导师姓名： 谢青 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 传染病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海瑞金二路197号瑞金医院36号楼，感染科
邮编： 200025 邮箱地址： xieqingrjh@163.com

研究方向 (点击浏览详细信息)
药物性肝损伤的发病机制、诊断及干预
肝硬化/肝衰竭免疫发病机制和临床队列研究
病毒性肝炎免疫发病机制与优化治疗

社会任职
中华传染病杂志副总编辑
上海医师协会感染科医师分会会长
中国医师协会感染科医师分会副会长
上海市感染性疾病临床质量控制中心主任
中华医学会感染病分会副主任委员
上海市医学会医疗事故技术鉴定专家库成员
卫生部国家医学继续教育委员会委员
中华医学会肝病学分会病毒性肝炎学组副组长
国家食品药品监督局新药评审中心评审专家
上海市医学会肝病学分会副主任委员
第八届上海医学会感染病分会主任委员
《肝脏》杂志副主编
上海市医学会内科学分会副主任委员
中华医学会感染病分会产科感染与肝病学组组长
上海市医院协会传染病专科医院管理委员会副主任委员
上海市“感染性疾病科临床质量控制中心”主任
中华肝脏病杂志编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
IN-CN-174-5648 Risk of Hepatocellular Carcinoma in Patients Treated with ETV vs TDF for Chronic Hepatitis B with Compensated Cirrhosis Glead Science.Inc 2019-08~2020-09 106.97万元 课题负责人
IN-CN-342-5424 Effectiveness, safety of DAAs therapy in HCV infection: Results from a EAST China real world cohort Glead Science.Inc 2019-01~2020-09 392.28万元 课题负责人
shslczdzk01103 上海市临床重点专科（感染病学-振龙头项目) 上海卫健委 2019-01~2021-12 1089万元 课题负责人
00000 infections and other complications of cirrhosis: a prospective multi-center study 上海交通大学医学院2018年国际及港澳地区国际合作项目 2018-01~2019-12 15万元 课题负责人
** IL-22介导自噬信号通路抑制NLRP3炎性小体活化在药物性肝损伤中发挥肝保护效应的作用及机制研究 国家自然基金（面上） 2018-01~2021-12 56万元 课题负责人
2018ZX**-004 2018ZX**-004 国家科技部十三五重大专项 2018-01~2021-12 80万元 子课题负责人
2017ZX**-005-004 乙型肝炎联合治疗新方案对疾病远期转归的影响 国际科技部十三五重大专项 2017-01~2020-12 107万元 子课题负责人
2017ZX**-008 重型乙型肝炎（肝衰竭）诊治新技术新方案研究-细菌感染诊治对预后转归影响的研究 国家科技部十三五重大专项 2017-01~2020-12 54.48万元 子课题负责人
16CR1002A 应用RGT(Response-GuidedTherapy)策略对HBeAg阳性慢性乙型肝炎患者使用核苷类似物后联合使用聚乙二醇干扰素a-2a的有效性和安全性的前瞻、随机、开放、多中心研究 第一轮促进市级医院临床技能与临床创新三年行动计划 2016-12~2019-06 200万元 课题负责人
** IL-22在药物性肝损中抑制氧应激诱导的炎症反应发挥肝保护效应的作用及机制研究 国家自然基金（面上） 2016-01~2019-10 79.2万元 课题负责人
16 重型乙型肝炎（肝衰竭）临床治疗新方案的研究-规范化抗病毒治疗对重型乙型肝炎长期临床结局的影响及各类并发症早期诊断和干预策略 市人力资源和社会保障局（上海领军人才队伍建设专项资金资助）中期考核优秀追加经费 2015-01~2016-12 15万元 课题负责人
15GWZK0102 上海市公共卫生三年行动计划重点学科建设项目传染病与卫生微生物学 上海市卫计委 2015-01~2017-12 750万元 课题负责人
2014ZX** 中医药联合恩替卡韦治疗乙肝肝硬化的临床研究 “艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项 2014-01~2016-12 77.5万元 子课题负责人
134119a2401 药物性肝损伤临床诊断评分系统的建立和应用 上海市科委（医学引导） 2013-06~2016-06 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiaolin Wang, Lu Chen, Hui Wang*, Wei Cai*, Qing Xie* （通讯作者） Modulation of bile acid profile by gut microbiota in chronic hepatitis B J Cell Mol Med. 2020 24:2573–2581
Fan R, Zhou B, Xu M, Tan D, Niu J, Wang H, Ren H, Chen X, Wang M, Ning Q, Shi G, Sheng J, Tang H, Bai X, Liu S, Lu F, Peng J, Sun J, Xie Q* （通讯作者）, Hou J* Chronic Hepatitis B Study Consortium. Association Between Negative Results From Tests for HBV DNA and RNA and Durability of Response After Discontinuation of Nucles(t)ide Analogue Therapy. Clin Gastroenterol Hepatol. 2020 18(3):719-727
Zhujun Cao, Yuhan Liu, Minghao Cai, Yumin Xu, Xiaogang Xiang, Gangde Zhao, Wei Cai,Hui Wang, Weijing Wang, and Qing Xie （通讯作者） The Use of NACSELD and EASL-CLIF Classification Systems of ACLF in the Prediction of Prognosis in Hospitalized Patients With Cirrhosis Am J Gastroenterol 2020 accept
Zhu-Jun Cao*, Yu-Han Liu*, Chuan-Wu Zhu*, Shan Yin, Wei-Jing Wang, Wei-Liang Tang, Gang-De Zhao, Yu-Min Xu, Lu Chen, Tian-Hui Zhou, Ming-Hao Cai, Hui Wang, Wei Cai, Shi-San Bao*, Hai Li*, Qing Xie* （通讯作者） Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: a retrospective cohort study World J Gastroenterol. 2020 26(6):645-656
