导师姓名： 周丽斌 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： libin_zhou@yahoo.com

研究方向 (点击浏览详细信息)
2型糖尿病和肥胖

社会任职
陈家伦主编《临床内分泌学》：学术秘书
《中华内分泌代谢杂志》、《生命的化学》、《Cell Death Disease》、《Aging》、《Oxid Med Cell Longev》、《Cell Mol Biol Letters》、《BBA-Molecular Basis of Disease》、《J Endocrinol》、《J Diabetes》、《PLoS One》、《Int J Biochem Cell Biol》等杂志特邀审稿专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SIRT3调节胰岛功能的机制研究 国家自然科学基金项目 2018-01~2021-01 64.8万元 课题负责人
** TPH1在葡萄糖诱导胰岛β细胞功能代偿中的作用研究 国家自然科学基金项目 2015-01~2018-12 73万元 课题负责人
** 蛋白乙酰化在CREB胰岛β细胞保护作用中的机制研究 国家自然科学基金项目 2013-01~2016-12 70万元 课题负责人
2011-278 tff3在妊娠胰岛β细胞代偿性增殖中的作用研究 上海市卫生局 2012-01~2014-12 3万元 课题负责人
** SIRT1对抗β细胞脂毒性的机制研究 国家自然科学基金项目 2011-01~2013-12 30万元 课题负责人
06BZ024 小檗碱调控调糖脂代谢的分子机制 上海市教委科研资助项目 2007-01~2009-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhu K, Zhang Y, Zhang J, Zhou F, Zhang L, Wang S, Zhu Q, Liu Q, Wang X, Zhou L. （通讯作者） Acetylation of Hsp90 reverses dexamethasone-mediated inhibition of insulin secretion Toxicol Lett 2020 2020, 320:19-27
Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L （通讯作者）, Wang X. Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling Theranostics 2020 2020,10(16):7351-7368
Zhang Y, Li M, Wang Y, Liu X, Zhou L （通讯作者）, Zhang C, Shao L. Histone deacetylase inhibition by MS-275 potentiates glucose-stimulated insulin secretion without affecting glucose oxidation Life Sci 2020 2020, 257:118073
Ji X, Wang S, Tang H, Zhang Y, Zhou F, Zhang L, Zhu Q, Zhu K, Liu Q, Liu Y, Wang X, Zhou L （通讯作者） PPP1R3C mediates metformin-inhibited hepatic gluconeogenesis. Metabolism 2019 98(9):62-75
Zhang Q, Zhu Q, Ruyuan D, Zhou F, Zhang L, Wang S, Zhu K, Xiao W, Libin Z （通讯作者）, Su Q MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal. J Mol Endocrinol 2019 62(4):187-196
Ji X, Zhou F, Zhang Y, Deng R, Xu W, Bai M, Liu Y, Shao L, Wang X, Zhou L （通讯作者） Butyrate stimulates hepatic gluconeogenesis in mouse primary hepatocytes. Exp Ther Med 2019 17(3):1677-1687
Zhang Y, Zhou F, Bai M, Liu Y, Zhang L, Zhu Q, Bi Y, Ning G, Zhou L （通讯作者）, Wang X The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to β-cell function Cell Death Dis 2019 10(2):66.
Zhu Q, Guo W, Zhang S, Feng Y, Wang X, Zhou L （通讯作者）, Huang GR Synergistic effect of PCPE1 and sFRP2 on the processing of procollagens via BMP1. FEBS Lett 2019 593(1):119-127
Zhang L, Bai M, Tang H, Zhou F, Zhu Q, Wang S, Zhu K, Liu Q, Liu Y, Wang X, Ma Y, Zhou L （通讯作者） Role of hepatic neuregulin 4 in the regulation of gluconeogenesis in mice. Life Sci 2019 217:185-192
Bai M, Liu Y, Zhou F, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Wang X, Zhou L （通讯作者） Berberine inhibits glucose oxidation and insulin secretion in rat islets. Endocr J 2018 65(4):469-477
Zhou F, Bai M, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Liu Y, Wang X, Zhou （通讯作者） Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77. Biochem Biophys Res Commun 2018 495(2):1936-1941
Wang Y, Tang H, Ji X, Zhang Y, Xu W, Yang X, Deng R, Liu Y, Li F, Wang X, Zhou L （通讯作者） Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes Int J Mol Med 2018 41(1):302-310
Zhang Y, Deng R, Yang X, Xu W, Liu Y, Li F, Zhang J, Tang H, Ji X, Bi Y, Wang X, Zhou L （通讯作者）, Ning G Glucose potentiates β-cell function by inducing Tph1 expression in rat islets FASEB J 2017 31(12):5342-5355
Xu W, Zhang Y, Bai M, Zhou F, Deng R, Ji X, Zhang J, Liu Y, Zhou L （通讯作者）, Wang X Glucose enhances rat islet function via stimulating CART expression Biochem Biophys Res Commun 2016 481(1-2):84-89
