导师姓名： 张欣欣 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 传染病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zhangxinxinrj@163.com上海市瑞金二路197号瑞金医院感染科
邮编： 200025 邮箱地址： xin-xin-zhang@163.com

研究方向 (点击浏览详细信息)
病毒性肝炎诊断治疗及发病机制的研究

社会任职
中华医学会肝脏病学分会常委兼副秘书长
中国病毒病杂志编委
上海医学病毒学分会前任主任委员
中华肝脏病杂志编委
中华传染病杂志编委
J of Hepatology Editorial Board member（2015-2018）
法国科学院中法基金会博士后俱乐部前任主席
上海医学会肝病学分会顾问
中华医学会微生物与免疫分会常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 乙型肝炎病毒特定突变通过TLR2信号通路异常活化介导感染慢性化及其机制研究 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
2018ZX**-001-003 乙肝抗病毒治疗过程中临床终点事件精准预测体系的建立 国家十三五科技重大专项 2018-01~2020-12 222.76万元 子课题负责人
2017ZX**-001-003 提高HBeAg阳性慢乙肝临床治愈率新方案的研究 国家十三五科技重大专项 2017-01~2020-12 60.72万元 子课题负责人
2017ZX**-002-003 提高HBeAg阴性慢乙肝临床治愈率新方案的研究 国家十三五科技重大专项 2017-01~2020-12 64.4万元 子课题负责人
** 乙型肝炎病毒多重突变在急性肝衰竭发病中的作用及其机制的研究 国家自然科学基金 2017-01~2020-12 57万元 课题负责人
SHDC** 提高HBeAg阳性慢性乙型肝炎抗病毒治疗应答率的新方案及预测指标的研究 上海申康医院发展中心(市级医院新兴前沿技术联合攻关项目) 2016-10~2019-10 180万元 课题负责人
** 基于病毒学指标和宿主免疫应答状态的慢性乙型肝炎个体化抗病毒治疗新方案及其机制的研究 上海市科委国际合作课题 2016-07~2019-06 50万元 课题负责人
** 乙型肝炎病毒亚病毒颗粒对抗病毒治疗应答的影响及其机制的研究 国家自然基金委 2014-01~2017-12 70万元 课题负责人
2013ZX** 提高HBeAg阳性慢性乙型肝炎患者HBsAg阴转率抗病毒/免疫治疗新方案的研究 国家十二五重大专项 2013-01~2015-12 64万元 子课题负责人
S2012GR0046 基于糖链生物标志物的疾病早期诊断新技术 国家国际科技合作专项 2012-03~2015-05 20万元 子课题负责人
** 乙型肝炎病毒表面抗原糖基化变异的生物学功能研究 国家自然科学基金 2012－01~2015-12 58万元 课题负责人
2012ZX** 乙型肝炎重症化转归预警预测 国家十二五重大专项 2012－01~2015-12 115万元 子课题负责人
慢性乙型肝炎患者免疫状态评估与分析 中法合作项目 2012-01~2014-12 238万元 课题负责人
11DZ** 乙型肝炎病毒生物信息数据共享平台建设与应用 上海市科委 2012-01~2013-09 25万元 子课题负责人
乙型肝炎病毒包膜蛋白糖基化变异对病毒适应性的影响研究 上海市科委政府间国际科技合作项目 2011-10~2013-09 50万元 课题负责人
** 乙型肝炎病毒准种特性及相互作用对抗病毒疗效影响的研究 国家自然基金委,面上项目 2009-01~2011-12 33万元 课题负责人
2009ZX10004－314 乙型肝炎病毒表型分析技术和耐药监测网络的建立及应用 国家十一五重大专项 2009-01~2011-12 791万元 课题负责人
2008ZX10002－007 影响乙型病毒性肝炎重症化转归的机制研究 国家十一五重大专项 2008-10~2010-12 138万元 子课题负责人
乙型肝炎病毒准种因素与抗病毒疗效关系的研究 上海市科委，国际合作项目 2008-09~2010-09 30万元 课题负责人
08XD** 乙型肝炎病毒变异及耐药机制的研究 上海市科委,学科带头人 2008-07~2010-07 40万元 课题负责人
08GWD08 乙型肝炎病毒表型分析及其耐药机制的研究 上海市卫生局，学科带头人 2008-07~2010-07 30万元 课题负责人
** 丙型肝炎病毒F蛋白在人体抗病毒免疫反应中作用的研究 国家自然基金委,面上项目 2007-01~2009-12 27万元 课题负责人
2005CB523104 乙性肝炎病毒耐药机制的研究 国家科技部,973项目 2005-12~2010-11 150万元 子课题负责人