Hong-lian Gui#, Chang-qing Zhao#, Yan Wang , Hong-tu Gu , Wei-jing Wang, Wei Cai, Qing Guo , Shi-san Bao , Lie-ming Xu* and Qing Xie* Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis Journal of Clinical and Translational Hepatology 2020 vol. 8: 1–8
Wei Tang,Zhujun Cao, Mingfeng Han, Zhengyan Wang, Junwen Chen, Wenjin Sun, Yaojie Wu, Wei Xiao, Shengyong Liu, Erzhen Chen, Wei Chen, Xiongbiao Wang, Jiuyong Yang, Jun Lin, Qingxia Zhao, Youqin Yan, Zhibin Xie, Dan Li, Yaofeng Yang, Leshan Liu, Jieming Qu, Guang Ning, Guochao Shi, Qing Xie. （通讯作者） Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial BMJ 2020 May 14;369:m1849. doi: 10.1136/bmj.m1849.
Zhujun Cao , Yuhan Liu, Shijin Wang, Xiaobo Lu, Shan Yin, Shaowen Jiang, Liuying Chen, Minghao Cai, Bo Zeng, Yujing Yao, Weiliang Tang, Gangde Zhao, Xiaogang Xiang （通讯作者）, Hui Wang, Wei Cai, Chuanwu Zhu, Hai Li, Qing Xie The Impact of HBV Flare on The Outcome of HBV-related Decompensated Cirrhosis Patients with Bacterial Infection Liver Int.?2019 Oct;39(10):1943-1953 2019 39(10):1943-1953
Fan R,Zhou B,Xu M,Tan D,Niu J,Wang H,Ren H,Chen X,Wang M,Ning Q,Shi G,Sheng J,Tang H,Bai X,Liu S,Lu F,Peng J,Sun J,Xie Q （通讯作者）,Hou J Chronic Hepatitis B Study Consortium.Association Between Negative Results From Tests for HBV DNA and RNA and Durability of Response After Discontinuation of Nucles(t)ide Analogue Therapy Clin Gastroenterol Hepatol 2019 3565(19)30790-6
Yumin Xu, Zhujun Cao, Yezhou Ding , Ziqiang Li, Xiaogang Xiang, Rongtao Lai, Zike Sheng , Yuhan Liu , Wei Cai , Ronggui Hu, Hui Wang and Qing Xie Long Non-coding RNA NEAT1 Alleviates Acute-on-Chronic Liver Failure Through Blocking TRAF6 Mediated Inflammatory Response Frontiers in Physiology 2019 10：1503
Qing Xie, Jian-Wei Xuan, Hong Tang, Xiao-Guang Ye, Peng Xu, I-Heng Lee, Shan-Lian Hu Hepatitis C virus cure with direct acting antivirals: Clinical, economic, societal and patient value for China World J Hepatol 2019 ?11(5): 421-441
Jie Lu?, Yupeng Feng?, Lichang Chen?, Zhengyu Zeng, Xianliang Liu, Wei Cai,Hui Wang, Xiaolei Guo, Huijuan Zhou*, Wanyin Tao* and Qing Xie* Subtype-Specific Prevalence of Hepatitis C Virus NS5A Resistance Associated Substitutions in Mainland China Subtype-Specific Prevalence of Hepatitis C Virus NS5A Resistance Associated Substitutions in Mainland China 2019 10:535
Yumin Xu, Yuhan Liu, Zhujun Cao, LinWanga, Ziqiang Li , Zike Sheng,Wei Cai,Hui Wang, Shisan Bao, Qing Xi （通讯作者） Comparison of FibroTouch and FibroScan for staging fibrosis in chronic liver disease: Single-center prospective study Dig?Liver?Dis 2019 51(9):1323-1329
Xiaogang Xiang, Dechun Feng, Seonghwan Hwang, Tianyi Ren, Xiaolin Wang, Eszter Trojnar, Csaba Matyas, Ruidong Mo, Dabao Shang, Yong He （通讯作者）, Wonhyo Seo, Vijay H. Shah, Pal Pacher, Qing Xie,* Bin Gao* Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming of impaired regeneration pathway J Hepatology, 2019, Nov 29 2019 72(4):736-745
Zhujun Cao; Liwen Chen; Jing Li; Yuhan Liu; Rebecca Bao; Kehui Liu; Lei Yan; Yezhou Ding; Qing Guo; Xiaogang Xiang; Jingdong Xie; Lanyi Lin; Qing Xie; Shisan Bao; Hui Wang Serum keratin-18 fragments as cell death biomarker in association with disease progression and prognosis in cirrhosis with HBV infection. J of viral hepatitis 2019 26(7):835-845
