导师姓名： 黄薇 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： huangwei@chgc.sh.cn

研究方向 (点击浏览详细信息)
复杂性状疾病（自身免疫性疾病等）的遗传易感性机制研究和个性化防治的临床基础研究

社会任职
中共全国第十八大党代表
上海市遗传学会第八届理事会会员、学术与国际工作委员会副主任
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上海人类基因组研究中心党支部书记、常务副主任
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《国际遗传学杂志》第八届编辑委员会编辑委员
中国共产党第十八次全国代表大会代表
中国遗传学会第八届理事会中国遗传学会基因组学委员会委员
上海市浦东新区研发机构联合会 副主席

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 非综合征型唇腭裂致病基因筛查与验证 国家自然科学基金面上项目 2016-01~2019-12 75.6万元 课题负责人
分子标志物在自身免疫性疾病诊疗中的应用与推广 卫生部卫生行业科研专项 2012-01~2014-12 2444万元 课题负责人
** Graves'病关联区域候选基因深度测序及致病变异的鉴定 国家自然基金面上项目 2012-01~2015-12 70万元 课题负责人
11DJ** 甲状腺疾病危险因素与分子诊断研究 上海市科委基础重大项目 2012-01~2014-09 75万元 子课题负责人
09JC** 中国人群Graves病全基因组关联研究初步结果的大规模验证及功能分析 上海市科委“创新行动计划”基础研究重点项目 2009-09~2011-08 50万元 课题负责人
09DZ** 基因组芯片技术综合平台服务能力的拓展 上海研发公共服务平台建设项目 2009-07~2011-06 100万元 课题负责人
** 特发性矮小症相关基因多态性与矮小易感性研究 国家自然科学基金面上项目 2008-01~2010-12 30万元 课题负责人
** 医学遗传学及遗传病 国家****科学基金项目 2007-01~2010-12 200万元 课题负责人
2006AA020706 心脑血管疾病预警和早期诊断芯片 国家高技术研究发展计划（863计划）重点项目 2006-12~2010-12 500万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang L, Shen X, Wang Z, Xiao X, Wei P, Wang Q, Ren F, Wang Y, Liu Z, Sheng W, Huang W, Zhou X, Du X. A molecular signature for the prediction of recurrence in colorectal cancer Molecular cancer,Mol Cancer 2015 14:22.
Li J, Shi J, Huang W, Sun J, Wu Y, Duan Q, Luo J, Lange LA, Gordon-Larsen P, Zheng SL, Yuan W, Wang Y, Popkin BM, Mo Z, Xu J, Du S, Mohlke KL, Lange EM. Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index. Am J Hypertens 2015 28(8):1031-7.
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Mok ZY, Nakatochi M, Sapari NS, Saxena R, Stewart AF, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytik?inen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Bryan MS, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LL, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Liewald DC, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Müller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Rozario MA, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Spars? T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WH, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang Y, Wang A, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye X, Young RD, Young TL, Yuan JM, Zhou X, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo Z, Hansen T, Jarvelin MR, J?rgensen T, Jukema JW, K?h?nen M, Kajio H, Kivimaki M, Lee JY, Lehtim?ki T, Linneberg A, Miki T, Pedersen O, Samani NJ, S?rensen TI, Takayanagi R, Toniolo D; BIOS-consortium; CARDIo GRAMplusCD; LifeLines Cohort Study; InterAct Consortium, Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu J, M?rz W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JB, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BH, Yokota M, Zheng W, Zhu D, Vineis P, Kyrtopoulos SA, Kleinjans JC, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 47(11):1282-93.
Niu Z, Wang J, Zou H, Yang C, Huang W （通讯作者）, Jin L. Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls. PLoS One 2015 10(9):e**.
Zhan M, Chen G, Pan CM, Gu ZH, Zhao SX, Liu W, Wang HN, Ye XP, Xie HJ, Yu SS, Liang J, Gao GQ, Yuan GY, Zhang XM, Zuo CL, Su B, Huang W, Ning G, Chen SJ, Chen JL, Song HD; China Consortium for the Genetics of Autoimmune Thyroid Disease. Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Hum Mol Genet 2014 23(20):5505-17.
Li C, Wang Z, Liu F, Zhu J, Yang L, Cai G, Zhang Z, Huang W （通讯作者）, Cai S, Xu Y. CXCL10 mRNA expression predicts response to neoadjuvant chemoradiotherapy in rectal cancer patients. Tumor Biol 2014 35:9683–9691.