** 丙性肝炎病毒F蛋白细胞表位及其免疫功能的研究 国家自然基金委,面上项目 2005-01~2007-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wei Huang, Mingjie Wang, Qiming Gong, Demin Yu, Peizhan Chen, Junyu Lin, Yue Han, Yu Su, Lihong Qu, Xinxin Zhang （通讯作者） Comparison of naturally occurring resistance-associated substitutions between 2008 and 2016 in Chinese chronic HCV infected patients Microbial Drug Resistance 2019 25(6):944-950
Zhu MY, Chen PZ, Li J, Yu DM, Huang D, Zhu XJ, Han Y, Chen J, Huang W, Chen YY, Gong QM, Jiang JH, Zhang DH, Zhang Y, Zhang JM, Zhang XX （通讯作者） Serum M2BPGi level is a novel predictive biomarker for the responses to pegylated interferon-α treatment in HBeAg-positive chronic hepatitis B patients. Journal of medical virology 2018 90(4):721-729
Dong Wei, De-Ming Yu, Ming-jie Wang, Dong-hua Zhang, Qi-jian Cheng, Jie-Ming Qu and Xin-xin Zhang Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit Emerging Microbes & Infections 2018 7:171
Mingjie Wang, Qiming Gong, Jiming Zhang, Liang Chen, Zhanqing Zhang, Lungen Lu, Demin Yu, Yue Han, Donghua Zhang, Peizhan Chen, Xiaonan Zhang, Zhenghong Yuan, Jinyan Huang, Xinxin Zhang （通讯作者） Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis. Scientific Report 2017 7:43446
Zhu MY, Zou X, Li Q, Yu DM, Yang ZT, Huang D, Chen J, Gong QM, Zhang DH, Zhang Y, Chen L, Chen PZ, Zhang XX. （通讯作者） A novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis B virus infection. Journal of viral hepatitis 2017 24(7):589-598
Huang D, Sansas B, Jiang JH, Gong QM, Jin GD1, Calais V, Yu DM, Zhu MY, Wei D, Zhang DH, Inchauspé G, Zhang XX （通讯作者）, Zhu R. Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients. Journal of viral hepatitis 2017 24:66–74
Yue Han, Leilei Gu, Jing Liu, Xinhua Li, Mingjie Wang, Qiming Gong, Demin Yu, Zhitao Yang, Donghua Zhang, Huijuan Yang, Zhongliang Shen, Hongguang Zhu, Youhua Xie, Xinxin Zhang （通讯作者） Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B–Related Acute Liver Failure. Journal of Infectious Diseases 2017 215(8):1221-1230
Xia Zou, Ming-Yu Zhu, De-Min Yu, Wei Li, Dong-Hua Zhang, Fei-Jie Lu, Qi-Ming Gong, Feng Liu, Jie-Hong Jiang, Min-Hua Zheng, Atsushi Kuno, Hisashi Narimatsu, Yan Zhang, Xin-Xin Zhang （通讯作者） Serum WFA+-M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection. Liver international 2017 37(1):35-44
Yuan Xue, Ming-Jie Wang, Zhi-Tao Yang, De-Min Yu, Yue Han, Dao Huang, Dong-Hua Zhang, Xin-Xin Zhang （通讯作者） Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant. Emerging microbes & infections 2017 6(3):e15.