Rui Yu, Deming Tan,Qin Ning, Junqi Niu, Xuefan Bai,Shijun Chen,Jun Cheng,Yanyan Yu,Hao Wang,Min Xu,Guangfeng Shi, Mobin Wan, Xinyue Chen,Hong Tang, Jifang Sheng, Xiaoguang Dou,Junping Shi, Hong Ren,MaorongWang,Hongfei Zhang, Zhiliang Gao,Chengwei Chen, Hong Ma, Jidong Jia, Jinlin Hou （通讯作者）,Qing Xie and Jian Sun Association of baseline vitamin D level with genetic Hepatology Research 2018 48: E213–E221
Tianhui Zhou, Ye Sun, Ming Li, Yongsen Ding, Rongkun Yin, Ziqiang Li, Qing Xie （通讯作者）, Shisan Bao and Wei Cai Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway Cell Death and Disease 2018 9:590
Ruidong Mo, Rongtao Lai1, Jie Lu1, Yan Zhuang, Tianhui Zhou, Shaowen Jiang1, Peipei Ren,Ziqiang Li, Zhujun Cao, Yuhan Liu, Lichang Chen, Lifu Xiong, Peng Wang, Hui Wang, WeiCai, Xiaogang Xiang, Shisan Bao, Qing Xie? （通讯作者） Enhanced autophagy contributes to protective effects of Theranostics 2018 8(15): 4170-4180
Heng Chi, Bettina E. Hansen, Simin Guo, Ning Ping Zhang, Xun Qi, Liang Chen, Qing Guo, Pauline Arends, Ji-Yao Wang, Elke Verhey,Robert J. de Knegt, Qing Xie （通讯作者）, and Harry L. A. Janssen Pegylated Interferon Alfa-2b Add-on Treatment in Hepatitis B Virus Envelope Antigen-Positive Chronic Hepatitis B Patients Treated with Nucleos(t)ide Analogue: A Randomized, Controlled Trial (PEGON) The Journal of Infectious Diseases 2017 215:1085-1093
Lu J, Xiang X, Cao Z, Wang W, Zhao G, Tang W, Chen L, Guo S, Zhuang Y, Shi D, Chen L, Bao S, Cai W, Wang H, Zhou H, Xie Q （通讯作者） Younger trend of cirrhosis incidence in genotype 3 HCV infected patients in Eastern China. J Med Virol 2017 89 (11):1973-1980
Mo R, Wang P, Lai R, Li F, Liu Y, Jiang S, Zhao G, Guo S, Zhou H, Lin L, Lu J, Cai W, Wang H, Yu H, Bao S, Xiang X, Xie Q （通讯作者） Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-related acute-on-chronic liver failure. J Gastroenterol Hepatol 2017 32(3):677-686
Jiang SW, Wang P, Xiang XG, Mo RD, Lin LY, Bao SS, Lu J, Xie Q （通讯作者） Serum soluble ST2 is a promising prognostic biomarker in HBV-related acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int. 2017 Apr;16(2):181-188. Hepatobiliary Pancreat Dis Int 2017 16(2):181-188
Cao Z, Li Z, Wang H, Liu Y, Xu Y, Mo R, Ren P, Chen L, Lu J, Li H, Zhuang Y, Liu Y, Wang X, Zhao G, Tang W, Xiang X, Cai W, Liu L, Bao S, Xie Q. （通讯作者） Algorithm of Golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection Liver Int 2017 37 (11):1612-1621
Cao Z, Li Z, Wang Y, Liu Y, Mo R, Ren P, Chen L, Lu J, Li H, Zhuang Y, Liu Y, Wang X, Zhao G, Tang W, Xiang X, Wang H, Cai W, Liu L, Zhu C, Bao S, Xie Q. （通讯作者） Assessment of serum Golgi protein 73 as a biomarker for the diagnosis of significant fibrosis in patients with chronic HBV infection. J Viral Hepat 2017 Suppl 1:57-65
Liu Y, Yu F, Han Y, Li Q, Cao Z, Xiang X, Jiang S, Wang X, Lu J, Lai R, Wang H, Cai W, Bao S, Xie Q （通讯作者） SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease. Sci Rep 2016 Nov 17, 6:37351. Sci Rep 2016 6:37351
Wang WJ, Lai RT, Lu J, Xiang XG, Zhao GD, Tang WL, Cai W, Wang H, Zhou HJ, Xie Q （通讯作者） Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure J Dig Dis 2016 17 (5):334-339.
Zhuang Y, Li Y, Li X, Xie Q （通讯作者）, Wu M. Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway PLoS One. 2016 11(3):e**