Weihua Shoua,Ying Wangb,Fang Xiea,Beilan Wangb,Lin Yangb, Hong Wuc,Yi Wangb,Zhimin Wangb,Jinxiu Shib,Wei Huanga （通讯作者） A functional polymorphism affecting the APOA5 gene expression is causally associated with plasma triglyceride levels conferring coronary atherosclerosis risk in Han Chinese Population Biochim Biophys Acta. 2014 Volume 1842, Issue 11, November 2014, Pages 2147–2154
王志敏,黄薇 （通讯作者） 个人基因组时代的机遇与挑战. 中华预防医学杂志 2014 48（8）：657-658
Qin J, Han TQ, Yuan WT, Zhang J, Fei J, Jiang ZY, Niu ZM, Zhang KY, Hua Q, Cai XX, Xu SJ, Huang W （通讯作者）, Zhang SD. The SNP rs** in the 3'-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese. J Gastroenterol Hepatol 2013 28(4):717-22.
Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Du WH, Liu BL, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Huang W, Liang L, Qi L, Chen SJ, Chen Z, Chen JL, Song HD; China Consortium for the Genetics of Autoimmune ThyroidDisease. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet. 2013 22(16):3347-62.
Liu J, Xiao Q, Wang Y, Xu ZM, Wang Y, Yang Q, Wang G, Tan YY, Ma JF, Zhang J, Huang W （通讯作者）, Chen SD. Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China. Mov Disord 2013 28(13):1892-5.
杨玉,黄慧,王伟,杨利,谢理玲,黄薇,吴限. 不同性别特发性矮小患儿胰岛素样生长因子-1 受体基因多态性与遗传易感性的相关性 中华实用儿科临床杂志 2013 28(8)：606-609
Wang Y1, Wang ZM, Teng YC, Shi JX, Wang HF, Yuan WT, Chu X, Wang DF, Wang W, Huang W. （通讯作者） An SNP of the ZBTB38 gene is associated with idiopathic short stature in the Chinese Han population. Clin Endocrinol (Oxf). 2013 Volume 79, Issue 3
郭文婷, 孙莲花, 徐汪洋,马建芳,陈生弟,冀保军,孙福廷,袁文涛,黄薇,王铸钢,顾鸣敏. 腓骨肌萎缩症 2 型大家系的基因定位及分子诊断 诊断学理论与实践 2013 12(1):32-37
Xun Chu,Min Shen,Fang Xie,Xiao-Jing Miao,Wei-Hua Shou,Lin Liu,Peng-Peng Yang,Ya-Nan Bai,Kai-Yue Zhang,Lin Yang,Qi Hua,Wen-Dong Liu,Yan Dong,Hai-Feng Wang,Jin-Xiu Shi,Yi Wang,Huai-Dong Song,Sai-Juan Chen,Zhu Chen,Wei Huang. （通讯作者） An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves’ disease. J Med Genet 2013 50(7):479-85.
Weihua Shou, Dazhi Wang, Kaiyue Zhang, Beilan Wang, Zhimin Wang, Jinxiu Shi, Wei Huang. （通讯作者） Gene-Wide Characterization of Common QuantitativeTrait Loci for ABCB1 mRNA Expression in Normal Liver Tissues in the Chinese Population. PLoS ONE 2012 Volume 7 | Issue 9 | e46295
Fang Xie, Xun Chu, Hong Wu, Weiwei Sun, Min Shen, Lin Yang, Ying Wang, Yi Wang, Jinxiu Shi, Wei Huang （通讯作者） Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population. PLoS ONE 2011 6(6):1-3
Xun Chu, Chun-Ming Pan, Shuang-Xia Zhao, Jun Liang, Qing Su, Yong-De Peng, Jia-Jun Zhao, Guang Ning, Zhu Chen, Jia-Lun Chen, Sai-Juan Chen, Wei Huang, Huai-Dong Song A genome-wide association study identifies two new risk loci for Graves’ disease. Nature Genetics 2011 43: 897-902
Bin Cui, Xiaolin Zhu, Min Xu, Ting Guo, Dalong Zhu, Gang Chen, Xuejun Li, Lingyan Xu, Yufang Bi, Yuhong Chen, Yu Xu, Xiaoying Li, Weiqing Wang, Haifeng Wang, Wei Huang （通讯作者）, Guang Ning Functional Evaluation of Genetic and A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese. PLoS ONE 2011 6(7):1-4
Dazhi Wang., Zhengwen Jiang., Zhongyang Shen., Hui Wang, Beilan Wang, Weihua Shou, Hong Zheng, Xun Chu, Jinxiu Shi, Wei Huang （通讯作者） Functional Evaluation of Genetic and Environmental Regulators of P450 mRNA Levels. PLoS ONE 2011 6(10):1-4
Ying Wang, Wenqing Fu, Fang Xie, Yi Wang, Xun Chu, Haifeng Wang, Min Shen, Ying Wang, Yi Wang, Weiwei Sun, Rong Lei, Lin Yang, Hong Wu, Jianee Foo, Jianjun Liu, Li Jin and Wei Huang. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. Journal of Human Genetics 2010 2010:1–5
Zhenmin Niu, Rong Lei, Jinxiu Shi, Dazhi Wang, Weihua Shou, Zhimin Wang, Yi Wang, Zhiqin Wang, Wei Huang. （通讯作者） Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene A polymorphism rs** in the PSMD7 gene is associated with ankylosing spondylitis in Chinese subjects. Annals of Rheumatic Diseasess 2010 7:1–2
Zhimin Wang,Yanping Li, Beilan Wang, Yungang He, Yi Wang, Huifeng Xi, Yifeng Li, Ying Wang, Ying Wang, Dingliang Zhu, Jianzhong Jin, Wei Huang （通讯作者）, and Li Jin. A Haplotype of the Catalase Gene Confers an Increased Risk of Essential Hypertension in Chinese Han. Human Mutation 2010 31(3):272–278
X Chu, C Dong, R Lei, L Sun, Z Wang, Y Dong, M Shen, Y Wang, B Wang, K Zhang, L Yang, Y Li, W Yuan, Y Wang, H Song, L Jin, M Xiong,W Huang. （通讯作者） Polymorphisms in the interleukin 3 gene show strong association with susceptibility to Graves' disease in Chinese population. Genes and Immunity 2009 10(3):260-266.