Yuan Xue, Ming Jie Wang, Su Yuan Huang, Zhi Tao Yang, De Min Yu, Yue Han, Ming Yu Zhu, Dao Huang, Dong Hua Zhang, Qi Ming Gong, Xin Xin Zhang. （通讯作者） Characteristics of CpG Islands and their quasispecies of full length hepatitis B virus genomes from patients at different phases of infection. SpringerPlus 2016 5(1): 1630
Jie Chen, Dong-Hua Zhang, Cheng-Run Xuc, Ming-Yu Zhu, Zhi-Tao Yang, Qi-Ming Gong, De-Min Yu, Xin-Xin Zhang. （通讯作者） Quantitative hepatitis B surface antigen combined with hepatitis B eantigen as sustained virological response predictors during extendedtherapy with Peginterferon alfa-2a for hepatitis B e antigen-positivechronic hepatitis B. Journal of Clinical Virology 2015 72: 88–94.
Xiaodong Li, Yan Liu, Pan Zhao, Yan Wang, Li Chen, Shaojie Xin, Xin-Xin Zhang （通讯作者）, Dongping Xu. Investigation on drug-resistant mutations of hepatitis B virus (HBV) from 845 nucleos(t)ide analog-na?ve Chinese patients with chronic HBV infection Anti-viral Therapy 2015 doi: 10.3851/IMP2813
Yue Han,Ling Gong,Jia Sheng,Feng Liu,Xin-Hua Li,Li Chen,De-Min Yu,Qi-Ming Gong,Pei Hao,Xin-Xin Zhang （通讯作者） Prediction of Virological Response by Pretreatment Hepatitis B Virus Reverse Transcriptase Quasispecies Heterogeneity: the advantage of using Next Generation Sequencing Clinical Microbiology and Infection 2015 21: 797e1-797e8
Zhi-Tao Yang,Su-Yuan Huang,Li Chen,Feng Liu,Xiao-Hui Cai,Yang-Fan Guo,Ming-Jie Wang,Yue Han,De-Min Yu,Jie-Hong Jiang,Dong-Hua Zhang,Qi-Ming Gong,Guo-Qing Zhang,Guo-Qing Zang,Zhong-Hua Lu,Li-Hua Huang,Xin-Xin Zhang （通讯作者） Characterization of full-length genome of hepatitis B virus quasispecies in serum of patients with different phases of infection Journal of Clinical Microbiology 2015 53(7):203-2214
Li Chen, Qiao-Rong Gan, Dong-Qing Zhang, Lv-Feng Yao, Rong-Sheng Lin, Qing Li, Ming-Hua Lin, De-Min Yu, Xin-Xin Zhang （通讯作者）, Chen Pan. Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in HBeAg-positive chronic hepatitis B patients Clinical Microbiology and Infection 2015 DOI: 10.1016/j.cmi.2015.10.007.
Baosen Jia, Minggao Guo, Gaiyun Li, Demin Yu, Xin-Xin Zhang, Ke LAN, and Qiang Deng. Hepatitis B core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7. Journal of Virology 2015 89(4) :2041-2051.
Dao Huang,Marie Hennequi,Alexei Elvachev,Thierry Menguy,Nathalie Silvestre,DeMing Yu,Yue Han,Geneviève Inchauspé,Xinxin Zhang,Ren Zhu The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China Arch Virol 2015 160:1125–1130
Xin-Hua Li, Qi-Ming Gong, Yun Ling, Chong Huang, De-MinYu, Lei-Lei Gu, Xiang-Wei Liao, Dong-Hua Zhang, Xi-Qi Hu, Yue Han, Xiao-Fei Kong, Xin-Xin Zhang. （通讯作者） Inherent lipid metabolic dysfunction in glycogen storage disease type IIIa BBRC 2014 455:90-97
De-Min Yu, Xin-Hua Li, Vannary Mom, Zhong-Hua Lu, Xiang-Wei Liao, Yue Han, Christian Pichoud, Qi-Ming Gong, Dong-hua Zhang, Yan Zhang, Paul Deny, Fabien Zoulim, Xin-XinZhang （通讯作者） Contribution of N-Glycosylation Mutations within Hepatitis B Virus Surface Major Hydrophilic Region to Immune Escape J Hepatol 2014 60(3):515-22
