导师姓名： 刘建民 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： ljm10586@rjh.com.cn
邮编： 邮箱地址： ljm10586@rjh.com.cn

研究方向 (点击浏览详细信息)
骨与糖代谢、中枢神经系统相互关系的临床和基础研究
代谢性骨病的临床和基础研究

社会任职
中华医学会骨质疏松和骨矿盐疾病学会 副主任委员
中华内分泌代谢杂志 副主编, 编辑部主任
上海市医学会内分泌学分会顾问
上海医学会骨质疏松学会名誉主任委员
Jounal of Diabetes 副主编

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** BMP9通过抑制白色脂肪分化和调节脂质代谢调控全身能量代谢 国家自然基金面上项目 2021-01~2024-12 55万元 课题负责人
** 骨钙素通过改善肠道菌群紊乱调控帕金森病黑质纹状体功能 国家自然基金面上项目 2019-01~2022-12 57万元 课题负责人
2016YFC** 内分泌代谢与血液系统罕见病的注册登记研究 科技部国家重点研发计划精准医学研究专项 2016-06~2020-12 500万元 课题负责人
** 骨钙素通过mTORC1调控阿尔茨海默病中的自噬异常 国家自然科学基金面上项目 2016-01~2019-12 70万元 课题负责人
** 骨对能量代谢调控的机制研究 国家自然基金面上项目 2014-01~2017-12 70万元 课题负责人
** 促进成骨、抑制成脂、改善胰岛功能的维生素D类似物的筛选及其作用机制研究 国家自然基金委，面上项目 2011-01~2013-12 31万元 课题负责人
** 通过干预谷氨酸信号系统改善骨细胞电生理和功能的研究 国家自然基金委,面上项目 2006-01~2008-12 24万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhou YM, Yang YY, Jing YX, Yuan TJ, Sun LH, Tao B, Liu JM （通讯作者）, Zhao HY. BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling. Journal of Bone and Mineral Research 2020 35(5):978-993
Yang YY, Liu JM （通讯作者） What can we learn from the Vitamin D and Type 2 Diabetes (D2d) Study? Journal of Diabetes 2020 12(3):259-261
Yang YY, Zheng SC, Wang WC, Yang ZW, Shan C, Zhang YW, Qi Y, Chen YH, Gu WQ, Wang WQ, Zhao HY, Liu JM （通讯作者）, Sun SY. Osteocalcin Levels in Male Idiopathic Hypogonadotropic Hypogonadism: Relationship With the Testosterone Secretion and Metabolic Profiles Front Endocrinol 2019 10:687
Shan C, Ghosh A, Guo XZ, Wang SM, Hou YF, Li ST, Liu JM. （通讯作者） Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders. Mol Brain 2019 12(1):23
Ling SY, Zhao ZY, Tao B, Zhao HY, Su TW, Jiang YR, Xie J, Sun QF, Bian LG, Sun K, He NY, Yan FH, Wang WQ, Ning G, Sun LH, Liu JM. （通讯作者） Pituitary stalk thickening in a large cohort – Towards more accurate predicators of pituitary dysfunction and etiology. Endocr Pract 2019 25(6):534-544
Shan C, Ghosh A, Guo XZ, Wang SM, Hou YF, Li ST, Liu JM. （通讯作者） Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders. Mol Brain. 2019 12(1):23.