Yang X, Zhang Y, Xu W, Deng R, Liu Y, Li F, Wang Y, Ji X, Bai M, Zhou F, Zhou L （通讯作者）, Wang X Potential role of Hsp90 in rat islet function under the condition of high glucose Acta Diabetol 2016 53(4):621-628
Zhang J, Tang H, Deng R, Wang N, Zhang Y, Wang Y, Liu Y, Li F, Wang X, Zhou L （通讯作者） Berberine Suppresses Adipocyte Differentiation via Decreasing CREB Transcriptional Activity PLoS One 2015 2015,10(4):e**
Sun Y, Zhang Y, Li N, Zhang H, Zhou L （通讯作者）, Shao L Exposure to high levels of glucose increases the expression levels of genes involved in cholesterol Exp Ther Med 2014 2014, 8(3):991-997
Hu H, Sun W, Yu S, Hong X, Qian W, Tang B, Wang D, Yang L, Wang J, Mao C, Zhou L, Yuan G. Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients Diabetes Care 2014 2014,37(10):2718-2722
Deng R, Nie A, Jian F, Liu Y, Tang H, Zhang J, Zhang Y, Shao L, Li F, Zhou L （通讯作者）, Wang X, Ning G Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK. Biochim Biophys Acta 2014 1840(1):577-85
Zhang J, Tang H, Zhang Y, Deng R, Shao L, Liu Y, Li F, Wang X, Zhou L （通讯作者） Identification of suitable reference genes for quantitative RT-PCR during 3T3-L1 adipocyte Int J Mol Med 2014 2014, 33(5):1209-1218
Wu L, Zhou L （共同第一作者）, Lu Y, Zhang J, Jian F, Liu Y, Li F, Li W, Wang X, Li G. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction BBA-Molecular Basis of Disease 2012 1822(11):1815-1825.
Zhou L （共同第一作者）, Wang X, Yang Y, Wu L, Li F, Zhang R, Yuan G, Wang N, Chen M, Ning G Berberine inhibits cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes BBA-Molecular Basis of Disease 2011 1812(4):527–535
Zhou Libin （共同第一作者）, Wang Xiao, Shao Li, Yang Ying, Shang Wenbin, Yuan Guoyue, Jiang Boren, Li Fengying, Tang Jinfeng, Jing Hua, Chen Mingdao Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway Endocrinology 2008 149(9):4510-4518
Shang W, Yang Y, Zhou L, Jiang B, Jin H, Chen M Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes J Endocrinol 2008 198（3）:561-569
Yang Y, Zhou L （共同第一作者）, Gu Y, Zhang Y, Tang J, Li F, Shang W, Jiang B, Yue X, Chen M Dietary chichpea reverses visceral adiposity, dislipidemia and insulin resistance in rats Br J Nutr 2007 98(4):720-726
Yang Y, Shang W, Zhou L, Jiang B, Jin H, Chen M Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells Biochem Biophys Res Commun 2007 353(2):225-230
Wang X, Zhou L （共同第一作者）, Shao L, Qian L, Fu X, Li G, Luo T, Gu Y, Li F, Li J, Zheng S, Luo M Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells Life Sci 2007 81(2)：160-165
Wang X, Zhou L （共同第一作者）, Li G, Luo T, Gu Y, Qian L, Fu X, Li F, Li J, Luo M Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells Biochem Biophys Res Commun 2007 352(2):463-468
Shang W, Yang Y, Jiang B, Jin H, Zhou L, Liu S, Chen M. Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression Life Sci 2007 80(7):618-625
Zhou L （共同第一作者）, Yang Y, Wang X, Liu S, Shang W, Yuan G, Li F, Tang J, Chen M, Chen J Berberine stimulates glucose transport through a mechanism distinct from insulin Metabolism 2007 56(3):405-412
Yuan G, Zhou L （共同第一作者）, Tang J,et al Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity Diabetes Res Clin Pract 2006 72(3):244-250
Yang Y, Zhou LB, Liiu SQ, Tang JF, Li FY, Li RY, Song HD, Chen MD Expression of feeding-related peptide receptors mRNA in GT1-7 cell line and the roles of leptin and orexins in the control of GnRH secretion Acta Pharmacologica Sinica 2005 26(8)：976-981
Yang YS, Song HD, Li RY, Zhou LB, Zhu ZD, Hu RM, Han ZG, Chen JL The gene expression profiling of human visceral adipose tissue and its secretory functions Biochem Biophys Res Commun 2003 300(4):839-846