Zhihua Qi, Gaiyun Li, Hao Hu, Chunhui Yang, Xiaoming Zhang, Qibin Leng, Youhua Xie, Demin Yu, Xin-Xin Zhang, Yueqiu Gao, Ke LAN, and Qiang Deng Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice J Virol. 2014 88(14):8045- 8056
Feng Liu,De-Min Yu,Su-Yuan Huang,Jia-Lun Yu,Dong-Hua Zhang,Qi-Ming Gong,Xin-Xin Zhang. （通讯作者） Clinical Implications of Evolutionary Patterns of Homologous, Full-Length Hepatitis B Virus Quasispecies in Different Hosts after Perinatal Infection Journal of Clinical Microbiology 2014 52(5):1556–1565
Lei-Lei Gu, Xin-Hua Li, Yue Han, Dong-Hua Zhang, Qi-Ming Gong, Xin-Xin Zhang （通讯作者） A novel homozygous no-stop mutation in G6PC gene from a Chinese patient with glycogen storage disease type Ia Gene 2014 536 :362-365
Zhuo Wang, Kai Zhu, Weiya Bai , Baosen Jia, Hao Hu, Dongming Zhou, Xiaoming Zhang, Xinxin Zhang, Youhua Xie, Maryline Mancini-Bourgine, Marie-Louise Michel, Ke Lan, Qiang Deng Adenoviral Delivery of Recombinant Hepatitis B Virus Expressing Foreign Antigenic Epitopes for Immunotherapy of Persistent Viral Infection J Virol. 2014 88(5) : 3004-3015
Zhu X, Gong Q, Yu D, Zhang D, Gu L, Han Y, Chen J, Zhang Y, Zhang X （通讯作者） Early serum hepatitis B virus large surface protein level: A stronger predictor of virological response to peginterferon alfa-2a than that to entecavir in HBeAg-positive patients with chronic hepatitis B. J Clin Virol 2013 29 : 123-126.
Xiao-Fei Kong, Yue Han, Xin-Hua Li, De-Yong Gao, Xin-Xin Zhang （通讯作者）, Qi-Ming Gong. Recurrent porphyria attacks in a Chinese patient with a heterozygous PBGD mutation Gene 2013 524:401-402
Xiaonan Zhang; Zhanqing Zhang; Fahui Dai; Bisheng Shi; Liang Chen; Xinxin Zhang; Guoqing Zang; Jiming Zhang; Xiaorong Chen; Fangxing Qian; Yunwen Hu; Zhenghong Yuan Comparison of circulating messenger RNA and microRNA as biomarkers for hepatitis B and C virus induced liver disease Plos One 2013 18 (3) :92112-92114
Valeria Cento1, Carmen Mirabelli1, Salvatore Dimonte1, Romina Salpini1, Yue Han, Pascale Trimoulet, Ada Bertoli, Valeria Micheli, Guido Gubertini, Giuseppina Cappiello, Alberto Spanò, Roberta Longo,Martina Bernassola, Francesco Mazzotta, Giuseppe Maria De Overlapping structure of HBV genome and immune selection pressure are are critical forces modulating HBV evolution Journal of General Virology 2013 94:143-149
Ling Gong, Yue Han, Li Chen, Feng Liu, Pei Hao, Jia Sheng, Xin-Hua Li, De-Min Yu, Qi-Ming Gong, Fei Tian, Xiao-kui Guo, Xin-Xin Zhang （通讯作者） Comparison of Next-Generation Sequencing and Clone-Based Sequencing in Analysis of Hepatitis B Virus Reverse Transcriptase Quasispecies Heterogeneity J Clinical Microbiol 2013 51 (12) :4087-4094
Dongning Du, Xuejuan Zhu, Atsushi Kuno, Atsushi Matsuda, Chikayuki Tsuruno, Demin Yu, Yan Zhang, Yuzuru Ikehara, Yasuhito Tanaka, Xinxin Zhang （通讯作者）, Hisashi Narimatsu. Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels Clinica Chimica Acta 2012 413:1796-1799.