He Y, Liu RX, Zhu MT, Shen WB, Xie J, Zhang ZY, Chen N, Shan C, Guo XZ, Lu YD, Tao B, Sun LH, Zhao HY, Guo R, Li B, Liu SM, Ning G, Wang JQ, Liu JM. （通讯作者） The browning of white adipose tissue and body weight loss in primary hyperparathyroidism. EBioMedicine 2019 40:56-66
Liu JM, Zhu DL, Mu YM, Xia WB Management of fracture risk in patients with diabetes-Chinese Expert Consensus. J Diabetes 2019 Jun 20. doi: 10.1111/1753-0407.12962
Wang XF, Yu JJ, Wang XJ, Jing YX, Sun LH, Tao B, Wang WQ, Ning G, Liu JM （通讯作者）, Zhao HY. The Associations between hypovitaminosis D, higher PTH levels with bone mineral densities, and risk of the 10-year probability of major osteoporotic fractures in Chinese patients with T2DM. Endocr Pract 2018 24(4):334-341
Liu DM,Mosialou I,Liu JM. （通讯作者） Bone: Another potential target to treat, prevent and predict diabetes Diabetes Obes Metab. 2018 20(8):1817-1828
Xing-zhi Guo, Chang Shan, Yan-fang Hou, Geng Zhu, Bei Tao, Li-hao Sun, Hong-yan Zhao, Guang Ning, Sheng-tian Li, Jian-Min Liu （通讯作者） Osteocalcin Ameliorates Motor Dysfunction in a 6-hydroxydopamine-induced Parkinson’s Disease Rat Model Through Akt/gsk3β Signaling. Front Mol Neurosci 2018 11:343
Liu DM, Zhao HY, Zhao L, Zhang MJ, Liu TT, Tao B, Sun LH, Liu JM. （通讯作者） The relationship among serum lipocalin 2, bone turnover markers, and bone mineral density in outpatient women. Endocrine 2018 59(2):304-310
Liu TT, Liu DM, Xuan Y, Zhao L, SUN LH,Zhao DD, Wang XF, He Y, Guo XZ, Du R, Wang JQ, Liu JM, Zhao HY, Tao B. The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years. Bone Research 2017 5:17020
Guo X, Liu T,Zhao D, Wang X,Liu D, He Y, Shan C,Kong Y, Hu W,Bao B, Sun L, Zhao H, Li S, Liu J. （通讯作者） FGF18 protects against 6-hydroxydopamine-induced migrostriatal damage in a rat model fo Parkinson's disease Neuroscience 2017 356:229-241
Khan AA, Hanley DA, Rizzoli R, Bollerslev J, Young JE,Rejnmark L, Thakker R, D'Amour P, Paul T, Van Uum S, Shrayyef MZ, Goltzman D, Kaiser S, Cusano NE, Bouillon R, Mosekilde L, Kung AW, Rao SD, Bhadada SK, Clarke BL, Liu J, Duh Q, Lewiecki EM, Bandeira F, Eastell R, Marcocci C, Silverberg SJ, Udelsman R, Davison KS, Potts JT Jr, Brandi ML, Bilezikian JP. Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus. Osteoporos Int. 2017 2017 ;28(1):1-19
Ioanna Mosialou, Steven Shikhel, Jian-Min Liu, Antonio Maurizi, Na Luo, Zhenyan He, Yiru Huang, Haihong Zong, Richard A. Friedman, Jonathan Barasch, Patricia Lanzano, Liyong Deng, Rudolph L. Leibel, Mishaela Rubin, Thomas Nicholas, Wendy Chung, Lori M. Zeltser, Kevin W. Williams, Jeffrey E. Pessin, Stavroula Kousteni. MC4R-Dependent Suppression of Appetite by Bone-Derived Lipocalin 2. Nature 2017 2017;543:385-390
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F. Primary Hyperparathyroidism. Nat Rev Dis Primers. 2016 2:16033
Lihao Sun, Lin Zhao, Lianjun Du, Peipei Zhang, Minjia Zhang, Min Li, Tingting Liu, Lei Ye, Bei Tao, Hongyan Zhao, Jianmin Liu and Xiaoyi Ding. （通讯作者） Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis. Bone Research 2016 2016; 4, 16038
Xue S, Chen H, Lv C, Shen X, Ding J, Liu J （通讯作者）, Chen X Preoperative diagnosis and prognosis in 40 Parathyroid Carcinoma Patients Clin Endocrinol (Oxf) 2016 85(1):29-36
Sun HX, Lu N, Liu DM, Zhao L, Sun LH, Zhao HY, Liu JM （通讯作者）, Tao B. The bone-preserving effects of exendin-4 in ovariectomized rats. Endocrine. 2016 51(2):323-32
Jian-Min Liu, Clifford J. Rosen, Patricia Ducy, Stavroula Kousteni, and Gerard Karsenty. Regulation of Glucose Handling by the Skeleton: Insights From Mouse and Human Studies Diabetes 2016 65(11): 3225-3232
Liu DM, Zhao L, Liu TT, Jiao PL, Zhao DD, Shih MS, Tao B, Sun LH, Zhao HY, Liu JM （通讯作者） Rictor/mTORC2 loss in osteoblasts impairs bone mass and strength. Bone 2016 90:50-58
Xuan Y, Sun LH, Liu DM, Zhao L, Tao B, Wang WQ, Zhao HY, Liu JM （通讯作者）, Ning G. Positive association between serum levels of bone resorption marker CTX and HbA1c in women with normal glucose tolerance. J Clin Endocrinol Metab. 2015 2015 ;100(1):274-81.