Shi Jinxiu, Wang Ying,Huang Wei. （通讯作者） Development and application of genotyping technologies. Sci China Ser C-Life Sci 2009 52:17-23
Xun Chu, Yan Dong, Min Shen, Lingling Sun, Changzheng Dong, Yi Wang, Beilan Wang, Kaiyue Zhang, Qi Hua, Shijie Xu, Wei Huang. （通讯作者） Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence. BMC Medical Genetics 2009
Ji Qian, Jianying Jing, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Haijian Wang, Rui Li, Weiwei Fan, Yu An, Weiwei Sun, Yi Wang, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang （通讯作者）, Daru Lu. Association between polymorphisms in the GSTA4 gene and risk of lung cancer: A case-control study in a Southeastern Chinese population Mol Carcinog. 2009 48(3):253-259
王莹,黄薇。 （通讯作者） 儿童自闭症的遗传学研究进展。 国际遗传学杂志 2009 2009年 第32卷 第5期, 366-371.
Shao M, Ma H, Wang Y, Xu L, Yuan J, Wang Y, Hu Z, Yang L, Wang F, Liu H, Qian J, Xun P, Chen W, Yuan W, Jing G, Chen F, Jin L, Wei Q, Wu T, Shen H, Huang W （通讯作者）, Lu D. Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. Lung Cancer 2008 60(3):332-9
施锦绣,王莹,黄薇。 （通讯作者） 基因组分型技术的发展和应用。 中国科学C辑： 生命科学 2008 第38卷 第10期 900-906
Aijun Sun, Huili Ma, Xueying Chen, Ying Wang, Yeming Fang, Yongli Ma, Keqiang Wang, Yunzeng Zou, Wei Huang （通讯作者）, Junbo Ge. Association of Fibrinogen and fibrinogen gene β148 and β854 Polymorphisms with Coronary Heart Disease. Cardiology 2008 111(3):167-170
Yu An, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Rui Li, Haijian Wang, Ji Qian, Weiwei Sun, Yi Wang, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang and Daru Lu. （通讯作者） Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer 2008 59(2):164-170.
Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, Fan W, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W （通讯作者）, Lu D. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Biomarkers 2008 13(6):607-17
Changzheng Dong, Xun Chu, Ying Wang, Yi Wang, Li Jin, Tieliu Shi, Wei Huang （通讯作者）, and Yixue Li. Exploration of gene–gene interaction effects using entropy-based methods. European Journal of Human Genetics 2008 16(2):229-235
Dan Chen, Guangfu Jin, Ying Wang, Haifeng Wang , Hongliang Liu, Yanhong Liu, Weiwei Fan, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Weiwei Sun, Ji Qian, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang （通讯作者）, Daru Lu. Genetic variants in peroxisome proliferator-activated receptor-γ gene are associated with risk of lung cancer in a Chinese population. Carcinogenesis 2008 29(2):342-350
Hongliang Liu, Guangfu Jin, Haifeng Wang, Wenting Wu, Yanhong Liu, Ji Qian, Weiwei Fan, Hongxia Ma, Ruifen Miao, Zhibin Hu, Weiwei Sun, Yi Wang, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang （通讯作者）, Daru Lu. Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population. Lung Cancer 2008 61:21—29
Yu An, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Rui Li, Haijian Wang, Ji Qian, Weiwei Sun, Yi Wang, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang and Daru Lu. （通讯作者） Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer 2008 59(2):164-170.
Zhibin Hu, Hongliang Liu, Haifeng Wang, RuifenMiao, Weiwei Sun, Guangfu Jin,Ying Wang, HongxiaMa, Li Jin, Qingyi Wei, Daru Lu, Wei Huang （通讯作者）, and Hongbing Shen. Tagging Single Nucleotide Polymorphisms in Phosphoinositide-3-Kinase-Related Protein Kinase Genes Involved in DNA Damage‘‘Checkpoints’’and Lung Cancer Susceptibility. Clin Cancer Res 2008 14(9):2887-2891