Xiaonan Zhang, Cuncun Chen, Min Wu, Liang Chen, Jiming Zhang, Xinxin Zhang （通讯作者）, Zhanqin Zhang, Jingdi Wu, Jiefei Wang, Xiaorong Chen, Tao Huang, Lixiang Chen, Zhenghong Yuan. Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients. Antiviral Therapy 2012 17:1243-1253
LING Yun,LIAO Xiang-Wei,LI Xin-Hua,HAN Yue,YANG Zhi-Tao,KONG Xiao-Fei,GU Lei-Lei,YU De-Ming,YAO Bi-Lian,ZHANG Dong-Hua,JIN Gen-Di,GONG Qi-Ming,ZHANG Xin-Xin （通讯作者） Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population. Journal of Microbes and lnfecions 2012 7(1):18-27
Xin-Hua Li,Yi Lu,Yun Ling,Qing-Chun Fu,Jie Xu,Guo-Qing Zang,Feng Zhou,De-Min Yu,Yue Han,Dong-Hua Zhang,Qi-Ming Gong,Zhi-Meng Lu,Xiao-Fei Kong,Jian-She Wang,Xin-Xin Zhang （通讯作者） Clinical and molecular characterization of Wilson's disease in China: identification of 14 novel mutations BioMedCentral medical genetics 2011 11;12(1):6
Xiang-wei Liao,Yun Ling,Xin-hua Li,Yue Han,Shen-ying Zhang,Lei-lei Gu,De-ming Yu,Chong Huang,Qin Zhan,Gen-di Jin,Zhi-meng Lu,Qi-ming Gong,Xin-xin Zhang （通讯作者） Association study of genetic variation in IL28B with the hepatitis C treatment-induced viral clearance in Chinese Han population Antiviral Therapy 2011 16：141－147
Feng Liu,Li Chen,De-Min Yu,Lin Deng,Rong Chen,Yin Jiang,Liang Chen, Su-Yuan Huang,Qi-Ming Gong,Xin-Xin Zhang （通讯作者） Evolutionary Patterns of Hepatitis B Virus Quasispecies under Different Selective Pressures: Correlation with Antiviral Efficacy Gut 2011 60:1269-1277
Valentina Svichera,aleria Centoa, Romina Salpinia, Fabio Mercurioa, Maria Frauneb,Bastian Beggelb, Yue Hanc, Caterina Gorid, Linda Wittkope, Ada Bertoli f, Valeria Michelig,Guido Gubertinig, Roberta Longoh, Sara Romanoh, Michela Viscah, Valentina Gallinar Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development Digestive and Liver Disease 2011 43:975-983
Xuan-Yi Wang,Xin-Xin Zhang,Xin Yao,Jie-Hong Jiang,You-Hua Xie,Zheng-Hong Yuan,Yu-Mei Wen Serum HBeAg sero-conversion correlated with decrease of HBsAg and HBV DNA in chronic hepatitis B patients treated with a therapeutic vaccine Vaccine 2010 28：8169-8174
De-Yong Gao,Gen-Di Jin,Bi-Lian Yao,Dong-Hua Zhang,Lei-Lei Gu,Zhi-Meng Lu,Qiming Gong,Yu-Chun Lone,Qiang Deng,Xin-Xin Zhang （通讯作者） Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection PloS ONE 2010 5(12),e 14237
Xiao-Fei Kong, Michael Ciancanelli, Sami Al-Hajjar, Laia Alsina, Timothy Zumwalt, Jacinta Bustamante, Jacqueline Feinberg, Magali Audry, Carolina Prando, Vanessa Bryant1, Alexandra Kreins, Dusan Bogunovic, Rabih Halwani, Xin-Xin Zhang, Laurent Abel, Damie A novel form of human STAT1 deficiency impairing early but not late responses to interferons Blood 2010 116:5895-5906
HAN Yue, HUANG Li Hua, LIU Chuan Miao, YANG Shu, LI Juan, LIN Zhi Mei, KONG Xiao Fei, YU De Min, ZHANG Dong Hua, JIN Gen Di, LU Zhi Meng, GONG Qi Ming, ZHANG Xin Xin （通讯作者） Sequence analysis of Hepatitis B virus reverse transcriptase in treatment na?ve patients. J Gastroenterolgy & Hepatology 2009 24:1417-1423.