Sun HX, Lu N, Luo X, Zhao L, Liu JM. （通讯作者） Liraglutide, the glucagon-like peptide-1 receptor agonist, has anabolic bone effects in diabetic Goto-Kakizaki rats. J Diabetes. 2015 7(4):584-8.
Lu N, Sun H, Yu J, Wang X, Liu D, Zhao L, Sun L, Zhao H, Tao B, Liu J. （通讯作者） Glucagon-like peptide-1 receptor agonist Liraglutide has anabolic bone effects in ovariectomized rats without diabetes. PLoS One. 2015 10(7):e**
Liu DM, Guo XZ, Tong HJ, Tao B, Sun LH, Zhao HY, Ning G, Liu JM. （通讯作者） Association between osteocalcin and glucose metabolism: a meta-analysis. Osteoporos Int. 2015 26(12):2823-33
Lu N, Sun H, Yu J, Wang X, Liu D, Zhao L, Sun L, Zhao H, Tao B, Liu J. （通讯作者） Glucagon-like peptide-1 receptor agonist Liraglutide has anabolic bone effects in ovariectomized rats without diabetes. PLoS On 2015 10(7):e**
Zhao L, Sun LH, Liu DM, He XY, Tao B, Ning G, Liu JM, Zhao HY. （通讯作者） Copy Number Variation in CCND1 Gene Is Implicated in the Pathogenesis of Sporadic Parathyroid Carcinoma. World J Surg. 2014 2014;38:1730-1737
Liu DM, Lu N, Zhao L, Zhang MJ, Tao B, Xuan Y, Sun LH, Zhao HY, Wang WQ, Liu JM （通讯作者）, Ning G. Serum Sema3A is in a weak positive association with bone formation marker osteocalcin but not related to bone mineral densities in postmenopausal women. J Clin Endocrinol Metab 2014 2014;99:E2504–E2509.
Lin Zhao, Jian-min Liu （共同第一作者）, Xiao-Yan He, Hong-yan Zhao, Li-hao Sun, Bei Tao, Min-jia Zhang, Xi Chen, Wei-qing Wang, Guang Ning. The changing clinical patterns of primary hyperparathyroidism in Chinese patients: Data from 2000-2010 in a single clinical center. J Clin Endocrinol Metab. 2013 2013;98:721-728
Tao B, Li Z, Zhao HY, Sun LH, Zhao L, Li XY, Wang WQ, Ning G, Liu JM. （通讯作者） A lower value for quantitative ultrasound at radius is an additional indicator of metabolic syndrome and cardiovascular risk. Clin Endocrinol (Oxf). 2013 2013;79:348-355
Jian-min Liu （共同第一作者）, Hong-yan Zhao, Lin Zhao, Ying Chen, Lian-zhen Zhang, Bei Tao, Li-hao Sun, Yong-ju Zhao, Wei-qing Wang, Man-yin Xu, Jia-lun Chen, Guang Ning. An independent positive relationship between the serum total osteocalcin level and fat-free mass in healthy premenopausal women. J Clin Endocrinol Metab 2013 2013;98:2146-2152.
