote inflammation in adipocytes J Mol Endocrinol 2015 54:161-170
Feng Wang, Xianfeng Zhang, Jiqiu Wang* （通讯作者）, Maopei Chen, Nengguang Fan, Qinyun Ma, Ruixin Liu, Rui Wang, Xiaoying Li, Mingyao Liu and Guang Ning* LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver J Mol Endocrinol 2015 52:133-143
Rui Wang#, Jie Hong#, Ruixin Liu#, Maopei Chen, Min Xu, Wiqiong Gu, Yifei Zhang, Qinyun Ma, Feng Wang, Juan Shi, Jiqiu Wang* （通讯作者）, Weiqing Wang and Guang Ning* SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis J Mol Endocrinol 2015 53:405-415
Yingkai Sun#, Jie Hong#, Maopei Chen#, Yingying Ke, Shaoqian Zhao, Wen Liu, Qinyun Ma, Juan Shi, Yaoyu Zou, Tinglu Ning, Zhiguo Zhang, Ruixin Liu*, Jiqiu Wang* （通讯作者）, Guang Ning Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway Biochem Bioph Res Co 2015 464:396-400
Zhiguo Zhang, Huizhi Zhang, Bo Li, Xiangjian Meng, Jiqiu Wang, Yifei Zhang, Shuangshuang Yao, Qinyun Ma, Lina Jin, Jian Yang, Weiqing Wang, Guang Ning Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun 2014 25:5393
Liyu Huang, Yuping Wang, Baofeng Wei, Jian Yang, Jiqiu Wang, Binghao Wu, Zhuangzhuang Zhang, Yingyong Hou, Weiming Sun, Renming Hu, Guang Ning, Zeguang Han* Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance Cell Res 2013 23:1310-1321
Jiqiu Wang#, Ruixin Liu#, Feng Wang#, Jie Hong, Xiaoying Li, Maopei Chen, Yingying Ke, Xianfeng Zhang, Qinyun Ma, Rui Wang, Juan Shi, Bin Cui, Weiqiong Gu, Yifei Zhang, Zhiguo Zhang, Weiqing Wang, Xuefeng Xia, Mingyao Liu and Guang Ning* Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol 2013 15:1455-1463
Jiqiu Wang, Xiaoying Li, Yingying Ke, Yan Lu, Feng Wang, Nengguang Fan, Haiyan Sun, Huijie Zhang, Ruixin Liu, Jun Yang, Lei Ye, Mingyao Liu, and Guang Ning* GPR48 Increases Mineralocorticoid Receptor Gene Expression J Am Soc Nephrol 2012 23:281-293
Xiaoying Li, Yan Lu, Haiyan Sun, Jiqiu Wang, Jun Yang, Huijie Zhang, Nengguang Fan, Jia Xu, Jingjing Jiang, Ruya Liu, Dali Li, Mingyao Liu, Guang Ning* G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract Development 2010 137:151-157