Jia Jidong,Hong Ma,Wei Lai,Zhang XinXin,Mao Yuan Li,Wang LanLan,Gao Zhiliang,Hou Jinlin,Zhang Jun Multicentre evaluation of the Elecsys? HBsAg II assay for detection of HBsAg in comparison with other commercially available assays Med Microbiol Immunol 2009 198: 263-269
GONG Qi-Ming, Kong Xiao-Fei, Yang Zhi-Tao, Xu Jie, Wang Lin, Li Xin-Hua, Jin Gen-Di, Gao Jian, Zhang Dong-Hua, Jiang Jie-Hong, Lu Zhi-Meng, ZHANG Xin-Xin. （通讯作者） Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. J Viral Hepatitis 2009 16:674-680.
Li Chen, Qian Zhang, De-min Yu, Mo-bin Wan, Xin-xin Zhang （通讯作者） Early changes of hepatitis B virus quasispecies during lamivudine treatment and its prediction for antiviral efficacy. J Hepatology 2009 50:895-905.
Xiao-Fei Kong,Michael Ciancanelli1, Sami Al-Hajjar,Laia Alsina,Timothy Zumwalt,Jacinta Bustamante,Jacqueline Feinberg,Magali Audry,Carolina Prando, Vanessa Bryant,Alexandra Kreins,Dusan Bogunovic,Xin-Xin Zhang,Laurent Abel,Damien Chaussabel,Saleh Al-Muhse A novel form of cell type-specific partial IFN-γR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon Human Molecular Genetics 2009
De-Yong Gao, Xin-Xin Zhang （通讯作者）, Gang Hou, Gen-Di Jin, Qiang Deng, Xiao-Fei Kong, Dong-Hua Zhang, Yun Ling, De-Min Yu, Qi-Ming Gong, Qin Zhan, Bi-Lian Yao and Zhi-Meng Lu. Assessment of specific antibodies to F protein in sera of Chinese hepatitis C patients treated with interferon plus ribavarin. J Clinical Microbiology 2008 46(11):3746-3751
Zhi-Tao Yang, Xin-Xin Zhang （通讯作者）, Xiao-Fei Kong, Dong-Hua Zhang, Shen-Ying Zhang, Jie-Hong Jiang, Qi-Ming Gong, Gen-Di Jin, Zhi-Meng Lu. Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus infected patients. World J Gastroenterology 2008 14(35):5454-5460.
Xiao-Fei Kong, Jing Ye, De-Yong Gao, Qi-Ming Gong, Dong-Hua, Zhang, Zhi-Meng Lu, Yi-Ming Lu, Xin-Xin Zhang （通讯作者） Identification of a Ferrochelatase Mutation in a Chinese Family with Erythropoietic Protoporphyria. .J Hepatology 2008 48:375-379
Kong XF, Zhang XX （通讯作者）, Gong QM, Gao J, Zhang SY, Wang L, Xu J, Han Y, Jin GD, Jiang JH, Zhang DH, Lu ZM MxA Induction May Predict Sustained Virologic Responses of Chronic Hepatitis B Patients with IFN-alpha Treatment. J Interferon Cytokine Research 2007 27(9):809-818
Shen-Ying Zhang, E Jouanguy, S Ugolini, A Smahi, G Elain, P Romero, D Segal, V Sancho-Shimizu, L Lorenzo, A Puel, C Picard, A Chapgier, S Plancoulaine, M Titeux, C Cognet, H von Bernuth, CL Ku, A Casrouge, Xin-Xin Zhang, L Barreiro, J Leonard, C Hamilton TLR3 Deficiency in Patients with Herpes Simplex Encephalitis Science 2007 317:1522-1527
Kong XF, Zhang XX （通讯作者）, Yu YY,Ying-Yan Yu, Qing Shi, Duan-Duan La, Chuan-De Zhu-Ge, Lin Deng, Qi-Ming Gong, Bai-Yong Shen, Cheng-Hong Peng,Hong-Wei Li No mutation was found in the alpha-subunit of the mitochondrial trifunctional protein in one patient of severe acute fatty liver of pregnancy and her relatives Journal of Gastroenterology and Hepatology 2006 22(12):2107-11