Deng YH, Zhao L, Zhang MJ, Pan CM, Zhao SX, Zhao HY, Sun LH, Tao B, Song HD, Wang WQ, Ning G, Liu JM. （通讯作者） The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women. Endocrine. 2013 2013; 43(1):127-35
Zhao HY, Bi YF, Ma LY, Zhao L, Wang TG, Zhang LZ, Tao B, Sun LH, Zhao YJ, Wang WQ, Li XY, Xu MY, Chen JL, Ning G, Liu JM （通讯作者） The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women Clin Biochem 2012 45:1602-1606
Sun K, Liu J （共同第一作者）, Ning G Active smoking and risk of metabolic syndrome: a meta-analysis of prospective studies PLoS One 2012 7(10):e47791-e47800
Liu JM （共同第一作者）, Ma LY, Bi YF, Xu Y, Huang Y, Xu M, Zhao HY, Sun LH, Tao B, Li XY, Wang WQ, Ning G A Population-Based Study Examining Calcaneus Quantitative Ultrasound and Its Optimal Cut-Points to Discriminate Osteoporotic Fractures among 9352 Chinese Women and Men J Clin Endocrinol Metab 2012 97(3):800-809
Zhao L, Cui B, Liu JM （通讯作者）, Zhang MJ, Zhao HY, Sun LH, Tao B, Zhang LZ, Ning G Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause and maximum height in Han Chinese women Menopause 2011 18(9):1018-1025
Liu JM, Gu LQ, Zhao L, Tang ZY, Sun LH, Hong J, Wang WQ, Luo BY, Zhao YJ, Xu MY, Chen X, Jiang XF, Zhu CM, Jin XL, Chen HZ, Tan YY, Ning G, Chen JL Two unusual cases of intractable hyperthyroidism responsive to octreotide: Munchausen syndrome or not? Clin Chim Acta 2011 412(11-12):1155-1160
Li JL, Zhao L, Cui B, Deng LF, Ning G, Liu JM （通讯作者） Multiple signaling pathways involved in stimulation of osteoblast differentiation by N-methyl-D-aspartate receptors activation in vitro Acta Pharmacol Sin. 2011 32(7):895-903
Zhao L, Zhang MJ, Zhao HY, Sun LH, Li JL, Tao B, Wang WQ, Ning G, Liu JM （通讯作者） PTH inhibition rate is useful in the detection of early-stage primary hyperparathyroidism Clin Biochem 2011 44(10-11):844-848
Liu JM （共同第一作者）, Zhang MJ, Zhao L, Cui B, Li ZB, Zhao HY, Sun LH, Tao B, Li M, Ning G Analysis of recently identified osteoporosis susceptibility genes in Han Chinese Women J Clin Endocrinol Metab 2010 95(9):E112-E120
Liu JM, Wai-Chee Kung A, Pheng CS, Zhu HM, Zhang ZL, Wu YY, Xu L, Meng XW, Huang ML, Chung LP, Hussain NH, Sufian SS, Chen JL Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis Bone 2009 45(3):460-465
Sun LH, Cui B, Zhao HY, Tao B, Wang WQ, Li XY, Ning G, Liu JM （通讯作者） Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese Family Endocrine 2009 36(1):25-29
Gu LQ, Zhao L, Liu JM （通讯作者）, Su TW, Wang WQ, Ning G Phaeochromocytoma presenting with coexisting acute renal failure, acidosis and in hyperglycaemic emergency Br J Biomed Sci 2008 65(3):153-155
Li JL, Cui B, Qi L, Li XY, Deng LF, Ning G, Liu JM （通讯作者） NMDA enhances stretching-induced differentiation of osteoblasts through the ERK1/2 signaling pathway Bone 2008 43(3):469-475
Zhao L, Gu LQ, Wang WQ, Ning G, Liu JM （通讯作者） Extreme hyperglycaemia and hypokalaemia in a 96-year-old diabetic patient: case report and discussion of management issues Br J Biomed Sci 2008 65(1):30-33
Liu JM, Zhao HY, Ning G, Chen Y, Zhang LZ, Sun LH, Zhao YJ, Xu MY, Chen JL IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women J Bone Miner Metab 2008 26(2):159-164
Zhou J, Sun LH, Cui B, Song HD, Li XY, Ning G, Liu JM （通讯作者） Genetic diagnosis of multiple affected tissues in a patient with McCune-Albright syndrome Endocrine 2007 31(2):212-217
Liu JM, Ning G, Chen JL Osteoporotic Fractures in Asia: Risk factors and Strategies for Prevention J Bone Miner Metab 2007 25(1):1-5
Liu JM, Zhao HY, Ning G, Zhao YJ, Chen Y, Zhang Zh, Sun LH, Xu MY, Chen JL Relationships between the changes of serum levels of OPG and RANKL with age, menopause, bone biochemical markers and bone mineral density in Chinese women aged 20-75 Calcif Tissue Int 2005 76(1):1-6
Liu JM, Zhao HY, Ning G, Zhao YJ, Zhang LZ, Sun LH, Xu MY, Chen JL The relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women Osteoporos Int 2004 15(3):238-242
Liu J, Zhu H, Zhu X, Dai M, Jiang L, Xu M, Chen J Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women Chin Med J (Engl) 2003 116(3):364-367