导师姓名： 刘峰 专业代码： 071000
性别： 男 专业名称： 生物学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海交通大学医学院附属瑞金医院上海瑞金二路197，科技楼401室
邮编： 200025 邮箱地址： fliu1978@126.com

研究方向 (点击浏览详细信息)
肿瘤表观基因组学

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 利用高通量单细胞RNA测序解析慢性粒单核细胞白血病特异分子标记物 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 急性髓系表观基因组重组与地西他滨作用机制研究 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
上海市**** 白血病表观基因组学研究 上海市高校**** 2017-09~2020-08 100万元 课题负责人
17PJ** 急性髓系白血病表观基因组重组的分子机理研究 上海市浦江人才计划 2017-07~2019-06 20万元 课题负责人
** 白血病表观基因组重组机制研究 上海交通大学医学院高峰高原计划 2017-07~2020-06 100万元 课题负责人
2017年度双**** 白血病表观基因组学研究 上海交通大学医学院临床专职科研队伍 2017-01~2020-12 100万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang X, Tan Y, Ling Y, Lu G, Liu F （共同第一作者）, Yi Z, Jia X, Wu M, Shi B, Xu S, Chen J, Wang W, Chen B, Jiang L, Yu S, Lu J, Wang J, Xu M, Yuan Z, Zhang Q, Zhang X, Zhao G, Wang S, Chen S, Lu H. Viral and host factors related to the clinical outcome of COVID-19 Nature 2020 583(7816):437-440
Zhang X*, Li T*, Liu F* （共同第一作者）, Chen Y*, Li Z, Huang Y , Wang J. Comparative analysis of droplet-based ultra-high-throughput single-cell RNA-seq systems Molecular Cell 2019 Jan 3;73(1):130-142.e5.
Xu PP, Fu D, Li JY, Hu JD, Wang X, Zhou JF, Yu H, Zhao X, Huang YH, Jiang L, Liu F, Su LP, Chen ZW, Zeng QS, Chen JP, Fang MY, Ma J, Liu T, Song YP, Yu K, Li Y, Qiu LG, Chen XQ, Gu J, Yan JS, Hou M, Huang HY, Wang L, Cheng S, Shen Y, Xiong H, Chen SJ, Zhao WL. Anthracycline dose optimisation in patients with diffuse large B-cell lymphoma: a multicentre, phase 3, randomised, controlled trial Lancet Haematology 2019 6(6):e328-e337
Chowdhry S*, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS# NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling Nature 2019 569 (7757), 570-575
Liu F （通讯作者）, Mischel PS Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2018 Jan;10(1).
Ji MM, Huang YH, Huang JY, Wang ZF, Fu D, Liu H, Liu F, Leboeuf C, Wang L, Ye J, Lu YM, Janin A, Cheng S, Zhao WL. Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified Haematologica 2018 103(4):679-687
Tang Y, Xiong S, Yu P, Liu F （通讯作者）, Cheng L Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210 Cell Reports 2018 July 31; 24(5): 1355-1362.E3
Ma Z, Wang H, Cai Y, Wang H, Niu K, Wu X, Ma H, Yang Y, Tong W, Liu F, Liu Z, Zhang Y, Liu R, Zhu ZJ, Liu N Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity Elife 2018 May 29;7
Ji MM, Huang YH, Huang JY, Wang ZF, Fu D, Liu H, Liu F, Leboeuf C, Wang L, Ye J, Lu YM, Janin A, Cheng S, Zhao WL Histone Modifier Gene Mutations in Peripheral T-cell Lymphoma Not Otherwise Specified Haematologica 2018 Apr;103(4):679-687
Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S, Hu B, Cheng SY, Feng H TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3 Cancer Research 2018 Apr 1;78(7):1792-1804
Liu F （通讯作者） Enhancer-derived RNA: A Primer. Genomics, Proteomics & Bioinformatics 2017 pii: S1672-0229(17)30076-1.
Liu F. （通讯作者） Genomic Regulation of microRNA Expression in Development and Disease Bioinformatics in MicroRNA Research 2017 Volume 1617 of the series Methods in Molecular Biology pp 159-167.
Liu F, Mischel PS, Cavenee WK. Precision Cancer Therapy is Impacted by Oncogene-dependent Epigenome Remodeling npj Precision Oncology 2017 March 20. doi:10.1038/s41698-017-0005-2.
Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB Glioblastoma Cellular Crosstalk Converges on NF-kB to Attenuate EGFR Inhibitor Sensitivity Genes & Development 2017 Jun 15;31(12):1212-1227
Villa GR, Hulce JJ, Zanca C, Ikegami S, Cahill GL, Gu Y, Bi J, Masui K, Yang H, Rong X, Hong C, Turner K, Liu F, Hon GC, Armando AM, Quehenberger O, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shaiu AK, Cravatt BF, Mischel PS. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers Cancer Cell 2016 Nov 14;30(5):683-693.
Liu F （共同第一作者）, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CB, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK,, Ren B, Mischel PS. EGFR mutation promotes Glioblastoma through epigenome and transcription factor network remodeling Molecular Cell 2015 60(2):307-318
Liu F, and Posakony, JW. An enhancer composed of interlocking sub-modules controls transcriptional autoregulation of Suppressor of Hairless Developmental Cell 2014 14;29(1):88-101.
Zheng D, Yang G, Li X, Wang Z, Liu F, He L. An efficient algorithm for computing attractors of synchronous and asynchronous Boolean networks. PLoS ONE 2013 8(4): e60593.
Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, Mellinghoff IK, Cavenee WK, Shaw RJ, Mischel PS. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metabolism 2013 18(5):726-39.
Rebeiz M, Castro B, Liu F, Yue F, Posakony JW. Ancestral and conserved cis-regulatory architecture in developmental control genes Development Biology 2012 362(2):282-94.
Liu F, Posakony JW. Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules PLoS Genetics 2012 8(7): e**
Lee Y, Liu F （共同第一作者）, Segil N. A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development Development 2006 133(15):2817-26
Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nature Cell Biology 2003 5(5):422-6.