导师姓名： 聂爱芳 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： afnie@126.com

研究方向 (点击浏览详细信息)
2型糖尿病发病机制及肥胖

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 脂联素通过下丘脑AMPK－mTOR－KATP通路调控能量代谢的机制研究 国家自然基金面上项目 2016-01~2019-12 58万元 课题负责人
** 脂联素改善胰岛β细胞功能的电生理机制研究 国家自然科学基金青年项目 2009-01~2011-12 20万元 课题负责人
2008Y042 脂联素改善胰岛β细胞功能的电生理机制研究 上海市卫生局青年课题 2009-01~2011-12 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Y, Sun J, Ni Q, Nie A, Gu Y, Wang S, Zhang W, Ning G, Wang W, Wang Q. Dual Effect of Raptor on Neonatal β-Cell Proliferation and Identity Maintenance. Diabetes. 2019 68(10):1950-1964
Fu L, Qiu Y, Shen L, Cui C, Wang S, Wang S, Xie Y, Zhao X, Gao X, Ning G, Nie A （通讯作者）, Gu Y. The delayed effects of antibiotics in type 2 diabetes, friend or foe? J Endocrinol. 2018 238(2):137-149.
Xie Y, Cui C, Nie A, Wang Y, Ni Q, Liu Y, Yin Q, Zhang H, Li Y, Wang Q, Gu Y, Ning G. The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress. Biochim Biophys Acta Gen Subj. 2017 1861(8):2039-2047
Ni Q, Gu Y, Xie Y, Yin Q, Zhang H, Nie A, Li W, Wang Y, Ning G, Wang W, Wang Q. Raptor regulates functional maturation of murine beta cells Nat Commun. 2017 8:15755.
Li W, Zhang H, Nie A, Ni Q, Li F, Ning G, Li X, Gu Y, Wang Q. mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice. Endocrine 2016 53(1):117-28
Chang G, Yang R, Cao Y, Nie A, Gu X, Zhang H. SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules. J.Mol.Endocrinol. 2016 56(3):249-59.
Chen M, Wang Z, Zhan M, Liu R, Nie A, Wang J, Ning G, Ma Q. Adiponectin regulates ACTH secretion and the HPAA in an AMPK-dependent manner in pituitary corticotroph cells Mol Cell Endocrinol. 2014 383(1-2):118-25
Deng R, Nie A （共同第一作者）, Jian F, Liu Y, Tang H, Zhang J, Zhang Y, Shao L, Li F, Zhou L, Wang X, Ning G Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK Biochim Biophys Acta. 2014 1840(1):577-585
Ma CJ, Nie AF, Zhang ZJ, Zhang ZG, Du L, Li XY, Ning G. Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism J Endocrinol 2013 216(3):353-62
Luo X, Pan L, Nie A, Wang Q, Gu Y, Li F, Zhang H, Li W, Li X Liraglutide protects pancreatic beta cells during an early intervention in Gato-Kakizaki rats (Gato-Kakizakiβ) J Diabetes. 2013 5(4):421-8
Lu H, Zhu S, Qian L, Xiang D, Zhang W, Nie A, Gao J, Wu M, Gao J, Lu B, Yu Y, Han W, Moldenhauer A Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity Blood 2012 119(21):4868-77
Nie A, Wei C, Meng Z Sodium metabisulfite modulation of potassium channels in pain-sensing dorsal root ganglion neurons Neurochem Res. 2009 34(12):2233-42.
Wen JP, Lv WS, Yang J, Nie AF, Cheng XB, Yang Y, Ge Y, Li XY, Ning G Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential Biochem Biophys Res Commun. 2008 371(4):756-61.
Nie A, Meng Z Sulfur dioxide derivatives modulate Na/Ca exchange currents and cytosolic [Ca2+]i in rat myocytes Biochem Biophys Res Commun. 2007 358(3):879-84
Nie A,Meng Z Modulation of L-type calcium current in rat cardiac myocytes by sulfur dioxide derivatives Food Chem Toxicol 2006 44(3):355-63
Nie A,Meng Z Study of the interaction of sulfur dioxide derivative with cardiac sodium channel Biochim Biophys Acta. 2005 1718(1-2):67-73
Nie A,Meng Z Sulfur dioxide derivative modulation of potassium channels in rat ventricular myocytes Arch Biochem Biophys 2005 442(2):187-95